LOCUS       NM_153071               2856 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus G protein-coupled receptor, family C, group 6, member
            A (Gprc6a), mRNA.
ACCESSION   NM_153071
VERSION     NM_153071.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2856)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2856)
  AUTHORS   Liu,G., Han,S., Jiang,S., Jiang,Y., Chen,C., Sun,N. and Che,H.
  TITLE     Extracellular Ca2+ aggravates IgE-induced allergic reaction in mast
            cells through GPRC6A, a novel family C G-protein-coupled receptor
  JOURNAL   Life Sci 311 (Pt A), 121013 (2022)
   PUBMED   36257460
  REMARK    GeneRIF: Extracellular Ca[2+] aggravates IgE-induced allergic
            reaction in mast cells through GPRC6A, a novel family C
            G-protein-coupled receptor.
REFERENCE   3  (bases 1 to 2856)
  AUTHORS   Hou,Q., Huang,J., Xiong,X., Guo,Y. and Zhang,B.
  TITLE     Role of Nutrient-sensing Receptor GPRC6A in Regulating Colonic
            Group 3 Innate Lymphoid Cells and Inflamed Mucosal Healing
  JOURNAL   J Crohns Colitis 16 (8), 1293-1305 (2022)
   PUBMED   35134872
  REMARK    GeneRIF: Role of Nutrient-sensing Receptor GPRC6A in Regulating
            Colonic Group 3 Innate Lymphoid Cells and Inflamed Mucosal Healing.
REFERENCE   4  (bases 1 to 2856)
  AUTHORS   Yadav,V.K., Berger,J.M., Singh,P., Nagarajan,P. and Karsenty,G.
  TITLE     Embryonic osteocalcin signaling determines lifelong adrenal
            steroidogenesis and homeostasis in the mouse
  JOURNAL   J Clin Invest 132 (4) (2022)
   PUBMED   34905510
REFERENCE   5  (bases 1 to 2856)
  AUTHORS   Mukai,S., Mizokami,A., Otani,T., Sano,T., Matsuda,M., Chishaki,S.,
            Gao,J., Kawakubo-Yasukochi,T., Tang,R., Kanematsu,T., Takeuchi,H.,
            Jimi,E. and Hirata,M.
  TITLE     Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by
            inhibiting lipolysis
  JOURNAL   J Biol Chem 296, 100274 (2021)
   PUBMED   33428938
  REMARK    GeneRIF: Adipocyte-specific GPRC6A ablation promotes diet-induced
            obesity by inhibiting lipolysis.
REFERENCE   6  (bases 1 to 2856)
  AUTHORS   Wellendorph,P., Burhenne,N., Christiansen,B., Walter,B., Schmale,H.
            and Brauner-Osborne,H.
  TITLE     The rat GPRC6A: cloning and characterization
  JOURNAL   Gene 396 (2), 257-267 (2007)
   PUBMED   17478059
REFERENCE   7  (bases 1 to 2856)
  AUTHORS   Alioto,T.S. and Ngai,J.
  TITLE     The repertoire of olfactory C family G protein-coupled receptors in
            zebrafish: candidate chemosensory receptors for amino acids
  JOURNAL   BMC Genomics 7, 309 (2006)
   PUBMED   17156446
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2856)
  AUTHORS   Pi,M., Faber,P., Ekema,G., Jackson,P.D., Ting,A., Wang,N.,
            Fontilla-Poole,M., Mays,R.W., Brunden,K.R., Harrington,J.J. and
            Quarles,L.D.
  TITLE     Identification of a novel extracellular cation-sensing
            G-protein-coupled receptor
  JOURNAL   J Biol Chem 280 (48), 40201-40209 (2005)
   PUBMED   16199532
  REMARK    GeneRIF: GPRC6A is a cation-, calcimimetic-, and
            osteocalcin-sensing receptor
REFERENCE   9  (bases 1 to 2856)
  AUTHORS   Kuang,D., Yao,Y., Lam,J., Tsushima,R.G. and Hampson,D.R.
  TITLE     Cloning and characterization of a family C orphan G-protein coupled
            receptor
  JOURNAL   J Neurochem 93 (2), 383-391 (2005)
   PUBMED   15816861
  REMARK    GeneRIF: Cloning and characterization of mouse GPRC6A family C
            orphan receptor show the highest degree of amino acid identity to
            the fish 5.24 odorant receptor and mammalian calcium-sensing
            receptor (CaSR).
REFERENCE   10 (bases 1 to 2856)
  AUTHORS   Wellendorph,P., Hansen,K.B., Balsgaard,A., Greenwood,J.R.,
            Egebjerg,J. and Brauner-Osborne,H.
  TITLE     Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid
            receptor with preference for basic amino acids
  JOURNAL   Mol Pharmacol 67 (3), 589-597 (2005)
   PUBMED   15576628
  REMARK    GeneRIF: GPRC6A is a promiscuous L-alpha-amino acid receptor most
            potently activated by basic amino acids.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY101365.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY101365.1, AY735399.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2856
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="Swiss Webster/NIH"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 25.66 cM"
     gene            1..2856
                     /gene="Gprc6a"
                     /note="G protein-coupled receptor, family C, group 6,
                     member A"
                     /db_xref="GeneID:210198"
                     /db_xref="MGI:MGI:2429498"
     exon            1..221
                     /gene="Gprc6a"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..2814
                     /gene="Gprc6a"
                     /codon_start=1
                     /product="G-protein coupled receptor family C group 6
                     member A precursor"
                     /protein_id="NP_694711.1"
                     /db_xref="CCDS:CCDS23834.1"
                     /db_xref="GeneID:210198"
                     /db_xref="MGI:MGI:2429498"
                     /translation="MALLITVVTCFMIILDTSQSCHTPDDFVAITSPGHIMIGGLFAI
                     HEKMLSSDDHPRRPQIQKCAGFEISVFLQTLAMIHSIEMINNSTLLSGVKLGYEIYDT
                     CTEVTAAMAATLRFLSKFNCSRETVVFQCDYSSYMPRVKAVIGAGYSETSIAVSRMLN
                     LQLMPQVSYESTAEILSDKIRFPSFLRTVPSDFYQTKAMAHLIRQSGWNWIGAITTDD
                     DYGRLALNTFAIQAAENNVCIAFKEVLPAFLSDNTIEVRINQTLEKIIAEAQVNVIVV
                     FLRKFHVFNLFTKAIERKISKIWIASDNWSTATKIITIPNVKKLGKVVGFAFRRGNTS
                     SFHSFLQTLHMYPNDNNKPLHEFAMLVSACKYIKDGDLSQCISNYSQATLTYDTTKTI
                     ENHLFKRNDFLWHYTEPGLIYSIQLAVFALGHAIRDLCQARDCKKPNAFQPWELLAVL
                     KNVTFTDGRNSFHFDAHGDLNTGYDVVLWKETNGLMTVTKMAEYDLQRDVFITTNQET
                     KHEFRKLKQILSKCSKECSPGQMKKATGSQHSCCYECVSCPENHYSNETDMDHCLLCN
                     NETHWAPVRSTTCFEKEVEYLDWDDSLALLLIALSLLGIAFVLAIGIIFTRNLKTPVV
                     KSSGGLVVCYVMLICHALNFASTGFFIGEPQDFACKTRQTLFGVSFTLCVSCILTKSL
                     KILLAFSFDPKLTMFLKCLYRPVPIVLTCTGIQVVICTLWLVLAAPSVEENISLPRVI
                     ILECEEGSALAFGTMLGYITVLAFICFVFAFKGRKLPENYNEAKFLTFGMLIYFIAWI
                     TFIPVYTTTFGKYLPAVEIIVILISNYGILCCIFFPKCYIILCKQKTNTKSAFLQMVY
                     NYSAHSVDSLALSHVSLDSTSYDTATTNQSPGNKMTACQNDNHLPAQVLPHTGTAKTI
                     KASKTLRQKRSSSI"
     exon            222..525
                     /gene="Gprc6a"
                     /inference="alignment:Splign:2.1.0"
     exon            526..1362
                     /gene="Gprc6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1575
                     /gene="Gprc6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1699
                     /gene="Gprc6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..2856
                     /gene="Gprc6a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catgaactga gcaaatgaga cagaaagatg gccctattga ttacagtagt tacttgcttc
       61 atgattattc ttgatacctc ccagtcttgt cataccccag atgacttcgt ggctatcact
      121 tctcctggac atatcatgat tggtggcttg tttgccattc atgaaaaaat gttgtcctca
      181 gatgaccatc ccagacgacc acaaatccag aaatgtgctg gctttgaaat atcagtgttt
      241 cttcaaactc tggctatgat acacagcatt gagatgatca ataattcaac actgttatcc
      301 ggagtcaagc tgggatatga aatctatgac acttgtaccg aagtcacagc agcaatggct
      361 gccactctga ggttcctctc aaaattcaac tgctctagag aaactgtggt ctttcagtgt
      421 gactattcca gctacatgcc aagggtcaag gctgtcatag gtgctggcta ctctgaaaca
      481 tccatcgcgg tctcaaggat gctgaactta cagctcatgc cacaggtgag ttatgaatcc
      541 actgcagaaa tcctgagtga caagatccgc tttccttcat ttttacggac tgtgcctagt
      601 gacttctacc aaactaaagc aatggcccac ctgatccgac aatcgggatg gaactggatt
      661 ggtgccataa caaccgatga tgattatgga agactagctc tcaacacatt tgcaatacag
      721 gctgctgaaa acaatgtgtg cattgccttc aaagaggttc tgccagcctt cctctcagat
      781 aataccattg aagtgagaat taaccagact ctggagaaga tcattgcaga agcccaggtt
      841 aatgtcattg tggtgtttct gagaaaattc catgttttca atctcttcac gaaagccatt
      901 gaaaggaaaa taagtaagat ctggattgct agtgataatt ggtcaaccgc taccaagatt
      961 atcaccatcc ctaatgttaa gaagcttggc aaagtggtgg ggtttgcctt taggagagga
     1021 aatacgtctt ctttccattc ttttcttcaa actctgcata tgtaccccaa tgacaataac
     1081 aaacccctac atgaatttgc catgctcgtt tctgcctgta aatacatcaa agacggtgat
     1141 ttgagccaat gcatatccaa ctattctcag gcaactttga cctatgacac taccaagacc
     1201 attgaaaacc acttattcaa gagaaatgat ttcctctggc attatactga gccgggactc
     1261 atttatagca ttcagcttgc agtgttcgcc cttggtcatg ccatccggga tctgtgccaa
     1321 gctcgagact gcaagaaacc caacgccttt cagccatggg agctacttgc cgtgctgaaa
     1381 aacgtgacat tcactgatgg aaggaattca tttcactttg atgcccacgg ggatttaaat
     1441 actggttatg acgtggtgct ctggaaggag accaatggcc tcatgactgt cacaaagatg
     1501 gcagaatatg acctgcagcg tgacgtcttc atcaccacaa accaagaaac aaaacatgaa
     1561 ttcaggaaac ttaagcaaat tctatctaaa tgctccaagg aatgcagccc tggtcaaatg
     1621 aagaaagcca caggaagcca acacagctgt tgctatgaat gtgtgagctg cccagaaaac
     1681 cactacagta atgagacaga tatggatcac tgccttttat gcaacaatga aacccactgg
     1741 gccccagtaa ggagcactac ctgctttgaa aaggaagtgg agtatctgga ctgggatgac
     1801 tccttggctc tcctcctcat tgccctctcc ctacttggaa tcgcctttgt tctggccatt
     1861 ggcataatat ttacaagaaa cctgaagaca cctgtcgtga aatcatctgg aggattagtg
     1921 gtctgctacg tgatgctcat ctgccacgcc cttaactttg ccagcacagg cttttttatt
     1981 ggagaaccac aagactttgc gtgcaagacc aggcagacct tatttggtgt gagctttact
     2041 ctctgtgtct cctgtatttt gaccaagtcc ctgaaaattt tgctagcttt cagttttgac
     2101 cccaagctga caatgttcct gaagtgcctt tataggcctg ttcccattgt tcttacctgc
     2161 acgggcattc aagtggtcat ttgcactctt tggctggtgc tggcagcacc tagtgtggaa
     2221 gagaatatct ccttgcctag agtcattatc ctggaatgtg aggaggggtc agcactggca
     2281 tttggtacca tgctgggcta catcacagtt ctggccttca tttgctttgt atttgcattc
     2341 aaggggagga aacttcctga gaattacaac gaagccaagt tcctgacctt tgggatgctg
     2401 atttacttca tagcttggat cacattcatc cctgtctata ctaccacatt cggcaagtat
     2461 ttgcccgccg tggagattat agtcattctg atatccaatt atgggattct ctgctgtata
     2521 ttcttcccca agtgctacat tattctttgc aagcagaaga ctaacaccaa atcagccttc
     2581 ctccagatgg tttacaacta ctctgctcac agtgtggaca gccttgcctt gagtcatgtt
     2641 tccctggact ccaccagcta cgatactgca acaaccaatc agagccctgg taacaagatg
     2701 acagcctgtc agaacgacaa ccatcttcct gcacaagtgc tcccacacac aggcacggca
     2761 aagactatca aagcgtctaa aactttgcgt cagaaaagaa gttcaagtat atgattgagt
     2821 tcctaggaga cgctgtgatc cccagtgaga tgtttc
//
