LOCUS       NM_001110337            3977 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus G protein-coupled receptor, family C, group 5, member
            C (Gprc5c), transcript variant 1, mRNA.
ACCESSION   NM_001110337
VERSION     NM_001110337.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3977)
  AUTHORS   Bhat,S., Dietz,A., Senf,K., Nietzsche,S., Hirabayashi,Y.,
            Westermann,M. and Neuhaus,E.M.
  TITLE     GPRC5C regulates the composition of cilia in the olfactory system
  JOURNAL   BMC Biol 21 (1), 292 (2023)
   PUBMED   38110903
  REMARK    GeneRIF: GPRC5C regulates the composition of cilia in the olfactory
            system.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3977)
  AUTHORS   Dashti,P., Thaler,R., Hawse,J.R., Galvan,M.L., van der Eerden,B.J.,
            van Wijnen,A.J. and Dudakovic,A.
  TITLE     G-protein coupled receptor 5C (GPRC5C) is required for osteoblast
            differentiation and responds to EZH2 inhibition and multiple
            osteogenic signals
  JOURNAL   Bone 176, 116866 (2023)
   PUBMED   37558192
  REMARK    GeneRIF: G-protein coupled receptor 5C (GPRC5C) is required for
            osteoblast differentiation and responds to EZH2 inhibition and
            multiple osteogenic signals.
REFERENCE   3  (bases 1 to 3977)
  AUTHORS   Kawabata,Y., Takai,S., Sanematsu,K., Iwata,S., Kawabata,F.,
            Kanematsu,T., Jimi,E. and Shigemura,N.
  TITLE     The G protein-coupled receptor GPRC5C is a saccharide sensor with a
            novel 'off' response
  JOURNAL   FEBS Lett 597 (15), 2006-2016 (2023)
   PUBMED   37418589
  REMARK    GeneRIF: The G protein-coupled receptor GPRC5C is a saccharide
            sensor with a novel 'off' response.
REFERENCE   4  (bases 1 to 3977)
  AUTHORS   Rajkumar,P., Cha,B., Yin,J., Arend,L.J., Paunescu,T.G.,
            Hirabayashi,Y., Donowitz,M. and Pluznick,J.L.
  TITLE     Identifying the localization and exploring a functional role for
            Gprc5c in the kidney
  JOURNAL   FASEB J 32 (4), 2046-2059 (2018)
   PUBMED   29196502
  REMARK    GeneRIF: Gprc5c KO mice have altered acid-base homeostasis and
            reduced NHE3 activity in the kidney.
REFERENCE   5  (bases 1 to 3977)
  AUTHORS   Khrimian,L., Obri,A., Ramos-Brossier,M., Rousseaud,A., Moriceau,S.,
            Nicot,A.S., Mera,P., Kosmidis,S., Karnavas,T., Saudou,F., Gao,X.B.,
            Oury,F., Kandel,E. and Karsenty,G.
  TITLE     Gpr158 mediates osteocalcin's regulation of cognition
  JOURNAL   J Exp Med 214 (10), 2859-2873 (2017)
   PUBMED   28851741
REFERENCE   6  (bases 1 to 3977)
  AUTHORS   Metzakopian,E., Lin,W., Salmon-Divon,M., Dvinge,H., Andersson,E.,
            Ericson,J., Perlmann,T., Whitsett,J.A., Bertone,P. and Ang,S.L.
  TITLE     Genome-wide characterization of Foxa2 targets reveals upregulation
            of floor plate genes and repression of ventrolateral genes in
            midbrain dopaminergic progenitors
  JOURNAL   Development 139 (14), 2625-2634 (2012)
   PUBMED   22696295
REFERENCE   7  (bases 1 to 3977)
  AUTHORS   Sano,T., Kim,Y.J., Oshima,E., Shimizu,C., Kiyonari,H., Abe,T.,
            Higashi,H., Yamada,K. and Hirabayashi,Y.
  TITLE     Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice;
            behavioral abnormalities in GPRC5B-deficient mice
  JOURNAL   Biochem Biophys Res Commun 412 (3), 460-465 (2011)
   PUBMED   21840300
  REMARK    GeneRIF: GPRC5C does not affect behavior, though it has a high
            sequence similarity to GPRC5B.
REFERENCE   8  (bases 1 to 3977)
  AUTHORS   Sherwood,R.I., Jitianu,C., Cleaver,O., Shaywitz,D.A., Lamenzo,J.O.,
            Chen,A.E., Golub,T.R. and Melton,D.A.
  TITLE     Prospective isolation and global gene expression analysis of
            definitive and visceral endoderm
  JOURNAL   Dev Biol 304 (2), 541-555 (2007)
   PUBMED   17328885
REFERENCE   9  (bases 1 to 3977)
  AUTHORS   Xu,J., Tian,J. and Shapiro,S.D.
  TITLE     Normal lung development in RAIG1-deficient mice despite unique lung
            epithelium-specific expression
  JOURNAL   Am J Respir Cell Mol Biol 32 (5), 381-387 (2005)
   PUBMED   15677768
REFERENCE   10 (bases 1 to 3977)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY003041.1, BY108149.1, AK128950.1, CO425185.1 and AW536310.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128950.1, SRR9219380.44365.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               BY003041.1         2-198
            198-218             BY108149.1         208-228
            219-310             BY003041.1         220-311
            311-1609            AK128950.1         1-1299
            1610-2179           CO425185.1         178-747
            2180-3712           AK128950.1         1870-3402
            3713-3977           AW536310.1         1-265               c
FEATURES             Location/Qualifiers
     source          1..3977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.54 cM"
     gene            1..3977
                     /gene="Gprc5c"
                     /gene_synonym="1110028I06Rik; 3200002M13Rik; Raig3"
                     /note="G protein-coupled receptor, family C, group 5,
                     member C"
                     /db_xref="GeneID:70355"
                     /db_xref="MGI:MGI:1917605"
     exon            1..355
                     /gene="Gprc5c"
                     /gene_synonym="1110028I06Rik; 3200002M13Rik; Raig3"
                     /inference="alignment:Splign:2.1.0"
     exon            356..1435
                     /gene="Gprc5c"
                     /gene_synonym="1110028I06Rik; 3200002M13Rik; Raig3"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1530
                     /gene="Gprc5c"
                     /gene_synonym="1110028I06Rik; 3200002M13Rik; Raig3"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1680
                     /gene="Gprc5c"
                     /gene_synonym="1110028I06Rik; 3200002M13Rik; Raig3"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..3977
                     /gene="Gprc5c"
                     /gene_synonym="1110028I06Rik; 3200002M13Rik; Raig3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3935..3940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gprc5c"
                     /gene_synonym="1110028I06Rik; 3200002M13Rik; Raig3"
                     /note="hexamer: ATTAAA"
     polyA_site      3976
                     /gene="Gprc5c"
                     /gene_synonym="1110028I06Rik; 3200002M13Rik; Raig3"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgttcc tcgctccagc ccggagcagc gaactgtgcc aggcatgtgt ctcatgggaa
       61 agccaggacg aaagtgacaa aggttgggtg tctgtcacgg gtagacgcgc caaggtggcc
      121 accgtgagtc tgtgggtgcg tgcgatcgct gggagatgca gcctaggggt gtactgagct
      181 gcaccccgaa cctctttcgg gagagaaagg cgaatccaga aagtgagtac gcgcaagtgc
      241 gcgcgcgccc gcgtgcgggg gcgtggcagt aaacagcaac aacccactag tcagtttggc
      301 cagaaactcc gatcgccttt cccaacccga aagtgcgcgt cggccgagcc tggagggacc
      361 cagctgaagc ctggcctggg agccaggatg gccactcaca gaaccttgct gatgtgccta
      421 ggactgcctc tcttcttccc aggagccttg gcccagaatc atgccccacc tggttgcagc
      481 ccagatctgg atcccctcta ctacaacctc tgtgaccgct cgggggcctg gggcattgtc
      541 ttggaggcag tggctggagc aggcatcatc acgacatttg tgttaaccat catccttgtg
      601 gctagccttc catttgtgca ggacactaag aagcggagcc tcttggggac ccaggtgttc
      661 ttcctgctgg gcaccctggg tctcttctgc ctcgtgtttg cctgtgtggt gaagccggac
      721 ttctctacct gtgcctctcg acgcttcctc tttggggtcc tgtttgccat ctgcttctcc
      781 tgtctggtag ctcacgtcct ttccctcaac ttcctaaccc ggaagaacca tgggccccga
      841 ggctgggtga tcttcaccgt ggcgctgctg ctcacccttg tggaggtcat cattaacacc
      901 gagtggctta tcatcaccct ggtacgggga ggtggccagg ttagccccct gggcaatgtc
      961 agtgccgact cgaccatgac ctctccgtgt gccatcgcca acatggactt tgtcatggct
     1021 ctcatctacg taatgctgtt gctgctgacg gccttcctag gagcctggcc caccttgtgt
     1081 ggccgcttca agcgctggcg gaaacacggg gtctttgtgt tgctcaccac tgtcatctcc
     1141 atcgccatct gggtggtatg gattgtcatg tacacctacg gcaacgagca gcaccatagc
     1201 cccacctggg atgaccccac gttggccatt gccctcgctg ccaatgcctg gacctttgtc
     1261 ctcttctatg tcatccctga ggtctcacag gtgaccaaac ctagcccaga acagagctac
     1321 cagggggaca tgtacccgac ccgaggggtg ggctatgaga ccatcctgaa ggagcagacg
     1381 ggccagagca tgtttgtgga gaacaaggca ttttctatgg acgaaccagc ctcagcaaag
     1441 agaccagtgt caccttacag tggctacaat ggacagctgc tgaccagcgt gtaccagccc
     1501 accgagatgg ccctgatgca caaaggcccg tctgaaggtg catacgacgt catcctccca
     1561 cgggccaccg ccaacagcca ggtgatgggc agtgccaact caaccctgcg ggccgaagac
     1621 atgtacatgg tccagagcca ccaggtggcc acgccaccaa aagacggcaa gatctctcag
     1681 gatcagtccc cgactaataa aacaagatgg tagatgccct cttccctgga ccacacctca
     1741 tctggatccc tcaatgctct gcatccatct gagcagggcc agcagctttc ccacctgtcc
     1801 ttggaactgg gagggaccag aggccaccaa tttgaaacag tggactgagt cgggaccttg
     1861 ggataggcct gaaatatgtg actggtgctc atagggccac ctgtcccttg cccatcccaa
     1921 cctcctggta tccaagaaac tgcagctaca gggagtgaac tgttgactcc catctcctgc
     1981 cttaacacat ccctcaggtc acagtgtctg tgttcccatg tggttctcca ggttgctgtc
     2041 tcgctgtgaa tgtccagtgt gtgacggacc ttcttggcca tgttggtgtc ccgtcagcat
     2101 gtctcacaat ggacatcagg tgaatctttg tgagtctttg gagacaagcc acacaacaga
     2161 agttgtccct taccctactt agggcctgct gcaccttcta ggaggtcact ggctagtttg
     2221 ggcaggctgt ttctcatgac ctgagggtct caggtcccag cacctttgaa tctggatgga
     2281 gtctactata ccttcagtgg gtcgtgtccc ctcaccaggg caggaccagt cggcctgttc
     2341 tgtcctcccc actgcccatc accattgaag atggcagtta cactggtccc atctgaggaa
     2401 gctcttcttg tccagccctg ccacacagag aacccacatc agagttgaag agcccgtggg
     2461 ccacagtggt gctagggttt tgcaccgttt gtatctcagt taatcccctg tttgaatctc
     2521 ccccagtctc cttttgcctt ctgtgctagc ttcctggggt agctcctggg acaggtgcag
     2581 atgtggatat tgctgaatta cctggatctc acaggttctg gaagcacctg cttgggctac
     2641 caggacatac gtggggtctg ggagttccct taggacatgt gggtggaatt cagggctgca
     2701 ttctcagggt gagttgaacc tttcctgtgt ccgactggtg ggatgtgcgg tccaggactg
     2761 tagatcgctt atggaaagac gtcttaagtt tctacctcag tttgggcagc agccgtcctt
     2821 gggacacatg gacatgatct gctgctttca acattagagg agagtccttg gccttaggac
     2881 atgcaccgga ggcacccgat ggccacccag gtcagagagg gccattttca ggcctgcaag
     2941 ctgctgacac cagtggctga gatggtgtca tggtaccaga ccctggactc gagatctcca
     3001 gaacatcatt ctttgttcta cttttgggta ccagacagag cctcttctat accctttccc
     3061 ccaagtgtgc taacttggcc ctcagcccag tcctgcttag tgccaaggta gaggtaaaga
     3121 tgagtggatt cccaggatag ccaggcactc catgcctagt tctcatgcca tccccagcaa
     3181 cctgtgcctt ttatcattgg atgaaaggtt cccacagagt aggaccatac ctccaaatga
     3241 tactcctctt gccctctgct gactgaggat gcttggtcct tccacaaggg aaccggtctc
     3301 catgcacctc acactgttct tgatctagag ccccaagatc tgccgcagta agcgagggac
     3361 tagtttgctg tcttaaatga gtcctttagg atgcagaaag ccccacatcc ctaggtgtgt
     3421 agcctgtggt gggtgtggct gtgtttatag cccaaggcct gcctgcacct gaagctgagg
     3481 agtgattgga ggctcctgga ggatgtaggc tatttgggag tgtcatggtt acccttcatg
     3541 gcaaccctgc gacttttagt tccagttcca gtggagaagt acatttttca cttgggaggc
     3601 agaagcaggc agatttctga gttcgaggcc agcctggtct acaaagtgat ttccatgaca
     3661 gccagggcta tacagagaaa ccctgtctca aaaaaacaaa acaaacaaca acaaaaaaaa
     3721 gtactttttt tttttttttt tttttaggag ggttgggggc ctccaaatga acagctctgt
     3781 atcatacaca agccttgagt gggagacatc aagtaggtcc aggcttgatc caagctcatc
     3841 atttgcaggc cactatccct taataaatgt cacacggacc ctattaaatc ctatagtgga
     3901 tgtaaaggga ggctcaacct tgtaactgct cagaattaaa cgactgccct ttctttgtga
     3961 ggggttactg cctctgt
//
