LOCUS       NP_001013778             603 aa            linear   ROD 07-DEC-2024
DEFINITION  grainyhead-like protein 3 homolog isoform 1 [Mus musculus].
ACCESSION   NP_001013778 XP_149533
VERSION     NP_001013778.1
DBSOURCE    REFSEQ: accession NM_001013756.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 603)
  AUTHORS   Deng,Z., Carpinelli,M.R., Butt,T., Magor,G.W., Zhao,P.,
            Gillinder,K.R., Perkins,A.C. and Jane,S.M.
  TITLE     Single-cell transcriptomics reveals the cellular identity of a
            novel progenitor population crucial for murine neural tube closure
  JOURNAL   Heliyon 10 (17), e37259 (2024)
   PUBMED   39296075
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 603)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 603)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   4  (residues 1 to 603)
  AUTHORS   Sun,B., Reynolds,K., Saha,S.K., Zhang,S., McMahon,M. and Zhou,C.J.
  TITLE     Ezh2-dependent methylation in oral epithelia promotes secondary
            palatogenesis
  JOURNAL   Birth Defects Res 115 (19), 1851-1865 (2023)
   PUBMED   37435868
REFERENCE   5  (residues 1 to 603)
  AUTHORS   Saroya,G., Hu,J., Hu,M., Panaretos,C., Mann,J., Kim,S., Bush,J.O.
            and Kaartinen,V.
  TITLE     Periderm Fate during Palatogenesis: TGF-beta and Periderm
            Dedifferentiation
  JOURNAL   J Dent Res 102 (4), 459-466 (2023)
   PUBMED   36751050
REFERENCE   6  (residues 1 to 603)
  AUTHORS   Cockroft,D.L., Brook,F.A. and Copp,A.J.
  TITLE     Inositol deficiency increases the susceptibility to neural tube
            defects of genetically predisposed (curly tail) mouse embryos in
            vitro
  JOURNAL   Teratology 45 (2), 223-232 (1992)
   PUBMED   1615432
REFERENCE   7  (residues 1 to 603)
  AUTHORS   van Straaten,H.W., Hekking,J.W., Copp,A.J. and Bernfield,M.
  TITLE     Deceleration and acceleration in the rate of posterior neuropore
            closure during neurulation in the curly tail (ct) mouse embryo
  JOURNAL   Anat Embryol (Berl) 185 (2), 169-174 (1992)
   PUBMED   1536449
REFERENCE   8  (residues 1 to 603)
  AUTHORS   Seller,M.J., Embury,S., Polani,P.E. and Adinolfi,M.
  TITLE     Neural tube defects in curly-tail mice. II. Effect of maternal
            administration of vitamin A
  JOURNAL   Proc R Soc Lond B Biol Sci 206 (1162), 95-107 (1979)
   PUBMED   42072
REFERENCE   9  (residues 1 to 603)
  AUTHORS   Embury,S., Seller,M.J., Adinolfi,M. and Polani,P.E.
  TITLE     Neural tube defects in curly-tail mice. I. Incidence, expression
            and similarity to the human condition
  JOURNAL   Proc R Soc Lond B Biol Sci 206 (1162), 85-94 (1979)
   PUBMED   42071
REFERENCE   10 (residues 1 to 603)
  AUTHORS   Adinolfi,M., Beck,S., Embury,S., Polani,P.E. and Seller,M.J.
  TITLE     Levels of alpha-fetoprotein in amniotic fluids of mice (curly-tail)
            with neural tube defects
  JOURNAL   J Med Genet 13 (6), 511-513 (1976)
   PUBMED   65471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670720.7.
            
            On Jul 30, 2005 this sequence version replaced XP_149533.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089372.1, SRR14995048.441965.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..603
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 67.76 cM"
     Protein         1..603
                     /product="grainyhead-like protein 3 homolog isoform 1"
                     /note="grainyhead-like protein 3 homolog; transcription
                     factor CP2-like 4; transcription factor hSOM1;
                     sister-of-mammalian grainyhead"
                     /calculated_mol_wt=67685
     Region          30..95
                     /region_name="Transcription activation.
                     /evidence=ECO:0000250|UniProtKB:Q8TE85"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FWH3.1)"
     Region          215..421
                     /region_name="CP2"
                     /note="CP2 transcription factor; pfam04516"
                     /db_xref="CDD:461338"
     CDS             1..603
                     /gene="Grhl3"
                     /gene_synonym="ct; Get1; Som; Tfcp2l4"
                     /coded_by="NM_001013756.3:209..2020"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS38920.1"
                     /db_xref="GeneID:230824"
                     /db_xref="MGI:MGI:2655333"
ORIGIN      
        1 msneldfrsv rllkndpvsf qkfpysnede awktylenpl taatkammrv ngdeesvaal
       61 sflydyymgp kekrilssst ggrndqgkkf yhsmdyepdl aplespthlm kfltenvsgs
      121 pdytdqlkkn nllglegvlp tpgktntvpp gpskleassm dsyllpasdi ydngslnslf
      181 esihgvpptq rwqpdstfkd dpqesllfpd ilktspdppc pedypglksd feytlgspka
      241 ihikagespm aylnkgqfyp vtlrtpaggk glalssskvk svvmvvfdnd kvpveqlrfw
      301 rhwhsrqpta kqrvidvadc kenfntvqhi eevaynalsf vwnvneeakv figvnclstd
      361 fssqkgvkgv plnlqidtyd cgagterlvh ravcqikifc dkgaerkmrd derkqfrrkv
      421 kcpdssnnag ikgcllsgfr gnettylrpe tdletqpvlf ipnlhfsslq rpggvvpsag
      481 hsssdrlplk rtcspfaeef eplpskqake ddlqrvllyv rreteevfda lmlktpdlkg
      541 lrnaisekyg lpeenickvy kkckrgilvn mdnniiqhys nhvaflldmg eldgkiqiil
      601 kel
//
