LOCUS       NM_001405272            1853 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus G protein pathway suppressor 1 (Gps1), transcript
            variant 5, mRNA.
ACCESSION   NM_001405272
VERSION     NM_001405272.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1853)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1853)
  AUTHORS   Horvath,A., Rona,G., Pagano,M. and Jordan,P.W.
  TITLE     Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to
            the COP9 signalosome
  JOURNAL   BMC Mol Cell Biol 21 (1), 36 (2020)
   PUBMED   32384871
  REMARK    GeneRIF: Interaction between NSMCE4A and GPS1 links the SMC5/6
            complex to the COP9 signalosome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1853)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1853)
  AUTHORS   Li,J.Y., Chai,B.X., Zhang,W., Liu,Y.Q., Ammori,J.B. and
            Mulholland,M.W.
  TITLE     Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts
            with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity
  JOURNAL   Cell Signal 19 (6), 1185-1192 (2007)
   PUBMED   17276034
  REMARK    GeneRIF: The present study demonstrates that Asb-4 interacts with
            GPS1 and inhibits JNK activity.
REFERENCE   5  (bases 1 to 1853)
  AUTHORS   Tomoda,K., Yoneda-Kato,N., Fukumoto,A., Yamanaka,S. and Kato,J.Y.
  TITLE     Multiple functions of Jab1 are required for early embryonic
            development and growth potential in mice
  JOURNAL   J Biol Chem 279 (41), 43013-43018 (2004)
   PUBMED   15299027
REFERENCE   6  (bases 1 to 1853)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 1853)
  AUTHORS   Carrabino,S., Carminati,E., Talarico,D., Pardi,R. and Bianchi,E.
  TITLE     Expression pattern of the JAB1/CSN5 gene during murine
            embryogenesis: colocalization with NEDD8
  JOURNAL   Gene Expr Patterns 4 (4), 423-431 (2004)
   PUBMED   15183309
REFERENCE   8  (bases 1 to 1853)
  AUTHORS   Lykke-Andersen,K., Schaefer,L., Menon,S., Deng,X.W., Miller,J.B.
            and Wei,N.
  TITLE     Disruption of the COP9 signalosome Csn2 subunit in mice causes
            deficient cell proliferation, accumulation of p53 and cyclin E, and
            early embryonic death
  JOURNAL   Mol Cell Biol 23 (19), 6790-6797 (2003)
   PUBMED   12972599
REFERENCE   9  (bases 1 to 1853)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663090.15.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.475811.1,
                                           SRR17784649.947352.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AL663090.15        29999-30071
            74-166              AL663090.15        30850-30942
            167-348             AL663090.15        31429-31610
            349-513             AL663090.15        32031-32195
            514-649             AL663090.15        32281-32416
            650-727             AL663090.15        32501-32578
            728-779             AL663090.15        32738-32789
            780-865             AL663090.15        33109-33194
            866-960             AL663090.15        33426-33520
            961-1066            AL663090.15        33605-33710
            1067-1147           AL663090.15        33791-33871
            1148-1285           AL663090.15        33973-34110
            1286-1420           AL663090.15        34191-34325
            1421-1853           AL663090.15        34399-34831
FEATURES             Location/Qualifiers
     source          1..1853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.54 cM"
     gene            1..1853
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /note="G protein pathway suppressor 1"
                     /db_xref="GeneID:209318"
                     /db_xref="MGI:MGI:2384801"
     exon            1..73
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1495
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /note="isoform 5 is encoded by transcript variant 5; COP9
                     signalosome complex subunit 1; JAB1-containing signalosome
                     subunit 1"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 1 isoform 5"
                     /protein_id="NP_001392201.1"
                     /db_xref="GeneID:209318"
                     /db_xref="MGI:MGI:2384801"
                     /translation="MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENPTLDL
                     EQYAASYSGLMRIERLQFIADRCPPLRVEALKMALSFVQRTFNVDMYEEIHRKLSEAT
                     RELQNAPDAIPESGVEPPPLDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRG
                     HDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYV
                     SKAESTPEIAEQRGERDSQTQAILTKLKCLAELAARKYKQAAKCFLLASFDHCDFPEL
                     LSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASC
                     LKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHKMAAAFNTTVAA
                     LEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMILRA
                     AVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM"
     exon            74..166
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..348
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..513
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..649
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..727
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..779
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..865
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..960
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1066
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1147
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1285
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1420
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1853
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1830..1835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /note="hexamer: ATTAAA"
     polyA_site      1853
                     /gene="Gps1"
                     /gene_synonym="Cops1; Csn1; Sgn1"
                     /note="major polyA site"
ORIGIN      
        1 gccccggaag cgaacgtcgc cgcggcgccg ggggtggaag atgccgctgc cggttcaggt
       61 gtttaacttg cagggggccg tggaacccat gcagattgat gtcgatccgc aggaagatcc
      121 gcagaacgca cctgatgtca actatgtggt ggagaatccc accctggatc tggagcagta
      181 tgcagccagc tacagtggcc tgatgcgaat tgagcgacta cagtttattg ctgaccgttg
      241 ccctccactg agggtagagg ccttgaaaat ggctctatcc ttcgtgcaga ggaccttcaa
      301 tgtggacatg tatgaagaga tacaccggaa gctctccgag gctaccaggg agctgcagaa
      361 tgcacctgat gccatccctg agagtggagt ggagcccccg cccctggaca cagcctgggt
      421 ggaggccact cggaagaagg ctctgttgaa actggagaag ctggacacgg acttgaagaa
      481 ctataagggc aattctatca aagagagcat caggcgcggc cacgatgacc tgggtgatca
      541 ctacctggac tgtggggacc tcagcaatgc cctcaaatgt tactcacgag cccgagacta
      601 ctgcaccagt gctaagcatg tcatcaacat gtgcctcaac gtcatcaagg tcagtgtcta
      661 cttgcaaaat tggtctcatg tgttaagcta tgtcagcaag gccgagtcta ctccagagat
      721 tgctgagcag cggggagagc gggacagcca gacgcaagcc atcctcacca agctcaagtg
      781 cttggctgag ctggccgcac ggaagtataa gcaagcagcc aagtgcttcc ttctggcttc
      841 ctttgatcac tgtgacttcc cagagctgct gtcccccagc aatgtggctg tctatggtgg
      901 cctgtgtgcc ttagccacct ttgaccggca ggagctgcaa cgaaatgtca tctccagcag
      961 ttccttcaag ctgttcctgg agctggagcc acaggtcaga gacatcatct tcaaattcta
     1021 tgaatccaag tatgcctcat gcttgaagat gctggacgag atgaaggata acctgctcct
     1081 ggacatgtac ctggcccctc acgtcaggac actgtacacc cagattcgta accgggctct
     1141 tatccaatac ttcagcccct atgtgtcagc tgatatgcac aagatggctg cagccttcaa
     1201 cacaacagtt gcagctctgg aagatgagct gacacagctc attctggagg gccttattaa
     1261 tgcccgcatc gactcacaca gcaagatact gtatgctcga gatgtggatc agcgtagcac
     1321 cacctttgag aagtccctgc tgatgggcaa ggaattccaa cgacgtgcca aagctatgat
     1381 tctgagagca gctgtgctcc gcaaccagat ccatgtcaag tctcctccta gagaagggag
     1441 ccaaggggag ctgactccag ccaacagcca gtcacgcatg agtaccaaca tgtgaaaggc
     1501 attcctgtga ccgtcagacc atagtctgca cacctactct gcctgtggaa gcagcacctg
     1561 ggcctcctgc ctgctttcct caagacgaga gagaccccag actgtgtgtg gttcattaga
     1621 gcagtctggc cactggggtg ccagttcgtt ggccttccac gctgaggtac cctctgcagt
     1681 ggtaggcagc ctgcccatat ggccacttgg gcctgactct aagtttctgc cccagtgaaa
     1741 cagaccatgt gcaattccca ggtaagggta cctcagaccc ttcctgtcca tgtagttccg
     1801 actgcagcag tgtcttaact gagtagtcca ttaaagtaca agttgatcat tgc
//
