LOCUS       NM_015764               8274 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus gene regulated by estrogen in breast cancer protein
            (Greb1), transcript variant 1, mRNA.
ACCESSION   NM_015764
VERSION     NM_015764.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8274)
  AUTHORS   Chadchan,S.B., Popli,P., Liao,Z., Andreas,E., Dias,M., Wang,T.,
            Gunderson,S.J., Jimenez,P.T., Lanza,D.G., Lanz,R.B., Foulds,C.E.,
            Monsivais,D., DeMayo,F.J., Yalamanchili,H.K., Jungheim,E.S.,
            Heaney,J.D., Lydon,J.P., Moley,K.H., O'Malley,B.W. and Kommagani,R.
  TITLE     A GREB1-steroid receptor feedforward mechanism governs differential
            GREB1 action in endometrial function and endometriosis
  JOURNAL   Nat Commun 15 (1), 1947 (2024)
   PUBMED   38431630
  REMARK    GeneRIF: A GREB1-steroid receptor feedforward mechanism governs
            differential GREB1 action in endometrial function and
            endometriosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8274)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 8274)
  AUTHORS   Li,R., Wang,T., Marquardt,R.M., Lydon,J.P., Wu,S.P. and DeMayo,F.J.
  TITLE     TRIM28 modulates nuclear receptor signaling to regulate uterine
            function
  JOURNAL   Nat Commun 14 (1), 4605 (2023)
   PUBMED   37528140
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8274)
  AUTHORS   Inada,A., Yasunami,Y., Yoshiki,A., Nabeshima,Y.I. and Inada,O.
  TITLE     Greb1 Transiently Accelerates Pancreatic beta-Cell Proliferation in
            Diabetic Mice Exposed to Estradiol
  JOURNAL   Am J Pathol 193 (8), 1081-1100 (2023)
   PUBMED   37516458
REFERENCE   5  (bases 1 to 8274)
  AUTHORS   Shin,E.M., Huynh,V.T., Neja,S.A., Liu,C.Y., Raju,A., Tan,K.,
            Tan,N.S., Gunaratne,J., Bi,X., Iyer,L.M., Aravind,L. and
            Tergaonkar,V.
  TITLE     GREB1: An evolutionarily conserved protein with a
            glycosyltransferase domain links ERalpha glycosylation and
            stability to cancer
  JOURNAL   Sci Adv 7 (12) (2021)
   PUBMED   33731348
  REMARK    GeneRIF: GREB1: An evolutionarily conserved protein with a
            glycosyltransferase domain links ERalpha glycosylation and
            stability to cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8274)
  AUTHORS   Boyle,M.P., Bernard,A., Thompson,C.L., Ng,L., Boe,A., Mortrud,M.,
            Hawrylycz,M.J., Jones,A.R., Hevner,R.F. and Lein,E.S.
  TITLE     Cell-type-specific consequences of Reelin deficiency in the mouse
            neocortex, hippocampus, and amygdala
  JOURNAL   J Comp Neurol 519 (11), 2061-2089 (2011)
   PUBMED   21491433
REFERENCE   7  (bases 1 to 8274)
  AUTHORS   Georgas,K.M., Chiu,H.S., Lesieur,E., Rumballe,B.A. and Little,M.H.
  TITLE     Expression of metanephric nephron-patterning genes in
            differentiating mesonephric tubules
  JOURNAL   Dev Dyn 240 (6), 1600-1612 (2011)
   PUBMED   21491542
REFERENCE   8  (bases 1 to 8274)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   9  (bases 1 to 8274)
  AUTHORS   Ghosh,M.G., Thompson,D.A. and Weigel,R.J.
  TITLE     PDZK1 and GREB1 are estrogen-regulated genes expressed in
            hormone-responsive breast cancer
  JOURNAL   Cancer Res 60 (22), 6367-6375 (2000)
   PUBMED   11103799
REFERENCE   10 (bases 1 to 8274)
  AUTHORS   Peterfy,M., Phan,J., Oswell,G.M., Xu,P. and Reue,K.
  TITLE     Genetic, physical, and transcript map of the fld region on mouse
            chromosome 12
  JOURNAL   Genomics 62 (3), 436-444 (1999)
   PUBMED   10644441
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ098754.1, AC157352.2, CJ099922.1, AC122228.4 and CN536594.1.
            
            On Nov 3, 2011 this sequence version replaced NM_015764.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK147337.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               CJ098754.1         1-109
            110-202             AC157352.2         50183-50275         c
            203-590             CJ099922.1         2-389
            591-787             AC122228.4         155191-155387       c
            788-907             AC122228.4         150448-150567       c
            908-1084            AC122228.4         148580-148756       c
            1085-1267           AC122228.4         140060-140242       c
            1268-1411           AC122228.4         138593-138736       c
            1412-1540           AC122228.4         136149-136277       c
            1541-1654           AC122228.4         132478-132591       c
            1655-1798           AC122228.4         131930-132073       c
            1799-1984           AC122228.4         130079-130264       c
            1985-2335           AC122228.4         126975-127325       c
            2336-2464           AC122228.4         125574-125702       c
            2465-2593           AC122228.4         124734-124862       c
            2594-2791           AC122228.4         123855-124052       c
            2792-2972           AC122228.4         123105-123285       c
            2973-3168           AC122228.4         121398-121593       c
            3169-3305           AC122228.4         119732-119868       c
            3306-3645           AC122228.4         117627-117966       c
            3646-3761           AC122228.4         116463-116578       c
            3762-3958           AC122228.4         114798-114994       c
            3959-4063           AC122228.4         113844-113948       c
            4064-4689           AC122228.4         111511-112136       c
            4690-4792           AC122228.4         107987-108089       c
            4793-4951           AC122228.4         106061-106219       c
            4952-5094           AC122228.4         103799-103941       c
            5095-5256           AC122228.4         99664-99825         c
            5257-5461           AC122228.4         97430-97634         c
            5462-5636           AC122228.4         96632-96806         c
            5637-5855           AC122228.4         95502-95720         c
            5856-5991           AC122228.4         92990-93125         c
            5992-6192           AC122228.4         89912-90112         c
            6193-6331           AC122228.4         89048-89186         c
            6332-8237           AC122228.4         85940-87845         c
            8238-8274           CN536594.1         704-740
FEATURES             Location/Qualifiers
     source          1..8274
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.0 cM"
     gene            1..8274
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /note="gene regulated by estrogen in breast cancer
                     protein"
                     /db_xref="GeneID:268527"
                     /db_xref="MGI:MGI:2149712"
     exon            1..240
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            241..322
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            323..421
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            422..787
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     CDS             631..6495
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein GREB1"
                     /codon_start=1
                     /product="protein GREB1 isoform 1"
                     /protein_id="NP_056579.2"
                     /db_xref="CCDS:CCDS36408.1"
                     /db_xref="GeneID:268527"
                     /db_xref="MGI:MGI:2149712"
                     /translation="MGNSYAGQLKSTRFEEVLHNSIEASLRSNTLVPRPIFSQLYLEA
                     EQQLSSLEGGSRADNEEEEEDGEGGLEPSSPPNAYQLPPPPEGCCTTDGFCQAGKDLR
                     LVSISSEPIEVPAGFLLVGAKSPSLPDHLLVCAVDKRFLPDDNGHNALLGFSGNCVGC
                     GKKGFCYFTEFSNHINLKLTTQPKKQKHLKYYLVRNAQGALTKGPLICWKGSEFRGRQ
                     NSTNTCSSSLFPPLESSGSLAAFPTEPVPGTNPSVPVGAQQAGPASDHPSVTTATGPA
                     VFNGKDSPKHPQLVKSSLSALPRPSALGILPNSGPPKKRHKGWSPESKSTTDGGFIQG
                     GGNRAKHEGTSIPCVPQAGLVGPASVTFPVVASGEPVSVPDNLLKICKAKPVIFKGHG
                     NFPYLCGNLNDVVVSPLLYTCYQNSQSLARAYEQHGASTMQPISEETQLLLTVYYLVQ
                     LAADQVPLMEDLEQIFLRSWRESHLTEIRQYQQAPPQPFPPATSTAAPVTSAQLPWLA
                     GLAASSCNDSVHVIECAYSLAEGLSEMFRLLIEGKLSKTNYVVIICACRNAAIDSCIA
                     VTGKYQARILSESLLSPAEYQREVHYELVTGKVDSLGTFFSSLCPEGDIDILLDKFHQ
                     ENQGHVSSSFTASSTKKTAVLDASGVPVCTSYHQEPRGVRPFQLAVAQKLLSHVCSIA
                     DSSTQNLDLGSFEKVDFLICIPPSEVTYQQTVFHVWHSGVLLELGLEKEPVTKQRAEQ
                     HVLKLDTEAQARFKAFLQNSFQNPHTLFVLIHDHAHWDLVSSAVHNIYSQSDPSVGLV
                     DRLLNCREVKEAPNIVTLHVTSFPYALQTQHTLISPYNEIHWPISFSNGVDLYHESKK
                     YFGLSEFIDSTLSGHSLPLLRYDSSFEAMVTALGKRFPRLHSAVIRTFVLVQHYAAAM
                     MAVSGLPQMKNHTSVETLEITQNLLNSPKQCPCGHGLMVLLRVPCSPLAAVAYERLAH
                     VRARLALEEHFEIILGHPSSGITVGKHFVKQLKMWQKIEDAEWRPQTYLELEGLPCIL
                     IFSGMDPHGESLPRSLRYCDLRLINSSCLVRTALEQELGLAAYFVSNDIPLEKGPKNE
                     ALESDGEKLSSTDEDEEAGTEGCFEAGSTSEQRGPVKRERSHSHDSASSSLSSRASGS
                     VLYGESLAQPSGPPQGELTRSPPSCGPAEEGRAPGEIQRLRVSQGSTVISRHSPGLVP
                     QPDSSLRTGRRSLQVPAAPSSQLSSSSGSSSTCAVPTANVLVLQASQCSMAKACRQPP
                     IVFLPKLVYDMLLSTDSSGLPKSASLLPSPSVMWTSSFRPLLSKMMTSTEQSLYYRQW
                     TVPRPSHMDYGNRAEGRVDSFHPRRLLLSGPPQIGKTGAYLQFLSILSRMLIRLTEVD
                     VYDEEEINTSFREESEWRYLQLADPWPDLELFQKMPFDYIIHDPKYEDASLICSHPQT
                     IKSEDRGMSRKPEDLYVRRQTARMRLSKYAAYNTYHHCEQCQQYMGFHPHYQLSESTL
                     HVFAFSCSMLGEEVQLHFIIPKSKEHHFVFSQPGGQLESMRLPLVTDKSHEHIKSPTF
                     TPTTGRHEHGLFNLYHAMDGANHLHVLVVKEYEMAIYKKYWPNHIMLVLPSIFNSAGV
                     GAAHFLIKELCYHNLELERNRQEELGVKPQDVWPFIVIADDSCVMWNVADVDCAGERS
                     REFSWSERNVSLKYIMLHIEASPNITHYALLGMRKWASKTRGREVQEPFSRCHVHDFI
                     ILNVDLTQNVQYNQNRFTCDDVDFNLRVHSAGLLLCRFNRFSVMKKQIAVGGHRSFHI
                     TSKVSDSSVAIVPSQYICAPDSKHTFLAAPAQLLLEKFLQYHSHRFFPLSLKNHSHPV
                     LSVDCYLNLGPQISVCYVSSRPHSLNISCSDMVFSGLLLYLCDSFVGASFLKKFHFLK
                     GATLCVICQDRNSLRQTVVRLELEDEWQFRLRDEFQTANAKEDRPLFFLTARHI"
     exon            788..907
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1084
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1267
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1411
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1540
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1654
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1798
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1984
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2335
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2464
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2593
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2791
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2972
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3168
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3305
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            3306..3645
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..3761
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            3762..3958
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            3959..4063
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            4064..4689
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            4690..4792
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            4793..4951
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            4952..5094
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            5095..5256
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            5257..5461
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            5462..5636
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            5637..5855
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            5856..5991
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            5992..6192
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            6193..6331
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     exon            6332..8260
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8238..8243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /note="hexamer: AATAAA"
     polyA_site      8260
                     /gene="Greb1"
                     /gene_synonym="5730583K22Rik; 9130004E13; mKIAA0575"
                     /note="major polyA site"
ORIGIN      
        1 tgcagcgggg acgggacggg gcaagccaat ctcctgtgcc tacacctgga cggagccgga
       61 gccggagcag cagtcccagc tcaggtctcc ccttgccgcc cccccccccc gccccccaat
      121 cacggtggcc cgcaagaccc ggacgggcgg actctcaggc tccgcggctc cgggctttgc
      181 gcagcgccgg ctccggtagc gcgggctccg aggacgccgg atgaggacaa agggcgcgag
      241 agctcccata aagcatcatt atcttcatgt acttccaagg aggtcggagg gcagaggcat
      301 gggatctgcc acgggtcaca agttggctac gtttctagaa ggaaggacag ctctctctgc
      361 tctttgatcc tggcacctag cccacaggat gacagttgat tgagttctat ataaatgaaa
      421 ggagctgtgg agagccgccc tctcctgtct ggtgctgagc agaggctgca acccgtcccc
      481 tcttgctgct gctgctgctg ctgctgctgc tgctgctgct gctgctgctg ctgcttgcct
      541 ctttgtcggg ctttgtgagg agtcagccct tctaggcaga actgaaatgt cattttaacc
      601 agaagactct gtcttctttg tgctccggag atgggcaatt cctatgctgg ccagctaaag
      661 agcacacggt ttgaagaggt cctccacaac tccatcgagg cttccttacg ctccaacacc
      721 ctggtgcccc ggcccatttt ctcgcagctg tatctggagg ctgagcagca gctgtcatcg
      781 ttagaaggcg gcagccgagc agacaatgag gaagaagaag aagatggaga aggagggtta
      841 gaacccagca gtcccccaaa tgcctaccag ctgccccctc ctcctgaagg ctgctgcacc
      901 acggatggct tctgtcaggc tgggaaggac ctacgtcttg tctccatttc cagtgagccc
      961 attgaagtcc ctgcaggctt cctcctggtg ggtgctaagt ctcccagcct gccggaccac
     1021 ctcctggtgt gtgcagtgga caagaggttc ttgcccgatg acaatggcca caatgccctg
     1081 cttggtttct ctgggaactg tgttggctgt ggaaagaaag gcttctgcta tttcaccgag
     1141 ttctccaacc acatcaacct gaagctgacc acccagccca agaaacagaa gcacctcaag
     1201 tactatctgg ttcggaatgc acaaggggca ctgaccaaag gacctttgat ttgctggaaa
     1261 ggctccgagt tcagaggtcg gcagaactcc accaacacct gctccagttc tctcttccca
     1321 ccgctggaga gctcggggtc cctggctgcc ttccccactg agcctgttcc tgggacaaac
     1381 cccagtgtcc cagtgggagc tcaacaggca ggaccagcct ctgatcaccc ctcagtgacc
     1441 acagcaacag gtcctgcagt cttcaatggc aaggattccc ccaagcaccc acagctggtg
     1501 aagagtagcc tgtctgccct gccgcgcccc tcagccttgg gtatcttgcc aaactctggg
     1561 cctcccaaaa aacggcacaa agggtggtcc ccggagtcta aatcaaccac ggatggtggc
     1621 ttcattcagg gtggtggcaa cagagccaag cacgaaggta ccagcatacc ttgtgtgccc
     1681 caggctggct tggtgggacc agcttcagtc accttcccgg tggtggcctc tggtgaacca
     1741 gtgtctgttc cggacaactt gctgaaaata tgcaaggcca agccagtgat atttaaaggc
     1801 catgggaact ttccctacct ctgcggaaac ctgaatgatg tggtcgtcag ccccctgctg
     1861 tacacctgct accagaactc ccagtcgctt gccagggcct atgagcaaca cggtgcctcc
     1921 accatgcagc ccatatctga ggagacacag ctgttgctga ccgtctacta cctcgtccaa
     1981 ctcgctgcag accaggtgcc gctgatggag gacctggagc agatcttcct acgctcctgg
     2041 cgagagtcac acctgacaga gataaggcag taccagcagg cgcctccaca gcccttcccg
     2101 ccagccacca gcacagcagc acctgtgact tctgcacagc tgccctggct ggccggcctg
     2161 gccgccagct cctgtaatga cagtgtgcat gttattgagt gtgcttactc cctggccgag
     2221 ggcctctctg agatgttccg gttgctcatc gaggggaaac tctccaagac caactatgtg
     2281 gtcattatct gtgcctgccg gaatgccgcc attgactcct gtattgctgt cacagggaaa
     2341 taccaagccc gcattctctc tgagagcctt ctcagtcctg ctgagtacca gagagaagtt
     2401 cactacgagc tggtcactgg caaagtggac tcgctgggga cattttttag cagcctctgt
     2461 ccagagggtg acattgacat tttgctggac aaatttcacc aggaaaatca aggccatgtc
     2521 tcttcctcat tcactgcttc ctctaccaag aagacagctg tgctggatgc cagtggggtc
     2581 ccggtgtgca caagttacca ccaggagcca cggggcgtcc ggccctttca gctggcggtg
     2641 gcacagaagc tcctttccca cgtgtgctcc atcgcagatt ccagcaccca gaatctggac
     2701 ctggggtcct tcgagaaggt ggactttctc atttgcattc caccgtcaga ggtgacctac
     2761 cagcagaccg tgttccacgt ctggcattca ggggttctgc tggagctggg cctggagaaa
     2821 gagcctgtga ccaagcagag ggcggagcaa cacgttctga aactagacac ggaggcccag
     2881 gcaagattta aggcctttct gcaaaactcc ttccagaacc cacatacgct ctttgtcctc
     2941 atccacgacc acgcccactg ggatctagtg agcagtgctg ttcataacat ctactctcaa
     3001 agtgacccat ctgtggggtt agtggacaga ctgctcaact gcagggaggt gaaagaggcg
     3061 cccaacattg tgaccctcca tgtgacctct ttcccgtatg cgctgcagac tcagcacacc
     3121 ctcattagcc catacaatga gatccattgg cccatctcct tcagtaatgg agtggacctg
     3181 tatcatgaga gtaagaagta cttcgggctg tctgagttta ttgactccac cctgtcagga
     3241 cacagtcttc ctctgctccg atatgacagt tcctttgagg ccatggtcac tgcattgggg
     3301 aaaaggttcc cccgcctgca cagcgcggtc atcaggacct ttgttcttgt gcagcactat
     3361 gcggccgcca tgatggccgt gagtggcctc ccgcagatga agaaccatac atcagtggag
     3421 accctagaga tcacccagaa cctcctcaac tccccgaagc agtgcccttg tggccacggg
     3481 ctcatggtcc tgctgcgcgt gccctgttca cccctggcag ccgtggccta tgagcgactg
     3541 gcccacgtgc gggctcgctt ggctctggag gaacactttg agatcatcct gggccacccc
     3601 agctccggta tcactgtagg caagcacttt gtgaagcagc tcaagatgtg gcagaaaatt
     3661 gaggatgcag aatggaggcc tcagacgtac ttagagttgg agggcctgcc ctgcatcctg
     3721 atcttcagtg ggatggaccc tcatggggag tcactgcccc ggtctctgag gtactgtgac
     3781 ctgcgtctaa taaactcctc ctgcctggtg aggacagccc tggagcagga gctgggtctg
     3841 gctgcctact ttgttagcaa tgatatcccc ttggagaagg ggcccaagaa cgaggccttg
     3901 gagagtgatg gggagaaact gagcagcacc gatgaagacg aggaggcggg gacagaaggg
     3961 tgttttgaag caggctctac gtcagagcag aggggccctg tgaagaggga acgctcccac
     4021 tcccacgact ctgcatcgtc atccctctcc tccagagcat ctggctcggt gctctatggt
     4081 gagtccctgg cccagccctc aggacctcct cagggagagc ttaccagatc acctccatcc
     4141 tgtggccctg cagaggaagg cagggcccct ggggaaatcc agcgcctccg agtgagtcag
     4201 gggtctacag tcatcagtag gcacagccct ggcctggtcc cacagcctga ttctagcctc
     4261 aggactggtc ggaggagctt gcaggtgcca gccgccccgt cctcccagct gtcctcctcc
     4321 tcgggctcat catccacatg tgcggtgccc actgccaatg tgctggtcct tcaagcctct
     4381 cagtgctcca tggccaaggc ctgccggcag ccacccatcg tcttcctgcc gaagcttgtg
     4441 tacgacatgc tcctgtccac cgacagcagc ggcttgccca agtctgcctc cctcctgcct
     4501 tccccttcag tcatgtggac cagctccttc cgccccctgc tcagcaagat gatgacatca
     4561 actgagcagt ctctctacta ccggcagtgg acagtgcccc ggcccagcca catggactac
     4621 ggcaacagag ctgagggccg tgtggacagc ttccaccccc gcaggctgct gctcagtggg
     4681 ccacctcaga ttgggaagac aggtgcctac ctgcagttcc tcagtatctt gtccaggatg
     4741 ctgattcggc tgacagaagt ggatgtttac gacgaagaag agatcaatac cagcttccga
     4801 gaggaatcgg agtggcgtta cctccagctg gccgacccct ggccagacct ggagctcttc
     4861 cagaagatgc cttttgatta catcattcat gacccgaagt atgaggacgc cagtctgatt
     4921 tgttcacacc ctcagaccat caagagtgaa gacagaggga tgtccaggaa gccggaggac
     4981 ctgtatgtgc ggcgtcagac ggcacgtatg agactgtcca agtatgcagc atacaacacg
     5041 taccaccact gtgagcagtg ccagcagtac atgggcttcc acccccacta ccagctctct
     5101 gagtccaccc tgcacgtctt tgccttctct tgctccatgc taggagagga ggtccaactt
     5161 cacttcatca tccccaagtc caaggagcac cactttgttt tcagccaacc cggaggccag
     5221 ctggagagca tgcgcttgcc cctcgtcaca gacaagagtc atgaacacat caaaagccca
     5281 accttcacac cgacaacggg ccggcacgag cacgggctct ttaatttgta ccatgcgatg
     5341 gatggagcca accacctaca cgtgctggtg gtcaaggagt acgaaatggc catttataag
     5401 aaatactggc ccaaccacat catgcttgtc ctcccaagca tctttaacag tgctggtgtc
     5461 ggggctgccc acttcctgat caaagagctt tgttaccaca acctggagct ggagcggaac
     5521 cggcaggagg agctgggggt caagcctcag gacgtctggc ccttcatcgt cattgctgat
     5581 gactcctgtg tgatgtggaa tgtagcagat gtggactgtg ccggagaacg gagcagggag
     5641 ttttcctggt cggagaggaa tgtctctctg aaatacatca tgctacacat tgaggcgtcc
     5701 cctaacatca cacactatgc cctgctcggc atgcggaagt gggccagcaa gacccggggc
     5761 cgagaggtac aggagccttt ttcacgatgt catgtgcacg acttcatcat cctcaacgtg
     5821 gacttgaccc agaatgtaca gtacaaccag aaccggttta catgtgacga tgtagacttc
     5881 aacctccgtg tgcacagtgc tggcctcctg ctctgccggt tcaatcgctt cagtgtcatg
     5941 aagaagcaga ttgcagtggg tgggcacagg tctttccaca tcacatccaa ggtatctgac
     6001 agctctgtgg ccattgtgcc gtcccagtac atctgtgccc ccgacagtaa gcatacgttc
     6061 ctggcagctc ccgcccagct cctgctggag aaattcctcc aataccatag ccatcgcttc
     6121 ttcccgctgt ctctgaagaa tcacagccac cccgtgttgt ctgtagactg ctacctgaac
     6181 ctgggacctc agatttctgt ttgttatgtg agctccaggc cccactcctt aaacatcagc
     6241 tgctctgaca tggtgttcag cgggctcctg ctgtacctct gtgactcttt tgtgggggct
     6301 agcttcttga agaagttcca ttttctgaaa ggagccacct tgtgtgtgat ctgccaagac
     6361 cggaactcac ttcgccagac ggtggtccgc ctggagctag aagatgagtg gcagttccgg
     6421 ctgcgggatg agttccagac agccaatgcc aaggaagaca ggccgctctt tttcctcacc
     6481 gcacggcaca tctgagagat ggaccctggc agagctcctg agagtgtgag gtcatcagaa
     6541 cccacctgcc actgaggcca gtgaaggtct cagaccaagg ggtacaagaa ctccagcaca
     6601 cccagagatg gtcatgcaca gcctcttgag acgcatgtca caatgtccta tgacagagaa
     6661 tgacttagag ccacaggcat gagtccttga taggcaggac tgaaaaacca aagagcacat
     6721 gcactgagct atcttgaagt ccgttatatg cagaatgaag ttttgccaag tctgctggca
     6781 ttcacacgct tccatggaca aacttgactt gctctaggga accttgggtt atcatgtcac
     6841 gatgcctgtg accatgattt cacgaagtag gtttcctctg gctccctaca gagcaatatt
     6901 ccaaaggaac attttaactg taaaggctag agacaagaag acaaaagagt agatcatttt
     6961 aataagaatt atttaatccc atacaagttt tctttgcagg agctagccca aaggcatcaa
     7021 atttaatatg ataaaatgaa ttgctatacc ttagaaacaa tgtgactcta ttaaaatagt
     7081 atggggtaag taccctacct cttataaagg gcaaaatgga aaagaagttt tcttacaaac
     7141 caaagggctt tagggaggac gttagggtta tagctgtgga ctgaagagtt gccttccaaa
     7201 ggaaagagga ccaaattgct tacatgataa aaaataagaa aaaccaaagg aaaaaaaaaa
     7261 aaaagaaaga aaaaccaaag agatccaggg gacagtgaag agggttgggg caatggctca
     7321 gctatgtaag tgtgtgtgtg cagttcaatc ccgaggactg gaatttggat cccaccacac
     7381 acataacaag ccacatattc tgtaaaagcc tgagagattc cagcccagag agatttgatg
     7441 ctttcttctg tcttctgtgt atgctcagac acacacacac acacacacac acacacacac
     7501 acacacacac acaatcttta aaaaaaatca acaaaacagt taagaaccag atttataatt
     7561 tattgaagtt ccccttttag tgagaccaac ccatgttttc ctattcatct tagttcattt
     7621 agggatagtc tgggtttccc agaaaatgtg gagccagaga gaaacaggcg gacgtgtgtt
     7681 agttaccacg atggtgttta aatcaacacc ctagcacgct acctgtcggc ctgttggtgt
     7741 ctggcctatg tgaacccttg aatgattctt ctcgtttgaa agatgagcag attagaacgc
     7801 agagagtaca gattgtggga agaagcagaa acacaattca gaacaccgtc ttctccaccc
     7861 acagtccaac tccaccccag acttccgtgt gtcagagcta aggggaacac cgagatcgct
     7921 gagaagttaa tcaggacaca gtgcacactt agacatggct cagcaccgcg ggtggtagta
     7981 gttcaaggag aaacctgtcc aagttgatgc caaagattta ctgccaacct tttcccccca
     8041 agggaaaaaa tatacgcaag tataaagcat ctacatcaat gtttataaag caatcatttg
     8101 tgaacgccgt gatgctgttt tgtaacacaa actgatctcc tttagttcag tttgtctcct
     8161 gtaaatagcg gctcctatgc catcctccct gctttattag ttaatttaaa tgaacactct
     8221 tatgttccag tcttataaat aaagcctata gtgcacttct aaaaaaaaaa aaaa
//
