LOCUS       NM_010346               2413 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus growth factor receptor bound protein 7 (Grb7), mRNA.
ACCESSION   NM_010346
VERSION     NM_010346.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2413)
  AUTHORS   Moorwood,K., Smith,F.M., Garfield,A.S., Cowley,M., Holt,L.J.,
            Daly,R.J. and Ward,A.
  TITLE     Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7
            family of signalling adaptor proteins have overlapping functions in
            the regulation of fetal growth and post-natal glucose metabolism
  JOURNAL   BMC Biol 22 (1), 221 (2024)
   PUBMED   39343875
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2413)
  AUTHORS   Lofgren,K.A. and Kenny,P.A.
  TITLE     Grb7 knockout mice develop normally but litters born to knockout
            females fail to thrive
  JOURNAL   Dev Dyn 253 (7), 677-689 (2024)
   PUBMED   38140940
  REMARK    Review article
REFERENCE   3  (bases 1 to 2413)
  AUTHORS   Vermehren-Schmaedick,A., Joshi,S., Wagoner,W., Norgard,M.A.,
            Packwood,W., Diba,P., Mendez,H., Fedorov,L.M., Rakshe,S., Park,B.,
            Marks,D.L., Grossberg,A. and Luoh,S.W.
  TITLE     Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin
            Signaling, and Increased Abdominal fat Mass in Females
  JOURNAL   Endocrinology 165 (5) (2024)
   PUBMED   38578949
  REMARK    GeneRIF: Grb7 Ablation in Mice Improved Glycemic Control, Enhanced
            Insulin Signaling, and Increased Abdominal fat Mass in Females.
REFERENCE   4  (bases 1 to 2413)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2413)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2413)
  AUTHORS   Jones,N., Master,Z., Jones,J., Bouchard,D., Gunji,Y., Sasaki,H.,
            Daly,R., Alitalo,K. and Dumont,D.J.
  TITLE     Identification of Tek/Tie2 binding partners. Binding to a
            multifunctional docking site mediates cell survival and migration
  JOURNAL   J Biol Chem 274 (43), 30896-30905 (1999)
   PUBMED   10521483
REFERENCE   7  (bases 1 to 2413)
  AUTHORS   Leavey,S.F., Arend,L.J., Dare,H., Dressler,G.R., Briggs,J.P. and
            Margolis,B.L.
  TITLE     Expression of Grb7 growth factor receptor signaling protein in
            kidney development and in adult kidney
  JOURNAL   Am J Physiol 275 (5), F770-F776 (1998)
   PUBMED   9815134
REFERENCE   8  (bases 1 to 2413)
  AUTHORS   Kishi,T., Sasaki,H., Akiyama,N., Ishizuka,T., Sakamoto,H.,
            Aizawa,S., Sugimura,T. and Terada,M.
  TITLE     Molecular cloning of human GRB-7 co-amplified with CAB1 and
            c-ERBB-2 in primary gastric cancer
  JOURNAL   Biochem Biophys Res Commun 232 (1), 5-9 (1997)
   PUBMED   9125150
REFERENCE   9  (bases 1 to 2413)
  AUTHORS   Stein,D., Wu,J., Fuqua,S.A., Roonprapunt,C., Yajnik,V.,
            D'Eustachio,P., Moskow,J.J., Buchberg,A.M., Osborne,C.K. and
            Margolis,B.
  TITLE     The SH2 domain protein GRB-7 is co-amplified, overexpressed and in
            a tight complex with HER2 in breast cancer
  JOURNAL   EMBO J 13 (6), 1331-1340 (1994)
   PUBMED   7907978
REFERENCE   10 (bases 1 to 2413)
  AUTHORS   Margolis,B., Silvennoinen,O., Comoglio,F., Roonprapunt,C.,
            Skolnik,E., Ullrich,A. and Schlessinger,J.
  TITLE     High-efficiency expression/cloning of epidermal growth
            factor-receptor-binding proteins with Src homology 2 domains
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8894-8898 (1992)
   PUBMED   1409582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA496861.1, AK168438.1 and AW494536.1.
            
            On Oct 21, 2006 this sequence version replaced NM_010346.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M94450.1, AK057640.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               CA496861.1         75-291
            218-2394            AK168438.1         2-2178
            2395-2413           AW494536.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2413
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.75 cM"
     gene            1..2413
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /note="growth factor receptor bound protein 7"
                     /db_xref="GeneID:14786"
                     /db_xref="MGI:MGI:102683"
     exon            1..416
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     exon            417..573
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     exon            574..724
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     exon            725..881
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1003
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1081
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1231
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1342
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1441
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1522
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1639
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1700
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1788
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1882
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2397
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2375..2380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /note="hexamer: AATAAA"
     polyA_site      2395
                     /gene="Grb7"
                     /gene_synonym="mKIAA4028"
                     /note="major polyA site"
ORIGIN      
        1 catgtagtca ggattctaga tttttctctg tccagcctgt tctctccggg gcacctgctc
       61 tctctctctc tctccctctc tcctagcacc tgctgctcag taggaagggc aagagcaatt
      121 cgaggcggtg cattgtgagg agtctccacc cctcctcctg cgcttccttc tccagggagc
      181 ctctcaggct ccgcccttac ctgcccgaga taattttagt ttccctgggc ctggaatctg
      241 gatacgcagg gctcgctcta tattctcccg cctcaacatt ccaaaggcgg gatagccttt
      301 ctaccatctg tagagaagag agaaaggatt cgaaatcaaa tctaagtgtc tgggatctct
      361 agacagagcc agactttggg ccgggtgtcc ggctccttct gttggaggtg ctccaggtgc
      421 catggaactg gatctgagcc cgactcatct cagcagctcc ccagaagatg tgtgcccaac
      481 tcctgctacc cctcctgaga ctcctccgcc ccctgataac cctccgccag gggatgtgaa
      541 gcggtcgcag cctttgccca tccccagcag caggaaactt cgagaagagg agtttcaggc
      601 aacctctctg ccttccatcc ccaacccctt ccctgagctc tgcagcccac cttcacagaa
      661 acccattctt ggtggttcct ccggtgcaag ggggttgctt cctcgagact ccagccgcct
      721 ctgtgtggtg aaggtgtaca gtgaggatgg ggcctgccgg tctgtggagg tggcagcggg
      781 cgccacagct cgtcacgtgt gtgagatgct ggtacagcga gctcacgccc tgagcgacga
      841 gagctgggga ctagtggaat cccaccccta cctggcactg gagcggggtc tggaggacca
      901 tgaatttgtg gtggaagtgc aggaggcctg gcctgtgggt ggagacagcc gcttcatctt
      961 tcgtaaaaac ttcgccaagt atgaactatt caagagcccc ccacacaccc tgttcccaga
     1021 aaagatggtc tcgagctgtc tggatgcaca aacaggcata tcccatgaag acctcatcca
     1081 gaacttcctg aacgctggca gcttccctga gatccagggc ttcctgcagc tgcggggatc
     1141 aggccggggg tcaggtcgaa agctttggaa acgtttcttc tgctttctgc gtcgatctgg
     1201 cctctactac tctaccaagg gtacctccaa ggaccccaga cacctacagt atgtggcaga
     1261 tgtgaatgag tccaatgtct atgtggtgac ccagggccgc aagctgtatg ggatgcccac
     1321 tgacttcggc ttctgtgtca agcccaacaa gcttcgaaac ggccacaagg ggctccacat
     1381 cttctgcagt gaggatgagc agagtcggac ctgctggctg gctgccttcc ggctcttcaa
     1441 gtacggggta cagctatata agaattatca gcaggcccag tctcgtcacc tgcgcctatc
     1501 ctatttgggg tctccaccct tgaggagcgt ctcagacaat accctagtgg ctatggactt
     1561 ctctggccat gcggggcgtg tcattgataa cccccgggaa gctctgagtg ccgccatgga
     1621 ggaggcccag gcctggagga agaagacaaa ccaccgtctg agcctgccca ccacatgctc
     1681 tggctcgagc ctcagcgcag ccattcatcg cacccagccc tggtttcatg gacgcatctc
     1741 tcgggaggag agccagcggc taattggaca gcagggcctg gtggatggtg tgttcctggt
     1801 ccgggagagc cagaggaacc cacagggctt tgtcctgtcc ttgtgccatc tgcagaaagt
     1861 caagcattat ctcattttgc caagcgaaga tgaaggttgc ctttacttca gcatggatga
     1921 gggccagacc cgtttcacag acctgctgca gctggtagaa ttccaccagc tgaaccgagg
     1981 catcctgccc tgcctgctgc gccactgctg tgcccgtgtg gccctctgag gccgcacaag
     2041 ctactgcagc catgggtttg cctaccacct ttctgttctg tggactcggt gcaggtgggt
     2101 ggggtggtaa acagtggaag agctcctccc cccaatttta tcccattttt taaaaacctc
     2161 tctcaaccag tgaaacatcc cctaaacctg tccatccctg actcctgtcc ccaagggagg
     2221 cattgtggtc ctgtcccctt ggtagagctc ctgaggtact gttccagtga ggggcattat
     2281 gagaggagcg gggcagccca ggaggtctca taccccaccc gtaatctgta cagactgaga
     2341 ggccagttga tctgctctgt tttataccag tagcaataaa gattattttt tgatacaaaa
     2401 aaaaaaaaaa aaa
//
