LOCUS       NM_001161406            3487 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus grainyhead like transcription factor 1 (Grhl1),
            transcript variant 1, mRNA.
ACCESSION   NM_001161406
VERSION     NM_001161406.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3487)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   2  (bases 1 to 3487)
  AUTHORS   Grigolon,G., Araldi,E., Erni,R., Wu,J.Y., Thomas,C., La
            Fortezza,M., Laube,B., Pohlmann,D., Stoffel,M., Zarse,K.,
            Carreira,E.M., Ristow,M. and Fischer,F.
  TITLE     Grainyhead 1 acts as a drug-inducible conserved transcriptional
            regulator linked to insulin signaling and lifespan
  JOURNAL   Nat Commun 13 (1), 107 (2022)
   PUBMED   35013237
  REMARK    GeneRIF: Grainyhead 1 acts as a drug-inducible conserved
            transcriptional regulator linked to insulin signaling and lifespan.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3487)
  AUTHORS   Kersbergen,A., Best,S.A., Dworkin,S., Ah-Cann,C., de Vries,M.E.,
            Asselin-Labat,M.L., Ritchie,M.E., Jane,S.M. and Sutherland,K.D.
  TITLE     Lung morphogenesis is orchestrated through Grainyhead-like 2
            (Grhl2) transcriptional programs
  JOURNAL   Dev Biol 443 (1), 1-9 (2018)
   PUBMED   30194919
REFERENCE   4  (bases 1 to 3487)
  AUTHORS   Matsushita,T., Sakai,M., Yoshida,H., Morita,S., Hieda,Y. and
            Sakai,T.
  TITLE     Grhl2 regulation of SPINT1 expression controls salivary gland
            development
  JOURNAL   Biochem Biophys Res Commun 504 (1), 263-269 (2018)
   PUBMED   30193734
  REMARK    GeneRIF: Grhl2 regulation of SPINT1 expression controls salivary
            gland development
REFERENCE   5  (bases 1 to 3487)
  AUTHORS   Dworkin,S., Auden,A., Partridge,D.D., Daglas,M., Medcalf,R.L.,
            Mantamadiotis,T., Georgy,S.R., Darido,C., Jane,S.M. and Ting,S.B.
  TITLE     Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered
            locomotor activity and decreased anxiety-like behaviors in aged
            mice
  JOURNAL   Dev Neurobiol 77 (6), 775-788 (2017)
   PUBMED   27907249
REFERENCE   6  (bases 1 to 3487)
  AUTHORS   Auden,A., Caddy,J., Wilanowski,T., Ting,S.B., Cunningham,J.M. and
            Jane,S.M.
  TITLE     Spatial and temporal expression of the Grainyhead-like
            transcription factor family during murine development
  JOURNAL   Gene Expr Patterns 6 (8), 964-970 (2006)
   PUBMED   16831572
  REMARK    GeneRIF: Grhl genes are highly expressed in the developing
            epidermis.
REFERENCE   7  (bases 1 to 3487)
  AUTHORS   Norman,B., Davis,J. and Piatigorsky,J.
  TITLE     Postnatal gene expression in the normal mouse cornea by SAGE
  JOURNAL   Invest Ophthalmol Vis Sci 45 (2), 429-440 (2004)
   PUBMED   14744882
REFERENCE   8  (bases 1 to 3487)
  AUTHORS   Wang,Z., Peters,B., Klussmann,S., Bender,H., Herb,A. and
            Krieglstein,K.
  TITLE     Gene structure and evolution of Tieg3, a new member of the Tieg
            family of proteins
  JOURNAL   Gene 325, 25-34 (2004)
   PUBMED   14697507
REFERENCE   9  (bases 1 to 3487)
  AUTHORS   Kudryavtseva,E.I., Sugihara,T.M., Wang,N., Lasso,R.J.,
            Gudnason,J.F., Lipkin,S.M. and Andersen,B.
  TITLE     Identification and characterization of Grainyhead-like epithelial
            transactivator (GET-1), a novel mammalian Grainyhead-like factor
  JOURNAL   Dev Dyn 226 (4), 604-617 (2003)
   PUBMED   12666198
  REMARK    GeneRIF: Grainyhead like 1 is a transcriptional regulator that may
            perform important functions in epithelial tissues of mammals and is
            epidermally expressed
REFERENCE   10 (bases 1 to 3487)
  AUTHORS   Wilanowski,T., Tuckfield,A., Cerruti,L., O'Connell,S., Saint,R.,
            Parekh,V., Tao,J., Cunningham,J.M. and Jane,S.M.
  TITLE     A highly conserved novel family of mammalian developmental
            transcription factors related to Drosophila grainyhead
  JOURNAL   Mech Dev 114 (1-2), 37-50 (2002)
   PUBMED   12175488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125067.4, AK161048.1 and DV553123.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161048.1, AK076307.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AC125067.4         114963-115081
            120-3458            AK161048.1         2-3340
            3459-3487           DV553123.1         231-259
FEATURES             Location/Qualifiers
     source          1..3487
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.49 cM"
     gene            1..3487
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /note="grainyhead like transcription factor 1"
                     /db_xref="GeneID:195733"
                     /db_xref="MGI:MGI:2182540"
     exon            1..172
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            173..359
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..430
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..821
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..898
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1055
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1167
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1262
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1421
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1473
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1613
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1651
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1743
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1829
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1894
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..3468
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3465
                     /gene="Grhl1"
                     /gene_synonym="LBP-32; MGR; Tcfcp2l2"
                     /note="major polyA site"
ORIGIN      
        1 cgagaaaagc gaacccaacc cgtcggggcc gccgctccgg acccaccgcc tgccgccgcg
       61 cgccgcccgc cgccgcctcc tccccccgga tcgggtgtac tgtcccaacc cgaaagtcca
      121 gttctgcggc ccggcagcgg cgagcgagcg cgatgacaca ggagtacgac aacaaaaggc
      181 ccgtgctggt acttcagaat gaagccctct acccacagcg gcgctcctat accagtgagg
      241 atgaagcctg gaagtcgttc ctggaaaacc ctctcactgc ggcaaccaaa gcgatgatga
      301 gcatcaacgg agacgaagac agcgcggctg cgctgggcct gctctatgac tactacaagg
      361 tccccagaga gcgccggtca tcagccgtaa agcccgaggg agagcaccca gagccagagc
      421 acagcaaaag aaacagcata ccaaatgtga cggagcagcc cctcatttct gctggagaaa
      481 acagggtgca agtgctgaaa aacgtgccct tcaacatcgt cctcccccat agcaaccagc
      541 tgggcattga taagagaggc catctgacag ctcccgatac aacagtcact gtctccatag
      601 caaccatgcc tacccactcc atcaagacag aaatccagcc gcacggcttt gctgtgggaa
      661 tcccaccagc cgtgtaccac tctgagccca ccgaacgtgt ggtggttttt gaccggagcc
      721 tcagcactga tcagttcagc tctggcactc agccccccaa tgctcagcgg aggactccag
      781 actccacctt ctccgagacc ttcaaggagg gcgttcagga ggttttcttc ccctcggaac
      841 tcagccttcg gatgccgggc atgaattcag aggactatgt ctttgacaat gtttctggga
      901 acaactttga gtataccctg gaagcctcca agtcactgcg gcagaagcaa ggggacagca
      961 ctatgacata cctgaataaa ggccagttct atcctgtcac cttaaaggaa ggaagcagca
     1021 atgaagggat tcaccaccct atcagcaaag ttcgaagtgt gatcatggtg gtttttgctg
     1081 aagacaaaag cagagaagac cagctgagac actggaagta ctggcactcc cgtcagcaca
     1141 cggccaaaca gaggtgcatt gacattgctg actacaaaga aagcttcaac actatcagca
     1201 acattgagga gatagcttat aacgccattt ccttcacgtg ggacatcaat gatgaggcaa
     1261 aggtcttcat ctctgtgaac tgcttgagca cagatttctc ttctcagaag ggtgtgaagg
     1321 gcttgccact caacattcaa atcgacacat acagctataa caaccgcagc aacaagccgg
     1381 ttcaccgggc ctactgccag ataaaggtct tctgcgacaa gggagctgaa aggaaaattc
     1441 gggatgaaga acgaaaacag agcaagagaa aagtgtctga cgttaaagtg cagctgcttc
     1501 cctcgcacaa acggacagac atcacagtgt tcaagccctt cctggacctc gacactcagc
     1561 ctgtcctctt cattccggac gtgcatttta ccaacctgca gcggggcagt catgttcttt
     1621 ccctcccctc tgaagaactg gaaggtgaag gctctgtctt gaaaagaggg ccattcggaa
     1681 ccgaagatga ctttggagtt cctcctcctg ctaagctgac tcggacagaa gaacccaaga
     1741 gagtgctgct ctatgtccga aaggaatcag aagaagtctt cgacgccctg atgctcaaga
     1801 cgccgtcttt gaagggcctg atggaggcaa tttcagacaa gtatgatgtc ccccatgaca
     1861 agattgggaa aatatttaag aagtgcaaaa aagggatcct cgtgaacatg gacgacaaca
     1921 ttgtgaagca ctactccaat gaggacacct tccagctgca gatagaggaa gccggcggct
     1981 cgtacaagct caccctgaca gagatttaaa ggggcagggg tggggggcgc tcggctccca
     2041 ggcgtgggaa ttcagtgaaa gtgttccagc tgagaagccc aggcacctac cctgcagaac
     2101 cttaaatatc agggaaggaa cctttcacgt aggaaatggc gctgtgtata ccgtgctgtg
     2161 ttgatgtttt cttttggata gaaatccatg tgttgttttg ttgttgttgt ttgaatttct
     2221 gatgtgctta gaaagcgaag catgagaact ttgtaccgga tctaagagac catgggaccg
     2281 tttgggttac ctgctccact acctgtcaaa gtctgcctgt gtccataaga gtggtgggct
     2341 actggctggc gagagagggg aaggcagtag cttgtctttg aggcttttgt gttctcgcct
     2401 gacctcagtc taactctgac tgccttgagg agtgggccca gccctcagca ataaagggct
     2461 aagccttctc cctccacctc tcctccagtg tttactaaat agggtgcatt actggaacct
     2521 tcccgtgcaa cttccttgga catgtggact gcctttctga tgaagaactt gcgtgagtga
     2581 cagtgtgaag ttagctctgt taaagctgcg ttgtatataa gtgcaatatc tttttgaagg
     2641 tctgcctgta aatgtgtaca tatatgtctg atataaatat ataatatata aatgcggtat
     2701 ctgtgtacag atagtgaagg tgagcaggaa gatctacctt gaaatccctc ttagagaaga
     2761 ggttaagtta ttattgataa tgtggaccaa gcaggtagaa cgctgttttc ccaaaaacaa
     2821 gcaagtgttc cctagcatag caaaaagcca tctcgtgtgg cagagccatc tgctcttgcg
     2881 aatgttgtca ccgtgtgggt ttctgcaccc tgagtggagc taatggaaga ctggactgca
     2941 gctactatat gaggtgtgtg tgcaggtgtc agccagctgt gcccatgcag agactcagcc
     3001 gttgtcatga gccagcgata caaaccaaaa tgggccgatt ctacaaggcc atgtttcaga
     3061 gcttccaagc atcagctacc gtgtgtttga actggaaggc attcatgaat ttacataact
     3121 gtggcagggg aatgttttgt gcacacttaa atatttaaga acaaaacgaa actttacaat
     3181 gtaattttat aatgaatcct gtaacagaaa tacaattgcg ggtttcttta ggttcaggga
     3241 actagaatag gtcatttgta tgagtaggat tgttagcggt atacgtaggt taaaaagtac
     3301 tctaatgaag tatgtgaaca aaatagctgg ttttctaaga tacgggatac gggtcatata
     3361 acaatatttt ctattttgtt ttatgaaatc agctttactt gttttaattg tatcattgaa
     3421 catgtgtttt aaaccaaagg gattgaattt tatatgtcta tttcacaaaa aaaaaaaaaa
     3481 aaaaaaa
//
