LOCUS       NM_010345               5089 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus growth factor receptor bound protein 10 (Grb10),
            transcript variant 1, mRNA.
ACCESSION   NM_010345
VERSION     NM_010345.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5089)
  AUTHORS   Moorwood,K., Smith,F.M., Garfield,A.S., Cowley,M., Holt,L.J.,
            Daly,R.J. and Ward,A.
  TITLE     Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7
            family of signalling adaptor proteins have overlapping functions in
            the regulation of fetal growth and post-natal glucose metabolism
  JOURNAL   BMC Biol 22 (1), 221 (2024)
   PUBMED   39343875
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5089)
  AUTHORS   Moorwood,K., Smith,F.M., Garfield,A.S. and Ward,A.
  TITLE     Imprinted Grb10, encoding growth factor receptor bound protein 10,
            regulates fetal growth independently of the insulin-like growth
            factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes
  JOURNAL   BMC Biol 22 (1), 127 (2024)
   PUBMED   38816743
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5089)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5089)
  AUTHORS   Charalambous,M., Cowley,M., Geoghegan,F., Smith,F.M., Radford,E.J.,
            Marlow,B.P., Graham,C.F., Hurst,L.D. and Ward,A.
  TITLE     Maternally-inherited Grb10 reduces placental size and efficiency
  JOURNAL   Dev Biol 337 (1), 1-8 (2010)
   PUBMED   19833122
  REMARK    GeneRIF: Grb10 can influence reproductive strategy through the
            allocation of maternal resources such that offspring number is
            offset against size.
REFERENCE   5  (bases 1 to 5089)
  AUTHORS   Monk,D., Arnaud,P., Frost,J., Hills,F.A., Stanier,P., Feil,R. and
            Moore,G.E.
  TITLE     Reciprocal imprinting of human GRB10 in placental trophoblast and
            brain: evolutionary conservation of reversed allelic expression
  JOURNAL   Hum Mol Genet 18 (16), 3066-3074 (2009)
   PUBMED   19487367
REFERENCE   6  (bases 1 to 5089)
  AUTHORS   Sanz,L.A., Chamberlain,S., Sabourin,J.C., Henckel,A., Magnuson,T.,
            Hugnot,J.P., Feil,R. and Arnaud,P.
  TITLE     A mono-allelic bivalent chromatin domain controls tissue-specific
            imprinting at Grb10
  JOURNAL   EMBO J 27 (19), 2523-2532 (2008)
   PUBMED   18650936
  REMARK    GeneRIF: Data indicate that bivalent chromatin, in combination with
            neuronal factors, controls the paternal expression of Grb10 in
            brain.
REFERENCE   7  (bases 1 to 5089)
  AUTHORS   Yamasaki-Ishizaki,Y., Kayashima,T., Mapendano,C.K., Soejima,H.,
            Ohta,T., Masuzaki,H., Kinoshita,A., Urano,T., Yoshiura,K.,
            Matsumoto,N., Ishimaru,T., Mukai,T., Niikawa,N. and Kishino,T.
  TITLE     Role of DNA methylation and histone H3 lysine 27 methylation in
            tissue-specific imprinting of mouse Grb10
  JOURNAL   Mol Cell Biol 27 (2), 732-742 (2007)
   PUBMED   17101788
  REMARK    GeneRIF: Grb10 gene is expressed from the paternal allele in brain,
            but from the maternal allele in most other tissues.
REFERENCE   8  (bases 1 to 5089)
  AUTHORS   O'Neill,T.J., Rose,D.W., Pillay,T.S., Hotta,K., Olefsky,J.M. and
            Gustafson,T.A.
  TITLE     Interaction of a GRB-IR splice variant (a human GRB10 homolog) with
            the insulin and insulin-like growth factor I receptors. Evidence
            for a role in mitogenic signaling
  JOURNAL   J Biol Chem 271 (37), 22506-22513 (1996)
   PUBMED   8798417
REFERENCE   9  (bases 1 to 5089)
  AUTHORS   Hansen,H., Svensson,U., Zhu,J., Laviola,L., Giorgino,F., Wolf,G.,
            Smith,R.J. and Riedel,H.
  TITLE     Interaction between the Grb10 SH2 domain and the insulin receptor
            carboxyl terminus
  JOURNAL   J Biol Chem 271 (15), 8882-8886 (1996)
   PUBMED   8621530
REFERENCE   10 (bases 1 to 5089)
  AUTHORS   Ooi,J., Yajnik,V., Immanuel,D., Gordon,M., Moskow,J.J.,
            Buchberg,A.M. and Margolis,B.
  TITLE     The cloning of Grb10 reveals a new family of SH2 domain proteins
  JOURNAL   Oncogene 10 (8), 1621-1630 (1995)
   PUBMED   7731717
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FJ425892.1, BC053842.1 and CK635114.1.
            
            On Apr 21, 2010 this sequence version replaced NM_010345.3.
            
            Transcript Variant: This variant (1) includes an alternate internal
            exon, compared to variant 3. It encodes isoform 1 which is shorter,
            compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053842.1, AK030727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 17101788, 19487367
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               FJ425892.1         8-234
            228-5080            BC053842.1         195-5047
            5081-5089           CK635114.1         60-68               c
FEATURES             Location/Qualifiers
     source          1..5089
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 7.15 cM"
     gene            1..5089
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /note="growth factor receptor bound protein 10"
                     /db_xref="GeneID:14783"
                     /db_xref="MGI:MGI:103232"
     exon            1..229
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            230..308
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            309..528
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..2125
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /note="isoform 1 is encoded by transcript variant 1; GRB10
                     adapter protein; maternally expressed gene 1 protein"
                     /codon_start=1
                     /product="growth factor receptor-bound protein 10 isoform
                     1"
                     /protein_id="NP_034475.2"
                     /db_xref="CCDS:CCDS24440.1"
                     /db_xref="GeneID:14783"
                     /db_xref="MGI:MGI:103232"
                     /translation="MNNDINSSVESLNSACNMQSDTDTAPLLEDGQHASNQGAASSSR
                     GQPQASPRQKMQRSQPVHILRRLQEEDQQLRTASLPAIPNPFPELTGAAPGSPPSVAP
                     SSLPPPPSQPPAKHFPPGFQLSKLTRPGLWTKTTARFSKKQPKNQCPTDTVNPVARMP
                     TSQMEKLRLRKDVKVFSEDGTSKVVEILTDMTARDLCQLLVYKSHCVDDNSWTLVEHH
                     PQLGLERCLEDHEIVVQVESTMPSESKFLFRKNYAKYEFFKNPVNFFPDQMVNWCQQS
                     NGGQAQLLQNFLNTSSCPEIQGFLQVKEVGRKSWKKLYVCLRRSGLYYSTKGTSKEPR
                     HLQLLADLEESSIFYLIAGKKQYNAPNEHGMCIKPNKAKTEMKELRLLCAEDEQIRTC
                     WMTAFRLLKYGMLLYQNYRIPQRKGLPPPFNAPMRSVSENSLVAMDFSGQIGRVIDNP
                     AEAQSAALEEGHAWRKRSTRMNILSSQSPLHPSTLNAVIHRTQHWFHGRISREESHRI
                     IKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFTLDDGNTKF
                     SDLIQLVDFYQLNKGVLPCKLKHHCIRVAL"
     exon            529..682
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            683..847
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1004
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1120
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1189
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1327
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1438
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1537
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1612
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1729
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1796
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1884
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1978
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..5089
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5060..5065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /note="hexamer: AATAAA"
     polyA_site      5080
                     /gene="Grb10"
                     /gene_synonym="5730571D09Rik; Meg1; mKIAA0207"
                     /note="major polyA site"
ORIGIN      
        1 atcgaggggg tggggtgcgg ggaggcggca ggaagggaag ggcgctgcga ccagtggcgg
       61 gcgggattcg cgttccgaga cccacgggag cacgaagttt ccgcgcaccg tctcacgcac
      121 ggcgactggg accgtccagt gtccggcttt gccttcggtt tttctccgtt gtgactcgtg
      181 caacgtgtgg ccagcggcca cgcggaggcg acgaggagct gcacgtcagg acaaagtggg
      241 gcagtcaacg tccaaacccg aaaacctagc taagtctggg ttttcgccac aacaaagaag
      301 ccaaccagag catggtcttg ggcttcaagt actaatgaac aacgatatta actcgtccgt
      361 ggaaagcctt aactcagctt gcaacatgca gtctgatact gatactgcac cacttcttga
      421 ggatggccag catgccagca accagggagc agcatctagc tcccggggac agccacaggc
      481 gtccccgagg cagaaaatgc aacgctcgca gcctgtgcac attctcaggc gccttcagga
      541 ggaagaccag cagttaagaa ctgcatctct tccggccatc cccaacccat ttccggagct
      601 cactggtgcg gcccctggga gccctccttc ggttgctcct agctccttac ctcctcctcc
      661 gagccagcca cctgccaagc atttccctcc aggctttcag ctgtcgaaac tcacccgtcc
      721 aggtctgtgg acaaagacca ctgcgagatt ttcaaagaaa caacctaaga accagtgtcc
      781 aaccgacact gtgaatccag tggcacggat gcccacttca cagatggaga agctgaggct
      841 cagaaaggat gtcaaagtct ttagtgaaga tgggaccagc aaagtggtgg agattctaac
      901 cgacatgaca gccagggacc tgtgccagct gctggtttac aaaagtcact gtgtggatga
      961 caacagctgg actctggtgg aacaccaccc acaactggga ttagagaggt gcctggagga
     1021 ccatgagatc gtggtccaag tggagagtac catgccaagt gagagcaaat tcttattcag
     1081 aaagaattat gcgaagtacg agttctttaa gaatccagtg aacttcttcc cggatcagat
     1141 ggtcaattgg tgccagcagt ccaacggtgg ccaggcgcag cttctgcaga attttctgaa
     1201 caccagcagc tgccctgaga tccaggggtt cttgcaggtg aaagaggtag gacgcaagtc
     1261 ttggaagaag ctgtatgtgt gcctgcgcag atctggcctc tattactcca ccaaggggac
     1321 ttcaaaagaa cccagacacc tgcagctgct ggctgacctg gaagaaagca gcatcttcta
     1381 cctgattgct ggaaagaagc agtacaacgc gccgaatgaa catgggatgt gcatcaagcc
     1441 aaacaaagcg aagaccgaga tgaaggagct tcgtctgctc tgtgccgaag atgagcagat
     1501 ccgtacttgc tggatgactg ccttcagact gctcaagtac ggaatgctcc tgtaccaaaa
     1561 ctatcgcatc ccacagagga agggtctgcc ccctcctttc aacgcaccta tgcgcagtgt
     1621 ttctgagaat tctcttgtgg ccatggattt ttctggacaa atcggaagag tgatcgataa
     1681 cccggctgaa gcccagagtg ctgccctgga agagggccat gcctggcgta agcggagcac
     1741 acggatgaat atcctaagca gccaaagccc actgcatcct tctaccctga atgcagtgat
     1801 tcacaggact cagcattggt tccatggacg tatctcccgc gaggagtctc acaggatcat
     1861 caagcaacaa ggtctcgtgg acgggctgtt cctccttcgt gacagccaga gtaatccaaa
     1921 ggcgttcgta ctgacactgt gccatcacca gaagattaaa aacttccaga tcttaccttg
     1981 cgaggatgat gggcagacct tcttcactct ggatgatggg aacaccaagt tctccgatct
     2041 gatccagctg gtcgacttct accagctcaa caaaggtgtt ctgccctgca agctgaaaca
     2101 ccactgcatc cgcgtggcct tatgacctcc ttgcccactc acagaggctg gaggcagcga
     2161 cactggaacg gagaagagag atctgcatga gggtgagaac acacacctac tcccacccaa
     2221 ggactcagaa caacatggct ttttgatcgg taccaaccga cctacatcaa ttagttattg
     2281 gacttcacaa agatttgccg ctgtggatca aacaggacca cctccctctg cgtcagccat
     2341 ttaaaattgg gggagggaag agatccagtg caagtgtggg aagaaactgg aatgacgatt
     2401 ttgattaggc cacgtagggt gaaaaccgca gaaaaatgat tggaaatgaa ctcttgccct
     2461 ggaataacct tgacaattca aaccgcgatg tttacttttt gtattgatca cttttttgca
     2521 ctccttcttc gttgtcgatg ttgtactcag cctatggtag gagaggatgt ggctttgcaa
     2581 ctcagatcag acaaagaatt tttgaattgg caggctttag cctacaaatg ggtcccccaa
     2641 gttttctaga taacatcctg ctctctgcag gttgcggcag tgtgggtttg gctccagtcc
     2701 ttcccattat acttgaaaag cttttttttt ttttttaaat aaaataataa gataaaaggt
     2761 gacaaccgca gttgacacct agcatgtttt gtggacgcag tcaagctgcc acagtctggt
     2821 catcgttgtt gttgtgctga cgtctggtca tgtattatta gtgtgtctcg ttctccacgg
     2881 tgctggagac ctcattactt tggaaaactc actgttcccc agcacagcac agctgcatga
     2941 cctcagcttc agactgatgt cagccagcct tcttggaaca cattgctatt cattgtggat
     3001 gccacacagt ccatctgggg tgccctgtgc ctcccatttt cacagccgcc cactgttgta
     3061 gaataatcgc tgcctttacc ctctgcagta ccctcagtca tttcacttct cccacagggg
     3121 tggggtaggg gtggggttaa aggatcgaaa gagaaaaaaa cgccaacttg ttggccttgt
     3181 gctctgtcac tctgagcatc tatggtgata aagagaagga aacgctgcag aggcacaagc
     3241 ataagctggc tttgagtctt tgaaagcttg atggcctctg caccctactg aaaaccccct
     3301 aagccagcag gagcagggta tgcagaggct ttgcctctgc tggcttaggg tgagaagtac
     3361 ctcacaatgg atgtgaacat tggacagatt ttaggagcat gatgtttgcc tcctccgaga
     3421 gagaggagtc agagagagag aggagtcaga aggtggccgg agttatcatt gggtcccctg
     3481 agctccatga aggaccctct gttgtcccct tgatgattta tcaggcatga gagtagcaga
     3541 caggattgcc ttgagaaaca cacagacaac aacggtggtg aacacatttc cctttcttga
     3601 taccacccag aaagtctgct acatacctga gttagccact agattgcctg tcccgactca
     3661 ttgaagtgct ccccagggag ccacttctga tttgccatgg ttgacagcat agtggaagat
     3721 agatatgaca gcgctttgta aagcaggcca gtggcaagct ggcccacagt agagaaacac
     3781 tgtagttcac agaccatgca accgtgtttc cacgagatgt tattacaaca aatgaagaat
     3841 ttttttcctt ttttttcatt ttaatctttt ttgacttttt tttagttaac cattttttat
     3901 gcataagtgc tcaaatgcat ttctctttct ttcgaaacta gttaatcgtt aagttgacaa
     3961 tgagagaatt ctcaagttca tacctggcag caggctccca ctgatcttcc ccttacagac
     4021 agataacaga catttcagtt ttaccgtgct catttctttt tgctgactta aggtcagaac
     4081 ttttacagac aacaaacaac cctagggttt ctttttccag tttacacaga ccggtcccca
     4141 cagtgcagaa tccatttctc tttcgtctca acagtagaca actaggatgt ggatctcata
     4201 tttataagta tgcattttat ttaagaggaa gtataggctt gactctggtt cacaatttcg
     4261 tacgtagctg gtttgacgta gaactttgta cttcccttgc cgaagtgaat tgttgaaggc
     4321 tgcaacccac ccaccttgag tgtagcagac ttcagtggcc ccgagatcgc cagccctttg
     4381 cacaggcagc tgggaattcc acctgaaaca gctggtccct aggttagcgg gttcccagcc
     4441 cccctaatca gagactgaag gacaattgac ttttattttt gtatttaatt gacatgaatg
     4501 taaaggggac agctcagggt tgttttggag cctgtttgac tttgtaatct ctgcctgtga
     4561 ttttcttttc taaatgacga ctccgtgtaa ccacctggac taagttgaga aggaaactgc
     4621 caaatgcttt gggtttttag ggttttaata ggtagactct gttctattat taggtgttaa
     4681 gagtttccaa acgtgttttc ttttttcttt tattgtttgc ttaaactttg aagaaatatg
     4741 tgcctcagct tagatgtttt gtcttcccct ttctgcactt aaatacctga cagcctgttc
     4801 gatcgctgtg cctccgaggg cgcttctagc tcatcgtaga tttgtgatgt catagtgcaa
     4861 actgcagtga ccggtaaaat gacctgacat gtaaccgttt tcagggaatg cagagggtgt
     4921 taactaatag acaaaacctt tatcccgcgt gctttgcttc accttgtgct atatagctct
     4981 ttggctcgtg aacctaattg taaactttca ggtatttttg tacaaataag ggactgatgt
     5041 tctgtttctt gttattagaa ataaacatta ataaagcgtt cttggtgtc
//
