LOCUS       NM_001405028            3659 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus glutamate receptor, ionotropic, kainate 1 (Grik1),
            transcript variant 4, mRNA.
ACCESSION   NM_001405028 XM_006522914
VERSION     NM_001405028.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3659)
  AUTHORS   Li,X.H., Shi,W., Zhao,Z.X., Matsuura,T., Lu,J.S., Che,J.,
            Chen,Q.Y., Zhou,Z., Xue,M., Hao,S., Xu,F., Bi,G.Q., Kaang,B.K.,
            Collingridge,G.L. and Zhuo,M.
  TITLE     Increased GluK1 Subunit Receptors in Corticostriatal Projection
            from the Anterior Cingulate Cortex Contributed to Seizure-Like
            Activities
  JOURNAL   Adv Sci (Weinh) 11 (39), e2308444 (2024)
   PUBMED   39225597
  REMARK    GeneRIF: Increased GluK1 Subunit Receptors in Corticostriatal
            Projection from the Anterior Cingulate Cortex Contributed to
            Seizure-Like Activities.
REFERENCE   2  (bases 1 to 3659)
  AUTHORS   Ratsika,A., Codagnone,M.G., Bastiaanssen,T.F.S., Hoffmann
            Sarda,F.A., Lynch,C.M.K., Ventura-Silva,A.P., Rosell-Cardona,C.,
            Caputi,V., Stanton,C., Fulling,C., Clarke,G. and Cryan,J.F.
  TITLE     Maternal high-fat diet-induced microbiota changes are associated
            with alterations in embryonic brain metabolites and adolescent
            behaviour
  JOURNAL   Brain Behav Immun 121, 317-330 (2024)
   PUBMED   39032541
REFERENCE   3  (bases 1 to 3659)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   4  (bases 1 to 3659)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3659)
  AUTHORS   Herb,A., Higuchi,M., Sprengel,R. and Seeburg,P.H.
  TITLE     Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs
            requires distant intronic sequences
  JOURNAL   Proc Natl Acad Sci U S A 93 (5), 1875-1880 (1996)
   PUBMED   8700852
REFERENCE   6  (bases 1 to 3659)
  AUTHORS   Duvoisin,R.M., Zhang,C., Hamassaki-Britto,D.E. and Britto,L.R.
  TITLE     Changes in expression of glutamate receptor subunits following
            photoreceptor degeneration in the rd mouse retina
  JOURNAL   Neurosci Lett 183 (1-2), 83-86 (1995)
   PUBMED   7538211
REFERENCE   7  (bases 1 to 3659)
  AUTHORS   Paschen,W., Hedreen,J.C. and Ross,C.A.
  TITLE     RNA editing of the glutamate receptor subunits GluR2 and GluR6 in
            human brain tissue
  JOURNAL   J Neurochem 63 (5), 1596-1602 (1994)
   PUBMED   7523595
REFERENCE   8  (bases 1 to 3659)
  AUTHORS   Morita,T., Sakimura,K., Kushiya,E., Yamazaki,M., Meguro,H.,
            Araki,K., Abe,T., Mori,K.J. and Mishina,M.
  TITLE     Cloning and functional expression of a cDNA encoding the mouse beta
            2 subunit of the kainate-selective glutamate receptor channel
  JOURNAL   Brain Res Mol Brain Res 14 (1-2), 143-146 (1992)
   PUBMED   1379666
REFERENCE   9  (bases 1 to 3659)
  AUTHORS   Sakimura,K., Morita,T., Kushiya,E. and Mishina,M.
  TITLE     Primary structure and expression of the gamma 2 subunit of the
            glutamate receptor channel selective for kainate
  JOURNAL   Neuron 8 (2), 267-274 (1992)
   PUBMED   1310861
REFERENCE   10 (bases 1 to 3659)
  AUTHORS   Sommer,B., Kohler,M., Sprengel,R. and Seeburg,P.H.
  TITLE     RNA editing in brain controls a determinant of ion flow in
            glutamate-gated channels
  JOURNAL   Cell 67 (1), 11-19 (1991)
   PUBMED   1717158
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093479.13, AC118681.6 and
            CT030723.18.
            
            On Apr 19, 2022 this sequence version replaced XM_006522914.4.
            
            Summary: Glutamate receptors are the predominant excitatory
            neurotransmitter receptors in the mammalian brain and are activated
            in a variety of normal neurophysiologic processes. This gene
            product belongs to the kainate family of glutamate receptors, which
            are composed of four subunits and function as ligand-activated ion
            channels. The subunit encoded by this gene is subject to RNA
            editing (CAG->CGG; Q->R) within the second transmembrane domain,
            which is thought to alter the properties of ion flow. Alternative
            splicing, resulting in transcript variants encoding different
            isoforms, has been noted for this gene. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.648200.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            undergoes RNA editing  :: PMID: 1717158, 8700852
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-632               AC093479.13        155117-155748       c
            633-800             AC118681.6         137923-138090
            801-1058            AC118681.6         142506-142763
            1059-1240           AC118681.6         159762-159943
            1241-1294           AC118681.6         184340-184393
            1295-1468           AC118681.6         187576-187749
            1469-1612           AC118681.6         198040-198183
            1613-1720           CT030723.18        2940-3047
            1721-1765           CT030723.18        5204-5248
            1766-1879           CT030723.18        10396-10509
            1880-2083           CT030723.18        12540-12743
            2084-2307           CT030723.18        13769-13992
            2308-2426           CT030723.18        19881-19999
            2427-2644           CT030723.18        24422-24639
            2645-2870           CT030723.18        37235-37460
            2871-3121           CT030723.18        46133-46383
            3122-3208           CT030723.18        63642-63728
            3209-3659           CT030723.18        64186-64636
FEATURES             Location/Qualifiers
     source          1..3659
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 50.23 cM"
     gene            1..3659
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /note="glutamate receptor, ionotropic, kainate 1"
                     /db_xref="GeneID:14805"
                     /db_xref="MGI:MGI:95814"
     exon            1..632
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     CDS             515..3364
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /note="isoform d is encoded by transcript variant 4;
                     glutamate receptor subunit 5"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, kainate 1 isoform
                     d"
                     /protein_id="NP_001391957.1"
                     /db_xref="GeneID:14805"
                     /db_xref="MGI:MGI:95814"
                     /translation="MERGTVLIQPGLWTRDTSWTLLYFLCYILPQTSPQVLRIGGIFE
                     TVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLAL
                     GVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNRDLFYINLYPDYAAISRA
                     VLDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKE
                     MKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVN
                     MTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGVMTTEAALMYDAVYMVAIA
                     SHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGRITFNKTDGLRKDFDLDI
                     ISLKEEGTEKASGEVSKHLYKVWKKIGIWNSNSGLNMTDGNRDRSNNITDSLANRTLI
                     VTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQN
                     DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPG
                     VFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLL
                     NSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESP
                     IDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGI
                     QRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAIL
                     QLQEEGKLHMMKEKWWRGNGCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGE
                     FIYKSRKNNDIEQKGKSSRLRFYFRNKVRFHGSKTESLGVEKCLSFNAIMEELGISLK
                     NQKKLKKKSRTKGKSSFTSILTCHQRRTQRKETVA"
     exon            633..800
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1058
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1240
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1294
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1468
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1612
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1720
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1765
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1879
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2083
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2307
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2426
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2644
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2870
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..3121
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3208
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3659
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3603..3608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /note="hexamer: AATAAA"
     regulatory      3638..3643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /note="hexamer: AACAAG"
     polyA_site      3639
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /note="major polyA site"
     polyA_site      3659
                     /gene="Grik1"
                     /gene_synonym="A830007B11Rik; D16Ium24; D16Ium24e; GluK1;
                     GluK5; Glur-5; Glur5; Glurbeta1"
                     /note="major polyA site"
ORIGIN      
        1 acagtaaacc cgctggagct catcctgttt ggttggagct ctgcaccaac tcccccagtt
       61 ccctctctcc ttgggtgtct tcttccctcc ttttctccct tttcctcact gcaccctgaa
      121 tccactaccc atttccccca cccatcactt ctgcatctga ccagaggacg aatgagtgag
      181 acgttccagc aaatcgaggc agcaactttc ctcagctggt ctctgggctc caggagcgaa
      241 atcctgctga ttcttggagg tatgcagccc atggaggagg aagaggacga gcagtgatgg
      301 gctaacgacc cgtgcaagaa gccccaagca gctcagtctc ggacgcccgc ttcacgcttg
      361 ttccctccac ctcgctctcc tgagagcaga gagcgcgcgg tgtgcagact cggaacatcc
      421 agggaggatg aggcggggac ccagcccaag ttgggtgcat cttgcgggcg tgaggccacg
      481 actgtgtttc ggcatgaatt aagaagcttg aaagatggag cgcggcacag tccttatcca
      541 acccgggctc tggaccaggg acaccagctg gacactcctc tatttcctgt gctacatcct
      601 tcctcagacc tcccctcaag tgctcaggat cggagggatt tttgaaactg tggaaaacga
      661 acctgttaat gttgaagaat tagctttcaa gtttgcagtc accagtatta accgaaaccg
      721 aaccttgatg cccaatacca cattaaccta tgacatccag agaattaatc tttttgatag
      781 ttttgaagcc tcccgaagag catgcgacca actggctctt ggggtggccg ccctcttcgg
      841 tccttcccac agctcctccg tcagtgctgt acagtctatt tgcaatgctc tggaagttcc
      901 acacattcag actcgctgga aacacccttc tgtggacaac agagacttat tttacatcaa
      961 cctctaccca gattatgcag ctatcagcag ggcagtcctg gatctggtcc tctattacaa
     1021 ctggaaaaca gtgacggtgg tgtacgaaga cagcacaggt ctaattcgtc tgcaagagct
     1081 catcaaagct ccctccagat acaacatcaa aatcaaaatc cgccagcttc cctctggcaa
     1141 taaggatgcc aaacctctgc tcaaggagat gaagaaaggc aaggagttct atgtgatatt
     1201 tgattgttcg cacgagacgg ctgctgaaat tcttaagcag attttgttca tgggcatgat
     1261 gactgaatac tatcactact tcttcacaac cctggacttg tttgctttgg atctggaact
     1321 ctacaggtac agtggtgtaa atatgactgg atttcggttg ctgaatattg acaaccctca
     1381 cgtgtcatcc atcattgaga agtggtccat ggagagattg caggccccac ccagacctga
     1441 gactggtctc ctggacggcg tgatgacaac tgaagcagct ctgatgtacg atgctgtgta
     1501 catggtagcc atcgcctctc accgtgcctc tcagctgacc gtcagttccc tgcagtgcca
     1561 tcgacataag ccatggcgcc taggacccag atttatgaac ctcatcaaag aggcgcggtg
     1621 ggatggcttg acggggcgga tcaccttcaa taagacggat ggcttgagaa aggattttga
     1681 cctggacatt atcagtctca aagaggaagg aactgaaaag gcctctggtg aagtgtctaa
     1741 gcacttgtat aaagtgtgga agaagattgg gatttggaac tccaacagtg ggctgaacat
     1801 gacggatggc aacagagaca ggtccaacaa tatcacagat tcgctggcta accgaacgct
     1861 cattgtcacc actattctgg aagagcccta cgtgatgtac aggaaatccg ataaaccact
     1921 gtacggaaat gacagatttg aaggatattg cctggatctg ctgaaagaac tgtcaaatat
     1981 cctaggtttc ctttatgatg ttaaactggt tcctgacggc aaatatggag cccagaatga
     2041 caaaggggag tggaacggga tggttaagga actcatcgac cacagagctg acctagcagt
     2101 ggcccctctc accatcacgt atgtacggga gaaagtcatt gacttctcca agcctttcat
     2161 gactctgggc attagcatcc tttaccggaa gcccaatgga accaaccccg gcgtcttctc
     2221 cttcctcaac cccctgtctc cagacatttg gatgtatgtg ctcctcgctt gcctaggagt
     2281 cagttgtgtg ctttttgtga ttgcaaggtt cacaccctac gagtggtata acccccaccc
     2341 gtgcaaccct gactcagacg tggtggaaaa caatttcact ttgctaaata gtttctggtt
     2401 tggcgttgga gctctcatgc agcaaggatc ggagctgatg cccaaggctc tatcgaccag
     2461 aatagttgga ggaatatggt ggtttttcac cctaatcatc atctcatcct acactgccaa
     2521 cctggctgcc ttcttgacag tagaaaggat ggaatccccc atcgattccg cagacgacct
     2581 ggccaaacaa accaagatag aatacggggc agtcagagat ggctcgacaa tgaccttctt
     2641 caagaaatca aaaatctcca cgtatgagaa aatgtgggct ttcatgagca gtagacagca
     2701 gagcgccctg gttaaaaaca gcgatgaggg gatccaaagg gtgcttacca ccgactacgc
     2761 cctgctgatg gagtccacca gcattgagta tgtgacacag aggaactgca acctcactca
     2821 gatcgggggc ctcatagact ccaaaggcta tggagtgggg acacctatcg gctcccctta
     2881 ccgggataaa attacaattg ctattcttca actacaagaa gaagggaagc ttcatatgat
     2941 gaaagagaaa tggtggaggg gaaatggctg ccctgaagaa gacagtaaag aagccagtgc
     3001 tctaggagtg gaaaatatcg ggggtatctt cattgttctg gctgcaggac tcgtcctttc
     3061 tgtgtttgta gccattggag aattcatata caaatcacgg aagaacaatg acattgagca
     3121 gaaaggaaag tcatcaagac ttagatttta ttttaggaac aaagtaaggt ttcatgggag
     3181 caaaacagaa agccttggtg tagagaagtg tctctctttc aatgccatca tggaagagct
     3241 gggaatctca ctcaagaatc agaaaaaatt aaagaaaaag tcaagaacta agggcaaatc
     3301 ttctttcaca agtatcctta cttgtcatca gagacgaact cagagaaaag agactgtggc
     3361 gtgacccaag aacacgcctg taaagaagaa aaaggccatg cccatgacac atatttggag
     3421 gacagatttc tgaggaacag gagatatgtt tccacatatc tttatccata actccagtca
     3481 tggatagagg gagaagaaat gcacaatttt taaagctcac atagatatta cttgaggagt
     3541 gaaactgatt cttttcagat gaatttgtat gcacaattat tttgaatttt ttcttttcct
     3601 ccaataaatt gctatgtgtg ctttctaaat aataataaac aagcggattt tgtttttca
//
