LOCUS       NM_027127               1048 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus glutathione peroxidase 8 (putative) (Gpx8), transcript
            variant 1, mRNA.
ACCESSION   NM_027127
VERSION     NM_027127.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1048)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1048)
  AUTHORS   Hsu,J.L., Chou,J.W., Chen,T.F., Hsu,J.T., Su,F.Y., Lan,J.L.,
            Wu,P.C., Hu,C.M., Lee,E.Y. and Lee,W.H.
  TITLE     Glutathione peroxidase 8 negatively regulates caspase-4/11 to
            protect against colitis
  JOURNAL   EMBO Mol Med 12 (1), e9386 (2020)
   PUBMED   31782617
  REMARK    GeneRIF: Glutathione peroxidase 8 negatively regulates caspase-4/11
            to protect against colitis.
REFERENCE   3  (bases 1 to 1048)
  AUTHORS   Kumada,T., Yamanaka,Y., Kitano,A., Shibata,M., Awaya,T., Kato,T.,
            Okawa,K., Abe,T., Oshima,N., Nakahata,T. and Heike,T.
  TITLE     Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic
            reticulum, is required for early embryonic development
  JOURNAL   Dev Dyn 239 (8), 2233-2245 (2010)
   PUBMED   20568244
REFERENCE   4  (bases 1 to 1048)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (bases 1 to 1048)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1048)
  AUTHORS   Kawaguchi,A., Ikawa,T., Kasukawa,T., Ueda,H.R., Kurimoto,K.,
            Saitou,M. and Matsuzaki,F.
  TITLE     Single-cell gene profiling defines differential progenitor
            subclasses in mammalian neurogenesis
  JOURNAL   Development 135 (18), 3113-3124 (2008)
   PUBMED   18725516
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159207.2 and AC165265.2.
            
            On Mar 22, 2023 this sequence version replaced NM_027127.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019664.1, AK009378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC159207.2         83346-83584
            240-501             AC159207.2         84063-84324
            502-1048            AC165265.2         235360-235906       c
FEATURES             Location/Qualifiers
     source          1..1048
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 63.93 cM"
     gene            1..1048
                     /gene="Gpx8"
                     /gene_synonym="2310016C16Rik; GPx-8; GSHPx-8"
                     /note="glutathione peroxidase 8 (putative)"
                     /db_xref="GeneID:69590"
                     /db_xref="MGI:MGI:1916840"
     exon            1..239
                     /gene="Gpx8"
                     /gene_synonym="2310016C16Rik; GPx-8; GSHPx-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..665
                     /gene="Gpx8"
                     /gene_synonym="2310016C16Rik; GPx-8; GSHPx-8"
                     /EC_number="1.11.1.9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable glutathione peroxidase 8"
                     /codon_start=1
                     /product="probable glutathione peroxidase 8 isoform 1"
                     /protein_id="NP_081403.1"
                     /db_xref="CCDS:CCDS26781.1"
                     /db_xref="GeneID:69590"
                     /db_xref="MGI:MGI:1916840"
                     /translation="MEPFAAYPLKCSGPKAKIFAVLLSMVLCTVMLFLLQLKFLKPRT
                     NSFYSFEVKDAKGRTVSLEKFKGKASLVVNVASDCRFTDKSYQTLRELHKEFGPYHFN
                     VLAFPCNQFGESEPKSSKEVESFARQNYGVTFPIFHKIKILGPEAEPAFRFIVDSSKK
                     EPRWNFWKYLVNPEGQVVKFWRPEEPLEAIRPHVSQMIGQIILKKKEDL"
     exon            240..501
                     /gene="Gpx8"
                     /gene_synonym="2310016C16Rik; GPx-8; GSHPx-8"
                     /inference="alignment:Splign:2.1.0"
     exon            502..1048
                     /gene="Gpx8"
                     /gene_synonym="2310016C16Rik; GPx-8; GSHPx-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1020..1025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpx8"
                     /gene_synonym="2310016C16Rik; GPx-8; GSHPx-8"
                     /note="hexamer: AATATA"
     regulatory      1027..1032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpx8"
                     /gene_synonym="2310016C16Rik; GPx-8; GSHPx-8"
                     /note="hexamer: AATGAA"
     polyA_site      1042
                     /gene="Gpx8"
                     /gene_synonym="2310016C16Rik; GPx-8; GSHPx-8"
                     /note="major polyA site"
     polyA_site      1048
                     /gene="Gpx8"
                     /gene_synonym="2310016C16Rik; GPx-8; GSHPx-8"
ORIGIN      
        1 attccagcct gctgagactc ccaggatcgt ccaaaatgga gcctttcgct gcctacccat
       61 taaaatgttc cgggcccaaa gcaaagatat ttgcagtttt gctctctatg gttctgtgca
      121 ccgtgatgct ttttctcctt cagttaaaat tcctgaagcc gagaaccaac agcttctact
      181 cctttgaagt aaaggatgcc aaaggaagga ccgtgtctct ggaaaagttc aaaggcaaag
      241 cttccctggt tgtaaacgtg gctagtgact gccgcttcac agacaagagt taccagactc
      301 tcagggagct acacaaggag ttcgggccct atcacttcaa cgtcctggct tttccgtgca
      361 atcagtttgg agaatcggag cccaagtcca gcaaggaggt agaatctttt gcgagacaga
      421 actacggagt cacattcccc atcttccaca agattaagat tttagggccg gaagcagaac
      481 ctgcgtttag atttattgtt gattcttcca agaaggagcc aaggtggaat ttttggaagt
      541 atctggtcaa ccctgaggga caagtcgtga agttctggag gccagaagaa ccccttgaag
      601 ccatcagacc tcatgtatca caaatgattg ggcaaattat tcttaaaaag aaagaggatc
      661 tatgaaacca ccgtggagtc aggccagtac aacaggacag aggttttaga ttccaaaaca
      721 tacggtacaa aaaagatgtt taaggccatc ttactatact actcagatgt aatggctgtc
      781 cccaagatag aaatgttacc tatagaggga agaaagaggc ttggaggcca acccatgatg
      841 aagtatatta cttctattga ccagaaggaa aaatctagaa tgttcagtca ccaataccct
      901 tcactgttgt ccaacttaac tttctctagg attaaccttg tgggaaaagc acacaccaca
      961 tgggacccgg aacactgtga gggtgccatt tttggagtaa ctaactctag ctgtaataaa
     1021 atatacaatg aatgttgcaa aatataaa
//
