LOCUS       NM_001159321            4144 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus glutamate receptor, ionotropic, delta 2 (Grid2)
            interacting protein 1 (Grid2ip), transcript variant 1, mRNA.
ACCESSION   NM_001159321
VERSION     NM_001159321.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4144)
  AUTHORS   Boyle,M.P., Bernard,A., Thompson,C.L., Ng,L., Boe,A., Mortrud,M.,
            Hawrylycz,M.J., Jones,A.R., Hevner,R.F. and Lein,E.S.
  TITLE     Cell-type-specific consequences of Reelin deficiency in the mouse
            neocortex, hippocampus, and amygdala
  JOURNAL   J Comp Neurol 519 (11), 2061-2089 (2011)
   PUBMED   21491433
REFERENCE   2  (bases 1 to 4144)
  AUTHORS   Takeuchi,T., Ohtsuki,G., Yoshida,T., Fukaya,M., Wainai,T.,
            Yamashita,M., Yamazaki,Y., Mori,H., Sakimura,K., Kawamoto,S.,
            Watanabe,M., Hirano,T. and Mishina,M.
  TITLE     Enhancement of both long-term depression induction and optokinetic
            response adaptation in mice lacking delphilin
  JOURNAL   PLoS One 3 (5), e2297 (2008)
   PUBMED   18509461
  REMARK    GeneRIF: findings are compatible with the idea that LTD induction
            at PF-PC synapses is a crucial rate-limiting step in optokinetic
            resonse gain-increase adaptation, a simple form of motor learning
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4144)
  AUTHORS   Matsuda,K., Matsuda,S., Gladding,C.M. and Yuzaki,M.
  TITLE     Characterization of the delta2 glutamate receptor-binding protein
            delphilin: Splicing variants with differential palmitoylation and
            an additional PDZ domain
  JOURNAL   J Biol Chem 281 (35), 25577-25587 (2006)
   PUBMED   16835239
REFERENCE   4  (bases 1 to 4144)
  AUTHORS   Yamashita,T., Miyagi,Y., Ono,M., Ito,H., Watanabe,K., Sonoda,T.,
            Tsuzuki,K., Ozawa,S., Aoki,I., Okuda,K., Mishina,M. and Kawamoto,S.
  TITLE     Identification and characterization of a novel Delphilin variant
            with an alternative N-terminus
  JOURNAL   Brain Res Mol Brain Res 141 (1), 83-94 (2005)
   PUBMED   16168524
  REMARK    GeneRIF: Results show that the Delphilin protein exhibits diversity
            at its N-terminus by variable usage of the first several exons.
REFERENCE   5  (bases 1 to 4144)
  AUTHORS   Selimi,F., Lohof,A.M., Heitz,S., Lalouette,A., Jarvis,C.I.,
            Bailly,Y. and Mariani,J.
  TITLE     Lurcher GRID2-induced death and depolarization can be dissociated
            in cerebellar Purkinje cells
  JOURNAL   Neuron 37 (5), 813-819 (2003)
   PUBMED   12628171
  REMARK    GeneRIF: Absence of GRID2 receptors in heteroallelic mutants
            induces an early and massive Purkinje cell death that is correlated
            with early signs of autophagy and is independent of depolarization.
REFERENCE   6  (bases 1 to 4144)
  AUTHORS   Yue,Z., Horton,A., Bravin,M., DeJager,P.L., Selimi,F. and Heintz,N.
  TITLE     A novel protein complex linking the delta 2 glutamate receptor and
            autophagy: implications for neurodegeneration in lurcher mice
  JOURNAL   Neuron 35 (5), 921-933 (2002)
   PUBMED   12372286
  REMARK    GeneRIF: A direct link exists between GluR2delta receptor and
            stimulation of the autophagic pathway in dying Purkinje cells of
            lurcher mice.
REFERENCE   7  (bases 1 to 4144)
  AUTHORS   Miyagi,Y., Yamashita,T., Fukaya,M., Sonoda,T., Okuno,T., Yamada,K.,
            Watanabe,M., Nagashima,Y., Aoki,I., Okuda,K., Mishina,M. and
            Kawamoto,S.
  TITLE     Delphilin: a novel PDZ and formin homology domain-containing
            protein that synaptically colocalizes and interacts with glutamate
            receptor delta 2 subunit
  JOURNAL   J Neurosci 22 (3), 803-814 (2002)
   PUBMED   11826110
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118226.7 and DQ193535.1.
            
            On Jun 19, 2019 this sequence version replaced NM_001159321.1.
            
            Transcript Variant: This variant (1) encodes the larger isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ193535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC118226.7         53491-53498         c
            9-3833              DQ193535.1         1-3825
            3834-4144           AC118226.7         19049-19359         c
FEATURES             Location/Qualifiers
     source          1..4144
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 82.1 cM"
     gene            1..4144
                     /gene="Grid2ip"
                     /note="glutamate receptor, ionotropic, delta 2 (Grid2)
                     interacting protein 1"
                     /db_xref="GeneID:170935"
                     /db_xref="MGI:MGI:2176213"
     exon            1..617
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..3833
                     /gene="Grid2ip"
                     /note="isoform 1 is encoded by transcript variant 1;
                     L-delphilin; glutamate receptor, ionotropic, delta
                     2-interacting protein 1; GluR-delta2 philic-protein"
                     /codon_start=1
                     /product="delphilin isoform 1"
                     /protein_id="NP_001152793.1"
                     /db_xref="CCDS:CCDS51689.1"
                     /db_xref="GeneID:170935"
                     /db_xref="MGI:MGI:2176213"
                     /translation="MPATNQGWPEDFGFQLGGSGPCFVIEVAEGSSAHAGGLRPGDQI
                     LEVEGLAVGGLSRERIVRLARRCPRVPPSLGVLPGPEGGPTALTAAWLTRRFGRSLPL
                     SRELLRLAGGPRPDAVHRERRRKAQEFSCQVDDILGDRLTAKEQVFTALKQFAAEQRV
                     DELVWTLTLVLPSEAQGPVLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQR
                     LRRSRSEERPERLLVSTRASAAPRRPDEPPPRKATSLLGGRTGPGGPRRTVRVYKGNK
                     SFGFTLRGHGPVWIESVLPGSPAENASLKSGDRILFLNGLDMRNCSHDKVVSMLQGSG
                     AMPTLVVEEGPVPFASDSDSLDSPTRASALTSLQWVADILPSSIRVQGRTFSQQLDHL
                     LTPPERYGVCRALERFFQHRNIDTLIVDVYPVLDTPAKQVLWQFLYQLLTYEEQELCQ
                     EKIACFLGYTAMTEPESSLDLEPESTPEPTPEPQPRSSLRASSMCRRSLRSQGLETSL
                     SCGPGDCPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKIGTM
                     SKSRASPPVPSLVGTSGPRTLSGVSWPSDRLLPSPCYDPLCSGGLASPSSSESHPYAS
                     LDSSRAPSPQPGLGSIHADSPPSPDPIRPPSRRKLFAFSRPVRSRDTDRFLDALSEQL
                     GPRLSIVDDFLTPENDYEEMSFHDDQGSFVTNERSSASECVSSSEEGSSLTYSSISDH
                     IPPPPLSPPPPPPLPFHDPKPSSRTSDGPRGPPQSLTKPLTQINHPVPPPPPPPLPPP
                     VPCAPPMLSRGVGHRRSETSHMSVKRLRWEQVENSEGTIWGQLGEDSDYDKLSDMVKY
                     LDLELHFGTQKPPKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLTPGELRQVLM
                     SMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRL
                     RSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTN
                     KTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQ
                     RALTGDLADLHDTVSEIQVACQSMAPSSEDRFAVVMASFLETAQPALRALDGLQREAM
                     EELGKALAFFGEDSKATTSEAFFGIFSEFMSKFERALSDLQAGDGPRSSGMVSPLAW"
     exon            618..772
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            773..1021
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1107
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1177
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1272
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1456
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1611
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1752
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1850
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1968
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2324
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2741
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2829
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2907
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3104
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3260
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3347
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..3477
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3596
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..3761
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            3762..4144
                     /gene="Grid2ip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4106..4111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grid2ip"
                     /note="hexamer: AATAAA"
     polyA_site      4144
                     /gene="Grid2ip"
                     /note="major polyA site"
ORIGIN      
        1 agtatagacc ctgaaccact gaggtagtat cccagctgac ctctgccctc ttcctaaaag
       61 cctcacgtgt gtctccacca tatgatgctt cagtgggata tgacacctgt ctgtgtccag
      121 caaacctgca gagggactca ggcctaggaa ggcctccaca gacagagccg taccagcttc
      181 tgtccctctc ttctctctcc agcagaaccg ccacggcagc aatgccagcc accaatcaag
      241 gctggcccga ggacttcggc ttccagctgg gcggctctgg cccctgcttc gtgatagagg
      301 tggctgaagg aagcagcgcg cacgctgggg ggttgcggcc gggggatcag atcctggaag
      361 tggaggggct ggctgtgggt ggcctgagcc gagagcgcat cgtgcgcttg gcacggcgct
      421 gccctcgagt gccacccagc ctcggtgtgc tcccaggccc cgagggtggc cccacagcct
      481 tgacagcagc ctggctaacc cggcgatttg gccgcagcct cccgctgagc cgcgaactgc
      541 tgcgtttggc tggtggtccc agaccagatg ctgtgcacag agagcgcagg cgcaaggccc
      601 aggagttcag ctgccaggta gatgacatct tgggggatcg gctgacagcc aaggagcagg
      661 tgtttactgc actgaagcag ttcgctgccg agcaacgggt ggatgagctg gtgtggaccc
      721 tcactctcgt gctgcccagc gaggcccagg ggccagtcct ggacaacctc aggatcttta
      781 ttcccaaaaa gcatcgggcg cgcttcgacg aggtggtgtc gcagggtctg ctgggcaagc
      841 tgtgccgtgc tcggagggcg cagggcgcac agcgtttgcg tcggagccgc agcgaggagc
      901 gcccggagcg cctcttagtg tccacgcgcg ctagcgccgc tccccgccgt ccggatgagc
      961 cacccccgcg gaaggcaacc tcgctgctgg gcggtcgcac tggccctggg ggtcctcgta
     1021 ggacggttcg agtttataaa ggcaacaaga gtttcggctt cactctgcga ggccatggac
     1081 cggtctggat cgaatctgtc ctgcctggca gcccggctga aaatgcctcc ctcaagtcag
     1141 gtgaccggat cctcttcctc aatggattgg acatgaggaa ctgctcccac gacaaggtgg
     1201 tgtccatgtt gcagggcagt ggcgccatgc ccacgctggt ggtagaggaa ggaccggtcc
     1261 ctttcgccag tgattcagat tctctggatt ccccgacccg ggcgtcagct ctcacctcgc
     1321 tgcagtgggt ggcggatatc ctgccttcca gtatccgagt ccaggggagg accttcagcc
     1381 agcagctgga ccacctcctc actcctcccg agcgctatgg agtctgccga gctctcgagc
     1441 gcttctttca gcacaggaac atcgataccc tcatcgtgga tgtctacccc gtcctggaca
     1501 cacccgccaa gcaggtactc tggcagttcc tctaccagct gctgacctac gaggagcagg
     1561 agctgtgtca ggagaagatc gcgtgcttcc tcggctacac agccatgacg gaacctgaat
     1621 cctcactgga cctcgagcca gagtctacac cagagcccac accagagcca caaccacgga
     1681 gttccctgag ggcctcttcc atgtgccgtc gcagcttgcg ctcccagggc ctggagacca
     1741 gcctcagctg tggtcctggt gactgccctg agatgcccct acctctgatc ccaggcgagc
     1801 gtcaggctgg cgatggcaca tccctcccgg aaacccctaa ccccaaaatg atgtcagcgg
     1861 tctatgcaga gctcgagtct cgactgaaca gcagcttcaa agggaagata gggaccatgt
     1921 ccaaatcccg ggcctctcca ccagtcccca gcctggtcgg cacatcaggg cccaggaccc
     1981 tgtctggagt ctcctggccc agtgaccggc tcctgccttc cccgtgctat gacccgctgt
     2041 gttctggggg tctggcctct cccagcagct cggaatccca cccctacgcc agcttggaca
     2101 gcagcagggc gccctcccca cagccaggcc ttggatccat ccacgccgac agccccccaa
     2161 gcccagaccc catccggccg cccagtcgcc ggaagctctt cgccttctca cgcccagtcc
     2221 ggagccgaga cacagatcgc ttcctggatg cgctgagcga gcagctgggt ccccgcctca
     2281 gcatcgtgga tgacttcctg acacccgaga atgactatga agagatgagc ttccatgatg
     2341 accagggcag ctttgtgacc aacgagagga gcagcgctag cgagtgtgtc agcagcagcg
     2401 aggagggcag ttctctgacc tactcctcca tctccgacca catcccccca cctccactca
     2461 gccccccgcc gccaccgccc ctgcctttcc atgaccccaa gcctagctcc cgcacctccg
     2521 atggtccccg aggtccccct cagtcattga ccaaacccct cacccagatc aaccatccag
     2581 tcccaccccc acccccaccc cctctacccc cacctgtgcc ctgtgcaccc cccatgctat
     2641 cccgaggcgt gggccaccgc cgcagtgaga ccagccatat gagcgtcaag cgcttacgct
     2701 gggaacaggt ggagaactca gaaggcacca tctggggtca gcttggggaa gactctgact
     2761 atgacaagct gagtgacatg gtgaaatacc tcgacctgga gctccacttc ggcacccaga
     2821 aacctccgaa gccagtgccc ggcccggagc ccttcaggaa gaaggaagtg gtggagatct
     2881 tgtcccacaa gaaggcctac aatacctcca ttctcctagc gcacctgaag ctgacccctg
     2941 gcgagctgcg gcaagtgctc atgagcatgg aaccccggcg cctggagcct gctcatctgg
     3001 cgcagctgct gctcttcgct cctgacgccg acgaggaaca gcgatatcag gctttccgcg
     3061 aggctccggg tcgcctcagt gagccggacc agttcgtcct gcagatgctg tcggttcccg
     3121 aatacaagac ccgcctgcgc agtctacact tccaggctac cttgcaggag aagacagagg
     3181 agatacgagg cagcctcgag tgtctgcgac aggcatctct ggagctcaaa aacagccgga
     3241 aactcgccaa gatcctggag tttgtgttgg ccatgggtaa ctatctcaac gatggacagc
     3301 ccaagaccaa caagaccact ggcttcaaga tcaacttcct gaccgagcta aactccacca
     3361 agacagtgga cgggaagtcc acctttctgc acatccttgc caaatcgcta agccagcact
     3421 tccctgagct cctgggcttt gcccaggacc tgcccactgt gcccctggct gccaaagtga
     3481 accagcgagc cctgactggt gacctggctg acctccatga caccgtcagt gagattcagg
     3541 tggcctgcca gagcatggcc ccttccagtg aggacaggtt tgctgtggtc atggcttcct
     3601 ttctggaaac agcgcagcca gccctgcgag cgttggatgg tctgcagcga gaggccatgg
     3661 aggagctagg gaaggctctg gccttcttcg gagaggactc caaggccact acctcagagg
     3721 ccttctttgg catcttttca gaattcatga gcaaatttga gagagccctc agcgacctgc
     3781 aggcagggga tggcccacgc agctcaggga tggtgtcacc cctggcctgg tgatagctgc
     3841 caccaagcat cttctgcagt ctgagcacgg agaccgatgc tggaggctgc accatggagg
     3901 aatgtcacag ggtccagggt acttgaccat gcaccttggc tgcaggaagg gcttgggtgc
     3961 ggtggggctg cagccacgtg tctccggcta cctcagctgc cgagttctgc ttggccctct
     4021 tttgcccata caccttggtc tcccaagaag gtctccctgg cttccggtgg ccacccaccc
     4081 ttccgcctcg atgcccacaa cggtgaataa aatgctgctg tgtgtcaggg aatgtcccac
     4141 cgga
//
