LOCUS       NM_011825               3745 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus gremlin 2, DAN family BMP antagonist (Grem2), mRNA.
ACCESSION   NM_011825
VERSION     NM_011825.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3745)
  AUTHORS   Rydze RT, Patton BK, Briley SM, Salazar Torralba H, Gipson G, James
            R, Rajkovic A, Thompson T and Pangas SA.
  TITLE     Deletion of Gremlin-2 alters estrous cyclicity and disrupts female
            fertility in micedagger
  JOURNAL   Biol Reprod 105 (5), 1205-1220 (2021)
   PUBMED   34333627
  REMARK    GeneRIF: Deletion of Gremlin-2 alters estrous cyclicity and
            disrupts female fertility in micedagger.
REFERENCE   2  (bases 1 to 3745)
  AUTHORS   Huycke TR, Miller BM, Gill HK, Nerurkar NL, Sprinzak D, Mahadevan L
            and Tabin CJ.
  TITLE     Genetic and Mechanical Regulation of Intestinal Smooth Muscle
            Development
  JOURNAL   Cell 179 (1), 90-105 (2019)
   PUBMED   31539501
REFERENCE   3  (bases 1 to 3745)
  AUTHORS   Li W, Lu Y, Han R, Yue Q, Song X, Wang F, Wu R, Hou F, Yang L, Xu
            L, Zhao R and Hu J.
  TITLE     Gremlin2 Regulates the Differentiation and Function of Cardiac
            Progenitor Cells via the Notch Signaling Pathway
  JOURNAL   Cell Physiol Biochem 47 (2), 579-589 (2018)
   PUBMED   29794428
  REMARK    GeneRIF: Grem2 knockdown inhibited cardiomyocyte differentiation,
            and this effect was similar to that of Notch1 pathway inhibition in
            vitro. Grem2 enhances the protective effect of cardiac progenitor
            cells on heart function in a mouse model of myocardial infarction.
REFERENCE   4  (bases 1 to 3745)
  AUTHORS   Sanders LN, Schoenhard JA, Saleh MA, Mukherjee A, Ryzhov S,
            McMaster WG Jr, Nolan K, Gumina RJ, Thompson TB, Magnuson MA,
            Harrison DG and Hatzopoulos AK.
  TITLE     BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial
            Infarction
  JOURNAL   Circ Res 119 (3), 434-449 (2016)
   PUBMED   27283840
  REMARK    GeneRIF: Grem2 provides a molecular barrier that controls the
            extent of inflammatory cell infiltration by suppressing BMP2 after
            myocardial infarction.
REFERENCE   5  (bases 1 to 3745)
  AUTHORS   Gurdziel K, Vogt KR, Walton KD, Schneider GK and Gumucio DL.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   6  (bases 1 to 3745)
  AUTHORS   Im J, Kim H, Kim S and Jho EH.
  TITLE     Wnt/beta-catenin signaling regulates expression of PRDC, an
            antagonist of the BMP-4 signaling pathway
  JOURNAL   Biochem Biophys Res Commun 354 (1), 296-301 (2007)
   PUBMED   17222801
  REMARK    GeneRIF: We propose that PRDC might serve as a mediator to
            antagonize BMP-4 signaling by Wnt.
REFERENCE   7  (bases 1 to 3745)
  AUTHORS   Kurek D, Garinis GA, van Doorninck JH, van der Wees J and Grosveld
            FG.
  TITLE     Transcriptome and phenotypic analysis reveals Gata3-dependent
            signalling pathways in murine hair follicles
  JOURNAL   Development 134 (2), 261-272 (2007)
   PUBMED   17151017
REFERENCE   8  (bases 1 to 3745)
  AUTHORS   Sudo S, Avsian-Kretchmer O, Wang LS and Hsueh AJ.
  TITLE     Protein related to DAN and cerberus is a bone morphogenetic protein
            antagonist that participates in ovarian paracrine regulation
  JOURNAL   J Biol Chem 279 (22), 23134-23141 (2004)
   PUBMED   15039429
  REMARK    GeneRIF: ovarian PRDC expressed in granulosa cells could be
            involved in follicular development by antagonizing the actions of
            theca cell-derived Bone morphogenetic proteins
REFERENCE   9  (bases 1 to 3745)
  AUTHORS   Lu MM, Yang H, Zhang L, Shu W, Blair DG and Morrisey EE.
  TITLE     The bone morphogenic protein antagonist gremlin regulates
            proximal-distal patterning of the lung
  JOURNAL   Dev Dyn 222 (4), 667-680 (2001)
   PUBMED   11748835
REFERENCE   10 (bases 1 to 3745)
  AUTHORS   Minabe-Saegusa C, Saegusa H, Tsukahara M and Noguchi S.
  TITLE     Sequence and expression of a novel mouse gene PRDC (protein related
            to DAN and cerberus) identified by a gene trap approach
  JOURNAL   Dev Growth Differ 40 (3), 343-353 (1998)
   PUBMED   9639362
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB011030.1.
            
            [WARNING] On May 18, 2023 this sequence was replaced by
            NM_011825.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011030.1, BC079905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..3745
                     /gene="Grem2"
                     /gene_synonym="Gremlin2; Prdc"
                     /note="gremlin 2, DAN family BMP antagonist"
                     /db_xref="GeneID:23893"
                     /db_xref="MGI:MGI:1344367"
     exon            1..247
                     /gene="Grem2"
                     /gene_synonym="Gremlin2; Prdc"
                     /inference="alignment:Splign:2.1.0"
     exon            248..3745
                     /gene="Grem2"
                     /gene_synonym="Gremlin2; Prdc"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..755
                     /gene="Grem2"
                     /gene_synonym="Gremlin2; Prdc"
                     /note="protein related to DAN and cerberus; gremlin-2;
                     cysteine knot superfamily 1, BMP antagonist 2; Gremlin1;
                     gremlin 2 homolog, cysteine knot superfamily"
                     /codon_start=1
                     /product="gremlin-2 precursor"
                     /protein_id="NP_035955.1"
                     /db_xref="CCDS:CCDS15545.1"
                     /db_xref="GeneID:23893"
                     /db_xref="MGI:MGI:1344367"
                     /translation="MFWKLSLTLLLVAVLVKVAETRKNRPAGAIPSPYKDGSSNNSER
                     WHHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCN
                     SFYIPRHVKKEEDSFQSCAFCKPQRVTSVIVELECPGLDPPFRIKKIQKVKHCRCMSV
                     NLSDSDKQ"
     polyA_site      3745
                     /gene="Grem2"
                     /gene_synonym="Gremlin2; Prdc"
                     /note="19 a nucleotides"
ORIGIN      
        1 gtgctgtctc cagctccttc cacatctgca ggcgcggctg ggacgcgctc cgccctctgt
       61 gcgctccact gggctccgct cgctccgcac accctcgctg cttcccaggc ctcctgcaga
      121 accaggctgc ggctgccccc gacgatacgg cgcacagccc gctgtggatc ctgtcattca
      181 cagagaggag agggacaggg agacacacaa gggaaccgag gaggaggctt ccatctcgtc
      241 attgcaggat gttctggaag ctctcgctga ccttgctcct ggtggctgtg ctggtaaagg
      301 tagctgaaac acggaagaac cggcctgcgg gcgccatccc ctcgccttac aaggatggta
      361 gcagcaacaa ctcagagagg tggcatcacc agatcaagga ggtgctggcc tccagccagg
      421 aggccctggt agtcaccgag cgcaagtacc tcaagagtga ctggtgcaag acgcagcctc
      481 tgcggcagac agtgagcgag gagggttgcc gcagccgcac catcctcaac cgcttctgct
      541 acggccagtg caactccttc tacatcccgc gacacgtgaa gaaggaggag gactccttcc
      601 aatcctgcgc tttctgcaag ccccagcgtg tcacctctgt catcgtagag ctcgaatgcc
      661 cgggtctcga cccacctttc cgaatcaaga aaatccagaa ggtgaagcat tgccggtgca
      721 tgtcagtgaa cctgagtgac tccgacaagc agtgaactca tggggcagga tgcagctcag
      781 ccttgagcac tcctacccct gggttgcgcc accgccactt ctgttgagct cactcacact
      841 ctgcccggtg tcccagtcag cagcaaatgt gtctcttagg gccaacagtg tccctgtcac
      901 aaatgaggac cacaagtgaa gctttgtcaa ctgtcccaga tccaccccag gctacacttg
      961 tgtctctaaa tccactttgt ggatgggaca cagaagatgt tggaaaactc cactcccaga
     1021 aactcgacaa gatttttcag gagatgcact gtcatctggg attgacgact ccaccatgtg
     1081 gaaaagccag tctttccctg gccacatcct acactccagc ttgagccttc ctctggtgaa
     1141 ggatgcacga ctcttctgtc gcaaactttt gttggtcacc ggacctctgt ggtgtgaaca
     1201 ttctttcttc tgacctggga gttgcccagc tctgccgctg ctgtgatgct gatgtgggca
     1261 gcatctataa aggagatgct cacccgcaag gggttccaga acaaatctgg tacccacgag
     1321 gacaagccaa accaagtgga tcaggaaatg gacttcccta ggaactgtac tgagcaggca
     1381 agactctcca cacctctgga caccaccacc tctttatttc cttctcatag cccctatctg
     1441 tagctcaaga taaactctgg tgtgcatgct attcctgctg ctgtgttaac actcacaagg
     1501 tctctgtatt agtgtcagtc ttataattga cctatcatgt taaaaacagt taaaagtatt
     1561 atcaacatat tcatatatca agtcacgtgt ttggactcta gcttagcatc actgttctga
     1621 atagggagta gagcatcgag tgatctgtgg aaaagtattt tacagaggaa aaactgccag
     1681 gtcagcaatt cactccccaa cccacccccc acccccccac ccccgcttgc tcacacacac
     1741 tctctctttc cagattgagc agggagatgg gacacatcat gattttactt ttaatatgac
     1801 atcacaggag agactaaagc attgtggcat agtgtacaaa ccggattggg acagaggtgt
     1861 gtacagagga gtcactagga agctgtaaag attaaaaggc acgtgtgaga ggagacctgg
     1921 tactgttttc actgccatta cactaagtaa aaaaatattt tctattaaaa gatatgtaag
     1981 aatatatggt attgagacat tttgtgacac aggcagaaat atagagccaa tatagagggt
     2041 agtaatgtag gtaaactgtc actcagagga tagcttcctg tacaaagaat agactcctaa
     2101 aataccaaga aacatttcag tcatcttcag ttctgctgat gagttgttgg agtctctgtt
     2161 gtgtggtctt ttgatgcgag gactttgaaa taatttattt ttccttcaaa attacactca
     2221 agttcaatct ctttgtgcaa ttgttctagg gaggcctccc tgagaatggc acgtatgcaa
     2281 tctgacaaat gtgaatgaga aaccttggtg ggaatccgaa tgtgctgaaa tcctttggtt
     2341 gataatttcc cagtccatgc tcttgccaag atgggtgtcc tagtatgtga gggagactat
     2401 ccataagctg ctctgagact caggcttgtg gatgcccagc agtgatgctg gctctccagt
     2461 ctgccacctg gaggagggtt gggatgagct ggggagggta tgccttggac tcttttgcct
     2521 gtattgcaat gtaagttttc tagtttcatc acttctgcta cacagcaacc atgagtagag
     2581 actatgtggt tttgaagggg atattagctt cagaaatgag agtgcacagc ctggaatcag
     2641 cagagagaaa caagggggaa atggaaaaat cacagagggc tggaaacccc agggataaag
     2701 gcaaaaaggg aagagggtgc caaaggtcag agatacaatt ttcactttta gcagaaaatc
     2761 tcgaggtaga gccaaagcag aacatgcagt agaaaagctg tgaaagagat atgagtgtcc
     2821 ttaatggagg atggtgacat gtaaccggag ggtgaggaga agagtctcac acccagctgc
     2881 gaagccagcc catgtcattc tattaatggg acccacacat caccaggaaa ggttaagcta
     2941 gggacccaca atgtatgtat gtgagcattc tttttgatcc taatggtggg tgtacccatg
     3001 aaggctatat gatatgctgt agtctgaggc tacttcttgg cttattgtat gtataaagtt
     3061 taccttcgaa tggctcaaat tgtatttaaa ttgtgtcttg tttataaatg aagaaaagct
     3121 ataagtataa tgtaattatt ttataggtat actattaagt tatagaacaa ataaagatac
     3181 tctaggattc tatgtgatcc tggcatcatg tgccataaaa gctgaattct gcacttgtgt
     3241 ccttgtgtac tcagagtgca tttatccagc ctctgagact tcacccacgg tccgtatcat
     3301 aaacgttcct tcggggggct tgggatcttc taggagaatt agaaacaggc atcaaacaag
     3361 aagaattggt gggatggctc tcacctccag tctatgggaa cttcaagcct ttattgaaac
     3421 acccaccagc tgaatacaga atgtactcag agtgttcttg gaataagaaa tattgaatga
     3481 ggaagctttg agagacagat gcaaagagaa gtccactgta agtctcttct tctctcctgt
     3541 agccagtgca ccacacttgt gtcttacaga agccagagat tgtattgttt tgttctattt
     3601 tatgtttact ttccacgggt ttcaacattt cttaatttaa acacatctca gcctcacagt
     3661 gttgtcatct tcctgcaaac tgagttatct gccatttaag acatgcaatg atcaataaaa
     3721 gaaataaaaa ccttgacaaa actgc
//
