LOCUS       NM_145451               1262 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus glutathione peroxidase 6 (Gpx6), mRNA.
ACCESSION   NM_145451
VERSION     NM_145451.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1262)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1262)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 1262)
  AUTHORS   Wu,Y., Wei,F.Y., Kawarada,L., Suzuki,T., Araki,K., Komohara,Y.,
            Fujimura,A., Kaitsuka,T., Takeya,M., Oike,Y., Suzuki,T. and
            Tomizawa,K.
  TITLE     Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is
            Required for Mitochondrial Translation and Is Involved in
            Reversible Infantile Liver Injury
  JOURNAL   PLoS Genet 12 (9), e1006355 (2016)
   PUBMED   27689697
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1262)
  AUTHORS   Shema,R., Kulicke,R., Cowley,G.S., Stein,R., Root,D.E. and
            Heiman,M.
  TITLE     Synthetic lethal screening in the mammalian central nervous system
            identifies Gpx6 as a modulator of Huntington's disease
  JOURNAL   Proc Natl Acad Sci U S A 112 (1), 268-272 (2015)
   PUBMED   25535386
  REMARK    GeneRIF: overexpression of Gpx6 can dramatically alleviate both
            behavioral and molecular phenotypes associated with a mouse model
            of Huntington's disease.
REFERENCE   5  (bases 1 to 1262)
  AUTHORS   Ciappio,E.D., Krausz,K.W., Rochman,M., Furusawa,T., Bonzo,J.A.,
            Tessarollo,L., Gonzalez,F.J. and Bustin,M.
  TITLE     Metabolomics reveals a role for the chromatin-binding protein HMGN5
            in glutathione metabolism
  JOURNAL   PLoS One 9 (1), e84583 (2014)
   PUBMED   24392144
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1262)
  AUTHORS   Brigelius-Flohe,R. and Maiorino,M.
  TITLE     Glutathione peroxidases
  JOURNAL   Biochim Biophys Acta 1830 (5), 3289-3303 (2013)
   PUBMED   23201771
  REMARK    Review article
REFERENCE   7  (bases 1 to 1262)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB955421.1, CD363995.1,
            AA068203.1, AV001252.1 and AV001457.1.
            
            On May 4, 2007 this sequence version replaced NM_145451.2.
            
            Summary: This gene encodes a member of the glutathione peroxidase
            family. Glutathione peroxidases catalyze the reduction of a variety
            of hydroperoxides using glutathione as a specific electron donor
            substrate, and thereby protect cells against oxidative damage.
            Expression of this gene is restricted to embryos and adult
            olfactory epithelium. The mouse and rat orthologs contain a
            cysteine (Cys) residue at the active site, unlike the human
            counterpart, which is a selenoprotein, containing selenocysteine
            (Sec) instead. [provided by RefSeq, Jul 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW012267.1, CB955103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               CB955421.1         24-483
            461-846             CD363995.1         309-694
            847-917             AA068203.1         69-139
            918-1240            AV001252.1         102-424
            1241-1262           AV001457.1         364-385
FEATURES             Location/Qualifiers
     source          1..1262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 7.74 cM"
     gene            1..1262
                     /gene="Gpx6"
                     /gene_synonym="1700020G18Rik; olfactory; Ry2d1"
                     /note="glutathione peroxidase 6"
                     /db_xref="GeneID:75512"
                     /db_xref="MGI:MGI:1922762"
     exon            1..142
                     /gene="Gpx6"
                     /gene_synonym="1700020G18Rik; olfactory; Ry2d1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..721
                     /gene="Gpx6"
                     /gene_synonym="1700020G18Rik; olfactory; Ry2d1"
                     /EC_number="1.11.1.9"
                     /note="odorant-metabolizing protein RY2D1; GPx-6; GSHPx-6"
                     /codon_start=1
                     /product="glutathione peroxidase 6 precursor"
                     /protein_id="NP_663426.2"
                     /db_xref="CCDS:CCDS26271.1"
                     /db_xref="GeneID:75512"
                     /db_xref="MGI:MGI:1922762"
                     /translation="MAQKLWGSCLFSLFMAALAQETLNPQKSKVDCNKGVTGTVYEYG
                     ANTIDGGEFVNFQQYAGKHILFVNVASFCGLTATYPELNTLQEELKPFNVTVLGFPCN
                     QFGKQEPGKNSEILLGLKYVRPGGGYVPNFQLFEKGDVNGDNEQKVFSFLKNSCPPTS
                     ELFGSPEHLFWDPMKVHDIRWNFEKFLVGPDGVPVMRWFHHTPVRIVQSDIMEYLNQT
                     STQ"
     exon            143..296
                     /gene="Gpx6"
                     /gene_synonym="1700020G18Rik; olfactory; Ry2d1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..414
                     /gene="Gpx6"
                     /gene_synonym="1700020G18Rik; olfactory; Ry2d1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..514
                     /gene="Gpx6"
                     /gene_synonym="1700020G18Rik; olfactory; Ry2d1"
                     /inference="alignment:Splign:2.1.0"
     exon            515..1262
                     /gene="Gpx6"
                     /gene_synonym="1700020G18Rik; olfactory; Ry2d1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1238..1243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpx6"
                     /gene_synonym="1700020G18Rik; olfactory; Ry2d1"
     polyA_site      1258
                     /gene="Gpx6"
                     /gene_synonym="1700020G18Rik; olfactory; Ry2d1"
ORIGIN      
        1 aaaagggatc acagttcctg agggtcaaga ctcaccaggt gttctttgta caaccatggc
       61 ccagaagttg tggggttcct gtcttttctc attgtttatg gctgccttag ctcaggagac
      121 tctgaatcct caaaaatcga aggtggattg caacaaaggg gtgactggca ccgtctatga
      181 gtatggagcc aacaccatag atggtgggga gtttgtcaac ttccagcagt atgcaggaaa
      241 gcacatcctc tttgtcaacg tggcatcctt ctgtggcctg acagctacgt accctgagct
      301 gaacacattg caggaggagc tgaagccatt caacgtcacg gttttgggct ttccatgcaa
      361 ccagtttgga aagcaagaac ctggaaagaa ctcagagatt ctccttggac tcaagtatgt
      421 gcgtccaggc ggtggctatg tccccaattt ccagctcttt gagaaggggg atgtgaacgg
      481 agacaatgaa caaaaggttt tttctttcct aaagaactcc tgccctccca cctctgaact
      541 ttttggctct ccagaacatc tcttctggga tcccatgaag gttcatgata tccgctggaa
      601 ctttgagaag ttcctggtgg gacctgatgg agtccctgtc atgcgctggt tccaccatac
      661 tcctgtcaga attgtccagt cagacatcat ggagtaccta aaccaaacca gtacccagta
      721 agaaaggctt tacaaatttt gtctttgttc cactcggtca ccagcctcca tatgaccaaa
      781 gcccacagca cttcctgtgt ccctactaat gcatgtgcaa tctacagaga tcctaatcta
      841 tcattcaaag cactggccgg ttaaaagaag tggggatggg tggccagatc ctctgggtcc
      901 cagcctcttc tcctccaaag ctgggcatgc tttgtcaagt tctccttctg tttagccctt
      961 tggtaccaca gcaccctgta gttttcttag ggaattttga aggctgagag cagaaacctc
     1021 tcatcacatg aagacagggc atttccacca ggatcccaag gtccctctgg ctcatatcct
     1081 accagccttc ctgagtgact tcctgtttgt gcattcaggt catggcactt ggctacagat
     1141 gtccttcaca ccaaatgatg tggtttgctc tcacccagag ttctcccacc tttaaattca
     1201 ttcctatgat cactgtctct aataatagta ataatctaat aaacaataaa agaactcacc
     1261 gc
//
