LOCUS       NM_026496               4950 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus grainyhead like transcription factor 2 (Grhl2), mRNA.
ACCESSION   NM_026496
VERSION     NM_026496.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4950)
  AUTHORS   Deng,Z., Carpinelli,M.R., Butt,T., Magor,G.W., Zhao,P.,
            Gillinder,K.R., Perkins,A.C. and Jane,S.M.
  TITLE     Single-cell transcriptomics reveals the cellular identity of a
            novel progenitor population crucial for murine neural tube closure
  JOURNAL   Heliyon 10 (17), e37259 (2024)
   PUBMED   39296075
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4950)
  AUTHORS   Elfeky,M., Matsuoka,S., Yamamoto,I., Elewa,Y.H.A., Nakamura,K.,
            Suzuki,H., Kamikawa,A., Okamatu-Ogura,Y. and Kimura,K.
  TITLE     Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in Mouse
            Mammary Gland Development During Pregnancy, Lactation, and Weaning
  JOURNAL   Microsc Microanal 30 (3), 552-563 (2024)
   PUBMED   38833344
  REMARK    GeneRIF: Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in
            Mouse Mammary Gland Development During Pregnancy, Lactation, and
            Weaning.
REFERENCE   3  (bases 1 to 4950)
  AUTHORS   de Vries,M.E., Carpinelli,M.R., Fuller,J.N., Sutton,Y.,
            Partridge,D.D., Auden,A., Anderson,P.J., Jane,S.M. and Dworkin,S.
  TITLE     Grainyhead-like 2 interacts with noggin to regulate tissue fusion
            in mouse
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38300806
  REMARK    GeneRIF: Grainyhead-like 2 interacts with noggin to regulate tissue
            fusion in mouse.
REFERENCE   4  (bases 1 to 4950)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4950)
  AUTHORS   Crane-Smith,Z., De Castro,S.C.P., Nikolopoulou,E., Wolujewicz,P.,
            Smedley,D., Lei,Y., Mather,E., Santos,C., Hopkinson,M.,
            Pitsillides,A.A., Finnell,R.H., Ross,M.E., Copp,A.J. and
            Greene,N.D.E.
  CONSRTM   Genomics England Research Consortium
  TITLE     A non-coding insertional mutation of Grhl2 causes gene
            over-expression and multiple structural anomalies including cleft
            palate, spina bifida and encephalocele
  JOURNAL   Hum Mol Genet 32 (17), 2681-2692 (2023)
   PUBMED   37364051
  REMARK    GeneRIF: A non-coding insertional mutation of Grhl2 causes gene
            over-expression and multiple structural anomalies including cleft
            palate, spina bifida and encephalocele.
REFERENCE   6  (bases 1 to 4950)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 4950)
  AUTHORS   Auden,A., Caddy,J., Wilanowski,T., Ting,S.B., Cunningham,J.M. and
            Jane,S.M.
  TITLE     Spatial and temporal expression of the Grainyhead-like
            transcription factor family during murine development
  JOURNAL   Gene Expr Patterns 6 (8), 964-970 (2006)
   PUBMED   16831572
  REMARK    GeneRIF: Grhl genes are highly expressed in the developing
            epidermis.
REFERENCE   8  (bases 1 to 4950)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4950)
  AUTHORS   Peters,L.M., Anderson,D.W., Griffith,A.J., Grundfast,K.M., San
            Agustin,T.B., Madeo,A.C., Friedman,T.B. and Morell,R.J.
  TITLE     Mutation of a transcription factor, TFCP2L3, causes progressive
            autosomal dominant hearing loss, DFNA28
  JOURNAL   Hum Mol Genet 11 (23), 2877-2885 (2002)
   PUBMED   12393799
REFERENCE   10 (bases 1 to 4950)
  AUTHORS   Wilanowski,T., Tuckfield,A., Cerruti,L., O'Connell,S., Saint,R.,
            Parekh,V., Tao,J., Cunningham,J.M. and Jane,S.M.
  TITLE     A highly conserved novel family of mammalian developmental
            transcription factors related to Drosophila grainyhead
  JOURNAL   Mech Dev 114 (1-2), 37-50 (2002)
   PUBMED   12175488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY703140.1, BY018142.1, BC055035.1 and CJ322576.1.
            
            On Dec 12, 2009 this sequence version replaced NM_026496.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055035.1, AF411213.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BY703140.1         2-55
            55-211              BY018142.1         1-157
            212-2614            BC055035.1         1-2403
            2615-4941           BC055035.1         2405-4731
            4942-4950           CJ322576.1         389-397
FEATURES             Location/Qualifiers
     source          1..4950
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.84 cM"
     gene            1..4950
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /note="grainyhead like transcription factor 2"
                     /db_xref="GeneID:252973"
                     /db_xref="MGI:MGI:2182543"
     exon            1..371
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..2229
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /note="transcription factor CP2-like 3; grainyhead like 2;
                     brother of mammalian grainyhead; grainyheadlike;
                     grainyhead-like 2"
                     /codon_start=1
                     /product="grainyhead-like protein 2 homolog"
                     /protein_id="NP_080772.2"
                     /db_xref="CCDS:CCDS27434.1"
                     /db_xref="GeneID:252973"
                     /db_xref="MGI:MGI:2182543"
                     /translation="MSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPL
                     TAATKAMMSINGDEDSAAALGLLYDYYKVPRDKRLLSVSKASDSQEDQDKRNCLGTSE
                     AQINLSGGENRVQVLKTVPVNLCLSQDHMENSKREQYSVSITESSAVIPVSGITVVKA
                     EDFTPVFMAPPVHYPRADSEEQRVVIFEQTQYDLPSIASHSSYLKDDQRSTPDSTYSE
                     SFKDGASEKFRSTSVGADEYTYDQTGSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFY
                     AITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDI
                     ADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQ
                     IDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKGQASQAQCNNSS
                     DGKMAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGSS
                     VLVKRMFRPMEEEFGPTPSKQIKEENVKRVLLYVRKENDDVFDALMLKSPTVKGLMEA
                     LSEKYGLPVEKITKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVEGFKITLME
                     I"
     exon            372..567
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            568..635
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            636..1029
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1085
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1242
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1354
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1449
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1608
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1696
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1836
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1868
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1963
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2049
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2114
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..4947
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4922..4927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /note="hexamer: AATAAA"
     polyA_site      4941
                     /gene="Grhl2"
                     /gene_synonym="0610015A08Rik; BOM; clft3; Tcfcp2l3"
                     /note="major polyA site"
ORIGIN      
        1 gaaagaattc agcgccttgc gagaaagtta cctgtggccg cccaagtccg ccactttgcg
       61 ctctgtgtct gcccattgca gcgatccggg aggactccgc gccgccgggc cgcctccgag
      121 cgcgggcccc atgtgagggc tccctccccc catcccacct ttccggctag gtgagggcgc
      181 gagcgagcgg gcgagcgaga gtggtgaggg gggacgaaag cagaattacc tgtagctctt
      241 gttctgccat ctcgggcgct ctcacacacc ttcacctgca cagacttgaa agtccagttt
      301 caccagaggc tgaggctcca ggaaaagggg agcgagttca ttggatcaaa catgtcacaa
      361 gagtcggaca ataataaaag actagtggcc ttagtgccca tgcccagtga ccctcccttc
      421 aacacccgaa gagcctacac aagtgaggat gaggcctgga agtcatatct ggagaacccc
      481 ctgactgcgg ccaccaaggc gatgatgagc atcaacgggg acgaggacag tgctgccgcc
      541 ctgggcctgc tctatgacta ctacaaggtt cctcgagaca agagacttct gtctgtgagc
      601 aaagcaagtg acagccaaga agaccaggat aaaagaaact gccttggcac cagtgaagcc
      661 cagatcaatt tgagcggagg cgagaacaga gtgcaggttc tgaagactgt cccggtgaac
      721 ctctgtctaa gtcaagacca catggagaat tcgaagcgcg agcagtacag tgtatccatc
      781 accgagagct ctgccgtcat ccccgtgtca ggcatcaccg tggtgaaagc cgaggatttc
      841 acaccggtgt tcatggcgcc cccggtgcac tatccccgcg cggacagtga ggagcagcgc
      901 gtggttatct ttgaacagac tcagtacgac ctgccctcca tagccagcca cagctcctat
      961 ctcaaggacg accagcgcag cacgccggac agcacctaca gcgagagctt taaggacggc
     1021 gcctcggaga aatttcggag tacttctgtt ggtgctgacg agtatacata tgaccagacg
     1081 ggaagtggta catttcagta caccctggaa gccaccaaat ctctccgtca gaagcagggg
     1141 gagggcccca tgacctacct caacaaagga caattctatg ccataacact cagtgagact
     1201 ggagacaaca aatgcttccg acaccccatc agcaaagtca ggagtgtggt gatggtggtc
     1261 tttagtgaag acaaaaaccg agatgagcag ctgaaatact ggaagtactg gcactcccgg
     1321 cagcacactg ccaagcagag ggtccttgac attgctgatt acaaggagag cttcaacacc
     1381 atcgggaaca ttgaagagat cgcatacaat gctgtttcct tcacctggga tgtgaacgag
     1441 gaggcaaaga tttttatcac cgtgaattgc ctgagtacag atttctcctc ccaaaagggt
     1501 gtaaaaggac ttcccctgat gattcagatc gacacgtaca gctacaacaa ccgcagcaat
     1561 aaacccatcc acagagcata ctgccagatc aaggtcttct gtgacaaggg agcagaaaga
     1621 aaaatccggg atgaagagag aaagcagaac aggaagaaag ggaagggcca ggcctctcaa
     1681 gcccagtgca acaactcctc tgatgggaag atggccgcca taccgttaca gaagaagagt
     1741 gacatcacgt acttcaaaac catgcccgac ctgcactcac agcctgtgct cttcatacca
     1801 gatgttcact ttgcaaacct acagaggacc ggacaggttt attacaacac agacgatgag
     1861 cgagaaggca gcagcgtcct tgttaagcgg atgttcaggc ccatggaaga ggagtttggt
     1921 ccaacaccgt ctaagcagat caaagaagaa aacgtaaaac gagtgctttt atatgtgagg
     1981 aaggagaacg atgacgtctt cgatgctctg atgctgaaat cacccacggt gaagggtctg
     2041 atggaagcgc tgtctgagaa gtatgggctg ccagtggaga aaatcacaaa gctttataag
     2101 aagagcaaaa agggcatcct ggtcaacatg gatgacaaca tcattgagca ctattcaaat
     2161 gaggacacct tcatcctcaa catggagagc atggtggaag gcttcaagat cacgctgatg
     2221 gagatctgag ccctgggtgt cccctcgata ggagcttttg gtatactcct tcctgggaga
     2281 gatgggatct ctgccgcccc aggacctgga gacccaccca tctcactcac ctctcaagac
     2341 tgttacaaga ctgctgggaa gggggcaggg cccaaggccc agtaatggac ttccttcaac
     2401 tcttccactt gctccctatg gagctgaagc ctgagcccct cagcaaattt ctttgagcct
     2461 ggtaggccct tatttattgc ccatttccct ccaagagccc tccaggactc tgcaagttac
     2521 tgatagctcc atgtgagact tccagagttc ccccttcaag ggagatagca agtccactca
     2581 tctcgaacct ggggaactgg tgtgtttttt ttttccttac ctctccacat ttcttgagtg
     2641 gttgggccag atgagctgct tcttggtaca gtcttcatgg atggggtaag aaggacacca
     2701 gtttgctggc cccaaacctt cggattgctc tgaggaaggt cattttgcta aatacctcca
     2761 ggagactctc agcaaatagc cactgggcct tgtacaggaa gatatcgtgc taccatgtca
     2821 gtaataagga acccgagtat gcctgatgac catgtacata acttatacaa aatattgcaa
     2881 taatatattt tacctatggt tggtgggcat gtttactgcc attggcctgg aggagacata
     2941 cctggagaat cagaatgttc tactctatcc agaggtggtt aggagagtgg tctttgggat
     3001 gtcatatgat ggtggtgaat gccaggatgg actctccatt gggccatgcc tgaggacttg
     3061 tttccccaga gccctctttc ctcaagcatg actctccctg gaggccattg tgggtttttt
     3121 ggtgatatat tgtctcagca cgccctttga gctgtctggg aagggccgta ctgttggtgc
     3181 cttctctagc tttggtgtgg ggcatctctt gagccttgtg caaagtctct gcagaggttt
     3241 gcctcggggc cctgtcactg agacctgctg cagagctgct tggccgacgt ggggatcctg
     3301 gacactgtag tgcctcatag tttacaagca cgtccttcat ctcaagtggc ccctttaaaa
     3361 acccacctgc agctttgtga actgagccag cggccttgct tctgatggga agaagtgagg
     3421 atgtccaccc tggctgtggg aagcgtggaa gcccttgcac ttctgaaacc aactctggga
     3481 ggtgtgctgg agagctaagg ctgtcaagag aaaatggctt acctgaacag tcacgcaagc
     3541 atgccccatg ggcctctgtt ctctttgaga gaacaggtca atagttctgt tttaaggatt
     3601 ggtatgtgcc cctgtgggcc gagcactagt ttggatagcc aggcacatcc catccgaaag
     3661 cctggataat ggaacagctt ctatggaaag gtctaagttt gtctgcgaag cactttgatg
     3721 ttttacctgg aggctctgct ctccggcccc tgtcttcttg ctctacctgt cccgaggccc
     3781 agaatagctg aggctgactc cagccaagct cttgctcttc aaagctgcag agaaattgag
     3841 tgggttggag agtaggtgcc gtagccaaga ggatcccaaa ggctagcagg ggcacctttc
     3901 tgagagccca ctggactcct tatccctctt tgtgttgcca aaggtttgca tcctgagcta
     3961 tgctctattc cagccccgca ctccaaatgc cgctccttga aactagcagt ctagggacac
     4021 tccagggtac gagtgggcct ctggtctaag atggacaaac tctgctggaa agatatgctc
     4081 tatgcgctcc ctgtgctata gcacttgggg ctagctgcaa acgtgattgg cagaccttag
     4141 aggtgggctc aggattccag agtagggaga cagatctgta gcaacctgac aggctaccag
     4201 ctctggaaaa ttgctggtct gctctagggc agaagacaaa ccagagccag cgttcccttt
     4261 gtcctgagtc cctacaatcc atgagatagc cattgccaga acaagggata ggaagccaca
     4321 aagcatcagg acagtgtcag gtccaggatg tctgctggtg gacttccatg tcgctgtgct
     4381 gtctgagctc tgctgtgcct cgtttcctaa acaaaaacac tccagacaca tagaaaatgc
     4441 ttgccttgcc ctgaactaat ctcacccaaa caaagaattt tttttttttt tttggtaatc
     4501 tataaaagat gagggacaca tgaagcaaac atttcattct atgtccccaa ttgtcaaaac
     4561 ttcctcagtg tttagaaatt gaacccaata gaaaaatact gagtgagctg tcatcttgag
     4621 gttggttcct aaaagactaa ggcacatccc aatgtagaaa cctgggaagt ttgaaatgaa
     4681 ttaaaacatt tttcccctca tattttaata gtcataaaaa tgcaacagga aataagggtt
     4741 tgtgccaaat tctaagaatg gccctttctg aaggacaagc aggggagact cgtgtgtaca
     4801 atctgttccc acattaaaaa aaaaagagta aatgtaactt aatagttttg taaatgggag
     4861 agggggaatc tataaactat aaatatgtta ttttattttt tgtacatttt taagaagaaa
     4921 aaataaatat tcacaacatg agtcaaaaaa
//
