LOCUS       NP_001104738             908 aa            linear   ROD 10-DEC-2024
DEFINITION  glutamate receptor ionotropic, kainate 2 isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_001104738
VERSION     NP_001104738.2
DBSOURCE    REFSEQ: accession NM_001111268.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 908)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (residues 1 to 908)
  AUTHORS   Cai,W., Zhang,W., Zheng,Q., Hor,C.C., Pan,T., Fatima,M., Dong,X.,
            Duan,B. and Xu,X.Z.S.
  TITLE     The kainate receptor GluK2 mediates cold sensing in mice
  JOURNAL   Nat Neurosci 27 (4), 679-688 (2024)
   PUBMED   38467901
  REMARK    GeneRIF: The kainate receptor GluK2 mediates cold sensing in mice.
REFERENCE   3  (residues 1 to 908)
  AUTHORS   Nomura,T., Taniguchi,S., Wang,Y.Z., Yeh,N.H., Wilen,A.P.,
            Castillon,C.C.M., Foote,K.M., Xu,J., Armstrong,J.N., Savas,J.N.,
            Swanson,G.T. and Contractor,A.
  TITLE     A Pathogenic Missense Mutation in Kainate Receptors Elevates
            Dendritic Excitability and Synaptic Integration through
            Dysregulation of SK Channels
  JOURNAL   J Neurosci 43 (47), 7913-7928 (2023)
   PUBMED   37802657
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 908)
  AUTHORS   Nair,J.D., Wilkinson,K.A., Yucel,B.P., Mulle,C., Vissel,B.,
            Mellor,J. and Henley,J.M.
  TITLE     GluK2 Q/R editing regulates kainate receptor signaling and
            long-term potentiation of AMPA receptors
  JOURNAL   iScience 26 (10), 107708 (2023)
   PUBMED   37720087
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 908)
  AUTHORS   Paschen,W., Hedreen,J.C. and Ross,C.A.
  TITLE     RNA editing of the glutamate receptor subunits GluR2 and GluR6 in
            human brain tissue
  JOURNAL   J Neurochem 63 (5), 1596-1602 (1994)
   PUBMED   7523595
REFERENCE   6  (residues 1 to 908)
  AUTHORS   Gregor,P., O'Hara,B.F., Yang,X. and Uhl,G.R.
  TITLE     Expression and novel subunit isoforms of glutamate receptor genes
            GluR5 and GluR6
  JOURNAL   Neuroreport 4 (12), 1343-1346 (1993)
   PUBMED   8260617
REFERENCE   7  (residues 1 to 908)
  AUTHORS   Kohler,M., Burnashev,N., Sakmann,B. and Seeburg,P.H.
  TITLE     Determinants of Ca2+ permeability in both TM1 and TM2 of high
            affinity kainate receptor channels: diversity by RNA editing
  JOURNAL   Neuron 10 (3), 491-500 (1993)
   PUBMED   7681676
REFERENCE   8  (residues 1 to 908)
  AUTHORS   Morita,T., Sakimura,K., Kushiya,E., Yamazaki,M., Meguro,H.,
            Araki,K., Abe,T., Mori,K.J. and Mishina,M.
  TITLE     Cloning and functional expression of a cDNA encoding the mouse beta
            2 subunit of the kainate-selective glutamate receptor channel
  JOURNAL   Brain Res Mol Brain Res 14 (1-2), 143-146 (1992)
   PUBMED   1379666
REFERENCE   9  (residues 1 to 908)
  AUTHORS   Sakimura,K., Morita,T., Kushiya,E. and Mishina,M.
  TITLE     Primary structure and expression of the gamma 2 subunit of the
            glutamate receptor channel selective for kainate
  JOURNAL   Neuron 8 (2), 267-274 (1992)
   PUBMED   1310861
REFERENCE   10 (residues 1 to 908)
  AUTHORS   Sommer,B., Kohler,M., Sprengel,R. and Seeburg,P.H.
  TITLE     RNA editing in brain controls a determinant of ion flow in
            glutamate-gated channels
  JOURNAL   Cell 67 (1), 11-19 (1991)
   PUBMED   1717158
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC115891.7, AC110043.6,
            AC152981.2, AC153953.2, AC153801.1 and AC113305.7.
            
            On Apr 16, 2020 this sequence version replaced NP_001104738.1.
            
            Summary: Glutamate receptors are the predominant excitatory
            neurotransmitter receptors in the mammalian brain and are activated
            in a variety of normal neurophysiologic processes. This gene
            product belongs to the kainate family of glutamate receptors, which
            are composed of four subunits and function as ligand-activated ion
            channels. The subunit encoded by this gene is subject to RNA
            editing at multiple sites within the first and second transmembrane
            domains, which is thought to alter the structure and function of
            the receptor complex. Alternatively spliced transcript variants
            encoding different isoforms have also been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10054.1, SRR7345562.1551917.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            undergoes RNA editing  :: PMID: 7681676
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..908
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 24.87 cM"
     Protein         1..908
                     /product="glutamate receptor ionotropic, kainate 2 isoform
                     1 precursor"
                     /note="glutamate receptor 6; glutamate receptor beta-2;
                     gluR beta-2; glutamate receptor ionotropic, kainate 2;
                     proteasome (prosome, macropain) subunit, alpha type 6
                     pseudogene"
                     /calculated_mol_wt=99025
     sig_peptide     1..31
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3479
     mat_peptide     32..908
                     /product="Glutamate receptor ionotropic, kainate 2.
                     /id=PRO_0000011545"
                     /note="propagated from UniProtKB/Swiss-Prot (P39087.4)"
                     /calculated_mol_wt=99025
     Region          37..414
                     /region_name="PBP1_iGluR_Kainate"
                     /note="N-terminal leucine-isoleucine-valine binding
                     protein (LIVBP)-like domain of the kainate receptors;
                     cd06382"
                     /db_xref="CDD:380605"
     Site            67
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39087.4)"
     Site            73
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39087.4)"
     Site            order(87..89,93,124,176,179,183,186,189..190,200..203)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:380605"
     Site            275
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39087.4)"
     Site            378
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39087.4)"
     Site            412
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39087.4)"
     Site            423
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39087.4)"
     Region          430..800
                     /region_name="Periplasmic_Binding_Protein_Type_2"
                     /note="Type 2 periplasmic binding fold superfamily;
                     cl21456"
                     /db_xref="CDD:473866"
     Site            430
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39087.4)"
     Site            546
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39087.4)"
     Site            562..582
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P39087.4)"
     Site            639..659
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P39087.4)"
     Site            751
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39087.4)"
     Site            820..840
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P39087.4)"
     Site            846
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000250|UniProtKB:Q13002; propagated from
                     UniProtKB/Swiss-Prot (P39087.4)"
     Site            868
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000250|UniProtKB:Q13002; propagated from
                     UniProtKB/Swiss-Prot (P39087.4)"
     CDS             1..908
                     /gene="Grik2"
                     /gene_synonym="C130030K03Rik; GluK2; Glur-6; Glur6;
                     Glurbeta2"
                     /coded_by="NM_001111268.3:414..3140"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS48554.1"
                     /db_xref="GeneID:14806"
                     /db_xref="MGI:MGI:95815"
ORIGIN      
        1 mkiispvlsn lvfsrsikvl lcllwigysq gtthvlrfgg ifeyvesgpm gaeelafrfa
       61 vntinrnrtl lpnttltydt qkinlydsfe askkacdqls lgvaaifgps hsssanavqs
      121 icnalgvphi qtrwkhqvsd nkdsfyvsly pdfsslsrai ldlvqffkwk tvtvvyddst
      181 glirlqelik apsrynlrlk irqlpadtkd akpllkemkr gkefhvifdc shemaagilk
      241 qalamgmmte yyhyifttld lfaldvepyr ysgvnmtgfr ilntentqvs siiekwsmer
      301 lqappkpdsg lldgfmttda almydavhvv svavqqfpqm tvsslqcnrh kpwrfgtrfm
      361 slikeahweg ltgritfnkt nglrtdfdld vislkeegle kigtwdpssg lnmtesqkgk
      421 panitdslsn rslivttile epyvlfkksd kplygndrfe gycidllrel stilgftyei
      481 rlvedgkyga qddvngqwng mvrelidhka dlavaplait yvrekvidfs kpfmtlgisi
      541 lyrkpngtnp gvfsflnpls pdiwmyilla ylgvscvlfv iarfspyewy nphpcnpdsd
      601 vvennftlln sfwfgvgalm qqgselmpka lstrivggiw wfftliiiss ytanlaaflt
      661 vermespids addlakqtki eygavedgat mtffkkskis tydkmwafms srrqsvlvks
      721 neegiqrvlt sdyaflmest tiefvtqrnc nltqigglid skgygvgtpm gspyrdkiti
      781 ailqlqeegk lhmmkekwwr gngcpeeesk easalgvqni ggifivlaag lvlsvfvavg
      841 eflykskkna qlekrsfcsa mveelrmslk cqrrlkhkpq apvivkteev inmhtfndrr
      901 lpgketma
//
