LOCUS       NM_053118               1324 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus G protein-coupled receptor, family C, group 5, member
            D (Gprc5d), transcript variant 2, mRNA.
ACCESSION   NM_053118
VERSION     NM_053118.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1324)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1324)
  AUTHORS   Khrimian,L., Obri,A., Ramos-Brossier,M., Rousseaud,A., Moriceau,S.,
            Nicot,A.S., Mera,P., Kosmidis,S., Karnavas,T., Saudou,F., Gao,X.B.,
            Oury,F., Kandel,E. and Karsenty,G.
  TITLE     Gpr158 mediates osteocalcin's regulation of cognition
  JOURNAL   J Exp Med 214 (10), 2859-2873 (2017)
   PUBMED   28851741
REFERENCE   3  (bases 1 to 1324)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1324)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1324)
  AUTHORS   Xu,J., Tian,J. and Shapiro,S.D.
  TITLE     Normal lung development in RAIG1-deficient mice despite unique lung
            epithelium-specific expression
  JOURNAL   Am J Respir Cell Mol Biol 32 (5), 381-387 (2005)
   PUBMED   15677768
REFERENCE   6  (bases 1 to 1324)
  AUTHORS   Inoue,S., Nambu,T. and Shimomura,T.
  TITLE     The RAIG family member, GPRC5D, is associated with hard-keratinized
            structures
  JOURNAL   J Invest Dermatol 122 (3), 565-573 (2004)
   PUBMED   15086536
  REMARK    GeneRIF: GPRC5D is involed in the regulation of keratin synthesis
            in hard epithelial tissue.
REFERENCE   7  (bases 1 to 1324)
  AUTHORS   Brauner-Osborne,H., Jensen,A.A., Sheppard,P.O., Brodin,B.,
            Krogsgaard-Larsen,P. and O'Hara,P.
  TITLE     Cloning and characterization of a human orphan family C G-protein
            coupled receptor GPRC5D
  JOURNAL   Biochim Biophys Acta 1518 (3), 237-248 (2001)
   PUBMED   11311935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF218809.1.
            
            Transcript Variant: This variant (2) lacks an exon in the 3' coding
            region, which results in a frameshift and an early stop codon,
            compared to variant 1. The encoded isoform (2) is shorter and has a
            distinct C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF218809.1, BC119192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1324
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 65.89 cM"
     gene            1..1324
                     /gene="Gprc5d"
                     /note="G protein-coupled receptor, family C, group 5,
                     member D"
                     /db_xref="GeneID:93746"
                     /db_xref="MGI:MGI:1935037"
     exon            1..104
                     /gene="Gprc5d"
                     /inference="alignment:Splign:2.1.0"
     exon            105..1042
                     /gene="Gprc5d"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1050
                     /gene="Gprc5d"
                     /note="similar to RAIG1, GPRC5B and GPRC5C; isoform 2 is
                     encoded by transcript variant 2"
                     /codon_start=1
                     /product="G-protein coupled receptor family C group 5
                     member D isoform 2"
                     /protein_id="NP_444348.1"
                     /db_xref="CCDS:CCDS39680.1"
                     /db_xref="GeneID:93746"
                     /db_xref="MGI:MGI:1935037"
                     /translation="MYEDCVKSTEDYYLFCDNEGPWAIVLESLAVIGIVVTILLLLAF
                     LFLMRKVQDCSQWNVLPTQFLFLLAVLGLFGLTFAFIIQLNHQTAPVRYFLFGVLFAI
                     CFSCLLAHASNLVKLVRGRVSFCWTTILFIAIGVSLLQTIIAIEYVTLIMTRGLMFEH
                     MTPYQLNVDFVCLLIYVLFLMALTFFVSKATFCGPCENWKQHGRLIFATVLVSIIIWV
                     VWISMLLRGNPQLQRQPHWDDAVICIGLVTNAWVFLLIYIIPELSILYRSCRQECPTQ
                     GNVCQVPVYQRSFRMDTQEPTREC"
     exon            1043..1317
                     /gene="Gprc5d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1295..1300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gprc5d"
                     /note="hexamer: ATTAAA"
     polyA_site      1317
                     /gene="Gprc5d"
                     /note="major polyA site"
ORIGIN      
        1 gaggagagat taaagcacct gaagttgtct cctccttact catttgcagc cacagcttcc
       61 ccaccagcac agcctcagag gcttccggag tagactcgga ggaggagacc agacatccgt
      121 tctcgtgagg tctacctata agtcaccatg tatgaggact gcgtgaagtc cacagaagac
      181 tattacctct tctgtgacaa cgaggggcca tgggccattg ttctggagtc cttggcagtg
      241 attggcatag tggttaccat attgctactc ctggcatttc tgttcctcat gcggaaggtt
      301 caggactgca gccagtggaa cgtgcttccc actcagttcc tcttcctgct ggctgtgctc
      361 gggctcttcg gacttacttt tgccttcatc atccaactca accatcaaac tgcccctgtt
      421 cgctacttcc tctttggggt tctctttgct atctgcttct cctgcctcct ggctcatgcc
      481 tccaacctgg tgaagctggt ccggggtaga gtctccttct gctggacaac aattctgttc
      541 attgctatcg gtgtcagcct gttgcagacc atcattgcga tagagtatgt gaccctcatc
      601 atgaccagag gcttgatgtt cgagcatatg acaccgtatc agctcaatgt ggactttgtc
      661 tgtctcctga tctatgtcct cttcctgatg gccctcactt tcttcgtctc caaggccacc
      721 ttctgtggcc catgtgagaa ctggaaacag cacggaaggc tcatatttgc tactgtgctg
      781 gtctctatca ttatctgggt ggtgtggatc tccatgctct tgagaggcaa cccccagctc
      841 cagcgacagc cccactggga cgatgcagtc atctgcattg gcctggtcac caacgcttgg
      901 gtcttcctgc tgatctacat catccctgag ctgagcatac tctacaggtc atgtaggcag
      961 gagtgtccta cacaaggcaa cgtctgccag gtccctgtct accaacgcag cttcaggatg
     1021 gatacccagg aacccaccag agagtgctga tcccagccgg gagtatctca tcccatcagc
     1081 tacactaagc ccacagcaag atgcaggatt gtaaagctac tggaaacagc atagagacaa
     1141 cctggaagag tgccctgctc cacacagccc taaagagccc aggggagcac tggacacact
     1201 gtcaatgaag catccttcct gtcccttcct ctctgtttcc ctgccctttc cactcttctg
     1261 gacccagcct ctgaagactg tcatgtcctg cacaattaaa atcttgttgc caccctaaaa
     1321 aaaa
//
