LOCUS       NM_134116               1359 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus G-protein signalling modulator 3 (AGS3-like, C.
            elegans) (Gpsm3), mRNA.
ACCESSION   NM_134116
VERSION     NM_134116.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1359)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1359)
  AUTHORS   Peters,L.A., Perrigoue,J., Mortha,A., Iuga,A., Song,W.M.,
            Neiman,E.M., Llewellyn,S.R., Di Narzo,A., Kidd,B.A., Telesco,S.E.,
            Zhao,Y., Stojmirovic,A., Sendecki,J., Shameer,K., Miotto,R.,
            Losic,B., Shah,H., Lee,E., Wang,M., Faith,J.J., Kasarskis,A.,
            Brodmerkel,C., Curran,M., Das,A., Friedman,J.R., Fukui,Y.,
            Humphrey,M.B., Iritani,B.M., Sibinga,N., Tarrant,T.K., Argmann,C.,
            Hao,K., Roussos,P., Zhu,J., Zhang,B., Dobrin,R., Mayer,L.F. and
            Schadt,E.E.
  TITLE     A functional genomics predictive network model identifies
            regulators of inflammatory bowel disease
  JOURNAL   Nat Genet 49 (10), 1437-1449 (2017)
   PUBMED   28892060
REFERENCE   3  (bases 1 to 1359)
  AUTHORS   Robichaux,W.G. 3rd, Branham-O'Connor,M., Hwang,I.Y., Vural,A.,
            Kehrl,J.H. and Blumer,J.B.
  TITLE     Regulation of Chemokine Signal Integration by Activator of
            G-Protein Signaling 4 (AGS4)
  JOURNAL   J Pharmacol Exp Ther 360 (3), 424-433 (2017)
   PUBMED   28062526
REFERENCE   4  (bases 1 to 1359)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1359)
  AUTHORS   Giguere,P.M., Gall,B.J., Ezekwe,E.A. Jr., Laroche,G., Buckley,B.K.,
            Kebaier,C., Wilson,J.E., Ting,J.P., Siderovski,D.P. and Duncan,J.A.
  TITLE     G Protein signaling modulator-3 inhibits the inflammasome activity
            of NLRP3
  JOURNAL   J Biol Chem 289 (48), 33245-33257 (2014)
   PUBMED   25271165
  REMARK    GeneRIF: findings suggest that GPSM3 acts as a direct negative
            regulator of NLRP3 function.
REFERENCE   6  (bases 1 to 1359)
  AUTHORS   Giguere,P.M., Billard,M.J., Laroche,G., Buckley,B.K.,
            Timoshchenko,R.G., McGinnis,M.W., Esserman,D., Foreman,O., Liu,P.,
            Siderovski,D.P. and Tarrant,T.K.
  TITLE     G-protein signaling modulator-3, a gene linked to autoimmune
            diseases, regulates monocyte function and its deficiency protects
            from inflammatory arthritis
  JOURNAL   Mol Immunol 54 (2), 193-198 (2013)
   PUBMED   23280397
  REMARK    GeneRIF: GPSM3 is an important regulator of monocyte function
            involving mechanisms of differentiation, survival, and chemotaxis,
            and deficiency in GPSM3 expression is protective in acute
            inflammatory arthritis.
REFERENCE   7  (bases 1 to 1359)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1359)
  AUTHORS   Brunskill,E.W., Georgas,K., Rumballe,B., Little,M.H. and
            Potter,S.S.
  TITLE     Defining the molecular character of the developing and adult kidney
            podocyte
  JOURNAL   PLoS One 6 (9), e24640 (2011)
   PUBMED   21931791
REFERENCE   9  (bases 1 to 1359)
  AUTHORS   Zhao,P., Nguyen,C.H. and Chidiac,P.
  TITLE     The proline-rich N-terminal domain of G18 exhibits a novel G
            protein regulatory function
  JOURNAL   J Biol Chem 285 (12), 9008-9017 (2010)
   PUBMED   20097748
  REMARK    GeneRIF: the N-terminal region of G18 is a novel G
            protein-interacting domain that may have distinct regulatory
            effects within the G(i/o) subfamily
REFERENCE   10 (bases 1 to 1359)
  AUTHORS   Cao,X., Cismowski,M.J., Sato,M., Blumer,J.B. and Lanier,S.M.
  TITLE     Identification and characterization of AGS4: a protein containing
            three G-protein regulatory motifs that regulate the activation
            state of Gialpha
  JOURNAL   J Biol Chem 279 (26), 27567-27574 (2004)
   PUBMED   15096500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK155617.1 and BQ031296.1.
            
            On Dec 11, 2009 this sequence version replaced NM_134116.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021942.1, BC085186.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-749               AK155617.1         2-750
            750-1359            BQ031296.1         1-610               c
FEATURES             Location/Qualifiers
     source          1..1359
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.17 cM"
     gene            1..1359
                     /gene="Gpsm3"
                     /gene_synonym="AGS4"
                     /note="G-protein signalling modulator 3 (AGS3-like, C.
                     elegans)"
                     /db_xref="GeneID:106512"
                     /db_xref="MGI:MGI:2146785"
     exon            1..455
                     /gene="Gpsm3"
                     /gene_synonym="AGS4"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..896
                     /gene="Gpsm3"
                     /gene_synonym="AGS4"
                     /codon_start=1
                     /product="G-protein-signaling modulator 3"
                     /protein_id="NP_598877.1"
                     /db_xref="CCDS:CCDS37589.1"
                     /db_xref="GeneID:106512"
                     /db_xref="MGI:MGI:2146785"
                     /translation="MEAERPQEEDGEQSLPQDDQGWPPVNATARPWRSAPPSPPPPGT
                     RHTALGPRSGSLLSLQTELLLDLVAEAQSRRLEEQRATFHTPEAPPNLAPAPPRLLED
                     KEQLYSTILSHQCQRIEAQRSDPPLPPGGQELLELLLRVQGGGRMEEQRSRPPTHTC"
     exon            456..558
                     /gene="Gpsm3"
                     /gene_synonym="AGS4"
                     /inference="alignment:Splign:2.1.0"
     exon            559..758
                     /gene="Gpsm3"
                     /gene_synonym="AGS4"
                     /inference="alignment:Splign:2.1.0"
     exon            759..1343
                     /gene="Gpsm3"
                     /gene_synonym="AGS4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1321..1326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpsm3"
                     /gene_synonym="AGS4"
                     /note="hexamer: AATAAA"
     polyA_site      1343
                     /gene="Gpsm3"
                     /gene_synonym="AGS4"
                     /note="major polyA site"
ORIGIN      
        1 agctagttcc ggtgttgaca gagaagagct ggaggggagg tggggatggt ggagcagtgt
       61 ggccggctag ggggttactg aggctctgga gatgagccgg caggaatccg ccctgtcagg
      121 agcttgctcc actcctgcag ctggagtctc tcccagtctc tgtcctcccc tggggcaaga
      181 gaggtcaaac aagctgtttg ggtgggaaaa agaggatgga ggaagttgac agagttgggc
      241 ggggcccatg ggggggctga ccaggaaccc ggcttcctgc tcagtaccct ggcatccagc
      301 ccccagctca cccccacccc gtccagcccc cattcccctc aggaacccaa ggttccgggt
      361 cctcctccca aattccagct actcttcccc atcagtgtct ctccccaagt ccagggatgg
      421 aggctgaaag accccaggaa gaagatggtg aacagagtct cccgcaggat gatcagggat
      481 ggccccctgt gaatgccacc gctcggcctt ggagatctgc tcctccctcc cctcctcctc
      541 ctggaacccg acacacagcc ctagggcccc gttctggctc cctgctctcc ctgcagactg
      601 agctccttct ggacctagtg gccgaagccc agtcccgccg cctagaggaa cagagggcca
      661 ccttccacac ccccgaggcc ccaccaaacc tagccccagc cccaccccgg cttcttgaag
      721 acaaagaaca gctctacagc accatcctta gtcaccagtg ccagcggatt gaagcccaac
      781 ggtctgaccc gccccttccc cccggggggc aggagcttct ggagttgctg ctgagagttc
      841 agggtggagg tcgaatggag gagcagagat cccggcctcc tacacacacc tgctgagacc
      901 ggagctcctc accagtccct tctctctggg actcaaagct gggacactcc ccgaaggtct
      961 tcaaccctgt ttggcagggg taaccagaga tggaagaccc ggctaaaatt gctgtattta
     1021 ccacccactt tccctgggga ctggacttgg gacaagtact ctaaccatga agataagcaa
     1081 ggtagggtgg acacaactcc cgaggacagt taaagagtct ctatcctgag ctgtcaagct
     1141 actaaacagg gtgtgagggc tgcggcctgc ccctgcctag tgagaaaaaa agggaagagt
     1201 aagacaattg tccagcacta gcagtctcag gccccaaggc agaggggccc agaggcggtg
     1261 aagcgactct taccccgccc ccaccctgct gctgagtctg tctgatgttt tggttgtatg
     1321 aataaacata attcccctct ggaaaaaaaa aaaaaaaaa
//
