LOCUS       NM_001013756            2791 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus grainyhead like transcription factor 3 (Grhl3),
            transcript variant 1, mRNA.
ACCESSION   NM_001013756 XM_149533
VERSION     NM_001013756.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2791)
  AUTHORS   Deng,Z., Carpinelli,M.R., Butt,T., Magor,G.W., Zhao,P.,
            Gillinder,K.R., Perkins,A.C. and Jane,S.M.
  TITLE     Single-cell transcriptomics reveals the cellular identity of a
            novel progenitor population crucial for murine neural tube closure
  JOURNAL   Heliyon 10 (17), e37259 (2024)
   PUBMED   39296075
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2791)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2791)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   4  (bases 1 to 2791)
  AUTHORS   Sun,B., Reynolds,K., Saha,S.K., Zhang,S., McMahon,M. and Zhou,C.J.
  TITLE     Ezh2-dependent methylation in oral epithelia promotes secondary
            palatogenesis
  JOURNAL   Birth Defects Res 115 (19), 1851-1865 (2023)
   PUBMED   37435868
REFERENCE   5  (bases 1 to 2791)
  AUTHORS   Saroya,G., Hu,J., Hu,M., Panaretos,C., Mann,J., Kim,S., Bush,J.O.
            and Kaartinen,V.
  TITLE     Periderm Fate during Palatogenesis: TGF-beta and Periderm
            Dedifferentiation
  JOURNAL   J Dent Res 102 (4), 459-466 (2023)
   PUBMED   36751050
REFERENCE   6  (bases 1 to 2791)
  AUTHORS   Cockroft,D.L., Brook,F.A. and Copp,A.J.
  TITLE     Inositol deficiency increases the susceptibility to neural tube
            defects of genetically predisposed (curly tail) mouse embryos in
            vitro
  JOURNAL   Teratology 45 (2), 223-232 (1992)
   PUBMED   1615432
REFERENCE   7  (bases 1 to 2791)
  AUTHORS   van Straaten,H.W., Hekking,J.W., Copp,A.J. and Bernfield,M.
  TITLE     Deceleration and acceleration in the rate of posterior neuropore
            closure during neurulation in the curly tail (ct) mouse embryo
  JOURNAL   Anat Embryol (Berl) 185 (2), 169-174 (1992)
   PUBMED   1536449
REFERENCE   8  (bases 1 to 2791)
  AUTHORS   Seller,M.J., Embury,S., Polani,P.E. and Adinolfi,M.
  TITLE     Neural tube defects in curly-tail mice. II. Effect of maternal
            administration of vitamin A
  JOURNAL   Proc R Soc Lond B Biol Sci 206 (1162), 95-107 (1979)
   PUBMED   42072
REFERENCE   9  (bases 1 to 2791)
  AUTHORS   Embury,S., Seller,M.J., Adinolfi,M. and Polani,P.E.
  TITLE     Neural tube defects in curly-tail mice. I. Incidence, expression
            and similarity to the human condition
  JOURNAL   Proc R Soc Lond B Biol Sci 206 (1162), 85-94 (1979)
   PUBMED   42071
REFERENCE   10 (bases 1 to 2791)
  AUTHORS   Adinolfi,M., Beck,S., Embury,S., Polani,P.E. and Seller,M.J.
  TITLE     Levels of alpha-fetoprotein in amniotic fluids of mice (curly-tail)
            with neural tube defects
  JOURNAL   J Med Genet 13 (6), 511-513 (1976)
   PUBMED   65471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670720.7.
            
            On Jan 3, 2023 this sequence version replaced NM_001013756.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089372.1, SRR14995048.441965.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AL670720.7         116656-116880       c
            226-412             AL670720.7         104417-104603       c
            413-474             AL670720.7         102351-102412       c
            475-820             AL670720.7         100416-100761       c
            821-894             AL670720.7         100092-100165       c
            895-1048            AL670720.7         99335-99488         c
            1049-1160           AL670720.7         99051-99162         c
            1161-1255           AL670720.7         97761-97855         c
            1256-1414           AL670720.7         95784-95942         c
            1415-1493           AL670720.7         95248-95326         c
            1494-1630           AL670720.7         94994-95130         c
            1631-1665           AL670720.7         93544-93578         c
            1666-1754           AL670720.7         92487-92575         c
            1755-1840           AL670720.7         91661-91746         c
            1841-1905           AL670720.7         89491-89555         c
            1906-2791           AL670720.7         85136-86021         c
FEATURES             Location/Qualifiers
     source          1..2791
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 67.76 cM"
     gene            1..2791
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /note="grainyhead like transcription factor 3"
                     /db_xref="GeneID:230824"
                     /db_xref="MGI:MGI:2655333"
     exon            1..225
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2020
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     grainyhead-like protein 3 homolog; transcription factor
                     CP2-like 4; transcription factor hSOM1;
                     sister-of-mammalian grainyhead"
                     /codon_start=1
                     /product="grainyhead-like protein 3 homolog isoform 1"
                     /protein_id="NP_001013778.1"
                     /db_xref="CCDS:CCDS38920.1"
                     /db_xref="GeneID:230824"
                     /db_xref="MGI:MGI:2655333"
                     /translation="MSNELDFRSVRLLKNDPVSFQKFPYSNEDEAWKTYLENPLTAAT
                     KAMMRVNGDEESVAALSFLYDYYMGPKEKRILSSSTGGRNDQGKKFYHSMDYEPDLAP
                     LESPTHLMKFLTENVSGSPDYTDQLKKNNLLGLEGVLPTPGKTNTVPPGPSKLEASSM
                     DSYLLPASDIYDNGSLNSLFESIHGVPPTQRWQPDSTFKDDPQESLLFPDILKTSPDP
                     PCPEDYPGLKSDFEYTLGSPKAIHIKAGESPMAYLNKGQFYPVTLRTPAGGKGLALSS
                     SKVKSVVMVVFDNDKVPVEQLRFWRHWHSRQPTAKQRVIDVADCKENFNTVQHIEEVA
                     YNALSFVWNVNEEAKVFIGVNCLSTDFSSQKGVKGVPLNLQIDTYDCGAGTERLVHRA
                     VCQIKIFCDKGAERKMRDDERKQFRRKVKCPDSSNNAGIKGCLLSGFRGNETTYLRPE
                     TDLETQPVLFIPNLHFSSLQRPGGVVPSAGHSSSDRLPLKRTCSPFAEEFEPLPSKQA
                     KEDDLQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEKYGLPEENICKVYKKCKRG
                     ILVNMDNNIIQHYSNHVAFLLDMGELDGKIQIILKEL"
     exon            226..412
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            413..474
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            475..820
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            821..894
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1048
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1160
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1255
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1414
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1493
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1630
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1665
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1754
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1840
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1905
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2791
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2767..2772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /note="hexamer: AATAAA"
     polyA_site      2791
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcggca cctgtgcttc cagccaatca gcgccaccgc agccggggac cgctgtcagc
       61 aaaatctcaa catccaaagc gcaacgtaga gcaaacgctt ccccgggcag gaagggaatg
      121 tctgtgtcag aggagaatta agagacgagt ggtcagcagc gcctgcgagc caaccagaga
      181 cggatcgctg gaacctcgga gaaggaagat gtcgaatgaa cttgatttca ggtctgtgcg
      241 gttgctgaag aatgaccctg tgagcttcca gaagtttccc tacagtaatg aggacgaggc
      301 ctggaagaca tacctggaga accctttgac ggctgccacc aaagccatga tgagagtcaa
      361 cggggacgag gagagtgtgg ctgctctgag cttcctctac gactactata tgggtcccaa
      421 ggagaagcgg atactgtcct ccagcactgg tggccggaat gaccaaggaa agaagttcta
      481 ccacagcatg gactatgagc cggatcttgc ccccctcgag agccccacac acctcatgaa
      541 atttttgaca gagaacgtgt ctggaagtcc agactacaca gaccagctca agaaaaacaa
      601 tctgctaggc ttggaggggg ttctacccac ccccggcaag accaataccg tccccccagg
      661 tccgagtaaa ctggaagcca gctccatgga cagctacctc ttgcccgcca gtgacatata
      721 tgacaatggc tccctcaact cattatttga gagcattcat ggggttccac ccacacagcg
      781 ctggcagcca gacagcacct tcaaagatga cccacaggag tctctgctct tccctgatat
      841 tctgaagaca tccccggacc ccccatgccc agaggattat ccaggcctca agagtgactt
      901 tgaatacacc ctgggctccc ccaaagccat tcacatcaaa gcaggggagt cacccatggc
      961 ctacctcaac aagggtcagt tctaccccgt caccctacgc accccagcag gagggaaagg
     1021 cctcgctctg tcctccagca aagtcaagag cgtggtgatg gtcgtgttcg ataatgacaa
     1081 ggtccccgtg gagcagctgc gtttctggag gcactggcat tcccggcagc ccaccgccaa
     1141 gcagcgcgtc atcgacgtag ctgactgtaa ggaaaacttc aacacggtcc agcacattga
     1201 agaggtggcc tataacgcgc tgtcctttgt gtggaatgtc aacgaggaag ccaaggtgtt
     1261 tatcggtgtc aactgtctga gcacagactt ctcctcgcag aagggagtga agggtgtccc
     1321 cctgaacttg caaattgaca cctatgactg tggagcaggc actgagcgcc tggtacaccg
     1381 tgctgtctgc cagatcaaga tcttctgtga taagggagct gagaggaaga tgcgcgatga
     1441 tgaacggaag cagtttcgaa ggaaggtcaa gtgcccagac tccagtaaca atgcaggaat
     1501 caagggctgc ctgctgtcag gcttcagggg caatgagacc acatacttgc ggccagaaac
     1561 tgacctggag acccagcctg tgttgtttat ccccaatctg catttttcca gcctacagcg
     1621 cccaggaggg gttgtcccct cagcaggaca cagcagctct gacaggctgc ctctgaagcg
     1681 aacctgctca ccctttgctg aggagtttga gcctcttcct tctaaacaag ccaaggaaga
     1741 tgaccttcag agagttctgt tgtatgtgag gagggagaca gaggaggtgt ttgacgcgct
     1801 catgttgaag accccggacc tgaagggcct gaggaatgcg atctctgaga agtacggcct
     1861 ccccgaggag aatatttgca aagtctacaa gaaatgcaag cgaggcatcc tggttaacat
     1921 ggacaacaac atcatccaac actacagcaa ccacgtggcc ttcctgctgg acatgggtga
     1981 gctggacggc aagatccaga tcatcctgaa ggagctatga gggcccggcc tcaagcgtcc
     2041 cacacccggg gcccggctca agccacgtac aacctcttct gtgtcagctg ttacttgaaa
     2101 tgcctttctt tgggaaagag gtctcgcaag caaccaactc ggtgatgtcc aagccaggga
     2161 gagaccaaga aggttccagg atctaaatgt cccacccagg ctcgaactca ctccagagct
     2221 tcctgaaagc acccagccca ccggagagtc tgagcaacac agacccaact gcctgctttc
     2281 tcttctaagt cccgctgcag aggcccttac aggggacggg ggtcacacca ccttctctgc
     2341 agggctacac ccgctgtctc gatcggttct gacgttcact gtttcctttc taccaacttc
     2401 agaccagaga gttctcacac tttggccaaa taacttgaaa actcgtgact ttcacagcag
     2461 atgcctttgt gaggcccttg gagaggaaac tttcttattg acttcctcgg cacaagatgt
     2521 aagtcaccat catcgagctg acaggaacaa atacccttgc cacctactgt tgtacacatt
     2581 tcttatttac agttttcatt atgtgattat atatatatat atgtaagtat atattatgta
     2641 catatatgca acattttgta tgtccatgtt acatttttat catttcaaaa atatgtattt
     2701 catatttctt gaactatttt tttagctgtt attcgattat gcattttgta tatcataggg
     2761 tttagtaata aaagcctacc catgcacact t
//
