LOCUS       NM_011824               1639 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus gremlin 1, DAN family BMP antagonist (Grem1), mRNA.
ACCESSION   NM_011824
VERSION     NM_011824.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1639)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1639)
  AUTHORS   Amato,C.M., Xu,X. and Yao,H.H.
  TITLE     An extragenital cell population contributes to urethra closure
            during mouse penis development
  JOURNAL   Sci Adv 10 (49), eadp0673 (2024)
   PUBMED   39642224
REFERENCE   3  (bases 1 to 1639)
  AUTHORS   Pang,S., Xie,B., Feng,B., Xu,G., Ye,Q., Chen,X., Ruan,L., Chen,H.,
            Pan,S.L., Xue,C. and Li,W.
  TITLE     miR-542-5p targets GREM1 to affect the progression of renal
            fibrosis
  JOURNAL   J Biochem Mol Toxicol 38 (9), e23818 (2024)
   PUBMED   39180371
  REMARK    GeneRIF: miR-542-5p targets GREM1 to affect the progression of
            renal fibrosis.
REFERENCE   4  (bases 1 to 1639)
  AUTHORS   Lozovska,A., Korovesi,A.G., Dias,A., Lopes,A., Fowler,D.A.,
            Martins,G.G., Novoa,A. and Mallo,M.
  TITLE     Tgfbr1 controls developmental plasticity between the hindlimb and
            external genitalia by remodeling their regulatory landscape
  JOURNAL   Nat Commun 15 (1), 2509 (2024)
   PUBMED   38509075
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1639)
  AUTHORS   Francis,R.J.B., San Agustin,J.T., Szabo Rogers,H.L., Cui,C.,
            Jonassen,J.A., Eguether,T., Follit,J.A., Lo,C.W. and Pazour,G.J.
  TITLE     Autonomous and non-cell autonomous role of cilia in structural
            birth defects in mice
  JOURNAL   PLoS Biol 21 (12), e3002425 (2023)
   PUBMED   38079449
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1639)
  AUTHORS   Vogt,T.F., Jackson-Grusby,L., Wynshaw-Boris,A.J., Chan,D.C. and
            Leder,P.
  TITLE     The same genomic region is disrupted in two transgene-induced limb
            deformity alleles
  JOURNAL   Mamm Genome 3 (8), 431-437 (1992)
   PUBMED   1643305
REFERENCE   7  (bases 1 to 1639)
  AUTHORS   Maas,R.L., Jepeal,L.I., Elfering,S.L., Holcombe,R.F., Morton,C.C.,
            Eddy,R.L., Byers,M.G., Shows,T.B. and Leder,P.
  TITLE     A human gene homologous to the formin gene residing at the murine
            limb deformity locus: chromosomal location and RFLPs
  JOURNAL   Am J Hum Genet 48 (4), 687-695 (1991)
   PUBMED   1673046
REFERENCE   8  (bases 1 to 1639)
  AUTHORS   Woychik,R.P., Generoso,W.M., Russell,L.B., Cain,K.T.,
            Cacheiro,N.L., Bultman,S.J., Selby,P.B., Dickinson,M.E., Hogan,B.L.
            and Rutledge,J.C.
  TITLE     Molecular and genetic characterization of a radiation-induced
            structural rearrangement in mouse chromosome 2 causing mutations at
            the limb deformity and agouti loci
  JOURNAL   Proc Natl Acad Sci U S A 87 (7), 2588-2592 (1990)
   PUBMED   2320577
REFERENCE   9  (bases 1 to 1639)
  AUTHORS   Zeller,R., Jackson-Grusby,L. and Leder,P.
  TITLE     The limb deformity gene is required for apical ectodermal ridge
            differentiation and anteroposterior limb pattern formation
  JOURNAL   Genes Dev 3 (10), 1481-1492 (1989)
   PUBMED   2612902
REFERENCE   10 (bases 1 to 1639)
  AUTHORS   Woychik,R.P., Stewart,T.A., Davis,L.G., D'Eustachio,P. and Leder,P.
  TITLE     An inherited limb deformity created by insertional mutagenesis in a
            transgenic mouse
  JOURNAL   Nature 318 (6041), 36-40 (1985)
   PUBMED   2997621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772405.11.
            
            On Dec 3, 2008 this sequence version replaced NM_011824.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015293.1, AK135022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AL772405.11        36208-36365         c
            159-1639            AL772405.11        26392-27872         c
FEATURES             Location/Qualifiers
     source          1..1639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 57.43 cM"
     gene            1..1639
                     /gene="Grem1"
                     /gene_synonym="Cktsf1b1; Drm; Grem; ld"
                     /note="gremlin 1, DAN family BMP antagonist"
                     /db_xref="GeneID:23892"
                     /db_xref="MGI:MGI:1344337"
     exon            1..158
                     /gene="Grem1"
                     /gene_synonym="Cktsf1b1; Drm; Grem; ld"
                     /inference="alignment:Splign:2.1.0"
     exon            159..1639
                     /gene="Grem1"
                     /gene_synonym="Cktsf1b1; Drm; Grem; ld"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..714
                     /gene="Grem1"
                     /gene_synonym="Cktsf1b1; Drm; Grem; ld"
                     /note="cysteine knot superfamily 1, BMP antagonist 1;
                     gremlin-1; down-regulated in Mos-transformed cells
                     protein; down-regulated in v-mos-transformed cells"
                     /codon_start=1
                     /product="gremlin-1 precursor"
                     /protein_id="NP_035954.1"
                     /db_xref="CCDS:CCDS16560.1"
                     /db_xref="GeneID:23892"
                     /db_xref="MGI:MGI:1344337"
                     /translation="MNRTAYTVGALLLLLGTLLPTAEGKKKGSQGAIPPPDKAQHNDS
                     EQTQSPPQPGSRTRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQT
                     IHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPE
                     LQPPTKKKRVTRVKQCRCISIDLD"
     regulatory      1615..1620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grem1"
                     /gene_synonym="Cktsf1b1; Drm; Grem; ld"
ORIGIN      
        1 actaggtgcg cccttcgcag acctggagac ccagagtacc gtggtagcgg cgctctcctt
       61 cgtcttcctc ccgcgtcgag cccaagtggc tcgagccgcg gtctcacgca gcgccactcg
      121 tccacagcga agaacctgag gacccacgga agtgacagaa tgaatcgcac cgcatacact
      181 gtgggagcgt tgcttctcct cctggggacc ctactgccaa cagctgaggg gaaaaagaaa
      241 ggttcccaag gagccattcc gcctcctgac aaggctcagc acaatgactc tgagcagacc
      301 cagtccccac cacaacctgg ctccaggacc cgggggcggg gccaggggcg gggcaccgcc
      361 atgcctggag aggaggtgct tgagtccagc caagaggccc tgcacgtgac agagcgcaag
      421 tatctgaagc gagattggtg caaaactcag cccctgaagc agaccatcca cgaggagggc
      481 tgcaacagcc gcactatcat caaccgcttc tgttatggcc agtgcaactc cttctacatc
      541 cccaggcaca tccgaaagga ggaagggtcc tttcagtctt gctccttctg caagcccaag
      601 aagttcacca ccatgatggt cacactcaac tgtcctgagc tacagccacc caccaagaag
      661 aaaagggtca cacgcgtgaa gcagtgccgt tgcatatcca tcgacttgga ttaagtcaaa
      721 gcgggcacat tcagcctgtc atagccatgc tgagagagcc acacccaaac cacccgattc
      781 ctacttggct taaacctaga ggccagaaga accagcagtt gcttcctggc tggaggctgc
      841 ttatgcatag tgtatgcgca tgagtgtgca tgggtgcctg tgggtgtttc caaacaccag
      901 ccggaaacag cctttgctag aaggcacttc ctgttactct gcttcagatg gtcggaaatg
      961 cccacaccac tggacccaaa catccacagg ggcagggctg tagttggctt tgtcattgtg
     1021 ttccatgtgc ctcctgggca ccaggatttc acttgagaat gaatactaat gggggaggta
     1081 actctgaggg ctgcattaga ctcggaactg ttcagtgctc gccctatgct cccatagccc
     1141 atccctttct ttgctctccc tgacatctca gtcgtagccc atgttcctaa attaattcac
     1201 ttgaccgcgg gtgtaagtct tttgtcttgt gaagaacctt cagaatgtgg ggagacacgt
     1261 ggtgatggca aacgggacag aggactgacg caggaacggt caggctgagg accagtctgg
     1321 gccagtgaaa ttcagtagtg agatgtctag agtttaaaag ttgtttccca aaacaatatt
     1381 agtcttgttt ttagcaaaag ggttttcctg atatttaaaa gaacccagac acacagagga
     1441 aaaatataat cagcaaaaaa acaaaacaaa acaaaataac acaacaataa caacaacaac
     1501 aaacaaaaac ccaattctct gtgccagctt ctgtgaccta ctgatactag ctgtaactga
     1561 tactagctgt taagggtgaa atgctgacca ctcctgtttt aagaaccaag tgaaattaaa
     1621 aaagaaaatg tggcctcct
//
