LOCUS       NM_001379572            4170 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus GRAM domain containing 4 (Gramd4), transcript variant
            3, mRNA.
ACCESSION   NM_001379572 XM_030248507
VERSION     NM_001379572.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4170)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4170)
  AUTHORS   Kimura,T., Endo,S., Inui,M., Saitoh,S., Miyake,K. and Takai,T.
  TITLE     Endoplasmic Protein Nogo-B (RTN4-B) Interacts with GRAMD4 and
            Regulates TLR9-Mediated Innate Immune Responses
  JOURNAL   J Immunol 194 (11), 5426-5436 (2015)
   PUBMED   25917084
  REMARK    GeneRIF: The findings indicate a critical role of Nogo-B and GRAMD4
            in trafficking of TLR9.
REFERENCE   3  (bases 1 to 4170)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   4  (bases 1 to 4170)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116764.10.
            
            On Apr 9, 2020 this sequence version replaced XM_030248507.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.23548.1,
                                           SRR13422598.155416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AC116764.10        172932-173131       c
            201-411             AC116764.10        140370-140580       c
            412-532             AC116764.10        130993-131113       c
            533-653             AC116764.10        113310-113430       c
            654-727             AC116764.10        109641-109714       c
            728-860             AC116764.10        106637-106769       c
            861-886             AC116764.10        106011-106036       c
            887-978             AC116764.10        104813-104904       c
            979-1070            AC116764.10        104252-104343       c
            1071-1119           AC116764.10        103180-103228       c
            1120-1191           AC116764.10        102172-102243       c
            1192-1235           AC116764.10        101703-101746       c
            1236-1345           AC116764.10        101527-101636       c
            1346-1500           AC116764.10        101236-101390       c
            1501-1645           AC116764.10        99895-100039        c
            1646-1739           AC116764.10        98985-99078         c
            1740-1824           AC116764.10        98134-98218         c
            1825-1893           AC116764.10        96944-97012         c
            1894-4170           AC116764.10        94267-96543         c
FEATURES             Location/Qualifiers
     source          1..4170
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 40.48 cM"
     gene            1..4170
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /note="GRAM domain containing 4"
                     /db_xref="GeneID:223752"
                     /db_xref="MGI:MGI:2676308"
     exon            1..200
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            201..411
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            412..532
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            533..653
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            654..727
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            728..860
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            861..886
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            887..978
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1070
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1119
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1191
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1235
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1345
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1500
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1645
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1739
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1824
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1893
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..4170
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4145..4150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /note="hexamer: AATAAA"
     polyA_site      4170
                     /gene="Gramd4"
                     /gene_synonym="9930016O13"
                     /note="major polyA site"
ORIGIN      
        1 agactccgcg cagcaggacg tgagcgcgcg acgcggcgcc gcctccgcgc tcgtggccgg
       61 cacccgcggg gccgcgtagt ccccgctccc cggcgccgct gggctcccgg gagggcggca
      121 ggtgcagcgc ggccgggtgg ccggccaggg gggcgccgcg gcggcgggtg gatgagagtt
      181 ggccccgatc atcccgcagg ggagcctccc cgtcatgtcc aggtgaggcc gaggagtgcc
      241 gtgctgaaca tgctcaggag gctggatagg atcaggttca gaggacacaa gagagaggac
      301 ctccttgatc tagccgagtc cccaaatgcc tcggacaccg agtgcggaga cgagatcccc
      361 ctgaagacgc cacggccctc gccccgggac agtgaggagc tcagggaccc tgctggtcca
      421 gggaccctca tcatggcggc aggcgtgcag gacttcaaca ggacagagtt cgatcgactg
      481 aacgagatca agggccatct ggaaatcgcc ttactggaaa agcactttct tcaggaggag
      541 ctccggaagc ttcgagaaga gaccaactca gagatgctgc ggcaggagct ggatcgggag
      601 cggcagcgcc ggatcgaact ggaacagaaa atgcaggagg tgctaaaggc caggtccgag
      661 gagcagccag cacagcctca gcagccacca aagggacaga gccaggccag caatggcaca
      721 ggcacagagc gccgcagcca gggcttggcc tcccgtgtac agaagtggtt ctatgagagg
      781 tttggggaat acatcgagga cttccgcttc caaccagagg agaacacagt agagacggag
      841 gagcccctca gcgcccgcag gttaactgaa aacatgagaa gactgaagcg cggtgccaag
      901 cctgtcacta acttcgtgaa gaacctgtct gccttatctg actggtactc catctacacc
      961 tccgccatcg ccttcacggt atacatgaat gctgtgtggc acggctgggc catccccatg
     1021 ttcctgttcc tagcaattct gaggttgtcc ctcaattacc tcatcgccag gggctggcgg
     1081 atacaatgga gcattgtgcc ggaagtgtct gaagctgtgg aacccgcaaa ggaagatctg
     1141 accgtgtctg agaagttcca gctggtgctg gatgtggccc agaaagcaca gaatctcttc
     1201 ggcaagatgg ccgacatcct ggaaaagatc aagaacttgt tcatgtgggt gcaacctgag
     1261 accacgcaga agctctatgt tgccctgtgg gccgcctttc tggcttcttg cttcttcccc
     1321 taccgcctgg tggggcttgc tgttggcctc tatgccggca tcaagttttt cttaattgac
     1381 ttcatcttca aacgctgccc aagacttcga gccaagtatg acacccccta tatcatctgg
     1441 aggagcctgc ccactgaccc tcagctcaaa gagcgtgctg gtgccaccgt gtcacgcagg
     1501 ctgcagacag cctcatcacg gagctacgtc tccagtgctc cagctggtct gagtaaggac
     1561 gaagatgctg gacgctttca cagcaccaag aaggggaact tccacgaaat cttcaacttg
     1621 actgaaaacg agcgcccgct agcagtgtgc gagaatggct ggcgctgctg cctcattaac
     1681 cgagaccgga agatgcccac ggactacatc aggaacgggg ttctgtatgt gacagagaat
     1741 tacctgtgct tcgagagctc caagtctggg tcatcaaaga ggaacaaggt gatcaaactg
     1801 atggacatca cagacatcca gaagtataaa gtcttgtctg tcctccctgg ctcaggcatg
     1861 ggaattgctg tttctacacc atcaacccag aaacccctgg tgttcggtgc catggtgcac
     1921 agagatgaag cctttgagac cattttcagc cagtatgtga aaatcacgtc tgcagcggcc
     1981 tctggcggtg acagctagta ttgactctgg ggtgttgctg gaatcctttc caaccgctgg
     2041 ctggaggagc ggacatcctc gcagtcttcg gcaataattc tcctggactg tggctggtta
     2101 tattggccta ggctctgcag accagaaggg ctggaactca catggaacgg tgccgggctg
     2161 gcccgtgcca agcgcatgaa gcaccttcat gaccacctgt ggacacaggt gggcagagga
     2221 tcctcttaac cagtctgaag gatggcacac aagacactgg tcctcaggcc ctgctaagca
     2281 cagcccctca ctctccttcc cggcctgggt gcagacccag cccctgccat cctgagaggc
     2341 tccttggtct tatgacccct gttcttcaga ggctttttcc accaaagcca tagctgggaa
     2401 tggttgtggc cccttcctgc aggggtggta agatggagag aatggtgggg aggcccctct
     2461 ccagtgaaga aatggccagt catctcaccc agccctcaga ccctccttcc acgttggacc
     2521 tgctgtgggc actccgaggc tgtgggtagg gcctcttagg gcttggtgtt ttgggggtac
     2581 ctgcccctcc atcagtgtct gggcatgagt tatcactcat ctggctcgtc ttggcctgac
     2641 actccagcta agaggtcagg ccagtggttg gtgtcctgtg agggcccaga ctggcgtagt
     2701 gtcggcaaaa gcacaccttt ttaacacttg gctctttgga aggtttcggg gcgagcattc
     2761 tccaccctgc tgttaagtga gagactccat ggtcatctgg ctggcgtttg gcctccaggc
     2821 tgcagtcact ctggagttat gggaggaccc tgtgccacag cagacagctg tgggcagagc
     2881 ctagaggtta ggggccagag ttgccttgtc ctctaacatc taacagtatt tattgtctct
     2941 tactgcacgc tctgcagggg taaggcacat cccatcccac ccatgctccc tgccccgaca
     3001 aaggtggaga cttcacaggt gggcgatctt gcaggcctgg gcctctgggg ggggcaacca
     3061 cgacgccacc tgtgaatctc ccaggtggac cactcttgtc tccttcagct tgtcccgagt
     3121 ccttcagatg tcactgagat tgcttttttg aagaaacaga agattatatt ttttacagag
     3181 agcaagctgt ctttcttatt tttgtaccat ttttcaaatg taatttttac ctttgctcca
     3241 acgctcgttt gccggcgtag gtgtgaggcc cggtggcttg ggctcatgac acctcattcc
     3301 caggggactt caggccacac actgggggtg ggaagggctt gccaggcaac cagatcaagc
     3361 acacatacca ctccagatgc gtagcagagg ccacacagct ccaggtacat agacggagga
     3421 gtctggatgg ggaggcggga ccctcgaccc agggccgtgg cttgggcccc tggaatatgc
     3481 ttgtgctatg aagagcacgg aatcagagaa ggagcacccc aacgtgccag agggaaggca
     3541 acatggcctc tgacctgtcc gtgaggatgg cttcatgggt gatagccaca catggtggct
     3601 aacacttcat ggaccctggc ggtgcctggg ttgtgagtgt tgccaccccg gtgtgctaca
     3661 gagaggcctt aagcagggaa ggctttcagg gtggaatacg tggtttagtt tgagtctctt
     3721 tctttgggaa agagagatga agactgacca tgggtcaggg cagtaggtca gggaggtggc
     3781 cccaagttct accattagcc accggcagat ctttgagtag agcttagggg gtcagggctg
     3841 ggccaggggc ctatgtagct tctaggcatc cttacagaga cactggggtt tgtactggat
     3901 tgtgtgatct gggcaggtgt ttaattgctc actaatcact gacctagaat gttcaatttt
     3961 gtatgtgtga agcttgagtc tgttttggat ctgtacataa ttgttgctgg tgtaactttt
     4021 gttctacaaa aggatcatat tctataaaga actgatagga aaaaaaatcc tctgtcactt
     4081 ttttttttaa aaaaagaaaa ccttgtttag atacaaagtc ttgtataaat tataattttt
     4141 atttaataaa cctaaaatgc tctgtgctga
//
