LOCUS       NM_182805               1809 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glutamic pyruvic transaminase, soluble (Gpt), mRNA.
ACCESSION   NM_182805
VERSION     NM_182805.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1809)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1809)
  AUTHORS   You,X., Ando,T., Xi,J., Cao,Y., Liu,W., Zhang,X., Honma,M.,
            Masumura,K. and Luan,Y.
  TITLE     Gene mutation and micronucleus assays in gpt delta mice treated
            with 2,2',4,4'-tetrabromodiphenyl ether
  JOURNAL   Mutagenesis 33 (2), 153-160 (2018)
   PUBMED   29462428
  REMARK    GeneRIF: We used the peripheral blood micronucleus assay to
            evaluate the chromosomal damage, and Pig-a gene mutation assay and
            gpt gene mutation assay to examine the mutagenicity of BDE-47.
REFERENCE   3  (bases 1 to 1809)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1809)
  AUTHORS   Reagan,W.J., Yang,R.Z., Park,S., Goldstein,R., Brees,D. and
            Gong,D.W.
  TITLE     Metabolic adaptive ALT isoenzyme response in livers of C57/BL6 mice
            treated with dexamethasone
  JOURNAL   Toxicol Pathol 40 (8), 1117-1127 (2012)
   PUBMED   22609950
  REMARK    GeneRIF: Dexamethasone induces a metabolic adaptive ALT isoenzyme
            response in livers of C57/BL6 mice.
REFERENCE   5  (bases 1 to 1809)
  AUTHORS   Wu,M., Xing,G., Qi,X., Feng,C., Liu,M., Gong,L., Luan,Y. and Ren,J.
  TITLE     Assessment of the mutagenic potential of arecoline in gpt delta
            transgenic mice
  JOURNAL   Mutat Res 748 (1-2), 65-69 (2012)
   PUBMED   22796562
REFERENCE   6  (bases 1 to 1809)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
REFERENCE   7  (bases 1 to 1809)
  AUTHORS   King,T.R., Lee,B.K., Behringer,R.R. and Eicher,E.M.
  TITLE     Mapping anti-mullerian hormone (Amh) and related sequences in the
            mouse: identification of a new region of homology between MMU10 and
            HSA19p
  JOURNAL   Genomics 11 (2), 273-283 (1991)
   PUBMED   1685136
REFERENCE   8  (bases 1 to 1809)
  AUTHORS   Eicher,E.M. and Lee,B.K.
  TITLE     The NXSM recombinant inbred strains of mice: genetic profile for 58
            loci including the Mtv proviral loci
  JOURNAL   Genetics 125 (2), 431-446 (1990)
   PUBMED   2165966
REFERENCE   9  (bases 1 to 1809)
  AUTHORS   Watanabe,T., Ohno,K., Shimizu,A., Sakai,Y., Takahashi,M. and
            Takahashi,N.
  TITLE     Mapping of the Hox-3.1 and Myc-1.2 genes on chromosome 15 of the
            mouse by restriction fragment length variations
  JOURNAL   Biochem Genet 28 (5-6), 257-266 (1990)
   PUBMED   1975491
REFERENCE   10 (bases 1 to 1809)
  AUTHORS   Eicher,E.M. and Womack,J.E.
  TITLE     Chromosomal location of soluble glutamic-pyruvic transaminase-1
            (Gpt-1) in the mouse
  JOURNAL   Biochem Genet 15 (1-2), 1-8 (1977)
   PUBMED   849243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU706045.1, AK009457.1, AC156550.5 and AI196515.1.
            
            On Nov 21, 2015 this sequence version replaced NM_182805.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022625.1, BK005127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BU706045.1         62-68
            8-756               AK009457.1         2-750
            757-757             AC156550.5         75069-75069
            758-874             AK009457.1         752-868
            875-1785            AK009457.1         870-1780
            1786-1809           AI196515.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..1809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.28 cM"
     gene            1..1809
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /note="glutamic pyruvic transaminase, soluble"
                     /db_xref="GeneID:76282"
                     /db_xref="MGI:MGI:95802"
     exon            1..294
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1623
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /EC_number="2.6.1.2"
                     /note="glutamic pyruvic transaminase 1, soluble; GPT 1;
                     glutamic--alanine transaminase 1; glutamic--pyruvic
                     transaminase 1; glutamate pyruvate transaminase 1"
                     /codon_start=1
                     /product="alanine aminotransferase 1"
                     /protein_id="NP_877957.1"
                     /db_xref="CCDS:CCDS27586.1"
                     /db_xref="GeneID:76282"
                     /db_xref="MGI:MGI:95802"
                     /translation="MASQRNDRIQASRNGLKGKVLTLDTMNPCVRRVEYAVRGPIVQR
                     ALELEQELRQGVKKPFTEVIRANIGDAQAMGQRPITFFRQVLALCVYPNLLSSPDFPE
                     DAKRRAERILQACGGHSLGAYSISSGIQPIREDVAQYIERRDGGIPADPNNIFLSTGA
                     SDAIVTMLKLLVAGEGRARTGVLIPIPQYPLYSAALAELDAVQVDYYLDEERAWALDI
                     AELRRALCQARDRCCPRVLCVINPGNPTGQVQTRECIEAVIRFAFEEGLFLMADEVYQ
                     DNVYAEGSQFHSFKKVLTEMGPPYATQQELASFHSVSKGYMGECGFRGGYVEVVNMDA
                     EVQKQMAKLMSVRLCPPVPGQALMGMVVSPPTPSEPSFKQFQAERQEVLAELAAKAKL
                     TEQVFNEAPGIRCNPVQGAMYSFPQIQLPLKAVQRAQDLGLAPDMFFCLCLLEETGIC
                     VVPGSGFGQQEGTYHFRMTILPPMEKLRVLLEKLRHFHAKFTHEYS"
     exon            295..384
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..493
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..627
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..871
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..951
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1088
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1263
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1419
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1532
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1788
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1739..1744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /note="hexamer: AATAAA"
     polyA_site      1788
                     /gene="Gpt"
                     /gene_synonym="1300007J06Rik; 2310022B03Rik; ALT; ALT1;
                     Gpt-1; Gpt1"
                     /note="major polyA site"
ORIGIN      
        1 ccctttcagt agggccagaa ggctgccgtg gagagggtgg tgccttacct cacgcagact
       61 ccccattccc agccctgctc cccaactgga cccttcttct tgagccagca ttcttgcctg
      121 ctttgagcag ccatggcctc acaaaggaat gaccggatcc aggcttcaag gaatggactg
      181 aaggggaagg tgctaactct ggataccatg aacccatgtg tgcggagggt ggagtatgca
      241 gtccgaggcc ccatcgtgca acgtgccttg gagctggagc aggagctgcg ccagggtgtg
      301 aagaagcctt ttactgaggt tatccgtgcc aatattgggg atgcacaagc catggggcag
      361 agacccatca ccttcttccg ccaggtcctg gccctctgtg tctaccccaa tcttctgagc
      421 agtccggact tcccagagga tgccaagaga agggcagaac gcatcttgca ggcatgcggg
      481 ggccacagcc tgggtgccta tagcattagc tctggaatcc agccgattcg ggaggatgtg
      541 gcgcaatata ttgagaggag agacggaggc atccctgcag acccgaacaa catatttctg
      601 tccacagggg ccagcgatgc catcgtgacc atgctcaagc tgctggtagc cggcgagggc
      661 cgtgcgcgaa ccggtgtact cattcccatt cctcagtacc cactgtactc agctgcgctg
      721 gctgagctgg acgccgtgca agtggactac tacctggacg aagagcgcgc ctgggctctt
      781 gacatcgctg agctgcggcg cgctctgtgc caggcacgtg accgctgctg ccctcgagta
      841 ctatgcgtca tcaaccccgg caaccccacg gggcaggtgc agacccgtga atgcatcgag
      901 gccgtaatcc gctttgcttt cgaagaggga ctcttcctga tggctgatga ggtataccaa
      961 gacaatgtat atgctgaggg ctctcagttc cattcattca agaaggtgct cacggagatg
     1021 gggccaccat atgccacgca gcaggagctc gcgtctttcc actcagtctc taagggctac
     1081 atgggcgagt gcgggtttcg tggtggctat gtggaagtgg taaacatgga tgccgaggtg
     1141 cagaaacaga tggcgaaact gatgagcgtg cggttgtgtc caccagtgcc gggccaggct
     1201 ttgatgggca tggtggtcag tccgccaacc ccctcggagc cgtccttcaa gcagtttcaa
     1261 gcagagaggc aggaggtgct ggctgaactg gcagccaagg ctaaactcac ggagcaggtc
     1321 ttcaacgagg cccccgggat ccgctgcaac ccggtgcagg gcgctatgta ttccttccct
     1381 caaattcagc tgcctttgaa agcagtgcag cgtgcgcagg acctgggcct ggcccctgac
     1441 atgttcttct gtctgtgcct cctggaagag actggcatct gcgttgtgcc tgggagtggc
     1501 tttgggcagc aggagggcac ctatcatttc cggatgacca ttctgccccc catggagaaa
     1561 ctgcgggtgc tgctggagaa actgaggcac ttccatgcta aattcactca tgagtactcc
     1621 tgaagccact gctagggcca cactggatgc tctctgactc aacaaactga gggtccttgg
     1681 gagccctcac tatttctgat tttgcatagg gtctgggtac ttgtccctgc aggtccctaa
     1741 taaagctggg tgtaggcctg atttgaggtg gctgcctggg tgaccccaaa aaaaaaaaaa
     1801 aaaaaaaaa
//
