LOCUS       NM_029522               3510 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus G-protein signalling modulator 2 (AGS3-like, C.
            elegans) (Gpsm2), mRNA.
ACCESSION   NM_029522
VERSION     NM_029522.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3510)
  AUTHORS   Housset,M., Filion,D., Cortes,N., Vali,H., Mandato,C.A.,
            Casanova,C. and Cayouette,M.
  TITLE     Identification of a non-canonical planar cell polarity pathway
            triggered by light in the developing mouse retina
  JOURNAL   Dev Cell 60 (3), 447-458 (2025)
   PUBMED   39561777
REFERENCE   2  (bases 1 to 3510)
  AUTHORS   Hartig,E.I., Day,M., Jarysta,A. and Tarchini,B.
  TITLE     Proteins required for stereocilia elongation during mammalian hair
            cell development ensure precise and steady heights during adult
            life
  JOURNAL   Proc Natl Acad Sci U S A 121 (40), e2405455121 (2024)
   PUBMED   39320919
REFERENCE   3  (bases 1 to 3510)
  AUTHORS   Jarysta,A., Tadenev,A.L.D., Day,M., Krawchuk,B., Low,B.E.,
            Wiles,M.V. and Tarchini,B.
  TITLE     Inhibitory G proteins play multiple roles to polarize sensory hair
            cell morphogenesis
  JOURNAL   Elife 12, 88186 (2024)
   PUBMED   38651641
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3510)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3510)
  AUTHORS   Viala,S., Hadjadj,C., Nathan,V., Guiot,M.C., McCaffrey,L.,
            Cockburn,K. and Bouchard,M.
  TITLE     LGN loss randomizes spindle orientation and accelerates
            tumorigenesis in PTEN-deficient epidermis
  JOURNAL   Mol Biol Cell 35 (2), br5 (2024)
   PUBMED   37991903
REFERENCE   6  (bases 1 to 3510)
  AUTHORS   Konno,D., Shioi,G., Shitamukai,A., Mori,A., Kiyonari,H., Miyata,T.
            and Matsuzaki,F.
  TITLE     Neuroepithelial progenitors undergo LGN-dependent planar divisions
            to maintain self-renewability during mammalian neurogenesis
  JOURNAL   Nat Cell Biol 10 (1), 93-101 (2008)
   PUBMED   18084280
  REMARK    GeneRIF: Knocking out LGN, (the G protein regulator), randomized
            the orientation of normally planar neuroepithelial divisions.
REFERENCE   7  (bases 1 to 3510)
  AUTHORS   Raji,B., Dansault,A., Vieira,V., de la Houssaye,G., Lacassagne,E.,
            Kobetz,A., Arbogast,L., Dufier,J.L., Blumer,J.B., Menasche,M. and
            Abitbol,M.
  TITLE     Analysis of partner of inscuteable (mPins) expression in the
            developing mouse eye
  JOURNAL   Mol Vis 14, 2575-2596 (2008)
   PUBMED   19122831
  REMARK    GeneRIF: The primary aim of this study was to determine the spatial
            distribution and time course of mouse homolog of Drosophila Partner
            of Inscuteable (mPins) expression in the developing and adult mouse
            eye.
REFERENCE   8  (bases 1 to 3510)
  AUTHORS   Lechler,T. and Fuchs,E.
  TITLE     Asymmetric cell divisions promote stratification and
            differentiation of mammalian skin
  JOURNAL   Nature 437 (7056), 275-280 (2005)
   PUBMED   16094321
REFERENCE   9  (bases 1 to 3510)
  AUTHORS   Yu,F., Morin,X., Kaushik,R., Bahri,S., Yang,X. and Chia,W.
  TITLE     A mouse homologue of Drosophila pins can asymmetrically localize
            and substitute for pins function in Drosophila neuroblasts
  JOURNAL   J Cell Sci 116 (Pt 5), 887-896 (2003)
   PUBMED   12571286
REFERENCE   10 (bases 1 to 3510)
  AUTHORS   Luo,Y. and Denker,B.M.
  TITLE     Interaction of heterotrimeric G protein Galphao with Purkinje cell
            protein-2. Evidence for a novel nucleotide exchange factor
  JOURNAL   J Biol Chem 274 (16), 10685-10688 (1999)
   PUBMED   10196137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143552.1 and AY081187.1.
            
            On Jan 9, 2008 this sequence version replaced NM_029522.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY081187.1, AK143552.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AK143552.1         2-157
            157-3510            AY081187.1         1-3354
FEATURES             Location/Qualifiers
     source          1..3510
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 47.53 cM"
     gene            1..3510
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /note="G-protein signalling modulator 2 (AGS3-like, C.
                     elegans)"
                     /db_xref="GeneID:76123"
                     /db_xref="MGI:MGI:1923373"
     exon            1..259
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     exon            260..563
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     CDS             508..2547
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /note="pins homolog (Drosophia)"
                     /codon_start=1
                     /product="G-protein-signaling modulator 2"
                     /protein_id="NP_083798.2"
                     /db_xref="CCDS:CCDS51048.1"
                     /db_xref="GeneID:76123"
                     /db_xref="MGI:MGI:1923373"
                     /translation="MEGNLISMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGV
                     SFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEA
                     KASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFG
                     CPGPQDTGEFPEDVRNALQAAVDLYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNF
                     RDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLK
                     DRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELKDRIGEGRACWSLGNAYTA
                     LGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYSTNNSMMSENIEI
                     DGSLHGAGAKLGRRHSMENLELMKLTPEKVPNWNSEILAKQKPLIAKPSAKLLFVNRL
                     KGKKYKSGSACTKVLQDASNSVDHRAPRSQKKISSDTIGDEGFFDLLRRFQSNRMDDQ
                     RCHLQGNCRTTSTAAASATPKLMKAPSVSVVSPNTDEFLDLLASSQSRRLDDQRASFS
                     NLPGLRLTKGNSPSVLERLMTNDKKEPDEDFFDILVKCQGSRLDDQRCAPPSAATKGP
                     TVPDEDFFSLILRSQAKRMDEQRVLLQRDPNRDSEFGLKELLQNNALLEFKHSGK"
     exon            564..785
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     exon            786..921
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1064
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1188
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1304
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1460
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1569
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1699
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1770
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1950
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2104
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2322
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..3488
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3016..3021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /note="hexamer: AATAAA"
     polyA_site      3036
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /note="major polyA site"
     regulatory      3465..3470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
                     /note="hexamer: AATAAA"
     polyA_site      3488
                     /gene="Gpsm2"
                     /gene_synonym="6230410J09Rik; LGN; Pins"
ORIGIN      
        1 gcagaggagt acaggcgctg agggagcctt gctggcggtg agaccctctg agaggccagg
       61 gggaggccga agctctggcc cacgtgacct gccgggggcg ggcgcccggg gcgctcgcca
      121 gcctcccgcg gtgcccctgc ttggctcggc gtcgccgccg ggacccgact tggggaagcg
      181 ccgcggttcc tagtctacgg ccagaggcgc tcatccctgc agcggttcct tgttctcagg
      241 agccgcgggc cggagggaga aatgttgctg aagtgctgct gaaggggcca gcgatgccag
      301 gatttgggac acatttgaac ctttaagctg tctgacattg acctcctttc attattaata
      361 aagaagaagc aggggcttag gatgtattaa caccagcgca ttactatact aaccggacag
      421 tgctctgcaa agccctctgc actctaaagg actggactgg cccaggacac aataatttcc
      481 cattttctca gcttataata tgactggatg gagggaaatt tgataagcat gagggaagac
      541 cattcctttc atgtccgcta cagaatggaa gcttcttgcc ttgagctggc cttggaagga
      601 gaacgtctat gtaaatcagg ggactgccgc gctggcgtgt cattttttga agccgcagtt
      661 caagttggaa ctgaagacct caaaacactc agtgctattt acagccaact gggcaatgct
      721 tacttctact tgcatgacta cgccaaagcg ttagaatacc accaccatga cttaactctt
      781 gcacggacta ttggagacca acttggggaa gctaaagcca gcggcaatct cggaaacacc
      841 ttaaaggtgc ttgggaattt tgatgaagcg atagtgtgtt gccagcgaca cctggatatc
      901 tccagagagc ttaatgacaa ggtgggagaa gcaagagcgc tctacaatct tggaaatgtc
      961 tatcacgcca aagggaaaag ctttggttgc ccgggtccgc aggatacagg agagtttcca
     1021 gaagacgtga gaaatgccct acaggcagct gtggatctct atgaggaaaa cctgtcctta
     1081 gtaactgctc taggtgaccg agcagcacag gggcgagcct ttgggaacct tggcaacaca
     1141 cactacctcc tcggcaactt cagggatgca gttatagctc acgagcagcg tctcctaatt
     1201 gcaaaggagt tcggagataa ggcggctgag agaagagcgt acagcaacct aggaaatgca
     1261 tacatattcc tgggtgaatt cgaaactgct tccgaatact acaagaagac actgctgctg
     1321 gctcggcagc ttaaagacag agccgtggaa gctcagtctt gctacagtct tgggaataca
     1381 tacactttgc ttcaggacta cgagaaggcc atcgattacc acctaaagca cttagcaatc
     1441 gcccaagagc tcaaggatcg gattggtgaa ggaagagcgt gttggagctt aggaaacgca
     1501 tacacagctc tgggaaatca tgaccaagca atgcattttg ctgaaaagca cttggaaatt
     1561 tcaagagagg ttggggacaa aagtggtgaa ctgactgcgc ggctgaacct ctcagacctg
     1621 cagatggttc ttggtctgag ctacagcaca aataattcca tgatgtctga gaacattgaa
     1681 attgatggca gcttacatgg tgcaggcgcc aagctgggac ggagacacag tatggagaac
     1741 ttggaactta tgaagttaac accagaaaag gtgccgaatt ggaacagtga aattctcgct
     1801 aaacagaaac ctctcattgc caaaccatct gcaaagctcc tgtttgtcaa cagactgaag
     1861 ggcaaaaagt acaaaagcgg cagcgcctgc actaaggttc tccaagacgc cagcaactcc
     1921 gtggaccacc gcgcgccacg ctcccagaag aaaatcagtt cagacacgat tggagatgaa
     1981 ggattctttg acttgctaag gcgatttcag agcaacagga tggatgacca gaggtgccac
     2041 ttacaaggaa actgtcgcac aacatccaca gcagctgctt ctgctacccc caagttgatg
     2101 aaagcaccgt ctgtctctgt ggtgtccccc aacacagatg agttcttaga tcttcttgct
     2161 agctcacaga gccgccgtct ggatgaccag agggccagtt tcagtaattt gccagggctc
     2221 cgcctgacaa aaggcaacag tccatctgta cttgagcgcc tgatgacaaa tgacaagaaa
     2281 gagcctgatg aagacttctt cgacatcctt gtaaagtgcc aggggtcaag attagatgat
     2341 caaagatgtg ctcctccatc tgctgccact aaggggccga ctgtcccgga tgaggacttc
     2401 tttagcctca tcttacgctc tcaagctaaa agaatggatg agcagagagt tctgctgcaa
     2461 agagatccaa acagagacag tgagtttgga ctaaaggaac ttttgcaaaa taacgctttg
     2521 ttggaattta agcattcggg aaaataacta gcaaaccaca ggatggtgtg gtaacctact
     2581 gaagaaaagg actggtcccc tcaggacact gcagggagct cgccactgta gcagtcacca
     2641 catttttagg gtgtgaatgt tgagtactga gggactgaca ttcttctgtc tcagggcaga
     2701 acgtcctgta aggtgctccg tcagcttaac tgaccttgag attctgtgtg cgtgactaga
     2761 ttccttggct agggtttgtg taatagggat ttaaatgact cctacattag aactcagtct
     2821 tttcttacag aggccatctt taaggagcta gttgacaggg actttttgta cctgcccatg
     2881 aatatagcag attgcattgt ttattggaaa taatgtaaat gtcctatgta aaaaagatga
     2941 aaatagtcat aaaattctag tttaagaaaa ctatattcaa tatattttta ggcaaagcca
     3001 gtgagggaaa tgagaaataa actgctttta gcatgctctg ggttatctgt ctcctttatt
     3061 acataacaca gttataaagt agcacaaggc ctacttttag gagatgtact gttaggaaaa
     3121 ctacataggc agaaaactca cagaaagtac gcaaggctta gttaatgtta gaccatgagc
     3181 cttcatctaa cgagtttacg agacagtgat cttctggccc gcatttggtg cagacactta
     3241 gaagaaaatt cactaagaaa gcaaagactg cacaccagac caaaataatg taaaaataag
     3301 tgtttatttt gtgtttacaa tggttaagca ttcaacaatt attctgtttt aaaaagtgct
     3361 ttaacaacta cctaccctgt tcttttctta aaagccagtt acaatgtgct ttaacctcag
     3421 atagtcacac taatcacttg agacaagccg cttctctttt ctgcaataaa ctggccttga
     3481 tatcgtcaaa aaaaaaaaaa aaaaaaaaaa
//
