LOCUS       NM_024198               1214 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glutathione peroxidase 7 (Gpx7), mRNA.
ACCESSION   NM_024198
VERSION     NM_024198.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1214)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1214)
  AUTHORS   Hu,X., Li,B., Wu,F., Liu,X., Liu,M., Wang,C., Shi,Y. and Ye,L.
  TITLE     GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress and mTOR
            Pathway
  JOURNAL   J Cell Mol Med 25 (22), 10454-10465 (2021)
   PUBMED   34626080
  REMARK    GeneRIF: GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress
            and mTOR Pathway.
REFERENCE   3  (bases 1 to 1214)
  AUTHORS   Kim,H.J., Lee,Y., Fang,S., Kim,W., Kim,H.J. and Kim,J.W.
  TITLE     GPx7 ameliorates non-alcoholic steatohepatitis by regulating
            oxidative stress
  JOURNAL   BMB Rep 53 (6), 317-322 (2020)
   PUBMED   32317079
  REMARK    GeneRIF: GPx7 ameliorates non-alcoholic steatohepatitis by
            regulating oxidative stress.
REFERENCE   4  (bases 1 to 1214)
  AUTHORS   Hsieh,Y.L., Su,F.Y., Tsai,L.K., Huang,C.C., Ko,Y.L., Su,L.W.,
            Chen,K.Y., Shih,H.M., Hu,C.M. and Lee,W.H.
  TITLE     NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor
            Neurons from Degeneration in Aging by Directly Modulating
            O-GlcNAcase
  JOURNAL   Cell Rep 29 (8), 2134-2143 (2019)
   PUBMED   31747588
REFERENCE   5  (bases 1 to 1214)
  AUTHORS   Wu,Y., Wei,F.Y., Kawarada,L., Suzuki,T., Araki,K., Komohara,Y.,
            Fujimura,A., Kaitsuka,T., Takeya,M., Oike,Y., Suzuki,T. and
            Tomizawa,K.
  TITLE     Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is
            Required for Mitochondrial Translation and Is Involved in
            Reversible Infantile Liver Injury
  JOURNAL   PLoS Genet 12 (9), e1006355 (2016)
   PUBMED   27689697
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1214)
  AUTHORS   Chang,Y.C., Yu,Y.H., Shew,J.Y., Lee,W.J., Hwang,J.J., Chen,Y.H.,
            Chen,Y.R., Wei,P.C., Chuang,L.M. and Lee,W.H.
  TITLE     Deficiency of NPGPx, an oxidative stress sensor, leads to obesity
            in mice and human
  JOURNAL   EMBO Mol Med 5 (8), 1165-1179 (2013)
   PUBMED   23828861
  REMARK    GeneRIF: NPGPx protects against fat accumulation in mice and human
            via modulating ROS
REFERENCE   7  (bases 1 to 1214)
  AUTHORS   Bosello-Travain,V., Conrad,M., Cozza,G., Negro,A., Quartesan,S.,
            Rossetto,M., Roveri,A., Toppo,S., Ursini,F., Zaccarin,M. and
            Maiorino,M.
  TITLE     Protein disulfide isomerase and glutathione are alternative
            substrates in the one Cys catalytic cycle of glutathione peroxidase
            7
  JOURNAL   Biochim Biophys Acta 1830 (6), 3846-3857 (2013)
   PUBMED   23454490
  REMARK    GeneRIF: GPx7 is an unusual CysGPx catalyzing the peroxidatic cycle
            by a one Cys mechanism in which GSH and PDI are alternative
            substrates.
REFERENCE   8  (bases 1 to 1214)
  AUTHORS   Wei,P.C., Hsieh,Y.H., Su,M.I., Jiang,X., Hsu,P.H., Lo,W.T.,
            Weng,J.Y., Jeng,Y.M., Wang,J.M., Chen,P.L., Chang,Y.C., Lee,K.F.,
            Tsai,M.D., Shew,J.Y. and Lee,W.H.
  TITLE     Loss of the oxidative stress sensor NPGPx compromises GRP78
            chaperone activity and induces systemic disease
  JOURNAL   Mol Cell 48 (5), 747-759 (2012)
   PUBMED   23123197
  REMARK    GeneRIF: NPGPx is essential for releasing excessive ER stress by
            enhancing GRP78 chaperone activity to maintain physiological
            homeostasis.
REFERENCE   9  (bases 1 to 1214)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   10 (bases 1 to 1214)
  AUTHORS   Seiler,A., Schneider,M., Forster,H., Roth,S., Wirth,E.K.,
            Culmsee,C., Plesnila,N., Kremmer,E., Radmark,O., Wurst,W.,
            Bornkamm,G.W., Schweizer,U. and Conrad,M.
  TITLE     Glutathione peroxidase 4 senses and translates oxidative stress
            into 12/15-lipoxygenase dependent- and AIF-mediated cell death
  JOURNAL   Cell Metab 8 (3), 237-248 (2008)
   PUBMED   18762024
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK165221.1.
            
            On Apr 6, 2007 this sequence version replaced NM_024198.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165221.1, AK014199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1214              AK165221.1         2-1215
FEATURES             Location/Qualifiers
     source          1..1214
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.5 cM"
     gene            1..1214
                     /gene="Gpx7"
                     /gene_synonym="3110050F08Rik; GPX6"
                     /note="glutathione peroxidase 7"
                     /db_xref="GeneID:67305"
                     /db_xref="MGI:MGI:1914555"
     exon            1..171
                     /gene="Gpx7"
                     /gene_synonym="3110050F08Rik; GPX6"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..597
                     /gene="Gpx7"
                     /gene_synonym="3110050F08Rik; GPX6"
                     /EC_number="1.11.1.9"
                     /note="GPx-7; GSHPx-7"
                     /codon_start=1
                     /product="glutathione peroxidase 7 precursor"
                     /protein_id="NP_077160.1"
                     /db_xref="CCDS:CCDS18450.1"
                     /db_xref="GeneID:67305"
                     /db_xref="MGI:MGI:1914555"
                     /translation="MVAAVATAWLLLWAAACAQSEQDFYDFKAVNIRGKLVSLEKYRG
                     SVSLVVNVASECGFTDQNYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDTNREIENF
                     ARRTYSVSFPMFSKIAVTGTGAHPAFKYLTQTSGKEPTWNFWKYLVDPDGKVVGAWDP
                     TVPVAEIKPRITEQVMKLILRKREDL"
     exon            172..433
                     /gene="Gpx7"
                     /gene_synonym="3110050F08Rik; GPX6"
                     /inference="alignment:Splign:2.1.0"
     exon            434..1214
                     /gene="Gpx7"
                     /gene_synonym="3110050F08Rik; GPX6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      997..1002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpx7"
                     /gene_synonym="3110050F08Rik; GPX6"
                     /note="hexamer: AATAAA"
     regulatory      1015..1020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpx7"
                     /gene_synonym="3110050F08Rik; GPX6"
                     /note="hexamer: CATAAA"
     polyA_site      1020
                     /gene="Gpx7"
                     /gene_synonym="3110050F08Rik; GPX6"
                     /note="major polyA site"
     polyA_site      1037
                     /gene="Gpx7"
                     /gene_synonym="3110050F08Rik; GPX6"
ORIGIN      
        1 tttgccctcg ccaagtcgcc acctcgggag tgaaccatgg ttgcagctgt ggcgacggcg
       61 tggctgctcc tgtgggccgc ggcctgcgcg caatccgagc aggacttcta cgacttcaag
      121 gcggtcaaca tccggggcaa gctggtgtcg ctggagaagt accgtggctc ggtttccctg
      181 gtggtgaacg tagctagcga atgtggcttc acagaccaga actaccgagc cttgcagcag
      241 ctgcagcggg acctgggccc ccatcatttt aatgtgcttg ccttcccttg caaccagttt
      301 ggccaacagg aaccagacac caacagggag attgagaact ttgcccgccg cacctacagt
      361 gtctcttttc ccatgtttag caagatcgca gtcactggca ctggtgccca ccctgccttc
      421 aagtacctaa cccagacttc tgggaaggag cccacctgga acttctggaa gtacctagtg
      481 gacccagacg gaaaggtggt gggagcatgg gaccccactg tgccagtggc ggagatcaag
      541 ccccgtatta cagagcaggt gatgaaactc atccttcgga aacgagaaga cttgtgaccg
      601 ggtccctctg gaactcccat ccctccgcaa actcaagtgg tgcttcaccg gcagagagct
      661 aaagcttctc ttcccttcac tcctcagagg acaaatccta agacttggat gatttgaatc
      721 caagagcaac ggacagcaac tgcttgctgg ccagtgagag ttcttaacag cacatcacca
      781 gccagcgggc ctctagccaa aggaaacatg gcaaggctat gaagaaaaca tgtagatgga
      841 tatgaggcaa tcctctacct acccatgcca agtcttacct cacagggagg ctgtgaagat
      901 tagcatctaa tacccgtgaa cacgcctggg gcagtgctag tcgaagggga agcactccgc
      961 acggttttct gcgtgtaaac aagcattatt tgtgataata aaacctgagt ttgacataaa
     1021 tgtctagccc gtggaaacct gggccaaatg tgtttgccat tcttgttatt gttttcttac
     1081 ttacagaaga cacatgttct taggcagtgt ggtaggggga aagactcaga gttcgaacac
     1141 ttgcaagact ctatctattc ccagagaggc aaacagaaag gcacatggag agcacactaa
     1201 taaaaacaca aatc
//
