LOCUS       NM_027817               1599 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus GRB2-related adaptor protein (Grap), mRNA.
ACCESSION   NM_027817 XM_918577
VERSION     NM_027817.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1599)
  AUTHORS   Wu,X., Zhu,Y., Guo,Y., Zhao,Z. and Li,Z.
  TITLE     Grb2-related adaptor protein GRAP is a novel regulator of liver
            fibrosis
  JOURNAL   Life Sci 327, 121861 (2023)
   PUBMED   37343720
  REMARK    GeneRIF: Grb2-related adaptor protein GRAP is a novel regulator of
            liver fibrosis.
REFERENCE   2  (bases 1 to 1599)
  AUTHORS   Li,C., Bademci,G., Subasioglu,A., Diaz-Horta,O., Zhu,Y., Liu,J.,
            Mitchell,T.G., Abad,C., Seyhan,S., Duman,D., Cengiz,F.B.,
            Tokgoz-Yilmaz,S., Blanton,S.H., Farooq,A., Walz,K., Zhai,R.G. and
            Tekin,M.
  TITLE     Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is
            linked to sensorineural hearing loss
  JOURNAL   Proc Natl Acad Sci U S A 116 (4), 1347-1352 (2019)
   PUBMED   30610177
REFERENCE   3  (bases 1 to 1599)
  AUTHORS   Cummins,T.D., Barati,M.T., Coventry,S.C., Salyer,S.A., Klein,J.B.
            and Powell,D.W.
  TITLE     Quantitative mass spectrometry of diabetic kidney tubules
            identifies GRAP as a novel regulator of TGF-beta signaling
  JOURNAL   Biochim Biophys Acta 1804 (4), 653-661 (2010)
   PUBMED   19836472
  REMARK    GeneRIF: Grb2-related adaptor protein (GRAP) was up-regulated in
            kidney tubules from diabetic mice, indicating a potential novel
            role for GRAP in TGF-beta-induced tubule injury in diabetic kidney
            disease.
REFERENCE   4  (bases 1 to 1599)
  AUTHORS   Isnardi,I., Lesourne,R., Bruhns,P., Fridman,W.H., Cambier,J.C. and
            Daeron,M.
  TITLE     Two distinct tyrosine-based motifs enable the inhibitory receptor
            FcgammaRIIB to cooperatively recruit the inositol phosphatases
            SHIP1/2 and the adapters Grb2/Grap
  JOURNAL   J Biol Chem 279 (50), 51931-51938 (2004)
   PUBMED   15456754
  REMARK    GeneRIF: FcgammaRIIB docking site for the SH2 domain-containing
            adapters Grb2 and Grap
REFERENCE   5  (bases 1 to 1599)
  AUTHORS   Shiraiwa,H., Takei,M., Yoshikawa,T., Azuma,T., Kato,M.,
            Mitamura,K., Ueki,T., Kida,A., Horie,T., Seki,N. and Sawada,S.
  TITLE     Detection of Grb-2-related adaptor protein gene (GRAP) and peptide
            molecule in salivary glands of MRL/lpr mice and patients with
            Sjogren's syndrome
  JOURNAL   J Int Med Res 32 (3), 284-291 (2004)
   PUBMED   15174222
  REMARK    GeneRIF: Results suggest that the GRAP gene might have a role in
            the pathogenesis of Sjogren's syndrome.
REFERENCE   6  (bases 1 to 1599)
  AUTHORS   Shen,R., Ouyang,Y.B., Qu,C.K., Alonso,A., Sperzel,L., Mustelin,T.,
            Kaplan,M.H. and Feng,G.S.
  TITLE     Grap negatively regulates T-cell receptor-elicited lymphocyte
            proliferation and interleukin-2 induction
  JOURNAL   Mol Cell Biol 22 (10), 3230-3236 (2002)
   PUBMED   11971956
  REMARK    GeneRIF: Data suggest that Grap, unlike Grb2, acts as a negative
            regulator of TCR-stimulated intracellular signaling by
            downregulating signal relay through the Ras/Erk pathway.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL596209.13.
            
            On Apr 30, 2007 this sequence version replaced NM_027817.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018457.1, AK153888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AL596209.13        148522-148625       c
            105-202             AL596209.13        141627-141724       c
            203-325             AL596209.13        137639-137761       c
            326-494             AL596209.13        131942-132110       c
            495-1599            AL596209.13        129169-130273       c
FEATURES             Location/Qualifiers
     source          1..1599
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     gene            1..1599
                     /gene="Grap"
                     /gene_synonym="8430435N19Rik"
                     /note="GRB2-related adaptor protein"
                     /db_xref="GeneID:71520"
                     /db_xref="MGI:MGI:1918770"
     exon            1..104
                     /gene="Grap"
                     /gene_synonym="8430435N19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..680
                     /gene="Grap"
                     /gene_synonym="8430435N19Rik"
                     /codon_start=1
                     /product="GRB2-related adapter protein"
                     /protein_id="NP_082093.1"
                     /db_xref="CCDS:CCDS24817.1"
                     /db_xref="GeneID:71520"
                     /db_xref="MGI:MGI:1918770"
                     /translation="MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGA
                     EGFVPKNYIRVKPHPWYSGRISRQLAEETLMKRNHLGAFLIRESESSPGEFSVSVNYG
                     DQVQHFKVLREASGKYFLWEEKFNSLNELVDFYRTTTIAKRRQIFLCDEQPLIKPSRA
                     CFAQAQFDFSAQDPSQLSLRRGDIVEVVEREDPHWWRGRAGGRLGFFPRSYVQPVHL"
     exon            105..202
                     /gene="Grap"
                     /gene_synonym="8430435N19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            203..325
                     /gene="Grap"
                     /gene_synonym="8430435N19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            326..494
                     /gene="Grap"
                     /gene_synonym="8430435N19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            495..1599
                     /gene="Grap"
                     /gene_synonym="8430435N19Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcggctgaa gcccagggac agtgggatgg agtccgtggc cctgtacagc ttccaggcta
       61 ccgagagtga cgagctggcc ttcaacaagg gggacacgct taagatcctg aacatggaag
      121 atgaccagaa ctggtacaaa gctgagctcc gaggagcgga gggttttgtt cccaagaact
      181 acatccgtgt aaagccacac ccgtggtact cgggcaggat ctctcgacag ctggctgaag
      241 agactctgat gaaacgcaac cacctaggag ccttcctgat cagggagagt gagagttccc
      301 ctggcgagtt ctccgtctct gtgaattatg gtgaccaggt gcagcacttc aaagtgcttc
      361 gagaggcctc agggaagtac ttcctgtggg aggagaagtt caactccctc aacgagctgg
      421 tcgacttcta ccgcaccacc accatcgcca agaggcggca gatcttcctg tgtgacgagc
      481 aaccactgat caagccatcc cgggcttgct ttgcccaggc ccagtttgac ttctcggcac
      541 aggatccatc tcagctcagc ctccgccgag gtgacatcgt ggaagttgtg gagcgtgagg
      601 atccacactg gtggcggggc cgggcaggcg ggcgcctggg cttcttccca cggagctacg
      661 tgcaaccggt acacttgtga ccacacaaga ccagaggagc gatgctctgg gctcagcttc
      721 ttcacactaa ccaggaccaa tatcggtcac caccaggctg ggagcggaag cccccgcccg
      781 caggcctgac tgctttccat tggtctctat gtgtgacatc acccgccatt gaccaggccc
      841 atcctctcca gacttgagga ccaactgcta atggctgggg cccagctcag aaagcgcttc
      901 ccttgagcag tttatcttcc aaacgccttt caggttgtgc aagttaccgg gaactggctt
      961 agccctgggc aacctcaacg tccataagag tgcaaagttc ctcccactcc aacagcttgg
     1021 ggcctcctgg ctttacccca ccagcactgg aatgaggtta tatagaggtg aatcccgttg
     1081 gaagaggcct gatagggaca gaggcaatgt agtgggtccc gtcctgttag ctacaggcag
     1141 agcccagctt ggaggccttg gctatgcagg ttcaggagga acagccaggc tatggccagc
     1201 actgagtgaa tgtacagtgc atgggggtgg tgcctggcta tgggggaatc ctgagctgct
     1261 gctacccaga gtcagagcat ctgcagattg gggaaactga gtcagacttg gcaaggcctg
     1321 gcatggtaat gggctttgat gtgggggtgg gagagagaga gagagagaga gagagagaga
     1381 gagagagaga gagaagcaga gaccaagaga taacagagac agagagacag agagagaacc
     1441 tctgtggctg tctttaagtc cctcgaagag cccaggttgc aggaactcgg ggttctccct
     1501 gagcccaggg ctgtcccaag accctctaag ctgtgagcct ggcataccct atgctcctaa
     1561 cctgtacctg cgtattcaaa ataaaacatt aaccagtgg
//
