LOCUS       NM_016719               2003 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus growth factor receptor bound protein 14 (Grb14),
            transcript variant 1, mRNA.
ACCESSION   NM_016719
VERSION     NM_016719.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2003)
  AUTHORS   Moorwood,K., Smith,F.M., Garfield,A.S., Cowley,M., Holt,L.J.,
            Daly,R.J. and Ward,A.
  TITLE     Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7
            family of signalling adaptor proteins have overlapping functions in
            the regulation of fetal growth and post-natal glucose metabolism
  JOURNAL   BMC Biol 22 (1), 221 (2024)
   PUBMED   39343875
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2003)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2003)
  AUTHORS   Rajala,R.V.S., McCauley,A., Rajala,R., Teel,K. and Rajala,A.
  TITLE     Regulation of Phosphoinositide Levels in the Retina by Protein
            Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14
  JOURNAL   Biomolecules 11 (4), 602 (2021)
   PUBMED   33921658
  REMARK    GeneRIF: Regulation of Phosphoinositide Levels in the Retina by
            Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound
            Protein 14.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2003)
  AUTHORS   Ding,X., Iyer,R., Novotny,C., Metzger,D., Zhou,H.H., Smith,G.I.,
            Yoshino,M., Yoshino,J., Klein,S., Swaminath,G., Talukdar,S. and
            Zhou,Y.
  TITLE     Inhibition of Grb14, a negative modulator of insulin signaling,
            improves glucose homeostasis without causing cardiac dysfunction
  JOURNAL   Sci Rep 10 (1), 3417 (2020)
   PUBMED   32099031
  REMARK    GeneRIF: Inhibition of Grb14, a negative modulator of insulin
            signaling, improves glucose homeostasis without causing cardiac
            dysfunction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2003)
  AUTHORS   Popineau,L., Morzyglod,L., Carre,N., Cauzac,M., Bossard,P.,
            Prip-Buus,C., Lenoir,V., Ragazzon,B., Fauveau,V., Robert,L.,
            Guilmeau,S., Postic,C., Komatsu,M., Canonne-Hergaux,F., Guillou,H.
            and Burnol,A.F.
  TITLE     Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2
            Pathways Regulates Liver Lipogenesis and Selective Insulin
            Resistance
  JOURNAL   Mol Cell Biol 36 (16), 2168-2181 (2016)
   PUBMED   27215388
  REMARK    GeneRIF: Study reveals that Grb14 acts as a new signaling node that
            regulates lipogenesis and modulates insulin sensitivity in the
            liver by acting at a crossroad between the insulin receptor and the
            p62-Nrf2-LXR signaling pathways.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2003)
  AUTHORS   Nef,S., Schaad,O., Stallings,N.R., Cederroth,C.R., Pitetti,J.L.,
            Schaer,G., Malki,S., Dubois-Dauphin,M., Boizet-Bonhoure,B.,
            Descombes,P., Parker,K.L. and Vassalli,J.D.
  TITLE     Gene expression during sex determination reveals a robust female
            genetic program at the onset of ovarian development
  JOURNAL   Dev Biol 287 (2), 361-377 (2005)
   PUBMED   16214126
REFERENCE   7  (bases 1 to 2003)
  AUTHORS   Cariou,B., Capitaine,N., Le Marcis,V., Vega,N., Bereziat,V.,
            Kergoat,M., Laville,M., Girard,J., Vidal,H. and Burnol,A.F.
  TITLE     Increased adipose tissue expression of Grb14 in several models of
            insulin resistance
  JOURNAL   FASEB J 18 (9), 965-967 (2004)
   PUBMED   15059968
  REMARK    GeneRIF: regulation of Grb14 expression in adipose tissue may play
            a physiological role in insulin sensitivity
REFERENCE   8  (bases 1 to 2003)
  AUTHORS   Cooney,G.J., Lyons,R.J., Crew,A.J., Jensen,T.E., Molero,J.C.,
            Mitchell,C.J., Biden,T.J., Ormandy,C.J., James,D.E. and Daly,R.J.
  TITLE     Improved glucose homeostasis and enhanced insulin signalling in
            Grb14-deficient mice
  JOURNAL   EMBO J 23 (3), 582-593 (2004)
   PUBMED   14749734
  REMARK    GeneRIF: Grb14 functions in vivo as a tissue-specific modulator of
            insulin action, most likely via repression of IR-mediated IRS-1
            tyrosine phosphorylation
REFERENCE   9  (bases 1 to 2003)
  AUTHORS   Reilly,J.F., Mickey,G. and Maher,P.A.
  TITLE     Association of fibroblast growth factor receptor 1 with the adaptor
            protein Grb14. Characterization of a new receptor binding partner
  JOURNAL   J Biol Chem 275 (11), 7771-7778 (2000)
   PUBMED   10713090
REFERENCE   10 (bases 1 to 2003)
  AUTHORS   Jones,N., Master,Z., Jones,J., Bouchard,D., Gunji,Y., Sasaki,H.,
            Daly,R., Alitalo,K. and Dumont,D.J.
  TITLE     Identification of Tek/Tie2 binding partners. Binding to a
            multifunctional docking site mediates cell survival and migration
  JOURNAL   J Biol Chem 274 (43), 30896-30905 (1999)
   PUBMED   10521483
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929129.6 and AL928703.9.
            
            On Oct 4, 2022 this sequence version replaced NM_016719.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF155647.1, AK147041.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               AL929129.6         66596-66935         c
            341-473             AL929129.6         65223-65355         c
            474-630             AL928703.9         105589-105745       c
            631-752             AL928703.9         90396-90517         c
            753-827             AL928703.9         88444-88518         c
            828-965             AL928703.9         85247-85384         c
            966-1076            AL928703.9         82213-82323         c
            1077-1172           AL928703.9         81927-82022         c
            1173-1253           AL928703.9         75564-75644         c
            1254-1370           AL928703.9         69226-69342         c
            1371-1443           AL928703.9         69062-69134         c
            1444-1531           AL928703.9         68856-68943         c
            1532-1625           AL928703.9         66743-66836         c
            1626-2003           AL928703.9         64503-64880         c
FEATURES             Location/Qualifiers
     source          1..2003
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 38.35 cM"
     gene            1..2003
                     /gene="Grb14"
                     /note="growth factor receptor bound protein 14"
                     /db_xref="GeneID:50915"
                     /db_xref="MGI:MGI:1355324"
     exon            1..340
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1772
                     /gene="Grb14"
                     /note="isoform 1 is encoded by transcript variant 1; GRB14
                     adapter protein"
                     /codon_start=1
                     /product="growth factor receptor-bound protein 14 isoform
                     1"
                     /protein_id="NP_057928.1"
                     /db_xref="CCDS:CCDS16071.1"
                     /db_xref="GeneID:50915"
                     /db_xref="MGI:MGI:1355324"
                     /translation="MTTSLQDGQSAAGRAGAQDSPLAVQVCRVAQGKGDAQDPAQVPG
                     LHALSPASDATLRGAIDRRKMKDLDVLEKPPIPNPFPELCCSPLTSVLSAGLFPRANS
                     RKKQVIKVYSEDETSRALEVPSDITARDVCQLLILKNHYVDDNSWTLFEHLSHIGLER
                     TVEDHELPTEVLSHWGVEEDNKLYLRKNYAKYEFFKNPMYFFPEHMVSFAAEMNGDRS
                     PTQILQVFLSSSTYPEIHGFLHAKEQGKKSWKKAYFFLRRSGLYFSTKGTSKEPRHLQ
                     LFSEFSTSHVYMSLAGKKKHGAPTPYGFCLKPNKAGGPRDLKMLCAEEEQSRTCWVTA
                     IRLLKDGMQLYQNYMHPYQGRSACNSQSMSPMRSVSENSLVAMDFSGEKSRVIDNPTE
                     ALSVAVEEGLAWRKKGCLRLGNHGSPSAPSQSSAVNMALHRSQPWFHHRISRDEAQRL
                     IIRQGPVDGVFLVRDSQSNPRTFVLSMSHGQKIKHYQIIPVEDDGELFHTLDDGHTKF
                     TDLIQLVEFYQLNRGVLPCKLKHYCARMAV"
     exon            341..473
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            474..630
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            631..752
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            753..827
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            828..965
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1076
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1172
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1253
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1370
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1443
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1531
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1625
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..2003
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1982..1987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grb14"
                     /note="hexamer: ATTAAA"
     polyA_site      2003
                     /gene="Grb14"
                     /note="major polyA site"
ORIGIN      
        1 accgcgtccc agccgccctg gccgtgagcg caggcggccc tgccaccgca cctgcaaggc
       61 gctcgctgcc tgcaaccgct cggctctgct cgcccccagc ccttcgtagc tttcgcctcg
      121 cggtcgatga ctccctagac ccctggccta cgaccatgac cacgtccctg caagacgggc
      181 agagcgccgc gggccgggca ggcgcccagg attcgccgct ggcagtgcag gtgtgccgcg
      241 ttgcccaggg caagggagac gcccaggacc cggcgcaggt ccccggactg cacgcgctgt
      301 cccccgcctc cgatgcgacc ctccgcggtg ccatagacag gagaaaaatg aaagatctgg
      361 atgttctgga aaagccaccc attcccaacc cctttcctga gctctgctgc tctccgctta
      421 catctgtgct gtcagcaggc ctgtttccca gggccaattc aaggaagaag caggtgatta
      481 aagtttacag cgaggatgaa accagcagag cattagaggt gcccagtgac atcacagccc
      541 gagatgtttg ccagctgttg atcctgaaga accactatgt ggacgacaac agctggaccc
      601 tttttgagca cctatctcac ataggtttag aaagaaccgt agaggaccac gagctgccaa
      661 ctgaagtgct gtctcactgg ggagtggaag aagacaataa gctgtatctt agaaagaatt
      721 atgccaaata tgaatttttt aagaacccaa tgtatttctt tccagagcac atggtgtctt
      781 ttgcagctga aatgaatggt gacagatccc ctacacagat actgcaggtg tttttaagct
      841 ccagcacgta tcctgaaatc catggcttct tacatgcaaa ggaacaggga aagaagtctt
      901 ggaaaaaagc ttactttttt ctcagaagat ctggcttata tttttctact aaaggcacat
      961 ccaaggaacc acggcatttg cagcttttca gtgaattcag cactagtcac gtttatatgt
     1021 cactggcagg aaaaaaaaaa cacggagcgc caactcccta tggattctgc ttaaagccta
     1081 acaaagcagg agggccccgg gacctgaaaa tgctctgtgc agaagaagag cagagcagga
     1141 cgtgctgggt gaccgccatc cgactgctga aggatggcat gcagctgtat cagaattata
     1201 tgcatccata ccaaggtaga agcgcctgca attctcagag catgtcaccc atgagaagcg
     1261 tatcagagaa ttccctagta gcaatggact tctcaggtga gaagagcaga gtcatagaca
     1321 accccactga agcgctttcg gttgctgttg aggaaggcct cgcgtggagg aaaaaaggct
     1381 gtttacgcct ggggaatcac ggaagcccca gtgccccctc ccagagctct gctgtgaaca
     1441 tggctctcca tcggtcccaa ccatggtttc accacagaat ttccagagat gaggctcagc
     1501 ggctgatcat tcggcagggg cctgtggatg gagttttctt ggtacgggat agtcagagta
     1561 accccagaac ttttgtactg tcaatgagtc atggacaaaa gataaaacac tatcaaatta
     1621 tacccgtaga agatgatggt gagctgttcc atactctgga tgatggccat acgaagttca
     1681 cagacctcat ccagctggtg gagttctacc agctcaacag gggggtcctt ccttgcaagc
     1741 tgaagcatta ctgtgctagg atggctgttt agccaaactg tgtgtcactc gttacactac
     1801 agaagaagaa ggatgcaaag gagaatgatt agagagagag agagagatca caaggctgaa
     1861 aacaaatcat ggtgaaaaga agatttcacc tgcgggttac aaaaaaaaat aggtcacaca
     1921 ttgcaaatta gtgaaaactt ggattcctat tacactcatg actttaaatt tattagttaa
     1981 aattaaacct tattaaaaaa ata
//
