LOCUS       NM_019691               5444 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus glutamate receptor, ionotropic, AMPA4 (alpha 4)
            (Gria4), transcript variant 1, mRNA.
ACCESSION   NM_019691
VERSION     NM_019691.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5444)
  AUTHORS   Mey,G.M., Evonuk,K.S., Shelestak,J., Irfan,M., Wolfe,L.M.,
            Laye,S.E., Schafer,D.P. and DeSilva,T.M.
  TITLE     Inhibiting AMPA receptor signaling in oligodendrocytes rescues
            synapse loss in a model of autoimmune demyelination
  JOURNAL   iScience 27 (11), 111226 (2024)
   PUBMED   39569383
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5444)
  AUTHORS   Wang,X., Zhang,Y., Luo,S., Zhao,K., Gao,C., Mei,D., Duan,Y. and
            Hu,S.
  TITLE     Restoration of nNOS Expression Rescues Autistic-Like Phenotypes
            Through Normalization of AMPA Receptor-Mediated Neurotransmission
  JOURNAL   Mol Neurobiol 61 (9), 6599-6612 (2024)
   PUBMED   38329681
REFERENCE   3  (bases 1 to 5444)
  AUTHORS   Teng,S., Zhen,F., McRae,B.R., Zhu,E., Frankel,W.N. and Peng,Y.
  TITLE     Sensory regulation of absence seizures in a mouse model of Gnb1
            encephalopathy
  JOURNAL   iScience 25 (11), 105488 (2022)
   PUBMED   36405774
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5444)
  AUTHORS   Spirkova,A., Kovarikova,V., Sefcikova,Z., Pisko,J., Ksinanova,M.,
            Koppel,J., Fabian,D. and Cikos,S.
  TITLE     Glutamate can act as a signaling molecule in mouse preimplantation
            embryosdagger
  JOURNAL   Biol Reprod 107 (4), 916-927 (2022)
   PUBMED   35746896
REFERENCE   5  (bases 1 to 5444)
  AUTHORS   Ma,P., Wan,L.P., Li,Y., He,C.H., Song,N.N., Zhao,S., Wang,H.,
            Ding,Y.Q., Mao,B. and Sheng,N.
  TITLE     RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate
            synaptic transmission
  JOURNAL   Sci Adv 8 (39), eabq4736 (2022)
   PUBMED   36179027
REFERENCE   6  (bases 1 to 5444)
  AUTHORS   Aruscavage,P.J. and Bass,B.L.
  TITLE     A phylogenetic analysis reveals an unusual sequence conservation
            within introns involved in RNA editing
  JOURNAL   RNA 6 (2), 257-269 (2000)
   PUBMED   10688364
REFERENCE   7  (bases 1 to 5444)
  AUTHORS   McNamara,J.O., Eubanks,J.H., McPherson,J.D., Wasmuth,J.J.,
            Evans,G.A. and Heinemann,S.F.
  TITLE     Chromosomal localization of human glutamate receptor genes
  JOURNAL   J Neurosci 12 (7), 2555-2562 (1992)
   PUBMED   1319477
REFERENCE   8  (bases 1 to 5444)
  AUTHORS   Morita,T., Sakimura,K., Kushiya,E., Yamazaki,M., Meguro,H.,
            Araki,K., Abe,T., Mori,K.J. and Mishina,M.
  TITLE     Cloning and functional expression of a cDNA encoding the mouse beta
            2 subunit of the kainate-selective glutamate receptor channel
  JOURNAL   Brain Res Mol Brain Res 14 (1-2), 143-146 (1992)
   PUBMED   1379666
REFERENCE   9  (bases 1 to 5444)
  AUTHORS   Sakimura,K., Morita,T., Kushiya,E. and Mishina,M.
  TITLE     Primary structure and expression of the gamma 2 subunit of the
            glutamate receptor channel selective for kainate
  JOURNAL   Neuron 8 (2), 267-274 (1992)
   PUBMED   1310861
REFERENCE   10 (bases 1 to 5444)
  AUTHORS   Sommer,B., Kohler,M., Sprengel,R. and Seeburg,P.H.
  TITLE     RNA editing in brain controls a determinant of ion flow in
            glutamate-gated channels
  JOURNAL   Cell 67 (1), 11-19 (1991)
   PUBMED   1717158
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC141562.4, AC127269.3,
            AC156503.1 and CT030685.6.
            
            On Apr 17, 2020 this sequence version replaced NM_019691.4.
            
            Summary: Glutamate receptors are the predominant excitatory
            neurotransmitter receptors in the mammalian brain and are activated
            in a variety of normal neurophysiologic processes. These receptors
            are heteromeric protein complexes composed of multiple subunits,
            arranged to form ligand-gated ion channels. The classification of
            glutamate receptors is based on their activation by different
            pharmacologic agonists. The subunit encoded by this gene belongs to
            a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole
            propionate)-sensitive glutamate receptors, and is subject to RNA
            editing (AGA->GGA; R->G). Alternative splicing of this gene results
            in transcript variants encoding different isoforms, which may vary
            in their signal transduction properties. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes isoform 1 (also known
            as flip isoform).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060697.1, SRR9219381.129236.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            undergoes RNA editing  :: PMID: 10688364
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               AC141562.4         139920-140309
            391-567             AC141562.4         140791-140967
            568-726             AC141562.4         142186-142344
            727-966             AC127269.3         9569-9808
            967-1151            AC156503.1         29984-30168
            1152-1205           AC156503.1         48264-48317
            1206-1364           AC156503.1         54422-54580
            1365-1532           AC156503.1         64074-64241
            1533-1637           AC156503.1         65325-65429
            1638-1748           CT030685.6         20371-20481
            1749-1955           CT030685.6         28441-28647
            1956-2326           CT030685.6         36175-36545
            2327-2525           CT030685.6         38555-38753
            2526-2773           CT030685.6         44407-44654
            2774-2888           CT030685.6         73515-73629
            2889-3023           CT030685.6         76205-76339
            3024-5444           CT030685.6         80343-82763
FEATURES             Location/Qualifiers
     source          1..5444
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..5444
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /note="glutamate receptor, ionotropic, AMPA4 (alpha 4)"
                     /db_xref="GeneID:14802"
                     /db_xref="MGI:MGI:95811"
     exon            1..390
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..567
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     CDS             480..3188
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; glutamate receptor channel alpha 4; glutamate
                     receptor 4; AMPA-selective glutamate receptor 4; glutamate
                     receptor ionotropic, AMPA 4; spike wave 1"
                     /codon_start=1
                     /product="glutamate receptor 4 isoform 1 precursor"
                     /protein_id="NP_062665.4"
                     /db_xref="CCDS:CCDS22797.1"
                     /db_xref="GeneID:14802"
                     /db_xref="MGI:MGI:95811"
                     /translation="MRIICRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAF
                     RLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRS
                     VHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDT
                     DRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERL
                     QNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLM
                     DRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLAN
                     PAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWND
                     MDKLVLIQDAPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDL
                     ASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVRE
                     EVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVS
                     RFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVG
                     GVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFR
                     RSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPC
                     DTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPK
                     DSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIR
                     NKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASDLP"
     exon            568..726
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..966
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1151
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1205
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1364
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1532
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1637
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1748
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1955
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2326
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2525
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2773
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2888
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3023
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..5444
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5423..5428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /note="hexamer: AATAAA"
     polyA_site      5444
                     /gene="Gria4"
                     /gene_synonym="GluA4; Glur-4; GluR-D; Glur4; Gluralpha4;
                     spkw1"
                     /note="major polyA site"
ORIGIN      
        1 agcagaagcg gactaggctg ggcaaggctg agaggaaagg gctgggagcc gggaggcagc
       61 ttgtcctccc gcgagcctgc aaggatgctg caggggactg agaccatggg gaggtgctaa
      121 cttcctctcc aaccccccag cccgggatcc gggctggcat acccggcccc ccggggtagt
      181 ttcctgccaa gctcaaccaa gaatccaaag gcgacttgga gggcataaaa agaaaaacac
      241 tggttctgaa gaggggcccc cacctccaga gccggttcct cggcaaacgc gcggaaggta
      301 ggaggaaggg gatcagatac tggagactgt acgccaaaac cccagcctga agactcgctc
      361 cagagcctcc ctgaagacct gggcgatctg cgccatcatc ttcaatgcct ctctgaaaat
      421 catttagcaa gagtgagaga aagagaggag agcgcgcacc agggagagga gcaaagaaga
      481 tgaggattat ttgcaggcag attgtcttgt tgttttctgg attttgggga ctcgccatgg
      541 gagcctttcc gagcagcgtt caaataggtg gtctctttat ccgaaacaca gaccaggaat
      601 acactgcttt tcggctagct atctttcttc ataacaccag ccccaatgca tctgaagccc
      661 ctttcaattt ggtacctcat gtggacaaca ttgagactgc caacagtttt gctgtgacaa
      721 atgcattctg ttcccagtat tctagagggg tgtttgccat ttttggactc tatgacaaga
      781 ggtcagtgca taccttgacc tccttctgca gtgctctgca catctctctc atcacaccaa
      841 gcttccccac tgaaggagag agccagttcg tgcttcagct aagaccttca ttgagaggtg
      901 cactcctgag cctcctggat cactatgaat ggaattgttt tgtcttcctg tatgatacag
      961 acagggggta ttcaatactt caagctataa tggaaaaagc aggacagaat ggatggcatg
     1021 tcagtgcgat atgtgtggaa aattttaacg atgtcagcta caggcaacta ctagaagagc
     1081 ttgacagaag acaagagaag aaatttgtaa tagattgtga gatagaaagg cttcaaaaca
     1141 tattagaaca aattgtgagt gttgggaagc acgtcaaagg ctaccattat atcatcgcaa
     1201 atttgggttt caaagatatt tctcttgaga gatttataca tggaggagca aatgtcactg
     1261 gattccagtt agtagatttt aatacgccca tggtgacgaa actaatggat cgctggaaga
     1321 aactagatca acgagaatat ccaggatctg aaacacctcc aaagtacact tctgctctca
     1381 cttacgatgg tgtcttggta atggctgaaa ctttccgaag tctcagaaga cagaaaattg
     1441 atatttcaag gagaggaaat gccggggatt gtctggcaaa ccctgctgct ccctggggcc
     1501 agggaattga catggagaga acactgaagc aggttcgaat tcaaggactg actgggaatg
     1561 ttcaatttga ccactatgga cgtagagtta attacacaat ggatgtgttt gaattaaaaa
     1621 gcacaggacc tcgaaaggtt ggctattgga acgatatgga taaattagtc ttgattcaag
     1681 atgcgcctac tcttggcaat gacacagcag ctatcgagaa cagaacagtg gttgtaacca
     1741 caattatgga atccccctac gttatgtaca agaaaaatca tgaaatgttt gaaggaaatg
     1801 acaagtatga aggctactgt gtagacttgg catctgaaat tgcgaaacat atcggtatca
     1861 aatataaaat tgccattgtc cctgatggaa aatatggagc aagggatgcg gacaccaaaa
     1921 tttggaatgg gatggtagga gagcttgtgt atgggaaagc agagattgcc attgcacctc
     1981 tgacaatcac gttggtgcga gaggaggtca tcgacttttc taagcctttt atgagtttag
     2041 gcatctctat catgatcaaa aaacctcaga aatctaaacc aggagtgttt tccttcttgg
     2101 accctctggc ctatgagatc tggatgtgca tagtgtttgc atacattggt gtcagcgtgg
     2161 tcttgttcct agtcagtagg tttagcccat atgagtggca cacagaagag cctgaggatg
     2221 gaaaagaagg acccagtgac caacctccca atgagtttgg catctttaac agcctctggt
     2281 tttccctggg tgcctttatg caacaaggat gtgacatttc acccagatcc ctgtccggtc
     2341 ggattgttgg aggcgtatgg tggttcttca ctctcatcat tatctcatcc tacactgcta
     2401 atctggctgc attcctgaca gtggagagaa tggtctcccc catagaaagt gcagaagacc
     2461 tggccaaaca aacagaaatt gcctatggaa cacttgattc gggatcaaca aaagaattct
     2521 tcagaagatc aaaaatagca gtatatgaaa agatgtggac ctacatgcga tcggcagagc
     2581 catctgtgtt cactagaact acagctgagg gcgtggcccg tgtccgcaag tccaagggca
     2641 aatttgcctt cctcctggag tccacgatga atgaatacat tgagcagcga aagccctgtg
     2701 acacgatgaa agtgggagga aacctggatt ccaaaggcta tggtgtagcg acgcccaagg
     2761 gttcctcatt aagaactcct gtaaaccttg ccgttttgaa actcagtgag gcaggcgtct
     2821 tagacaagct gaaaaacaaa tggtggtacg ataaaggtga atgtggaccc aaggactcgg
     2881 gaagcaagga caagacgagt gccttgagcc tgagcaacgt agcaggcgtc ttctacattc
     2941 tggttggcgg cttgggcttg gcaatgctgg tggctttgat agagttctgt tacaagtcca
     3001 gggcagaggc gaagagaatg aagctgactt tttccgaagc cataagaaac aaagccaggt
     3061 tatccatcac tgggagtgtg ggagaaaacg gccgtgtgct gacccccgac tgccccaagg
     3121 ccgtacacac aggaactgcg attagacaga gctcgggatt ggctgtcatt gcatcggacc
     3181 taccataaaa accaaaaaat taattgagtg ccttaatcaa actgtgttgg tgactgatgg
     3241 aaacgcagcc ccgagggaca ggccaagcgt gggtcttggc taaacccatc ctttgactga
     3301 gcaggaagga catcctgagt gccggacaga accagtgcat gagttccgca cggaaatgca
     3361 gactcggatt tttttatcag gaaatctcac agtttagttt tttgggggga gtgggtgggg
     3421 taccttaggt gtattaacag caacagatct cacttgagcg cacttaaaac taatcagact
     3481 ggccagttag cgcattaaac tgtgaagttc tttctcagaa aggtcgtggt caccacagcc
     3541 agggatcaac agttaataga ggtcaaagaa cctgctacct gtgtctccag aacacccata
     3601 tagtccatgg aataatcttc cgctgagaca agccgtcact aacatgtgat aggaaaataa
     3661 taaatagata aagcctgtga acaaacaatg agatttaaag aaagtattta cagttacttt
     3721 ggaaataaaa caatactgaa acatgcttgc tttttaactg aagttaatcc agtagaggac
     3781 aacgcaattg ttttttctaa ccatcttagg gaacaataca ttgcaataat tgataatagt
     3841 gccatcactg taataaactt tagagacttt ttttaatgta aaagttgttg gtcaccttgt
     3901 ttcctgtaac cttcactctg tcacacaagt tggctcatag gttgtgtttg tctatcagaa
     3961 ataagaaaaa cacaagtgaa gaaaatgttg gcatgaagtc atccatctgc aatgaaaaac
     4021 ctaaaagact acgggtcact catgttatca atataattta taatcctgtt cagtgtacaa
     4081 aattgtgggt tttgtactca cccaaaagac taaaacacca gtttttctta cagtatctat
     4141 ctacagagct tattctcccc tattatttgg gaaactctga gactccatat tgcagaagtc
     4201 aaggaatagg ccatataaga aaatgtagct tgtttttatt atttctgcat atttatttct
     4261 agatcttggg ctcatttgtt aacagaataa gttgtcaaag gtaaagtcct tgagtctggg
     4321 aatgagccat cgttccaaaa ccaacacacc ctgtgtggaa attttacttg actctgtttt
     4381 gctgcataga attcagtgtc tcttggccat tccccctcat tcctatacta aattctttga
     4441 agacactggt aacagtttgt ggtagactac agttgaaaaa actcaatcct tatttctacc
     4501 aagtaattgt gagtaaaatt ataccatgat catttttaag aaaagaaaac ccttatggtt
     4561 caaaaggtct ggttcatttg aaatgatgaa tgagttcaat gatacagttt ttaaaaaacc
     4621 aaaacaaaca aacaaacaaa aacaaatcac agattgaggg atctttgcag aaagcacaaa
     4681 ttaggatgat gcccaaagtg tggccttgaa gaatgagttg agttttcaca ggagaaggtg
     4741 ctggtaagat cctaggcgtg agcagcacac atagctgctt cttttatcag tgtttcatgt
     4801 acaaggcttg tgcaaccagg tggcctggtg agggcacagg gtgtgacacc atggaagctc
     4861 tgtcagaaat atggagaatt ggtttccttc cctcaatact tacaatccca ttcaataact
     4921 gtgtgtcact acaatgtaat ccttataata catgtatgca ctgtcctttg ggaaaggtta
     4981 cttctctgtt gttgagcaat gattcatttc acaacctagg ccactccctg gtatcttcct
     5041 cttcctctct cactcctacc caagctctca gccagcaaat ggacctccac agcacacgga
     5101 acacggcatc tactgtgtct ttgatctgta gatctttttt gtctttacct gactgtcaca
     5161 catccttcag ccctgaaatt gaattttatg tgtactgaga agatttccat gattacccac
     5221 caccctgccc atgacactga gttacctgcc attcttaatg tttcttaccc atcatggcac
     5281 tcatcgtact gcattgtaat tgcctgtgta cttgtctata aactactaga ctgtcagctc
     5341 cttgagggca gggactgtgt ctattttgtt cacagttgta tccccagcac ccagcacagt
     5401 gcctggcata ttgtaggtgc ttaataaata tttgttgaat gaaa
//
