LOCUS       NM_133355               3435 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus glutamate receptor, ionotropic, delta 2 (Grid2)
            interacting protein 1 (Grid2ip), transcript variant 2, mRNA.
ACCESSION   NM_133355 XM_982526
VERSION     NM_133355.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3435)
  AUTHORS   Boyle,M.P., Bernard,A., Thompson,C.L., Ng,L., Boe,A., Mortrud,M.,
            Hawrylycz,M.J., Jones,A.R., Hevner,R.F. and Lein,E.S.
  TITLE     Cell-type-specific consequences of Reelin deficiency in the mouse
            neocortex, hippocampus, and amygdala
  JOURNAL   J Comp Neurol 519 (11), 2061-2089 (2011)
   PUBMED   21491433
REFERENCE   2  (bases 1 to 3435)
  AUTHORS   Takeuchi,T., Ohtsuki,G., Yoshida,T., Fukaya,M., Wainai,T.,
            Yamashita,M., Yamazaki,Y., Mori,H., Sakimura,K., Kawamoto,S.,
            Watanabe,M., Hirano,T. and Mishina,M.
  TITLE     Enhancement of both long-term depression induction and optokinetic
            response adaptation in mice lacking delphilin
  JOURNAL   PLoS One 3 (5), e2297 (2008)
   PUBMED   18509461
  REMARK    GeneRIF: findings are compatible with the idea that LTD induction
            at PF-PC synapses is a crucial rate-limiting step in optokinetic
            resonse gain-increase adaptation, a simple form of motor learning
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3435)
  AUTHORS   Matsuda,K., Matsuda,S., Gladding,C.M. and Yuzaki,M.
  TITLE     Characterization of the delta2 glutamate receptor-binding protein
            delphilin: Splicing variants with differential palmitoylation and
            an additional PDZ domain
  JOURNAL   J Biol Chem 281 (35), 25577-25587 (2006)
   PUBMED   16835239
REFERENCE   4  (bases 1 to 3435)
  AUTHORS   Yamashita,T., Miyagi,Y., Ono,M., Ito,H., Watanabe,K., Sonoda,T.,
            Tsuzuki,K., Ozawa,S., Aoki,I., Okuda,K., Mishina,M. and Kawamoto,S.
  TITLE     Identification and characterization of a novel Delphilin variant
            with an alternative N-terminus
  JOURNAL   Brain Res Mol Brain Res 141 (1), 83-94 (2005)
   PUBMED   16168524
  REMARK    GeneRIF: Results show that the Delphilin protein exhibits diversity
            at its N-terminus by variable usage of the first several exons.
REFERENCE   5  (bases 1 to 3435)
  AUTHORS   Selimi,F., Lohof,A.M., Heitz,S., Lalouette,A., Jarvis,C.I.,
            Bailly,Y. and Mariani,J.
  TITLE     Lurcher GRID2-induced death and depolarization can be dissociated
            in cerebellar Purkinje cells
  JOURNAL   Neuron 37 (5), 813-819 (2003)
   PUBMED   12628171
  REMARK    GeneRIF: Absence of GRID2 receptors in heteroallelic mutants
            induces an early and massive Purkinje cell death that is correlated
            with early signs of autophagy and is independent of depolarization.
REFERENCE   6  (bases 1 to 3435)
  AUTHORS   Yue,Z., Horton,A., Bravin,M., DeJager,P.L., Selimi,F. and Heintz,N.
  TITLE     A novel protein complex linking the delta 2 glutamate receptor and
            autophagy: implications for neurodegeneration in lurcher mice
  JOURNAL   Neuron 35 (5), 921-933 (2002)
   PUBMED   12372286
  REMARK    GeneRIF: A direct link exists between GluR2delta receptor and
            stimulation of the autophagic pathway in dying Purkinje cells of
            lurcher mice.
REFERENCE   7  (bases 1 to 3435)
  AUTHORS   Miyagi,Y., Yamashita,T., Fukaya,M., Sonoda,T., Okuno,T., Yamada,K.,
            Watanabe,M., Nagashima,Y., Aoki,I., Okuda,K., Mishina,M. and
            Kawamoto,S.
  TITLE     Delphilin: a novel PDZ and formin homology domain-containing
            protein that synaptically colocalizes and interacts with glutamate
            receptor delta 2 subunit
  JOURNAL   J Neurosci 22 (3), 803-814 (2002)
   PUBMED   11826110
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF099933.2.
            
            On Jun 19, 2019 this sequence version replaced NM_133355.1.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR and 5'
            coding region, compared to variant 1. The encoded isoform (2) has a
            distinct N-terminus and is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF099933.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3435              AF099933.2         6-3440
FEATURES             Location/Qualifiers
     source          1..3435
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 82.1 cM"
     gene            1..3435
                     /gene="Grid2ip"
                     /note="glutamate receptor, ionotropic, delta 2 (Grid2)
                     interacting protein 1"
                     /db_xref="GeneID:170935"
                     /db_xref="MGI:MGI:2176213"
     exon            1..63
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..3124
                     /gene="Grid2ip"
                     /note="isoform 2 is encoded by transcript variant 2;
                     L-delphilin; glutamate receptor, ionotropic, delta
                     2-interacting protein 1; GluR-delta2 philic-protein"
                     /codon_start=1
                     /product="delphilin isoform 2"
                     /protein_id="NP_579933.1"
                     /db_xref="CCDS:CCDS19841.1"
                     /db_xref="GeneID:170935"
                     /db_xref="MGI:MGI:2176213"
                     /translation="MSCLGIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSR
                     SEERPERLLVSTRASAAPRRPDEPPPRKATSLLGGRTGPGGPRRTVRVYKGNKSFGFT
                     LRGHGPVWIESVLPGSPAENASLKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTL
                     VVEEGPVPFASDSDSLDSPTRASALTSLQWVADILPSSIRVQGRTFSQQLDHLLTPPE
                     RYGVCRALERFFQHRNIDTLIVDVYPVLDTPAKQVLWQFLYQLLTYEEQELCQEKIAC
                     FLGYTAMTEPESSLDLEPESTPEPTPEPQPRSSLRASSMCRRSLRSQGLETSLSCGPG
                     DCPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKIGTMSKSRA
                     SPPVPSLVGTSGPRTLSGVSWPSDRLLPSPCYDPLCSGGLASPSSSESHPYASLDSSR
                     APSPQPGLGSIHADSPPSPDPIRPPSRRKLFAFSRPVRSRDTDRFLDALSEQLGPRLS
                     IVDDFLTPENDYEEMSFHDDQGSFVTNERSSASECVSSSEEGSSLTYSSISDHIPPPP
                     LSPPPPPPLPFHDPKPSSRTSDGPRGPPQSLTKPLTQINHPVPPPPPPPLPPPVPCAP
                     PMLSRGVGHRRSETSHMSVKRLRWEQVENSEGTIWGQLGEDSDYDKLSDMVKYLDLEL
                     HFGTQKPPKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLTPGELRQVLMSMEPR
                     RLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHF
                     QATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGF
                     KINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTG
                     DLADLHDTVSEIQVACQSMAPSSEDRFAVVMASFLETAQPALRALDGLQREAMEELGK
                     ALAFFGEDSKATTSEAFFGIFSEFMSKFERALSDLQAGDGPRSSGMVSPLAW"
     exon            64..312
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            313..398
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            399..468
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            469..563
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            564..747
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            748..902
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1043
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1141
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1259
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1615
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..2032
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2120
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2198
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2395
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2551
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2638
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2768
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2887
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3052
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3435
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3397..3402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grid2ip"
                     /note="hexamer: AATAAA"
     polyA_site      3435
                     /gene="Grid2ip"
                     /note="major polyA site"
ORIGIN      
        1 atctcgactc agcagcgaaa cgcataggag gccaccgaaa gaggccacca tgagctgcct
       61 agggatcttt attcccaaaa agcatcgggc gcgcttcgac gaggtggtgt cgcagggtct
      121 gctgggcaag ctgtgccgtg ctcggagggc gcagggcgca cagcgtttgc gtcggagccg
      181 cagcgaggag cgcccggagc gcctcttagt gtccacgcgc gctagcgccg ctccccgccg
      241 tccggatgag ccacccccgc ggaaggcaac ctcgctgctg ggcggtcgca ctggccctgg
      301 gggtcctcgt aggacggttc gagtttataa aggcaacaag agtttcggct tcactctgcg
      361 aggccatgga ccggtctgga tcgaatctgt cctgcctggc agcccggctg aaaatgcctc
      421 cctcaagtca ggtgaccgga tcctcttcct caatggattg gacatgagga actgctccca
      481 cgacaaggtg gtgtccatgt tgcagggcag tggcgccatg cccacgctgg tggtagagga
      541 aggaccggtc cctttcgcca gtgattcaga ttctctggat tccccgaccc gggcgtcagc
      601 tctcacctcg ctgcagtggg tggcggatat cctgccttcc agtatccgag tccaggggag
      661 gaccttcagc cagcagctgg accacctcct cactcctccc gagcgctatg gagtctgccg
      721 agctctcgag cgcttctttc agcacaggaa catcgatacc ctcatcgtgg atgtctaccc
      781 cgtcctggac acacccgcca agcaggtact ctggcagttc ctctaccagc tgctgaccta
      841 cgaggagcag gagctgtgtc aggagaagat cgcgtgcttc ctcggctaca cagccatgac
      901 ggaacctgaa tcctcactgg acctcgagcc agagtctaca ccagagccca caccagagcc
      961 acaaccacgg agttccctga gggcctcttc catgtgccgt cgcagcttgc gctcccaggg
     1021 cctggagacc agcctcagct gtggtcctgg tgactgccct gagatgcccc tacctctgat
     1081 cccaggcgag cgtcaggctg gcgatggcac atccctcccg gaaaccccta accccaaaat
     1141 gatgtcagcg gtctatgcag agctcgagtc tcgactgaac agcagcttca aagggaagat
     1201 agggaccatg tccaaatccc gggcctctcc accagtcccc agcctggtcg gcacatcagg
     1261 gcccaggacc ctgtctggag tctcctggcc cagtgaccgg ctcctgcctt ccccgtgcta
     1321 tgacccgctg tgttctgggg gtctggcctc tcccagcagc tcggaatccc acccctacgc
     1381 cagcttggac agcagcaggg cgccctcccc acagccaggc cttggatcca tccacgccga
     1441 cagcccccca agcccagacc ccatccggcc gcccagtcgc cggaagctct tcgccttctc
     1501 acgcccagtc cggagccgag acacagatcg cttcctggat gcgctgagcg agcagctggg
     1561 tccccgcctc agcatcgtgg atgacttcct gacacccgag aatgactatg aagagatgag
     1621 cttccatgat gaccagggca gctttgtgac caacgagagg agcagcgcta gcgagtgtgt
     1681 cagcagcagc gaggagggca gttctctgac ctactcctcc atctccgacc acatcccccc
     1741 acctccactc agccccccgc cgccaccgcc cctgcctttc catgacccca agcctagctc
     1801 ccgcacctcc gatggtcccc gaggtccccc tcagtcattg accaaacccc tcacccagat
     1861 caaccatcca gtcccacccc cacccccacc ccctctaccc ccacctgtgc cctgtgcacc
     1921 ccccatgcta tcccgaggcg tgggccaccg ccgcagtgag accagccata tgagcgtcaa
     1981 gcgcttacgc tgggaacagg tggagaactc agaaggcacc atctggggtc agcttgggga
     2041 agactctgac tatgacaagc tgagtgacat ggtgaaatac ctcgacctgg agctccactt
     2101 cggcacccag aaacctccga agccagtgcc cggcccggag cccttcagga agaaggaagt
     2161 ggtggagatc ttgtcccaca agaaggccta caatacctcc attctcctag cgcacctgaa
     2221 gctgacccct ggcgagctgc ggcaagtgct catgagcatg gaaccccggc gcctggagcc
     2281 tgctcatctg gcgcagctgc tgctcttcgc tcctgacgcc gacgaggaac agcgatatca
     2341 ggctttccgc gaggctccgg gtcgcctcag tgagccggac cagttcgtcc tgcagatgct
     2401 gtcggttccc gaatacaaga cccgcctgcg cagtctacac ttccaggcta ccttgcagga
     2461 gaagacagag gagatacgag gcagcctcga gtgtctgcga caggcatctc tggagctcaa
     2521 aaacagccgg aaactcgcca agatcctgga gtttgtgttg gccatgggta actatctcaa
     2581 cgatggacag cccaagacca acaagaccac tggcttcaag atcaacttcc tgaccgagct
     2641 aaactccacc aagacagtgg acgggaagtc cacctttctg cacatccttg ccaaatcgct
     2701 aagccagcac ttccctgagc tcctgggctt tgcccaggac ctgcccactg tgcccctggc
     2761 tgccaaagtg aaccagcgag ccctgactgg tgacctggct gacctccatg acaccgtcag
     2821 tgagattcag gtggcctgcc agagcatggc cccttccagt gaggacaggt ttgctgtggt
     2881 catggcttcc tttctggaaa cagcgcagcc agccctgcga gcgttggatg gtctgcagcg
     2941 agaggccatg gaggagctag ggaaggctct ggccttcttc ggagaggact ccaaggccac
     3001 tacctcagag gccttctttg gcatcttttc agaattcatg agcaaatttg agagagccct
     3061 cagcgacctg caggcagggg atggcccacg cagctcaggg atggtgtcac ccctggcctg
     3121 gtgatagctg ccaccaagca tcttctgcag tctgagcacg gagaccgatg ctggaggctg
     3181 caccatggag gaatgtcaca gggtccaggg tacttgacca tgcaccttgg ctgcaggaag
     3241 ggcttgggtg cggtggggct gcagccacgt gtctccggct acctcagctg ccgagttctg
     3301 cttggccctc ttttgcccat acaccttggt ctcccaagaa ggtctccctg gcttccggtg
     3361 gccacccacc cttccgcctc gatgcccaca acggtgaata aaatgctgct gtgtgtcagg
     3421 gaatgtccca ccgga
//
