LOCUS       NP_057928                538 aa            linear   ROD 19-NOV-2024
DEFINITION  growth factor receptor-bound protein 14 isoform 1 [Mus musculus].
ACCESSION   NP_057928
VERSION     NP_057928.1
DBSOURCE    REFSEQ: accession NM_016719.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 538)
  AUTHORS   Moorwood,K., Smith,F.M., Garfield,A.S., Cowley,M., Holt,L.J.,
            Daly,R.J. and Ward,A.
  TITLE     Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7
            family of signalling adaptor proteins have overlapping functions in
            the regulation of fetal growth and post-natal glucose metabolism
  JOURNAL   BMC Biol 22 (1), 221 (2024)
   PUBMED   39343875
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 538)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 538)
  AUTHORS   Rajala,R.V.S., McCauley,A., Rajala,R., Teel,K. and Rajala,A.
  TITLE     Regulation of Phosphoinositide Levels in the Retina by Protein
            Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14
  JOURNAL   Biomolecules 11 (4), 602 (2021)
   PUBMED   33921658
  REMARK    GeneRIF: Regulation of Phosphoinositide Levels in the Retina by
            Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound
            Protein 14.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 538)
  AUTHORS   Ding,X., Iyer,R., Novotny,C., Metzger,D., Zhou,H.H., Smith,G.I.,
            Yoshino,M., Yoshino,J., Klein,S., Swaminath,G., Talukdar,S. and
            Zhou,Y.
  TITLE     Inhibition of Grb14, a negative modulator of insulin signaling,
            improves glucose homeostasis without causing cardiac dysfunction
  JOURNAL   Sci Rep 10 (1), 3417 (2020)
   PUBMED   32099031
  REMARK    GeneRIF: Inhibition of Grb14, a negative modulator of insulin
            signaling, improves glucose homeostasis without causing cardiac
            dysfunction.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 538)
  AUTHORS   Popineau,L., Morzyglod,L., Carre,N., Cauzac,M., Bossard,P.,
            Prip-Buus,C., Lenoir,V., Ragazzon,B., Fauveau,V., Robert,L.,
            Guilmeau,S., Postic,C., Komatsu,M., Canonne-Hergaux,F., Guillou,H.
            and Burnol,A.F.
  TITLE     Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2
            Pathways Regulates Liver Lipogenesis and Selective Insulin
            Resistance
  JOURNAL   Mol Cell Biol 36 (16), 2168-2181 (2016)
   PUBMED   27215388
  REMARK    GeneRIF: Study reveals that Grb14 acts as a new signaling node that
            regulates lipogenesis and modulates insulin sensitivity in the
            liver by acting at a crossroad between the insulin receptor and the
            p62-Nrf2-LXR signaling pathways.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 538)
  AUTHORS   Nef,S., Schaad,O., Stallings,N.R., Cederroth,C.R., Pitetti,J.L.,
            Schaer,G., Malki,S., Dubois-Dauphin,M., Boizet-Bonhoure,B.,
            Descombes,P., Parker,K.L. and Vassalli,J.D.
  TITLE     Gene expression during sex determination reveals a robust female
            genetic program at the onset of ovarian development
  JOURNAL   Dev Biol 287 (2), 361-377 (2005)
   PUBMED   16214126
REFERENCE   7  (residues 1 to 538)
  AUTHORS   Cariou,B., Capitaine,N., Le Marcis,V., Vega,N., Bereziat,V.,
            Kergoat,M., Laville,M., Girard,J., Vidal,H. and Burnol,A.F.
  TITLE     Increased adipose tissue expression of Grb14 in several models of
            insulin resistance
  JOURNAL   FASEB J 18 (9), 965-967 (2004)
   PUBMED   15059968
  REMARK    GeneRIF: regulation of Grb14 expression in adipose tissue may play
            a physiological role in insulin sensitivity
REFERENCE   8  (residues 1 to 538)
  AUTHORS   Cooney,G.J., Lyons,R.J., Crew,A.J., Jensen,T.E., Molero,J.C.,
            Mitchell,C.J., Biden,T.J., Ormandy,C.J., James,D.E. and Daly,R.J.
  TITLE     Improved glucose homeostasis and enhanced insulin signalling in
            Grb14-deficient mice
  JOURNAL   EMBO J 23 (3), 582-593 (2004)
   PUBMED   14749734
  REMARK    GeneRIF: Grb14 functions in vivo as a tissue-specific modulator of
            insulin action, most likely via repression of IR-mediated IRS-1
            tyrosine phosphorylation
REFERENCE   9  (residues 1 to 538)
  AUTHORS   Reilly,J.F., Mickey,G. and Maher,P.A.
  TITLE     Association of fibroblast growth factor receptor 1 with the adaptor
            protein Grb14. Characterization of a new receptor binding partner
  JOURNAL   J Biol Chem 275 (11), 7771-7778 (2000)
   PUBMED   10713090
REFERENCE   10 (residues 1 to 538)
  AUTHORS   Jones,N., Master,Z., Jones,J., Bouchard,D., Gunji,Y., Sasaki,H.,
            Daly,R., Alitalo,K. and Dumont,D.J.
  TITLE     Identification of Tek/Tie2 binding partners. Binding to a
            multifunctional docking site mediates cell survival and migration
  JOURNAL   J Biol Chem 274 (43), 30896-30905 (1999)
   PUBMED   10521483
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929129.6 and AL928703.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF155647.1, AK147041.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 38.35 cM"
     Protein         1..538
                     /product="growth factor receptor-bound protein 14 isoform
                     1"
                     /note="GRB14 adapter protein"
                     /calculated_mol_wt=60442
     Region          1..20
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLM9.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylthreonine.
                     /evidence=ECO:0000250|UniProtKB:Q14449; propagated from
                     UniProtKB/Swiss-Prot (Q9JLM9.1)"
     Region          105..189
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     Region          228..349
                     /region_name="PH_APBB1IP"
                     /note="Amyloid beta (A4) Precursor protein-Binding, family
                     B, member 1 Interacting Protein pleckstrin homology (PH)
                     domain; cd01259"
                     /db_xref="CDD:269961"
     Region          367..412
                     /region_name="BPS"
                     /note="BPS (Between PH and SH2); pfam08947"
                     /db_xref="CDD:462644"
     Site            370
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O88900; propagated from
                     UniProtKB/Swiss-Prot (Q9JLM9.1)"
     Site            373
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JLM9.1)"
     Region          431..538
                     /region_name="SH2_Grb14"
                     /note="Src homology 2 (SH2) domain found in the growth
                     factor receptor bound, subclass 14 (Grb14) proteins;
                     cd10414"
                     /db_xref="CDD:198277"
     Site            order(444,464..466,469,485)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198277"
     Site            order(486,518)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198277"
     CDS             1..538
                     /gene="Grb14"
                     /coded_by="NM_016719.2:156..1772"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS16071.1"
                     /db_xref="GeneID:50915"
                     /db_xref="MGI:MGI:1355324"
ORIGIN      
        1 mttslqdgqs aagragaqds plavqvcrva qgkgdaqdpa qvpglhalsp asdatlrgai
       61 drrkmkdldv lekppipnpf pelccsplts vlsaglfpra nsrkkqvikv ysedetsral
      121 evpsditard vcqllilknh yvddnswtlf ehlshigler tvedhelpte vlshwgveed
      181 nklylrknya kyeffknpmy ffpehmvsfa aemngdrspt qilqvflsss typeihgflh
      241 akeqgkkswk kayfflrrsg lyfstkgtsk eprhlqlfse fstshvymsl agkkkhgapt
      301 pygfclkpnk aggprdlkml caeeeqsrtc wvtairllkd gmqlyqnymh pyqgrsacns
      361 qsmspmrsvs enslvamdfs geksrvidnp tealsvavee glawrkkgcl rlgnhgspsa
      421 psqssavnma lhrsqpwfhh risrdeaqrl iirqgpvdgv flvrdsqsnp rtfvlsmshg
      481 qkikhyqiip veddgelfht lddghtkftd liqlvefyql nrgvlpcklk hycarmav
//
