LOCUS       NM_001408334            3788 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus GRAM domain containing 1C (Gramd1c), transcript
            variant 4, mRNA.
ACCESSION   NM_001408334 XM_006521894
VERSION     NM_001408334.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3788)
  AUTHORS   Banerjee,R., Hohe,R.C., Cao,S., Jung,B.M., Horak,A.J.,
            Ramachandiran,I., Massey,W.J., Varadharajan,V., Zajczenko,N.I.,
            Burrows,A.C., Dutta,S., Goudarzi,M., Mahen,K., Carter,A.,
            Helsley,R.N., Gordon,S.M., Morton,R.E., Strauch,C., Willard,B.,
            Gogonea,C.B., Gogonea,V., Pedrelli,M., Parini,P. and Brown,J.M.
  TITLE     The nonvesicular sterol transporter Aster-C plays a minor role in
            whole body cholesterol balance
  JOURNAL   Front Physiol 15, 1371096 (2024)
   PUBMED   38694206
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3788)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3788)
  AUTHORS   Ferrari,A., Whang,E., Xiao,X., Kennelly,J.P., Romartinez-Alonso,B.,
            Mack,J.J., Weston,T., Chen,K., Kim,Y., Tol,M.J., Bideyan,L.,
            Nguyen,A., Gao,Y., Cui,L., Bedard,A.H., Sandhu,J., Lee,S.D.,
            Fairall,L., Williams,K.J., Song,W., Munguia,P., Russell,R.A.,
            Martin,M.G., Jung,M.E., Jiang,H., Schwabe,J.W.R., Young,S.G. and
            Tontonoz,P.
  TITLE     Aster-dependent nonvesicular transport facilitates dietary
            cholesterol uptake
  JOURNAL   Science 382 (6671), eadf0966 (2023)
   PUBMED   37943936
REFERENCE   4  (bases 1 to 3788)
  AUTHORS   Sandhu,J., Li,S., Fairall,L., Pfisterer,S.G., Gurnett,J.E.,
            Xiao,X., Weston,T.A., Vashi,D., Ferrari,A., Orozco,J.L.,
            Hartman,C.L., Strugatsky,D., Lee,S.D., He,C., Hong,C., Jiang,H.,
            Bentolila,L.A., Gatta,A.T., Levine,T.P., Ferng,A., Lee,R.,
            Ford,D.A., Young,S.G., Ikonen,E., Schwabe,J.W.R. and Tontonoz,P.
  TITLE     Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER
            Cholesterol Transport in Mammalian Cells
  JOURNAL   Cell 175 (2), 514-529 (2018)
   PUBMED   30220461
REFERENCE   5  (bases 1 to 3788)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3788)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125098.4, AC132310.3 and AC129306.5.
            
            On Jun 15, 2022 this sequence version replaced XM_006521894.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.525453.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC125098.4         148898-149020
            124-270             AC125098.4         153044-153190
            271-355             AC132310.3         2-86
            356-459             AC132310.3         9077-9180
            460-555             AC132310.3         9771-9866
            556-636             AC132310.3         11401-11481
            637-752             AC132310.3         27123-27238
            753-885             AC132310.3         30623-30755
            886-1048            AC132310.3         34538-34700
            1049-1186           AC129306.5         1744-1881
            1187-1305           AC129306.5         7430-7548
            1306-1448           AC129306.5         8842-8984
            1449-1552           AC129306.5         9736-9839
            1553-1729           AC129306.5         11350-11526
            1730-1787           AC129306.5         12628-12685
            1788-1898           AC129306.5         15989-16099
            1899-2004           AC129306.5         16361-16466
            2005-3788           AC129306.5         17469-19252
FEATURES             Location/Qualifiers
     source          1..3788
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 28.44 cM"
     gene            1..3788
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /note="GRAM domain containing 1C"
                     /db_xref="GeneID:207798"
                     /db_xref="MGI:MGI:2443024"
     exon            1..123
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2085
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /note="isoform 3 is encoded by transcript variant 4; GRAM
                     domain-containing protein 1C; protein Aster-C"
                     /codon_start=1
                     /product="protein Aster-C isoform 3"
                     /protein_id="NP_001395263.1"
                     /db_xref="GeneID:207798"
                     /db_xref="MGI:MGI:2443024"
                     /translation="MEGALTARQIVNEGDSSLATELQEEPEESPGPVVDENIVSAKKQ
                     GQSTHNWSGDWSFWISSSTYKDRNEEYRQQFTHLPDSEKLIADYACALQKDILVQGRL
                     YLSEKWLCFYSNIFRWETTISIALKNITFMTKEKTARLIPNAIQIITEGEKFFFTSFG
                     ARDRSYLIIFRLWQNVLLDKSLTRQEFWQLLQQNYGTELGLNAEEMEHLLSVEENVQP
                     RSPGRSSVDDAGERDEKFSKAVSFTQESVSRASETEPLDGNSPKRGLGKEDSQSERNV
                     RKSPSLASEKRISRAPSKSLDLNKNEYLSLDKSSTSDSVDEENIPEKDLQGRLYINRV
                     FHISAERMFELLFTSSHFMQRFANSRNIIDVVSTPWTVESGGNQLRTMTYTIVLSNPL
                     TGKYTAATEKQTLYKESREAQFYLVDSEVLTHDVPYHDYFYTLNRYCIVRSAKQRCRL
                     RVSTDLKYRKQPWGLIKSLIEKNSWSSLESYFKKLESDLLMEESVLSQSIEDAGKHSS
                     LRRRRRTLNRTAEPVPKLSSQRSSTDLGFEAKVDVTGKRKTVDSYDTALIVVMSIFLL
                     LLVLLNVTLFLKLSKIEHATQSFYQLHLQGEKSLNLVSDRFSRTENIQKNKDQAHRLK
                     GVLQDSIVMLEQLKSSLIMLQKTFDLLNKNKSGVAVES"
     exon            124..270
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            271..355
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            356..459
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            460..555
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            556..636
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            637..752
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            753..885
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1048
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1186
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1305
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1448
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1552
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1729
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1787
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1898
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2004
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..3788
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3768..3773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3788
                     /gene="Gramd1c"
                     /gene_synonym="4921521N14Rik"
                     /note="major polyA site"
ORIGIN      
        1 agccaggacc gcgcgtcggg cacgcgcctg tccggccctc tcccacccgg gagctctcag
       61 ggacgcgcgt gcggggtgtc gcgggagggt gcggcgatgg agggcgctct cacggcgcgc
      121 cagatagtaa atgaagggga ttcaagtctt gcgacggagc tacaggaaga gcccgaggaa
      181 agtcctggcc ctgttgtgga tgagaatata gtatcagcca aaaaacaggg acagagcaca
      241 cataattgga gcggcgactg gagcttttgg atctcgagtt ccacctataa agacaggaat
      301 gaggaataca gacagcagtt cacacacctg ccggactcgg agaagctgat agcagattat
      361 gcttgcgctc tccagaagga tatcttggtt caggggaggc tgtacctttc agaaaaatgg
      421 ctgtgtttct atagcaacat cttcagatgg gaaactacaa tttctattgc tttaaagaat
      481 ataaccttta tgaccaagga gaaaactgct cgactcatcc caaatgctat ccagatcatc
      541 acggaggggg aaaagttttt ctttacatct tttggtgcca gagacagaag ttacctgatc
      601 atatttaggt tgtggcagaa tgtattacta gataagagcc tgaccagaca ggagttctgg
      661 caactgctcc agcagaacta tggcacggag ctaggcttaa acgctgaaga aatggaacac
      721 ttgttatcag ttgaagaaaa tgtgcagcca agaagtccag gaagaagcag cgtggatgac
      781 gctggggaaa gagatgagaa gttctccaag gccgtcagct ttacacagga gtcagttagc
      841 agagcttcag aaacagagcc attggacggg aactcaccga aaagaggact aggaaaagag
      901 gattcccaga gcgagagaaa tgtgagaaaa agtccttcgc tagcttcaga aaagaggata
      961 agcagagcac cctccaagtc actggacttg aataagaatg agtacctttc tctggataaa
     1021 agcagcactt cagattctgt ggacgaagaa aatattcccg agaaagatct tcaaggaaga
     1081 ctttatatca accgtgtctt tcacatcagt gctgagagaa tgttcgaact gctgttcact
     1141 agctcacact ttatgcagag atttgcaaat tctagaaata taatagatgt ggtatctacc
     1201 ccctggacag ttgaatctgg aggcaatcag ctgcgaacca tgacctatac catagtcctc
     1261 agcaacccgc taactgggaa gtatactgct gccacagaaa agcagaccct gtataaagag
     1321 agccgggaag cacagttcta cctggtagac tccgaagtgc tgacacatga tgtgccctat
     1381 cacgactact tctacacttt gaacagatac tgtatcgtga gatctgcaaa acagagatgc
     1441 aggctgagag tctccacaga cttgaagtac aggaaacaac catggggcct tatcaagtct
     1501 ttaattgaga agaattcctg gagttcactg gagagctact tcaaaaagct tgaatccgat
     1561 ttgttaatgg aagagtctgt gttgagtcaa tccattgaag atgctggaaa acatagcagc
     1621 ctacgccgga gaaggcggac cttgaaccgg acagcagagc ccgttccaaa gctgtcctct
     1681 cagcgctctt ccacagattt gggcttcgag gccaaagtag atgttacagg aaagagaaag
     1741 accgtggaca gttatgacac cgcccttatt gtggtgatga gcatattctt gctgctgctc
     1801 gttctgctga atgtgacact atttctgaag ctgtcaaaga tagaacacgc tacccagtcc
     1861 ttctaccagc ttcacctcca gggagaaaaa tctttaaatt tagtctctga caggttctca
     1921 agaacagaaa atattcaaaa gaacaaagat caggcccacc gcctaaaagg agtactccaa
     1981 gattccatag tgatgttgga acagctgaag agctcactca ttatgcttca aaaaaccttt
     2041 gatttactaa ataagaacaa gtctggggtg gctgtggaga gctagtgctg aaatgtggaa
     2101 accaaagaga catctggacc tagaaggcaa catctggaag gaatcggagg atgaagactg
     2161 tcactgtcat aaggacattt ctgatatttt tattaccagg atttctacca ggaaagctgt
     2221 atttaaataa catttactca atgactactc tccaatagcc ttaagactct atcttttcac
     2281 ttcttataga tacttttaag ctgtgaattt ctccagtgaa ccatgaaata tattttggaa
     2341 ttgaaattct gtgacacaaa aggggaagga aggcactgtg ggtaggatgg ctattcttct
     2401 atagtgaggc ttgctacttg atcctttaaa tttatgttag cacagagtcc ctgtgtgccc
     2461 agggtggggg tggggggctg cgtttgtaac tgagtttaag agcctaaaaa ggtaagaaga
     2521 aacccctcaa tcatttatca ccttaaagga tcgttttcca agtgcataca ttccaggctt
     2581 gtatctttaa attttacagt gccttccttg acttggcctc aaggccaatg gtcagacctt
     2641 ttgtatgtcc gaaagagtca ttggccatgt tgtatctgaa tgaagggata tatatgtata
     2701 tatatacaca catatataca tgtacatata tatacatatg tgtgtgcata tatgtatgta
     2761 cgtataagta ccaaaggtga gattatcctt tatatatcaa aaagactgaa cagtaattta
     2821 ggagaaggaa gtatatagga catcaatgct cataatgaac tactttcagt tttagaagtc
     2881 gtaagattat tataaaatct gggcattcca tgacagatca aattgagtcc atgagtaatg
     2941 cttagattca gcttagcaac acccatgata gaggtggccc atcaggtaga aaataattaa
     3001 tcacttttca gtagcagcta acttgtcttg ctggcaaatt ataagctgga cacaaacttg
     3061 cactcagcaa taaagactgg ggggcatgca agctgaccgg agttgagagg cgcaagcttg
     3121 ggctctcggg aaaaccactc aggcacttgt gtcagcacca gtggtttgtg aaaataagga
     3181 cttggcgact tgacttgaaa ttagctgcgt cccccgggat ttaggaaatg ttcaggacgt
     3241 atttattgtt ttgttctcta gctgtctttc tagaacacgc acatatattt atttttattg
     3301 aatatccatt gcctttagtc aatgtttcct ttccctcagt gtcaccaaag ccaaatgtca
     3361 ttgctaacaa tgtttttgag acgcctgtag ggaataaaaa tactggctaa agggaagggt
     3421 ttctcttcat gaatcctaac taatctccct ggggcagggg gcttcggagt aataccttct
     3481 gttctgttct gttctgttct gctttgtttt gttctgttct gttctgttct gttttgtttg
     3541 tgataagaac ataggaagtc tctggctgtg agtttgagtg actggattag aaacttcaga
     3601 ttgttaaatt tagaaaaatg ttaactgtca aagtgaatgc ttttgtggtt tctcttaaag
     3661 cacttcacca tatacctcaa agattaccaa cgtcactttg tagataaaac actaaatatg
     3721 tacgtagaat taatgagatc ttaatctgtt atgtatggat tgacttcaat aaaaccggaa
     3781 atgtttaa
//
