LOCUS       NM_001113325            5755 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Mus musculus glutamate receptor, ionotropic, AMPA1 (alpha 1)
            (Gria1), transcript variant 1, mRNA.
ACCESSION   NM_001113325
VERSION     NM_001113325.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5755)
  AUTHORS   Ide,H., Miike,K., Ohmori,T., Maruyama,K., Izumi,Y., Tanigawa,S. and
            Nishinakamura,R.
  TITLE     Mouse embryonic kidney transplantation identifies maturation
            defects in the medulla
  JOURNAL   Sci Rep 14 (1), 30293 (2024)
   PUBMED   39639083
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5755)
  AUTHORS   Borruto,A.M., Calpe-Lopez,C., Spanagel,R. and Bernardi,R.E.
  TITLE     Conditional deletion of the AMPA-GluA1 and NMDA-GluN1 receptor
            subunit genes in midbrain D1 neurons does not alter cocaine reward
            in mice
  JOURNAL   Neuropharmacology 258, 110081 (2024)
   PUBMED   39002853
REFERENCE   3  (bases 1 to 5755)
  AUTHORS   Hong,I., Kim,J., Hainmueller,T., Kim,D.W., Keijser,J.,
            Johnson,R.C., Park,S.H., Limjunyawong,N., Yang,Z., Cheon,D.,
            Hwang,T., Agarwal,A., Cholvin,T., Krienen,F.M., McCarroll,S.A.,
            Dong,X., Leopold,D.A., Blackshaw,S., Sprekeler,H., Bergles,D.E.,
            Bartos,M., Brown,S.P. and Huganir,R.L.
  TITLE     Calcium-permeable AMPA receptors govern PV neuron feature
            selectivity
  JOURNAL   Nature 635 (8038), 398-405 (2024)
   PUBMED   39358515
REFERENCE   4  (bases 1 to 5755)
  AUTHORS   Xing,M., Yang,X., Jin,S. and Xu,X.
  TITLE     Inhibition of neuronal pentraxin 2 relieved epileptic seizure via
            reducing GluA1 phosphorylation
  JOURNAL   Cell Biochem Funct 42 (3), e4003 (2024)
   PUBMED   38597235
  REMARK    GeneRIF: Inhibition of neuronal pentraxin 2 relieved epileptic
            seizure via reducing GluA1 phosphorylation.
REFERENCE   5  (bases 1 to 5755)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 5755)
  AUTHORS   Brusa,R., Zimmermann,F., Koh,D.S., Feldmeyer,D., Gass,P.,
            Seeburg,P.H. and Sprengel,R.
  TITLE     Early-onset epilepsy and postnatal lethality associated with an
            editing-deficient GluR-B allele in mice
  JOURNAL   Science 270 (5242), 1677-1680 (1995)
   PUBMED   7502080
REFERENCE   7  (bases 1 to 5755)
  AUTHORS   Seeburg,P.H.
  TITLE     The TiPS/TINS lecture: the molecular biology of mammalian glutamate
            receptor channels
  JOURNAL   Trends Pharmacol Sci 14 (8), 297-303 (1993)
   PUBMED   7504359
  REMARK    Review article
REFERENCE   8  (bases 1 to 5755)
  AUTHORS   McNamara,J.O., Eubanks,J.H., McPherson,J.D., Wasmuth,J.J.,
            Evans,G.A. and Heinemann,S.F.
  TITLE     Chromosomal localization of human glutamate receptor genes
  JOURNAL   J Neurosci 12 (7), 2555-2562 (1992)
   PUBMED   1319477
REFERENCE   9  (bases 1 to 5755)
  AUTHORS   Sakimura,K., Morita,T., Kushiya,E. and Mishina,M.
  TITLE     Primary structure and expression of the gamma 2 subunit of the
            glutamate receptor channel selective for kainate
  JOURNAL   Neuron 8 (2), 267-274 (1992)
   PUBMED   1310861
REFERENCE   10 (bases 1 to 5755)
  AUTHORS   Sakimura,K., Bujo,H., Kushiya,E., Araki,K., Yamazaki,M.,
            Yamazaki,M., Meguro,H., Warashina,A., Numa,S. and Mishina,M.
  TITLE     Functional expression from cloned cDNAs of glutamate receptor
            species responsive to kainate and quisqualate
  JOURNAL   FEBS Lett 272 (1-2), 73-80 (1990)
   PUBMED   1699805
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663055.13, AK049958.1 and BC056397.1.
            
            On Nov 18, 2011 this sequence version replaced NM_001113325.1.
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            exon, compared to variant 2, resulting in a protein (isoform 1)
            with a distinct internal segment compared to isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049958.1, X57497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-434               AL663055.13        160297-160730
            435-3230            AK049958.1         245-3040
            3231-3302           BC056397.1         2893-2964
            3303-5755           BC056397.1         2968-5420
FEATURES             Location/Qualifiers
     source          1..5755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 34.51 cM"
     gene            1..5755
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /note="glutamate receptor, ionotropic, AMPA1 (alpha 1)"
                     /db_xref="GeneID:14799"
                     /db_xref="MGI:MGI:95808"
     exon            1..498
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..636
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..876
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1061
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1115
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1277
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1445
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1550
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1661
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1868
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2239
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2438
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2686
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2801
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..2936
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..5738
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5511..5516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /note="hexamer: ATTAAA"
     polyA_site      5531
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /note="major polyA site"
     regulatory      5716..5721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
                     /note="hexamer: ATTAAA"
     polyA_site      5738
                     /gene="Gria1"
                     /gene_synonym="2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1;
                     GluR-A; gluR-K1; Glur1; GluRA; HIPA1"
ORIGIN      
        1 gaggagagag agagagagag agagagagag agagagagag agagagagag agagagagag
       61 agagagagag agagagagag agagaacggg agggtgagag aggctggctg ctagagaaga
      121 ggaggagagc agagggagag ggggagcgag ctagcgctcc aagcatgagg acgggctgct
      181 cccggctcag ttaatctggc tgtcagtcgg tgttaacgct gcagtttaac tgctcggctc
      241 cccttccaag agaaacaaga gaaacctcac agaaggaagg gaggaaggaa agaagcaagc
      301 aaggaattgc aggaagaaaa gagccggcag agcatccaga agaatcaaag ggaggggagg
      361 gaagaccaaa tctatggttg gaccagggct tctttttcgc caatgtaaaa aggaatatgc
      421 cgtacatctt tgcctttttc tgcaccggtt ttctaggtgc ggttgtgggt gccaatttcc
      481 ccaacaatat ccagataggg ggattatttc caaaccaaca atcacaggaa catgcggctt
      541 ttaggtttgc tttgtcacaa ctcacggagc cccccaagct gcttccccag atcgatattg
      601 tgaacatcag cgacagcttt gagatgactt accgattctg ttcccagttc tccaaaggag
      661 tgtacgccat ctttggattt tatgaacgaa ggactgtcaa catgctgacc tccttctgtg
      721 gggccctcca tgtgtgcttc atcactccaa gttttcccgt tgacacatcc aatcagtttg
      781 tccttcagct gcgcccggaa ctacaggaag ctctcattag cattatcgac cattacaagt
      841 ggcagacttt tgtctacatt tatgatgctg accggggcct gtcagtcctg cagagagtct
      901 tggatacagc cgccgagaag aactggcagg tgacggctgt caacattcta acaaccacgg
      961 aggaaggata ccggatgctc tttcaggacc tggagaagaa aaaggagagg ctggtggtgg
     1021 tggactgtga atcagaacgc ctcaacgcca tcctgggcca gattgtgaag ctagaaaaga
     1081 acggcatcgg gtaccactac atcctcgcca acctgggctt catggacatt gacttaaata
     1141 agttcaagga gagtggagcc aatgtgacag gtttccaact ggtgaactac acagacacga
     1201 tcccagccag aatcatgcag cagtggagga caagtgacgc tcgggaccac accagggtgg
     1261 actggaagag gccaaagtac acttctgctc ttacctatga tggtgtgaag gtgatggcgg
     1321 aggccttcca gagcctgcgg aggcagagga ttgacatatc ccggcgaggg aatgctgggg
     1381 actgtctggc taacccagct gtgccctggg gccaagggat cgacatccag agagccctgc
     1441 agcaggtgcg ctttgaaggt ttgacaggaa atgtgcagtt taacgagaaa gggcgccgga
     1501 ccaactacac cctccatgtg atcgaaatga agcatgatgg aatccgcaag attggttact
     1561 ggaatgaaga tgataaattt gtccccgcag ccacggacgc tcaggctgga ggggacaact
     1621 caagcgtcca gaatagaacc tacatcgtca cgactatcct cgaagatcct tacgtgatgc
     1681 ttaaaaagaa tgccaaccaa tttgaaggca atgaccgcta tgagggctac tgcgtggaac
     1741 tggctgcgga gatcgccaag cacgtgggct attcctaccg acttgagatt gtcagcgacg
     1801 gcaaatacgg agcccgggat cctgacacaa aggcctggaa tggcatggtg ggagagctag
     1861 tctatggaag agcagatgtg gcggtggccc ccttgaccat aaccttggtc cgggaggaag
     1921 tcatcgactt ctccaagcca ttcatgagtt tgggaatctc cattatgatt aagaagccac
     1981 agaagtccaa gccaggtgtc ttctcctttc ttgacccttt ggcctacgag atctggatgt
     2041 gtatagtgtt tgcctacatt ggagtgagcg tcgtcctctt cctggtcagc cgtttcagtc
     2101 cttatgaatg gcacagtgaa gagtttgaag aaggacgaga tcagacaacc agtgaccagt
     2161 caaatgagtt tggcatattc aacagcctgt ggttctcgct gggggccttc atgcagcaag
     2221 gatgtgacat ttcccccagg tccctgtctg gacgcatcgt cggcggtgtc tggtggttct
     2281 tcactttgat tatcatctcc tcatacacag ccaacctggc tgccttcctg actgtggaaa
     2341 ggatggtgtc tcccatcgag agtgcagagg acctggcaaa gcagacggaa attgcttatg
     2401 ggacattgga agcaggatcc actaaggagt tcttcaggag gtctaaaatc gctgtgtttg
     2461 agaagatgtg gacatacatg aagtctgcag aaccgtctgt gtttgttcgg accacagagg
     2521 agggcatgat cagagtgaga aagtctaaag gcaaatatgc ctacctcctg gagtccacca
     2581 tgaatgagta cattgagcaa cgcaagccct gtgacaccat gaaagtggga ggtaacttgg
     2641 attccaaagg ctatggcatt gcaacaccca aggggtccgc cctgagaggt cccgtaaacc
     2701 tagcggtttt gaaactcagt gagcaaggcg tcttagacaa gctgaaaagc aaatggtggt
     2761 acgataaagg ggaatgtgga agcaaggact ccggaagtaa ggacaagacc agtgctctga
     2821 gcctgagcaa tgtggcaggc gtgttctaca tcctgattgg agggctggga ttggccatgc
     2881 tggttgcctt aatcgagttc tgctacaaat cccgtagcga gtcgaagcgg atgaagggtt
     2941 tctgtttgat tccacagcaa tccatcaatg aagccatacg gacatcgacc ctccccagga
     3001 acagcggggc aggagccagc ggaggaagtg gcagtggaga gaatggcaga gtggtcagcc
     3061 aggacttccc caagtccatg caatccattc cctgcatgag ccacagttca gggatgccct
     3121 tgggagccac aggattgtaa ctggagcaga caggaaaccc ttggggagca ggctcaggct
     3181 tccccagccc catcccaagc ccttcagtgc caaaaacaaa gaaatgaaac accgcctcca
     3241 accaccacaa ccatatggag ggcaattcag ccaatgtccc tgaagaatta aaaaaaaaaa
     3301 aattccacta gaccaccatc ccttttgttt tgggattttt tttcaacctt ttccatttgc
     3361 tgagtgaaga tggtcactaa ctctatgctg caataacggg agagatcctg tccaaggaag
     3421 tctaacgtct ataaaaatgg agtcactggg atatcaatga agaaatcaaa ctgtttaatt
     3481 ttaattcagt tgttaatgtg tcttagtgtg tgcattattt tcttactatt aacccatggt
     3541 ttgcaggctc tgttcaaccc ttttccttct tcctatcccc agcccccacc cccaccccac
     3601 cccttcccat cacttttcag tttcagattg aagactcacg attggttcca ccttacaagc
     3661 aaggaaagga atattgacct tcaaactcat tcagtgttgg agctctctat gaggccttct
     3721 atcctttggc ccatgccttg gatggagaca gacactactg gagaaggggg ctgccttccc
     3781 cagaaagaat actacctaaa tgctggttca tcagagagta actgtgaaga gcatctcaga
     3841 taagggttct taaaaggggg gatgggcaga gtacagtaga ggaggacttg ttaggttcat
     3901 tgttccccgg aagaagcttc ctgcaatgcc caggagcatc ccacaggcaa tagagtacca
     3961 atatggtaga cctctttcac agtcaatctc agccctggaa attatgttct actatgctca
     4021 ggcccaaagg caatgtgggg gccaaagggc aactggcctt ctgacccact agagccttgc
     4081 aaagagttgg cagtcagggg ggtgtcatac atgattcttg ccttttcctt tgcttgatgt
     4141 ctatactgga tccccatggt ggagtaggac tctctgtgga gcctctggca taagaggaaa
     4201 tgttgcccga gctaagagca aaaggaaggt gatagggaat tatggaagtc catccaagcc
     4261 cctgacacag agccttctgt gctgtttcct gtcctaggtt tgagagacca aatatgaact
     4321 tgtgagttgt gtcaatgcag agaaccgggg ttttgtgtta atagagtatt gttttagcat
     4381 gtgatcagat cttaagaaag aaagaaagaa agacagcaaa gcctgaattc tttttgagag
     4441 atggagatga ggtacatcag gggaccttaa gatgcctgag cccatctttt aactctaaca
     4501 cagggatact aacctttttc cctggctaag acagactgag ggcattgcat tacaatggcc
     4561 agaaactaca cccatgagtg caacgaccaa ggtgaaggac agccagacag gaaaggtgac
     4621 aaaagccacc ctgagtgata ctaggctgcc tgaacctttg ggtgggagtg gaagtcccta
     4681 gcacacagct ttgtggagac ctccactctc actcttggtg caactgactt ccacttctta
     4741 tgcagccact cccaggtgca tgcttcagtg agtgccacat gccactagct tttaccaata
     4801 accatattct ggcttattct cctaccctct gcttccattc aatcttcccc actaggggtt
     4861 atcattggca atggacgagc tgaagatttt ggagcctatc catggttcag ggcagtagaa
     4921 ctggcttcct ctatggatgc ttccagcgga caaccaccat ctctgtgtct ctctcattct
     4981 ctcttcacct gccatagcaa agaaacatcc cagaatcgac ccttctccca ttgatccatg
     5041 tctcccgtgt caccatgggc atggcatgtg aagcaatgtc ctgcagatgg attaccacct
     5101 tttatttctg ccagctaaca tcctcccagc ctcctgccta ctactgtaga ctccggtgtg
     5161 acccaccact ggggagttca cacctagaaa gagatggaac taaactctac tatcagctgc
     5221 ttcaaaaacc ttttgtctac ggcctgggaa gatgttctcc agcccctgag cctattggtt
     5281 ggatagagag agactgtggt ggaaatgagg gtcttgctgg gaggggtcca tgactccggg
     5341 gaagacgctt ctcaacgagg gatgtgtgga aagaaaacag aagtgagaaa gaagttacct
     5401 tgtattatgt atttttacta cacttttctt aaaaatggag cagtgggaaa actctgaaag
     5461 agattgacat ttttctcaac aggaatccat acttaacagt tctggctttc attaaatttt
     5521 gctctttggt acctgggcct tttatttaac atatatattt attttaactc tcttggaaga
     5581 tgtgtgaggg aaaaaaataa ctctcatttg atcagacact aaatatttgg ggtagggatt
     5641 tctgtcttat tttcaaatag ccagggtttt tcttcatttt tttggtattt gcataaagtg
     5701 aacaatatca caagaattaa atcactgtgg acccattaaa aaaaaaaaaa aaaaa
//
