LOCUS       NM_019726               1411 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus G protein pathway suppressor 2 (Gps2), transcript
            variant 1, mRNA.
ACCESSION   NM_019726 XM_126221
VERSION     NM_019726.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1411)
  AUTHORS   English,J., Orofino,J., Cederquist,C.T., Paul,I., Li,H., Auwerx,J.,
            Emili,A., Belkina,A., Cardamone,D. and Perissi,V.
  TITLE     GPS2-mediated regulation of the adipocyte secretome modulates
            adipose tissue remodeling at the onset of diet-induced obesity
  JOURNAL   Mol Metab 69, 101682 (2023)
   PUBMED   36731652
  REMARK    GeneRIF: GPS2-mediated regulation of the adipocyte secretome
            modulates adipose tissue remodeling at the onset of diet-induced
            obesity.
REFERENCE   2  (bases 1 to 1411)
  AUTHORS   Huang,Z., Efthymiadou,A., Liang,N., Fan,R. and Treuter,E.
  TITLE     Antagonistic action of GPS2 and KDM1A at enhancers governs
            alternative macrophage activation by interleukin 4
  JOURNAL   Nucleic Acids Res 51 (3), 1067-1086 (2023)
   PUBMED   36610795
  REMARK    GeneRIF: Antagonistic action of GPS2 and KDM1A at enhancers governs
            alternative macrophage activation by interleukin 4.
REFERENCE   3  (bases 1 to 1411)
  AUTHORS   Huang,Z., Liang,N., Goni,S., Damdimopoulos,A., Wang,C.,
            Ballaire,R., Jager,J., Niskanen,H., Han,H., Jakobsson,T.,
            Bracken,A.P., Aouadi,M., Venteclef,N., Kaikkonen,M.U., Fan,R. and
            Treuter,E.
  TITLE     The corepressors GPS2 and SMRT control enhancer and silencer
            remodeling via eRNA transcription during inflammatory activation of
            macrophages
  JOURNAL   Mol Cell 81 (5), 953-968 (2021)
   PUBMED   33503407
  REMARK    GeneRIF: The corepressors GPS2 and SMRT control enhancer and
            silencer remodeling via eRNA transcription during inflammatory
            activation of macrophages.
REFERENCE   4  (bases 1 to 1411)
  AUTHORS   Drareni,K., Ballaire,R., Alzaid,F., Goncalves,A., Chollet,C.,
            Barilla,S., Nguewa,J.L., Dias,K., Lemoine,S., Riveline,J.P.,
            Roussel,R., Dalmas,E., Velho,G., Treuter,E., Gautier,J.F. and
            Venteclef,N.
  TITLE     Adipocyte Reprogramming by the Transcriptional Coregulator GPS2
            Impacts Beta Cell Insulin Secretion
  JOURNAL   Cell Rep 32 (11), 108141 (2020)
   PUBMED   32937117
  REMARK    GeneRIF: Adipocyte Reprogramming by the Transcriptional Coregulator
            GPS2 Impacts Beta Cell Insulin Secretion.
REFERENCE   5  (bases 1 to 1411)
  AUTHORS   Ma,W.B., Wang,X.H., Li,C.Y., Tian,H.H., Zhang,J., Bi,J.J.,
            Ren,G.M., Tao,S.S., Liu,X., Zhang,W., Li,D.X., Chen,H., Zhan,Y.Q.,
            Yu,M., Ge,C.H., Yang,X.M. and Yin,R.H.
  TITLE     GPS2 promotes erythroid differentiation by control of the stability
            of EKLF protein
  JOURNAL   Blood 135 (25), 2302-2315 (2020)
   PUBMED   32384137
  REMARK    GeneRIF: GPS2 promotes erythroid differentiation by control of the
            stability of EKLF protein.
REFERENCE   6  (bases 1 to 1411)
  AUTHORS   Cardamone,M.D., Krones,A., Tanasa,B., Taylor,H., Ricci,L.,
            Ohgi,K.A., Glass,C.K., Rosenfeld,M.G. and Perissi,V.
  TITLE     A protective strategy against hyperinflammatory responses requiring
            the nontranscriptional actions of GPS2
  JOURNAL   Mol Cell 46 (1), 91-104 (2012)
   PUBMED   22424771
  REMARK    GeneRIF: GPS2 as a molecular guardian required for precise control
            of inflammatory responses involved in immunity and homeostasis.
REFERENCE   7  (bases 1 to 1411)
  AUTHORS   Venteclef,N., Jakobsson,T., Ehrlund,A., Damdimopoulos,A.,
            Mikkonen,L., Ellis,E., Nilsson,L.M., Parini,P., Janne,O.A.,
            Gustafsson,J.A., Steffensen,K.R. and Treuter,E.
  TITLE     GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory
            actions of LRH-1 and LXRbeta in the hepatic acute phase response
  JOURNAL   Genes Dev 24 (4), 381-395 (2010)
   PUBMED   20159957
  REMARK    GeneRIF: metabolically important coregulator GPS2 functions as a
            hitherto unrecognized transrepression mediator of interactions
            between SUMOylated nuclear receptors and the N-CoR corepressor
            complex
REFERENCE   8  (bases 1 to 1411)
  AUTHORS   Zhang,D., Harry,G.J., Blackshear,P.J. and Zeldin,D.C.
  TITLE     G-protein pathway suppressor 2 (GPS2) interacts with the regulatory
            factor X4 variant 3 (RFX4_v3) and functions as a transcriptional
            co-activator
  JOURNAL   J Biol Chem 283 (13), 8580-8590 (2008)
   PUBMED   18218630
REFERENCE   9  (bases 1 to 1411)
  AUTHORS   Ishizuka,T. and Lazar,M.A.
  TITLE     The nuclear receptor corepressor deacetylase activating domain is
            essential for repression by thyroid hormone receptor
  JOURNAL   Mol Endocrinol 19 (6), 1443-1451 (2005)
   PUBMED   15695367
REFERENCE   10 (bases 1 to 1411)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596185.12, CJ092297.1, BC138880.1 and AW046264.1.
            
            On May 1, 2018 this sequence version replaced NM_019726.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011317.1, SRR7652917.936951.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AL596185.12        25665-25697
            34-215              CJ092297.1         1-182
            216-1326            BC138880.1         1-1111
            1327-1411           AW046264.1         1-85                c
FEATURES             Location/Qualifiers
     source          1..1411
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.92 cM"
     gene            1..1411
                     /gene="Gps2"
                     /gene_synonym="GPS-2"
                     /note="G protein pathway suppressor 2"
                     /db_xref="GeneID:56310"
                     /db_xref="MGI:MGI:1891751"
     exon            1..414
                     /gene="Gps2"
                     /gene_synonym="GPS-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1304
                     /gene="Gps2"
                     /gene_synonym="GPS-2"
                     /codon_start=1
                     /product="G protein pathway suppressor 2"
                     /protein_id="NP_062700.2"
                     /db_xref="CCDS:CCDS24922.1"
                     /db_xref="GeneID:56310"
                     /db_xref="MGI:MGI:1891751"
                     /translation="MPALLERPKLSNAMARALHRHIMMERERKRQEEEEVDKMMEQKM
                     KEEQERRKKKEMEERMSLEETKEQILKLQEKLSALQEEKHQLFLQLKKVLHEEEKRRR
                     KEQSDLTTLTSAAYQQSLTVHTGTHLLSMQGSPGGHNRPGTLMAADRAKQMFGPQVLT
                     TRHYVGSAAAFAGTPEHGQFQGSPGGAYGTAQPPPHYGPTQPAYSPSQQLRAPSAFPA
                     VQYLSQPQPQPYAVHGHFQPTQTGFLQPGSTLSLQKQMEHANQQTSFSDSSSLRPMHP
                     QALHPAPGLLASPQLPVQIQAAGKSGFATTSQPGPRLPFIQHSQNPRFYHK"
     exon            415..524
                     /gene="Gps2"
                     /gene_synonym="GPS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            525..637
                     /gene="Gps2"
                     /gene_synonym="GPS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            638..717
                     /gene="Gps2"
                     /gene_synonym="GPS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..800
                     /gene="Gps2"
                     /gene_synonym="GPS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            801..954
                     /gene="Gps2"
                     /gene_synonym="GPS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1044
                     /gene="Gps2"
                     /gene_synonym="GPS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1124
                     /gene="Gps2"
                     /gene_synonym="GPS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1220
                     /gene="Gps2"
                     /gene_synonym="GPS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1395
                     /gene="Gps2"
                     /gene_synonym="GPS-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1366..1371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gps2"
                     /gene_synonym="GPS-2"
                     /note="hexamer: AATAAA"
     polyA_site      1392
                     /gene="Gps2"
                     /gene_synonym="GPS-2"
                     /note="major polyA site"
ORIGIN      
        1 atgacgtaga ggccaaggcg cgccgaaggc ctcggagaaa gcgccgacaa ggcgggttgc
       61 gggggttggc gccagggcta cgagggaggg gcgggggcgc ggagcctaag accctcgcac
      121 gcgccccggc gctgaggcag agaccccgga gggacgctgg tgcccgggac acgtgatcga
      181 agtggcgagc gggcggcgga cgggcttccg cttcggcgcg tcgcagtctc tctaagctcc
      241 cacttccctg caggccccgc ctgaggtctg gcagtcagtg agagtcgggt gcccactgcc
      301 caagcgtcac caacagcatc atgcccgcac tcctggagcg ccccaagctt tccaacgcta
      361 tggccagggc tctgcaccgg cacatcatga tggagcggga gcgcaaacgg caggaggagg
      421 aagaggtgga caagatgatg gaacagaaga tgaaagaaga gcaggagaga agaaagaaaa
      481 aggaaatgga agagagaatg tcactagagg agaccaagga acagatcctg aagctgcagg
      541 agaagctttc tgctctacag gaggagaagc accagctttt cttgcagctc aagaaagttt
      601 tgcatgagga agaaaaacgg aggcgaaagg aacagagtga cttaaccact ctgacatcag
      661 ctgcatacca gcagagcctg acggttcata caggaaccca cctcctcagc atgcagggga
      721 gccctggagg acacaatcgc ccaggtactc tgatggcagc tgacagagcc aagcagatgt
      781 ttggaccaca agtgcttacg acccggcact acgtgggatc agcagctgct tttgcaggaa
      841 ccccagaaca tggacaattc caaggcagtc cagggggtgc ttatgggact gctcagcccc
      901 cacctcatta tgggccaaca caaccagcct atagtcctag ccagcagctc agagccccat
      961 cagcatttcc tgcagtgcag tacctatctc agccacagcc acaaccctat gcagtgcatg
     1021 gccactttca gcccactcag acagggttcc tccagcccgg cagtaccctc tctttgcaga
     1081 aacagatgga gcatgccaac cagcagacca gcttctcgga ctcatcttct ctgcggccca
     1141 tgcaccccca agctctgcat ccagcccctg gactcctggc ttccccccag cttcccgtac
     1201 agatacaagc agcagggaag tcaggctttg ccaccaccag ccaacctggc ccccgactcc
     1261 ctttcatcca acacagccag aacccaagat tctatcacaa gtaaccacca gagagctcca
     1321 gcccaccctc catccctcag gctggggtct tatgtgcccc aaaccaataa aatgtacaaa
     1381 atgtacccac catcaaaaaa aaaaaaaaaa a
//
