LOCUS       NM_080289               1281 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus glyoxylate reductase/hydroxypyruvate reductase
            (Grhpr), transcript variant 1, mRNA.
ACCESSION   NM_080289
VERSION     NM_080289.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1281)
  AUTHORS   Buchalski,B., Wood,K.D., Challa,A., Fargue,S., Holmes,R.P.,
            Lowther,W.T. and Knight,J.
  TITLE     The effects of the inactivation of Hydroxyproline dehydrogenase on
            urinary oxalate and glycolate excretion in mouse models of primary
            hyperoxaluria
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (3), 165633 (2020)
   PUBMED   31821850
REFERENCE   2  (bases 1 to 1281)
  AUTHORS   Wood,K.D., Holmes,R.P., Erbe,D., Liebow,A., Fargue,S. and Knight,J.
  TITLE     Reduction in urinary oxalate excretion in mouse models of Primary
            Hyperoxaluria by RNA interference inhibition of liver lactate
            dehydrogenase activity
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (9), 2203-2209 (2019)
   PUBMED   31055082
REFERENCE   3  (bases 1 to 1281)
  AUTHORS   Zong,C., Nie,X., Zhang,D., Ji,Q., Qin,Y., Wang,L., Jiang,D.,
            Gong,C., Liu,Y. and Zhou,G.
  TITLE     Up regulation of glyoxylate reductase/hydroxypyruvate reductase
            (GRHPR) is associated with intestinal epithelial cells apoptosis in
            TNBS-induced experimental colitis
  JOURNAL   Pathol Res Pract 212 (5), 365-371 (2016)
   PUBMED   26997491
  REMARK    GeneRIF: These data suggested that GRHPR might exert its
            pro-apoptosis function in intestinal epithelial cells. Thus, GRHPR
            might play an important role in regulating IECs apoptosis, and
            might be a potential therapeutic target for Crohn's disease.
REFERENCE   4  (bases 1 to 1281)
  AUTHORS   Li,X., Knight,J., Fargue,S., Buchalski,B., Guan,Z., Inscho,E.W.,
            Liebow,A., Fitzgerald,K., Querbes,W., Todd Lowther,W. and
            Holmes,R.P.
  TITLE     Metabolism of (13)C5-hydroxyproline in mouse models of Primary
            Hyperoxaluria and its inhibition by RNAi therapeutics targeting
            liver glycolate oxidase and hydroxyproline dehydrogenase
  JOURNAL   Biochim Biophys Acta 1862 (2), 233-239 (2016)
   PUBMED   26655602
REFERENCE   5  (bases 1 to 1281)
  AUTHORS   Knight,J., Holmes,R.P., Cramer,S.D., Takayama,T. and Salido,E.
  TITLE     Hydroxyproline metabolism in mouse models of primary hyperoxaluria
  JOURNAL   Am J Physiol Renal Physiol 302 (6), F688-F693 (2012)
   PUBMED   22189945
REFERENCE   6  (bases 1 to 1281)
  AUTHORS   Genolet,R., Kersten,S., Braissant,O., Mandard,S., Tan,N.S.,
            Bucher,P., Desvergne,B., Michalik,L. and Wahli,W.
  TITLE     Promoter rearrangements cause species-specific hepatic regulation
            of the glyoxylate reductase/hydroxypyruvate reductase gene by the
            peroxisome proliferator-activated receptor alpha
  JOURNAL   J Biol Chem 280 (25), 24143-24152 (2005)
   PUBMED   15840574
  REMARK    GeneRIF: data indicate a species-specific regulation by PPARalpha
            of GRHPR, a key gene of the glyoxylate cycle
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK004307.1, BB869843.1,
            CF738475.1 and AL824706.8.
            
            On Aug 20, 2015 this sequence version replaced NM_080289.1.
            
            Summary: This gene encodes a member of the D-isomer specific
            2-hydroxyacid dehydrogenase family of proteins. The encoded protein
            catalyzes three enzymatic reactions: the conversion of
            hydroxypyruvate to D-glycerate as well as the reverse reaction, and
            the conversion of glyoxylate to glycolate. Homozygous knockout mice
            exhibit elevated synthesis of oxalate and glycerate. [provided by
            RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010194.1, AY113690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK004307.1         2-25
            25-345              BB869843.1         20-340
            346-912             AK004307.1         345-911
            913-1245            CF738475.1         134-466
            1246-1281           AL824706.8         11659-11694
FEATURES             Location/Qualifiers
     source          1..1281
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.65 cM"
     gene            1..1281
                     /gene="Grhpr"
                     /gene_synonym="1110059D05Rik; 6430629L09Rik; Glxr"
                     /note="glyoxylate reductase/hydroxypyruvate reductase"
                     /db_xref="GeneID:76238"
                     /db_xref="MGI:MGI:1923488"
     exon            1..141
                     /gene="Grhpr"
                     /gene_synonym="1110059D05Rik; 6430629L09Rik; Glxr"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1045
                     /gene="Grhpr"
                     /gene_synonym="1110059D05Rik; 6430629L09Rik; Glxr"
                     /EC_number="1.1.1.79"
                     /EC_number="1.1.1.81"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="glyoxylate reductase/hydroxypyruvate reductase
                     isoform 1"
                     /protein_id="NP_525028.1"
                     /db_xref="CCDS:CCDS18128.1"
                     /db_xref="GeneID:76238"
                     /db_xref="MGI:MGI:1923488"
                     /translation="MKPARLMKVFVTGPLPAEGRAALAQAADCEVEQWNSDDPIPRKD
                     LEQGVVGAHGLLCRLSDRVDKKLLDAAGANLRVISTLSVGVDHLALDEIKKRGIRVGY
                     TPGVLTDATAELAVSLLLTTCRRLPEAIEEVKNGGWSSWSPLWMCGYGLSQSTVGIVG
                     LGRIGQAIARRLKPFGVQRFLYTGRQPRPQEAAEFQAEFVPIAQLAAESDFIVVSCSL
                     TPDTMGLCSKDFFQKMKNTAIFINISRGDVVNQEDLYQALASGQIAAAGLDVTTPEPL
                     PPSHPLLTLKNCVILPHIGSATYKTRNTMSLLAANNLLAGLRGEAMPSELKL"
     exon            142..272
                     /gene="Grhpr"
                     /gene_synonym="1110059D05Rik; 6430629L09Rik; Glxr"
                     /inference="alignment:Splign:2.1.0"
     exon            273..345
                     /gene="Grhpr"
                     /gene_synonym="1110059D05Rik; 6430629L09Rik; Glxr"
                     /inference="alignment:Splign:2.1.0"
     exon            346..462
                     /gene="Grhpr"
                     /gene_synonym="1110059D05Rik; 6430629L09Rik; Glxr"
                     /inference="alignment:Splign:2.1.0"
     exon            463..551
                     /gene="Grhpr"
                     /gene_synonym="1110059D05Rik; 6430629L09Rik; Glxr"
                     /inference="alignment:Splign:2.1.0"
     exon            552..656
                     /gene="Grhpr"
                     /gene_synonym="1110059D05Rik; 6430629L09Rik; Glxr"
                     /inference="alignment:Splign:2.1.0"
     exon            657..792
                     /gene="Grhpr"
                     /gene_synonym="1110059D05Rik; 6430629L09Rik; Glxr"
                     /inference="alignment:Splign:2.1.0"
     exon            793..923
                     /gene="Grhpr"
                     /gene_synonym="1110059D05Rik; 6430629L09Rik; Glxr"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1281
                     /gene="Grhpr"
                     /gene_synonym="1110059D05Rik; 6430629L09Rik; Glxr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1226..1231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grhpr"
                     /gene_synonym="1110059D05Rik; 6430629L09Rik; Glxr"
                     /note="hexamer: ATTAAA"
     polyA_site      1248
                     /gene="Grhpr"
                     /gene_synonym="1110059D05Rik; 6430629L09Rik; Glxr"
                     /note="major polyA site"
     polyA_site      1280
                     /gene="Grhpr"
                     /gene_synonym="1110059D05Rik; 6430629L09Rik; Glxr"
ORIGIN      
        1 cacacttccg tcgtctcctg caaggccagc ctggtacgtg tttgctgctg cgggtcttat
       61 gaaaccggcg cgactcatga aggtgttcgt cactggcccg ttgcctgccg agggcagggc
      121 tgcgctcgcc caggccgcag actgtgaggt ggaacagtgg aattcggatg accccatccc
      181 cagaaaggat ctggagcaag gtgtggtggg ggcccatggc ttgctctgcc gcctctctga
      241 ccgtgtggac aagaaacttc tggatgccgc aggagccaac ctcagagtca tcagcacctt
      301 gtctgtgggg gtcgaccact tggctttgga tgaaatcaag aagcgcggga tccgggtggg
      361 ctacacgcca ggtgtcctga cagatgccac tgcagaactc gccgtctccc tcctcctcac
      421 cacctgccgc cggttgccgg aggccataga ggaagtgaag aacggcggct ggagctcctg
      481 gagcccatta tggatgtgcg gctacggact ctcgcagagc actgttggca ttgtggggct
      541 ggggcgcata ggtcaggcca tcgctcgacg actgaaacca ttcggtgtcc agagatttct
      601 ttacacgggg cgccagccca ggcctcagga agcagccgag tttcaggcag agtttgtgcc
      661 tattgctcag ctggccgcag agtcagactt cattgtcgtg tcctgctcct taacacccga
      721 taccatgggg ctctgcagca aggatttctt ccagaagatg aagaacacag ctatcttcat
      781 caacatcagc agaggagatg tggtaaacca ggaagacctg taccaggcac tagccagtgg
      841 tcagattgca gcagcgggac tggatgtgac cacccctgaa ccactgcctc cgagccaccc
      901 cctgctgacc ctcaagaact gcgtgatcct gccccacatt ggcagtgcca cctacaaaac
      961 tcgcaacacc atgtccttgc tggcggctaa caacttgctg gctggcctaa gaggggaggc
     1021 catgcccagc gaactcaagc tgtaaccaga tgggctttca tgggctggag acatcttgcc
     1081 agacagagcc aagctggact tcggactttg gtgagagcct ggggcaggcc tcctctactg
     1141 cattttcagg ggacctggaa atgggcagat gggcttgcca ctttgggggc ttgccacata
     1201 cttgccaaaa gcctgtaatt ctagcattaa acaacttctg acacagtgtc tgggcctatg
     1261 acttggggca ctaacaaaga g
//
