LOCUS       NM_010343               1629 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus glutathione peroxidase 5 (Gpx5), mRNA.
ACCESSION   NM_010343
VERSION     NM_010343.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1629)
  AUTHORS   Li,L., Jin,T., Chen,S., Cao,H., Ma,Y., Fang,W., Wang,Y., Liu,Q.,
            Zheng,L., Wijayanti,D. and Dong,W.
  TITLE     Exploring novel function of Gpx5 antioxidant activity: Assisting
            epididymal cells secrete functional extracellular vesicles
  JOURNAL   J Cell Physiol 239 (6), e31273 (2024)
   PUBMED   38666419
  REMARK    GeneRIF: Exploring novel function of Gpx5 antioxidant activity:
            Assisting epididymal cells secrete functional extracellular
            vesicles.
REFERENCE   2  (bases 1 to 1629)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1629)
  AUTHORS   Chu,C., Yu,L., Henry-Berger,J., Ru,Y.F., Kocer,A., Champroux,A.,
            Li,Z.T., He,M., Xie,S.S., Ma,W.B., Ni,M.J., Ni,Z.M., Guo,Y.L.,
            Fei,Z.L., Gou,L.T., Liu,Q., Sharma,S., Zhou,Y., Liu,M.F.,
            Chen,C.D., Eamens,A.L., Nixon,B., Zhou,Y.C., Drevet,J.R. and
            Zhang,Y.L.
  TITLE     Knockout of glutathione peroxidase 5 down-regulates the piRNAs in
            the caput epididymidis of aged mice
  JOURNAL   Asian J Androl 22 (6), 590-601 (2020)
   PUBMED   32270769
  REMARK    GeneRIF: Knockout of glutathione peroxidase 5 down-regulates the
            piRNAs in the caput epididymidis of aged mice.
REFERENCE   4  (bases 1 to 1629)
  AUTHORS   Borowiec,A.S., Sion,B., Chalmel,F., D Rolland,A., Lemonnier,L., De
            Clerck,T., Bokhobza,A., Derouiche,S., Dewailly,E., Slomianny,C.,
            Mauduit,C., Benahmed,M., Roudbaraki,M., Jegou,B., Prevarskaya,N.
            and Bidaux,G.
  TITLE     Cold/menthol TRPM8 receptors initiate the cold-shock response and
            protect germ cells from cold-shock-induced oxidation
  JOURNAL   FASEB J 30 (9), 3155-3170 (2016)
   PUBMED   27317670
REFERENCE   5  (bases 1 to 1629)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1629)
  AUTHORS   Maser,R.L., Magenheimer,B.S. and Calvet,J.P.
  TITLE     Mouse plasma glutathione peroxidase. cDNA sequence analysis and
            renal proximal tubular expression and secretion
  JOURNAL   J Biol Chem 269 (43), 27066-27073 (1994)
   PUBMED   7929449
REFERENCE   7  (bases 1 to 1629)
  AUTHORS   Ghyselinck,N.B., Jimenez,C. and Dufaure,J.P.
  TITLE     Sequence homology of androgen-regulated epididymal proteins with
            glutathione peroxidase in mice
  JOURNAL   J Reprod Fertil 93 (2), 461-466 (1991)
   PUBMED   1787466
REFERENCE   8  (bases 1 to 1629)
  AUTHORS   Ghyselinck,N.B., Rigaudiere,N. and Dufaure,J.P.
  TITLE     [Androgen-dependent protein secreted by mouse caput epididymis
            shows high homologies with different glutathione peroxidases]
  JOURNAL   C R Acad Sci III 313 (1), 1-6 (1991)
   PUBMED   1913244
REFERENCE   9  (bases 1 to 1629)
  AUTHORS   Ghyselinck,N.B. and Dufaure,J.P.
  TITLE     A mouse cDNA sequence for epididymal androgen-regulated proteins
            related to glutathione peroxidase
  JOURNAL   Nucleic Acids Res 18 (23), 7144 (1990)
   PUBMED   2263479
REFERENCE   10 (bases 1 to 1629)
  AUTHORS   Ghyselinck,N.B., Jimenez,C., Lefrancois,A.M. and Dufaure,J.P.
  TITLE     Molecular cloning of a cDNA for androgen-regulated proteins
            secreted by the mouse epididymis
  JOURNAL   J Mol Endocrinol 4 (1), 5-12 (1990)
   PUBMED   2322385
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC105648.1, AK029731.1 and AK033841.1.
            
            On Apr 1, 2008 this sequence version replaced NM_010343.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103589.1, AK029731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               BC105648.1         1-130
            131-899             AK029731.1         132-900
            900-1091            AK033841.1         493-684
            1092-1629           AK033841.1         686-1223
FEATURES             Location/Qualifiers
     source          1..1629
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 7.73 cM"
     gene            1..1629
                     /gene="Gpx5"
                     /gene_synonym="Arep"
                     /note="glutathione peroxidase 5"
                     /db_xref="GeneID:14780"
                     /db_xref="MGI:MGI:104886"
     exon            1..113
                     /gene="Gpx5"
                     /gene_synonym="Arep"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..692
                     /gene="Gpx5"
                     /gene_synonym="Arep"
                     /EC_number="1.11.1.9"
                     /note="epididymal secretory glutathione peroxidase; EGLP;
                     GPx-5; GSHPx-5; arMEP24; major androgen-regulated protein;
                     epididymis-specific glutathione peroxidase-like protein;
                     lysosomal trafficking regulator, long splice form"
                     /codon_start=1
                     /product="epididymal secretory glutathione peroxidase
                     precursor"
                     /protein_id="NP_034473.2"
                     /db_xref="CCDS:CCDS26270.1"
                     /db_xref="GeneID:14780"
                     /db_xref="MGI:MGI:104886"
                     /translation="MVTELRVFYLVPLLLASYVQTTPRPEKMKMDCYKDVKGTIYDYE
                     ALSLNGKEHIPFKQYAGKHVLFVNVATYCGLTIQYPELNALQEDLKPFGLVILGFPCN
                     QFGKQEPGDNLEILPGLKYVRPGKGFLPNFQLFAKGDVNGENEQKIFTFLKRSCPHPS
                     ETVVMSKHTFWEPIKVHDIRWNFEKFLVGPDGIPVMRWFHQAPVSTVKSDIMAYLSHF
                     KTI"
     exon            114..267
                     /gene="Gpx5"
                     /gene_synonym="Arep"
                     /inference="alignment:Splign:2.1.0"
     exon            268..385
                     /gene="Gpx5"
                     /gene_synonym="Arep"
                     /inference="alignment:Splign:2.1.0"
     exon            386..485
                     /gene="Gpx5"
                     /gene_synonym="Arep"
                     /inference="alignment:Splign:2.1.0"
     exon            486..1629
                     /gene="Gpx5"
                     /gene_synonym="Arep"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1606..1611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpx5"
                     /gene_synonym="Arep"
                     /note="putative"
     polyA_site      1629
                     /gene="Gpx5"
                     /gene_synonym="Arep"
                     /note="putative"
ORIGIN      
        1 cagaccagaa atcggcagta ctagtcatgg ttacagagtt aagagtcttc tatcttgttc
       61 cacttcttct agccagctat gtgcagacaa cccccaggcc ggaaaagatg aagatggact
      121 gctacaaaga tgtgaaaggc accatctacg actatgaggc tctgtctctt aatgggaagg
      181 aacacattcc attcaagcag tatgcaggaa agcacgtcct ctttgtcaat gtggctacct
      241 attgcggtct gacaatccag taccctgagc tgaatgcact ccaggaggat ctgaagccat
      301 ttggcttggt tatattgggc tttccctgca accaatttgg aaagcaagaa ccaggagaca
      361 atttagagat tcttcctggg ctcaagtatg ttcgtccagg aaaagggttt ttacctaact
      421 tccagctttt tgcaaaaggg gatgtaaatg gtgaaaacga gcagaaaatc ttcaccttct
      481 tgaagcgttc ttgtcctcac ccctcagaga ctgtggtcat gagcaaacat accttctggg
      541 agccaataaa agtccatgac atccgctgga actttgagaa gttcctggtg ggacccgatg
      601 gcatccctgt catgcgctgg ttccaccagg ctcctgtcag cactgtcaag tctgacatca
      661 tggcgtacct gagccatttc aaaaccatat aggaaggcca agcttctgac ctcttcctcc
      721 ttccccctta aagactgctc tgaaaaaaag actccatctt ctcagcacac tcttcactga
      781 aatggactct acctccccaa gtcaccccta aattgcctaa gttcttcccc tgcacaagta
      841 gatttgtgtc tgggaagctg tagatgtttt tccttgttag atttatgagt tgaagagaga
      901 aaataaaaga aaaaagaaaa agctaaatcc agagacctca gaggtttggc tgagtatgtt
      961 agtactcacc tataatgtca gcactcagca gacattacag acatttcaga caggcagcga
     1021 caggaggaac atgaatggca ggccagccta agctacaaga tatcatgtgt ccaaaaaaaa
     1081 aaaaaaaaaa atccaccacc accaacacaa cccgattgaa ctactctaat tcaccaaagg
     1141 atatggggat agcttggttg gaggctgtat ctgaaggaag agtccccttg gccattctga
     1201 gtctttctct tcccagcctg aaggtggaga aagagcaatg gaggctggtc agacaatcta
     1261 gtttgctcct ctgaaactgt gtgtctcctg agacaaatgc cttgtcagtt cctgaggtct
     1321 tttaattcgg tcttcatctc tgtctccatc ctctctgccc ttctcctgcg gccaatctga
     1381 gggagagtct gagcagattg actcgcacag gaggagggca tctccctgat gccaggatcg
     1441 gggacttgtc cctgattctg cataagtgct cctttctgtg tgatcttcac ggggtcagct
     1501 agtgcttatg agtggggatg cctttcatca tctgaagaat aggacccccc acatacacac
     1561 cccaacctgg gattcttcaa cttcagaact agacatatta tttccaataa aatgttttct
     1621 gaagcattc
//
