LOCUS       NM_001081097            8977 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus glutamate receptor, ionotropic, kainate 3 (Grik3),
            mRNA.
ACCESSION   NM_001081097 XM_131647
VERSION     NM_001081097.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8977)
  AUTHORS   Ratsika,A., Codagnone,M.G., Bastiaanssen,T.F.S., Hoffmann
            Sarda,F.A., Lynch,C.M.K., Ventura-Silva,A.P., Rosell-Cardona,C.,
            Caputi,V., Stanton,C., Fulling,C., Clarke,G. and Cryan,J.F.
  TITLE     Maternal high-fat diet-induced microbiota changes are associated
            with alterations in embryonic brain metabolites and adolescent
            behaviour
  JOURNAL   Brain Behav Immun 121, 317-330 (2024)
   PUBMED   39032541
REFERENCE   2  (bases 1 to 8977)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 8977)
  AUTHORS   Iida,I., Konno,K., Natsume,R., Abe,M., Watanabe,M., Sakimura,K. and
            Terunuma,M.
  TITLE     Behavioral analysis of kainate receptor KO mice and the role of
            GluK3 subunit in anxiety
  JOURNAL   Sci Rep 14 (1), 4521 (2024)
   PUBMED   38402313
  REMARK    GeneRIF: Behavioral analysis of kainate receptor KO mice and the
            role of GluK3 subunit in anxiety.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8977)
  AUTHORS   Spirkova,A., Kovarikova,V., Sefcikova,Z., Pisko,J., Ksinanova,M.,
            Koppel,J., Fabian,D. and Cikos,S.
  TITLE     Glutamate can act as a signaling molecule in mouse preimplantation
            embryosdagger
  JOURNAL   Biol Reprod 107 (4), 916-927 (2022)
   PUBMED   35746896
REFERENCE   5  (bases 1 to 8977)
  AUTHORS   Pigoni,M., Hsia,H.E., Hartmann,J., Rudan Njavro,J., Shmueli,M.D.,
            Muller,S.A., Guner,G., Tushaus,J., Kuhn,P.H., Kumar,R., Gao,P.,
            Tran,M.L., Ramazanov,B., Blank,B., Hipgrave Ederveen,A.L., Von
            Blume,J., Mulle,C., Gunnersen,J.M., Wuhrer,M., Rammes,G.,
            Busche,M.A., Koeglsperger,T. and Lichtenthaler,S.F.
  TITLE     Seizure protein 6 controls glycosylation and trafficking of kainate
            receptor subunits GluK2 and GluK3
  JOURNAL   EMBO J 39 (15), e103457 (2020)
   PUBMED   32567721
  REMARK    GeneRIF: Seizure protein 6 controls glycosylation and trafficking
            of kainate receptor subunits GluK2 and GluK3.
REFERENCE   6  (bases 1 to 8977)
  AUTHORS   Sinha,S., Maity,S.N., Seldin,M.F. and de Crombrugghe,B.
  TITLE     Chromosomal assignment and tissue expression of CBF-C/NFY-C, the
            third subunit of the mammalian CCAAT-binding factor
  JOURNAL   Genomics 37 (2), 260-263 (1996)
   PUBMED   8921405
REFERENCE   7  (bases 1 to 8977)
  AUTHORS   Janne,P.A., Rochelle,J.M., Martin-DeLeon,P.A., Stambolian,D.,
            Seldin,M.F. and Nussbaum,R.L.
  TITLE     Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b)
            to distal mouse chromosome 4 and its exclusion as a candidate gene
            for dysgenetic lens
  JOURNAL   Genomics 28 (2), 280-285 (1995)
   PUBMED   8530037
REFERENCE   8  (bases 1 to 8977)
  AUTHORS   Duvoisin,R.M., Zhang,C., Hamassaki-Britto,D.E. and Britto,L.R.
  TITLE     Changes in expression of glutamate receptor subunits following
            photoreceptor degeneration in the rd mouse retina
  JOURNAL   Neurosci Lett 183 (1-2), 83-86 (1995)
   PUBMED   7538211
REFERENCE   9  (bases 1 to 8977)
  AUTHORS   Gregor,P., Reeves,R.H., Jabs,E.W., Yang,X., Dackowski,W.,
            Rochelle,J.M., Brown,R.H. Jr., Haines,J.L., O'Hara,B.F., Uhl,G.R.
            et al.
  TITLE     Chromosomal localization of glutamate receptor genes: relationship
            to familial amyotrophic lateral sclerosis and other neurological
            disorders of mice and humans
  JOURNAL   Proc Natl Acad Sci U S A 90 (7), 3053-3057 (1993)
   PUBMED   8464923
REFERENCE   10 (bases 1 to 8977)
  AUTHORS   Sakimura,K., Morita,T., Kushiya,E. and Mishina,M.
  TITLE     Primary structure and expression of the gamma 2 subunit of the
            glutamate receptor channel selective for kainate
  JOURNAL   Neuron 8 (2), 267-274 (1992)
   PUBMED   1310861
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL627328.17 and AL607090.12.
            
            On Jun 20, 2019 this sequence version replaced NM_001081097.2.
            
            Summary: Glutamate receptors are the predominant excitatory
            neurotransmitter receptors in the mammalian brain and are activated
            in a variety of normal neurophysiologic processes. This gene
            product belongs to the kainate family of glutamate receptors, which
            are composed of four subunits and function as ligand-activated ion
            channels. Transcript variants encoding different isoforms have been
            described for this gene, however, their full-length nature is not
            known. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data from rat
            and human.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC118004.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AL627328.17        132163-132412
            251-427             AL607090.12        37454-37630
            428-685             AL607090.12        46241-46498
            686-867             AL607090.12        53254-53435
            868-921             AL607090.12        55517-55570
            922-1095            AL607090.12        63652-63825
            1096-1239           AL607090.12        64421-64564
            1240-1347           AL607090.12        70261-70368
            1348-1461           AL607090.12        73662-73775
            1462-1665           AL607090.12        84526-84729
            1666-1889           AL607090.12        99967-100190
            1890-2008           AL607090.12        105068-105186
            2009-2226           AL607090.12        107935-108152
            2227-2449           AL607090.12        118306-118528
            2450-2700           AL607090.12        118928-119178
            2701-8977           AL607090.12        121870-128146
FEATURES             Location/Qualifiers
     source          1..8977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 58.91 cM"
     gene            1..8977
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /note="glutamate receptor, ionotropic, kainate 3"
                     /db_xref="GeneID:14807"
                     /db_xref="MGI:MGI:95816"
     exon            1..250
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..2895
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /note="glutamate receptor 7"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, kainate 3
                     precursor"
                     /protein_id="NP_001074566.1"
                     /db_xref="CCDS:CCDS38878.1"
                     /db_xref="GeneID:14807"
                     /db_xref="MGI:MGI:95816"
                     /translation="MTAPWRRLRSLVWEYWAGFLVCAFWIPDSRGMPHVIRIGGIFEY
                     ADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQL
                     ALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLS
                     HAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLL
                     KEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSG
                     VNLTGFRILNVDNPHVSAIVEKWAMERLQAAPRAESGLLDGVMMTDAALLYDAVHIVS
                     VCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDL
                     DIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFR
                     KSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELI
                     DHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIW
                     MYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQ
                     GSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKI
                     EYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMES
                     TTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEK
                     WWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQR
                     SFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMSCSTSL
                     APVFP"
     exon            251..427
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            428..685
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..867
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            868..921
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1095
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1239
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1347
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1461
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1665
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1889
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2008
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2226
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2449
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2700
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..8977
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8855..8860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /note="hexamer: AATAAA"
     polyA_site      8872
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
     regulatory      8955..8960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /note="hexamer: AATAAA"
     polyA_site      8977
                     /gene="Grik3"
                     /gene_synonym="9630027E11; GluK3; Glur-7; Glur7; GluR7-3"
                     /note="major polyA site"
ORIGIN      
        1 actcgcagag gcgctccgga gccgggcggc tgggccaggc ggcgcctcgg gggctgctgc
       61 gcgcccgcgc ctagagctgc cgccccaggg agcccgccac ggccgcgccc cgggcacgct
      121 ccgtggcgcc caacgatgac cgctccctgg cggcgcctcc ggagtctggt ttgggaatac
      181 tgggccgggt tcctagtgtg cgccttctgg atcccagact cgcgcgggat gccccacgtc
      241 atccggatcg gaggaatctt tgagtatgcg gatggtccca acgcccaggt catgaacgct
      301 gaagagcacg cctttcgatt ttctgccaac atcatcaaca gaaacaggac tctgctgccc
      361 aacacgaccc tgacttacga cattcagagg attcacttcc atgacagttt tgaggccacc
      421 aagaaggcct gtgaccagtt ggcactgggt gttgtagcca tctttgggcc atcgcagggc
      481 tcctgcacca atgctgtcca gtccatttgc aacgccttgg aggttcccca catccaactg
      541 cgctggaagc accacccact ggacaacaag gacaccttct acgtgaacct ctaccctgac
      601 tatgcctctc tcagccacgc catcctcgac ttggtccagt ccctcaagtg gcgatcagcc
      661 accgtggtct atgatgacag tacaggtctc atccgtctgc aggaactcat catggcccct
      721 tcgaggtaca acattcgcct gaagattcgc cagctcccga ttgactcgga tgactcccgc
      781 cccttgctca aagagatgaa gcggggcagg gagttccgga tcatcttcga ctgcagccac
      841 accatggcag cccagatcct caagcaggcc atggccatgg gcatgatgac ggaatactac
      901 cacttcatct tcaccactct ggatctctac gcactagacc tggagcccta ccgctactcg
      961 ggagtgaacc tgactgggtt ccgcatactc aacgtggaca atccccatgt ctcagccatt
     1021 gtggagaagt gggccatgga gcgactgcag gcagctcccc gggcagagtc aggcctgctg
     1081 gatggtgtga tgatgacgga tgctgccctg ctctatgacg cggtccacat tgtgtctgtg
     1141 tgctaccagc gagcgccaca gatgaccgtg aactccctgc agtgccatcg gcacaaggcc
     1201 tggcgctttg gtggccgctt catgaacttc atcaaggagg ctcaatggga aggattaact
     1261 ggacggattg tgttcaacaa aaccagtggc ttgcggactg attttgatct ggacatcatc
     1321 agcctgaagg aagatggcct cgagaaggtt ggagtatgga gtccagctga cggtctcaat
     1381 atcactgagg ttgccaaagg ccgaggtcct aatgtcactg actctctgac caataggtca
     1441 ctcatcgtca ccactgtgct ggaggagcct tttgtcatgt tccgcaagtc tgataggacc
     1501 ctttatggca atgaccggtt tgagggctac tgcatcgact tgctcaagga gctggcacac
     1561 atcctgggct tctcctacga gatccggctg gtggaagacg gcaagtacgg ggcccaggat
     1621 gacaaaggcc agtggaacgg catggtcaag gaactcattg accacaaagc agatctggct
     1681 gtggctcccc tgaccatcac ccatgtccga gagaaggcca ttgacttctc taaacctttt
     1741 atgacccttg gagtgagcat cttataccgc aagcccaatg gcaccaaccc cagtgtcttc
     1801 tccttcctca accccctgtc cccggacatc tggatgtacg tgctccttgc ctacctgggt
     1861 gtcagctgtg tcctcttcgt catcgccaga ttcagccctt acgagtggta tgatgctcat
     1921 ccctgcaacc ccggctcaga ggtggtggag aataacttca cactgctcaa cagcttctgg
     1981 tttggaatgg gctccctgat gcagcaagga tctgaactga tgcccaaagc tctgtctacc
     2041 cgcatcattg gcggcatctg gtggttcttc accctcatta tcatctcctc ctacacggcc
     2101 aacctggctg ccttcctgac tgtggagcgt atggagtcgc ccatcgactc cgctgatgac
     2161 ctggccaagc agaccaaaat agagtacggt gctgtcaagg acggggccac catgaccttc
     2221 ttcaagaaat ccaagatctc cacctttgag aagatgtggg ccttcatgag cagcaagccc
     2281 tcggctctgg tgaagaacaa cgaggagggc atccagcgga cgctcacagc tgactacgcc
     2341 ctgctcatgg agtccactac catagagtac atcacacaga ggaactgcaa cctcacccag
     2401 atcggtggcc tcatcgactc caagggctat ggcatcggca cacccatggg ctccccctac
     2461 cgggacaaaa tcaccatcgc cattctgcag ctacaggagg aggacaaact gcacatcatg
     2521 aaggagaagt ggtggcgtgg cagtgggtgc cccgaggagg agaacaagga ggccagcgcc
     2581 ctgggcatcc agaagatcgg cggcatcttc atcgtcctgg ccgccggctt ggtcctgtcc
     2641 gtgttggtgg cagtgggcga gttcatatac aaactccgca agacagcgga gcgggagcag
     2701 cgctccttct gcagcacagt ggccgacgag atccgcttct ccctcacctg ccaacggcgt
     2761 ctcaagcaca agccccagcc tcctatgatg gtcaagacgg atgcggttat caacatgcac
     2821 acctttaatg accgaaggct gccaggcaag gacagcatga gctgcagcac ctcgctagcc
     2881 cctgtcttcc cctagacatg ggtccagcgg ggacttcagg cccagtccac gcagaggaag
     2941 gcaaaggaga cccgaaagga cggacatcct catctcgtgc tggccttggg gatggagctg
     3001 ctggccgcat ccagctgtga accatcagct cttaacctac cgggaaaccc acacggaccc
     3061 tcggccggct gctcgggctt catctcctct tgtcttgtct atggctttct gaagctgtga
     3121 aggccagcgg aagcacatgc ctctcaggct ccatcaccaa ccatctctct tctcctccat
     3181 agccaggtat ttctggcagg cctctgccga ggccgcagaa cacggaagat ggctctaaag
     3241 ctcccctcat tcccctcaag ccaggccttc tagcacgcag ccacgagagc agagactccg
     3301 actcgggaca ccttatgggt gtttggatga ggctgccagt gggagctcaa aggcagtcat
     3361 ccatacctgg acagaagcaa cgcttcagcc cttaagggct attcacctgg gtctgctcat
     3421 ctcaatatgg cttcaccaac agcagcagcc ccttggcaac atgaaaagct gtgtggaaag
     3481 gaggtgtttg gtacgggaga aggaaacaca gatggagact gtgatctcag atgcttcggg
     3541 tcagtgtcct gagccacaaa cgtctcgaga gtccccagga atgcgaacga ggtcgtcatc
     3601 acagcagatt gttctccaag gctgcacaga acagagaagg tgccctccct cacaaggaac
     3661 gtccaaagac tcagttgaca ttggtaggcc agcagaagaa atatggactc tataaaaatc
     3721 ccacaggccc ttcaaccaat agaccaactt tgctggcaaa caagccagca gtcgggaccc
     3781 tgggttctct accatctact cattggcgat ttcctgtccc cggccatttg aatttggcct
     3841 ccctctgtca tcctgagaag agaagagcgg tctcagctga agcgcaagcc aagtcaacag
     3901 ctcctcagaa gaggaattgc tgtcccccct ccacagacta actttggggt aggtgggaga
     3961 agccagaggg gacctgaaga actttctggg tacgcccaac ctaatgagcc ccctaaagaa
     4021 agaaagcttt cagggacagg atataagacc tccagaggcc cccagggtag gaagggagta
     4081 gctgcctcct ggaagattaa ccaaagaccc aacacagaga cacaaggcca ttctggcccc
     4141 tgatctcttt tctggagcag ctatggtctt aggggattga agggagaccc cagaggagaa
     4201 gccagagaag gtgacagcca aagggatgag cagatggcct gtggttccat ctctggaggt
     4261 ttgaaaccgt catggtcatt ggaaaggatc agatgtgagg ggttaggcaa aaagtgtcct
     4321 tacagagagc atgacagggc cataggggcc tccacagctg gatggatgtt ggtctctgat
     4381 cagggaccag ggtgagcaat atgggttgag aactgagaac tgggggacac cagtcaccca
     4441 caatccctca cttttctggt gctgctggag ggggcaggct tggatgagct acatctagag
     4501 cttaagtctt ctcagcagag gtgaaggaac cccttcagcc aacggggtgg cccccatgat
     4561 gggcacatgt gatcactccc accatgccgg ttcttgggag ctctggctgg ctggctgcac
     4621 tgggggaggg aggaaagggg agactcgcag ccaagcccag tgcacatgat gataggagaa
     4681 gccacgctgg cccgggagag gagagcacac atgtctgcgt gtttgacttt ctgtgtgtga
     4741 gttccagccg ctggtgatga aggacagata taacacagcc ctagcaggca ggaatagggg
     4801 cctcctttag gacgagtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgag
     4861 agagagagag agagagagag agagaaacgg gtagcaaaga gctcaatcag gaccggtaac
     4921 agagtctcat ctatgtaaaa acaggagaag ccatgtggag atggggctct ggtgagtgta
     4981 taatggatgc aagcgtgaat aaatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     5041 gtgtgtgtgt gtgtgcactg aatggcagag ggtagggacc aggacacagc ctgaagtata
     5101 gccaaatact tgtaaaagga gaagccatgt catcagagat ccttgtgtga gtgcgtgtac
     5161 atccacactc gtgtgcatcc acatttgtgt gcaggcttgt gtgccctgaa gacagcacgg
     5221 gagggcagac cagactgctg tgcccattgg gtgggtgtgt gctatacagg aggagtcgta
     5281 aaaatggaat gagtgagtgt gtgtgtgtgt gtgtgtgtgt atgtgtgtgt gtgtgtactc
     5341 atacccatgt atgtgcagac atgtacctaa gttccaattc aaatcctgcg ttgaggcagc
     5401 agagcagtta gtacggcagg gtaccaggat gtgtcagcat gcctgctatg ggagggatca
     5461 ctggccacag ctttcctgag ggctccatgg gaaaatgcac agggagacac cttctggggc
     5521 tcaccttctg gggtgatgcc ttctcctttg ctgttcatag agtgtcctgt tgagagggga
     5581 aaaattcttc cttccttcct tccttccttc cttccttcct tccttccttc cttcctgcct
     5641 gccttccttc cttcctgcct tccttccttc cttccttaaa tcacccctac tgacaggatc
     5701 ctcatgaaac cattgtcaac tccgttctca tccgctgtag tctttaacca ctgtcttctg
     5761 ttgtccaata ccattttata acacacaccc acctccatgt tcatatcaca catgtgcttt
     5821 tgtgcatgac actgcagacg tgtcatgttc tttcgaggct atgcacatat gtagactgtg
     5881 atgggagaag ggacggggtg tggttggtgg gaagggtgtt cagagaggta atgaccactg
     5941 ggtgacggca gtgggggtgg gggttggtta tagactcatt ccgggaagag gggtggcgtg
     6001 ctgcaggatc tcccctccca cctgagcctt atatccagag gtatggctaa cgcttgccct
     6061 ctggctgaag tcctgtgttt gttctagaga ccagcccagt cccaaacagc ctggagacca
     6121 ccctgcccag ctaagctgtg tctctgccag ggtagggaag ggagtcaaga gggaggcaga
     6181 tcattcaagt gaaaacctgt cccaaccccc taaggggtgc acagagctga ggctggaaca
     6241 cacaaatgct ctgaggagca atgggaaaca caaagattgg tttggatgga gcagatggga
     6301 catacctgag caggaccatg gctggctggc tctgtctgat catataggcc agccccgaat
     6361 agaagaatgc ctcacacaac tatgtctggg cttgagctcc acctatttat accagccctg
     6421 tggtggggca gcacccattc tgtccgggcc ctgggggcta ttggacaaag actgcctcta
     6481 ccttggcctg tgcctgcttt ctcttatgga cagtcactga tgaaatttga gcactttgtg
     6541 ggggctcagg tggctcctgg gcagttgtgt tggccagtga gttggactta gaatccttga
     6601 ggtaagagac tgcccctcgg tcagcctgga ctgtcacagc tggaagagca catgctgagc
     6661 cctgcctttg tagcatgcaa tgcggggagg ggtgtgcaga ttaaatatct ccacgaggga
     6721 gcggaagtca gaccaggctc acgttcacca agaaccgtct gtcccttcct accttccttt
     6781 ctggtccagg gagggctgaa ggtggggtgc agctgctgct gcttcatgcc gcatgaggcc
     6841 atgctacaca cacacacaca cacacacaca cacacacaca cacacacacg ccccaaagcc
     6901 attccctact gtaggcacca gcatctgaac atgacaaact ccatggtcca cctctggaat
     6961 tgccctgcgt ggatgcccac ctggaagggc cttcatgcca tggacaaaca accgtatgga
     7021 gttaacatct gggacccacc cagtccagtg gacagatctg agaattgggt ccaatcctgt
     7081 gcgcagatct ctgagtaaga tatatctgga tgtcccaggt tgttggagca aggtgcacat
     7141 ctggaatagg cctaaccact tgccacggtg gaaggggcct tgcccttttg tctctgtctc
     7201 ctagagttga aattttagag ctgaggtata tgtgaagtca cagaattgtt ttagatagaa
     7261 ggctaatgtt ctgtacaata tatatatgaa tgtaaaaaat atatatatgc ttatatatat
     7321 gcacagtgta tatatgaccc acaacccctg tgtatacaac ccttccctgc acgtctacac
     7381 acaaagtgta cagaacccag ccagtatggg tggggaccca gtgagagaca ggggctgcag
     7441 cagagaggtc aggtttacac agccctctgg atcaagccag accttgccag catcagtact
     7501 gtggaccacg tcaaagaagg cagactagtg cggaggtgac aggaaaggga cagccatgga
     7561 tgagcatctc ctccagggag tttgtatgag gcaggacagc gggcacacct gaggaaaacg
     7621 gccttgctag tcgttgatcc ctgagccaat atcacagtct agtcccagta cctagtgcca
     7681 gaggaaaatg gaagtagatt gccaggcctg cccttatccc tgcctgcaga gtagcctgga
     7741 aagttgtcaa gctgcatctg aaatcaccca gatgtcagag gatcctgggt ggcaaaggcc
     7801 tcacatatgc aaggtgccca cagctcaggg ctagagcgtg tctcttttga agagaacagc
     7861 ccgagggcac tgccgacatg cccgttcagc atcctgataa actagttatg aatctagttc
     7921 ttctaccctc gccttctaga atagaggctc ccaaatcacc ccgcagctgt ctggtttact
     7981 tttatagacc aaaactctga ggcctcccag tagtagaaaa aaacccatag attcagatgc
     8041 tagctaagag tctgccccag ttcattctga gacaggtaca aagtggcagg gagctatcaa
     8101 ggaaccagag agattcaaga tggcagcgcc tggccttgca cagcccctta ctgtctgcca
     8161 gtcctcgttg ttgttcttct cccaacaggg cagctggtag aaagcctctg tcaggtaggt
     8221 cacagacctc tgtccctgcc gcacctggat ctgtctcttg ccagtaattt gaggccttca
     8281 tccctttcct gggtccgagc atctctagag tgtgctgggg agaggagacc tgggctttgc
     8341 ttttgtgtgg tctgcagcct gccctttgct tcaaccccag cccttgggcc atctacactt
     8401 aaaagccagg cccgctcctg cagccacggc caagcgcacc gaaatctcca gctgccgctg
     8461 atgagggtcc tgtcctggct ccacagagac cagaggctcc aagagccctc acgccactgt
     8521 gctctgaaac cccactttat ccctgcctgg gctgacttcc tggctgggcc tccgtggtgg
     8581 ggacctcagc tcccagctct tgggctgagc ccccagacag taccatggga ctctaagagc
     8641 cctggcctgt cccactaccc agaccagagt gcctggacac cccctccccc aactcccact
     8701 caacaaggtt cccacacact ggtctctggg ccattcaggg ggtgcccttt gtggacatgc
     8761 agaatttcta tgaatatagt tttttgtaaa cattttgtaa cgatttgggt ttcatagtaa
     8821 ctgtgttact tgccaatcat tctaagcgga tgtaaataaa tttccaaaca aatctgatta
     8881 ttttcctttt taagacactg tgatatatca aagtgcacag tttgctgtat gaagtaatat
     8941 ggttttaaat tttaaataaa tgtttttaga aaatggg
//
