LOCUS       NM_145370               1985 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus G protein pathway suppressor 1 (Gps1), transcript
            variant 1, mRNA.
ACCESSION   NM_145370 XM_489586
VERSION     NM_145370.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1985)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1985)
  AUTHORS   Horvath,A., Rona,G., Pagano,M. and Jordan,P.W.
  TITLE     Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to
            the COP9 signalosome
  JOURNAL   BMC Mol Cell Biol 21 (1), 36 (2020)
   PUBMED   32384871
  REMARK    GeneRIF: Interaction between NSMCE4A and GPS1 links the SMC5/6
            complex to the COP9 signalosome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1985)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1985)
  AUTHORS   Li,J.Y., Chai,B.X., Zhang,W., Liu,Y.Q., Ammori,J.B. and
            Mulholland,M.W.
  TITLE     Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts
            with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity
  JOURNAL   Cell Signal 19 (6), 1185-1192 (2007)
   PUBMED   17276034
  REMARK    GeneRIF: The present study demonstrates that Asb-4 interacts with
            GPS1 and inhibits JNK activity.
REFERENCE   5  (bases 1 to 1985)
  AUTHORS   Tomoda,K., Yoneda-Kato,N., Fukumoto,A., Yamanaka,S. and Kato,J.Y.
  TITLE     Multiple functions of Jab1 are required for early embryonic
            development and growth potential in mice
  JOURNAL   J Biol Chem 279 (41), 43013-43018 (2004)
   PUBMED   15299027
REFERENCE   6  (bases 1 to 1985)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 1985)
  AUTHORS   Carrabino,S., Carminati,E., Talarico,D., Pardi,R. and Bianchi,E.
  TITLE     Expression pattern of the JAB1/CSN5 gene during murine
            embryogenesis: colocalization with NEDD8
  JOURNAL   Gene Expr Patterns 4 (4), 423-431 (2004)
   PUBMED   15183309
REFERENCE   8  (bases 1 to 1985)
  AUTHORS   Lykke-Andersen,K., Schaefer,L., Menon,S., Deng,X.W., Miller,J.B.
            and Wei,N.
  TITLE     Disruption of the COP9 signalosome Csn2 subunit in mice causes
            deficient cell proliferation, accumulation of p53 and cyclin E, and
            early embryonic death
  JOURNAL   Mol Cell Biol 23 (19), 6790-6797 (2003)
   PUBMED   12972599
REFERENCE   9  (bases 1 to 1985)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663090.15.
            
            On Apr 21, 2022 this sequence version replaced NM_145370.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003350.1, SRR7652917.978001.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AL663090.15        30259-30454
            197-289             AL663090.15        30850-30942
            290-471             AL663090.15        31429-31610
            472-636             AL663090.15        32031-32195
            637-772             AL663090.15        32281-32416
            773-850             AL663090.15        32501-32578
            851-911             AL663090.15        32738-32798
            912-997             AL663090.15        33109-33194
            998-1092            AL663090.15        33426-33520
            1093-1198           AL663090.15        33605-33710
            1199-1279           AL663090.15        33791-33871
            1280-1417           AL663090.15        33973-34110
            1418-1552           AL663090.15        34191-34325
            1553-1985           AL663090.15        34399-34831
FEATURES             Location/Qualifiers
     source          1..1985
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.54 cM"
     gene            1..1985
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /note="G protein pathway suppressor 1"
                     /db_xref="GeneID:209318"
                     /db_xref="MGI:MGI:2384801"
     exon            1..196
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1627
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /note="isoform 1 is encoded by transcript variant 1; COP9
                     signalosome complex subunit 1; JAB1-containing signalosome
                     subunit 1"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 1 isoform 1"
                     /protein_id="NP_663345.2"
                     /db_xref="CCDS:CCDS25758.2"
                     /db_xref="GeneID:209318"
                     /db_xref="MGI:MGI:2384801"
                     /translation="MRGSPAPSSASSSASDLSRSPAHSRSDLRPGTAGDYSLSASLSA
                     CTLLSEGAVEPMQIDVDPQEDPQNAPDVNYVVENPTLDLEQYAASYSGLMRIERLQFI
                     ADRCPPLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAIPESGVEPPP
                     LDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALK
                     CYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQ
                     TQAILTKLKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALA
                     TFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMY
                     LAPHVRTLYTQIRNRALIQYFSPYVSADMHKMAAAFNTTVAALEDELTQLILEGLINA
                     RIDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMILRAAVLRNQIHVKSPPREG
                     SQGELTPANSQSRMSTNM"
     exon            197..289
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            290..471
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..636
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..772
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            773..850
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..911
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..997
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1092
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1198
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1279
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1417
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1552
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1985
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1962..1967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /note="hexamer: ATTAAA"
     polyA_site      1985
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /note="major polyA site"
ORIGIN      
        1 gctttccgtg cggtgccggc ctcgcagaga ggcgcgtcag gccaacatgc ggggcagccc
       61 ggcgcccagc tcggcctcgt cgtcggcctc cgacctgagc cgcagccctg cgcacagcag
      121 gtccgacttg cggcccggca cggcgggcga ctacagcctg agcgccagcc tgtcggcctg
      181 cacgttgctt tccgaggggg ccgtggaacc catgcagatt gatgtcgatc cgcaggaaga
      241 tccgcagaac gcacctgatg tcaactatgt ggtggagaat cccaccctgg atctggagca
      301 gtatgcagcc agctacagtg gcctgatgcg aattgagcga ctacagttta ttgctgaccg
      361 ttgccctcca ctgagggtag aggccttgaa aatggctcta tccttcgtgc agaggacctt
      421 caatgtggac atgtatgaag agatacaccg gaagctctcc gaggctacca gggagctgca
      481 gaatgcacct gatgccatcc ctgagagtgg agtggagccc ccgcccctgg acacagcctg
      541 ggtggaggcc actcggaaga aggctctgtt gaaactggag aagctggaca cggacttgaa
      601 gaactataag ggcaattcta tcaaagagag catcaggcgc ggccacgatg acctgggtga
      661 tcactacctg gactgtgggg acctcagcaa tgccctcaaa tgttactcac gagcccgaga
      721 ctactgcacc agtgctaagc atgtcatcaa catgtgcctc aacgtcatca aggtcagtgt
      781 ctacttgcaa aattggtctc atgtgttaag ctatgtcagc aaggccgagt ctactccaga
      841 gattgctgag cagcggggag agcgggacag ccagacgcaa gccatcctca ccaagctcaa
      901 gtgtgctgca ggcttggctg agctggccgc acggaagtat aagcaagcag ccaagtgctt
      961 ccttctggct tcctttgatc actgtgactt cccagagctg ctgtccccca gcaatgtggc
     1021 tgtctatggt ggcctgtgtg ccttagccac ctttgaccgg caggagctgc aacgaaatgt
     1081 catctccagc agttccttca agctgttcct ggagctggag ccacaggtca gagacatcat
     1141 cttcaaattc tatgaatcca agtatgcctc atgcttgaag atgctggacg agatgaagga
     1201 taacctgctc ctggacatgt acctggcccc tcacgtcagg acactgtaca cccagattcg
     1261 taaccgggct cttatccaat acttcagccc ctatgtgtca gctgatatgc acaagatggc
     1321 tgcagccttc aacacaacag ttgcagctct ggaagatgag ctgacacagc tcattctgga
     1381 gggccttatt aatgcccgca tcgactcaca cagcaagata ctgtatgctc gagatgtgga
     1441 tcagcgtagc accacctttg agaagtccct gctgatgggc aaggaattcc aacgacgtgc
     1501 caaagctatg attctgagag cagctgtgct ccgcaaccag atccatgtca agtctcctcc
     1561 tagagaaggg agccaagggg agctgactcc agccaacagc cagtcacgca tgagtaccaa
     1621 catgtgaaag gcattcctgt gaccgtcaga ccatagtctg cacacctact ctgcctgtgg
     1681 aagcagcacc tgggcctcct gcctgctttc ctcaagacga gagagacccc agactgtgtg
     1741 tggttcatta gagcagtctg gccactgggg tgccagttcg ttggccttcc acgctgaggt
     1801 accctctgca gtggtaggca gcctgcccat atggccactt gggcctgact ctaagtttct
     1861 gccccagtga aacagaccat gtgcaattcc caggtaaggg tacctcagac ccttcctgtc
     1921 catgtagttc cgactgcagc agtgtcttaa ctgagtagtc cattaaagta caagttgatc
     1981 attgc
//
