LOCUS       NM_181444               2072 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus G protein-coupled receptor, family C, group 5, member
            A (Gprc5a), mRNA.
ACCESSION   NM_181444
VERSION     NM_181444.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2072)
  AUTHORS   Li,Y., Cui,W.W., Yang,Z.F., Liu,W.H., Bian,M.W., Deng,J. and
            Wang,T.
  TITLE     Influence of GPRC5A-Regulated ABCB1 Expression on Lung
            Adenocarcinoma Proliferation
  JOURNAL   Chin Med Sci J 39 (1), 9-18 (2024)
   PUBMED   38426412
  REMARK    GeneRIF: Influence of GPRC5A-Regulated ABCB1 Expression on Lung
            Adenocarcinoma Proliferation.
REFERENCE   2  (bases 1 to 2072)
  AUTHORS   Han,G., Sinjab,A., Rahal,Z., Lynch,A.M., Treekitkarnmongkol,W.,
            Liu,Y., Serrano,A.G., Feng,J., Liang,K., Khan,K., Lu,W.,
            Hernandez,S.D., Liu,Y., Cao,X., Dai,E., Pei,G., Hu,J., Abaya,C.,
            Gomez-Bolanos,L.I., Peng,F., Chen,M., Parra,E.R., Cascone,T.,
            Sepesi,B., Moghaddam,S.J., Scheet,P., Negrao,M.V., Heymach,J.V.,
            Li,M., Dubinett,S.M., Stevenson,C.S., Spira,A.E., Fujimoto,J.,
            Solis,L.M., Wistuba,I.I., Chen,J., Wang,L. and Kadara,H.
  TITLE     An atlas of epithelial cell states and plasticity in lung
            adenocarcinoma
  JOURNAL   Nature 627 (8004), 656-663 (2024)
   PUBMED   38418883
  REMARK    Erratum:[Nature. 2024 Apr;628(8006):E1. doi:
            10.1038/s41586-024-07277-4. PMID: 38499683]
REFERENCE   3  (bases 1 to 2072)
  AUTHORS   Finnicum,C.T., Rahal,Z., Hassane,M., Treekitkarnmongkol,W.,
            Sinjab,A., Morris,R., Liu,Y., Tang,E.L., Viet,S., Petersen,J.L.,
            Lorenzi,P.L., Tan,L., Petrosino,J., Hoffman,K.L., Fujimoto,J.,
            Moghaddam,S.J. and Kadara,H.
  TITLE     Pathogenesis of Tobacco-Associated Lung Adenocarcinoma Is Closely
            Coupled with Changes in the Gut and Lung Microbiomes
  JOURNAL   Int J Mol Sci 23 (18), 10930 (2022)
   PUBMED   36142843
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2072)
  AUTHORS   Yin,H., Jing,B., Xu,D., Guo,W., Sun,B., Zhang,J., Liao,Y., Song,H.,
            Wang,T., Liu,S., Kuang,Y., Hu,M., Li,K., Zhang,S., Zhang,H., Xu,J.,
            Li,X., Du,J., Wu,Y., Wu,Y., Wang,Q., Yao,F., Chin,Y.E., Zhou,B.P.
            and Deng,J.
  TITLE     Identification of Active Bronchioalveolar Stem Cells as the Cell of
            Origin in Lung Adenocarcinoma
  JOURNAL   Cancer Res 82 (6), 1025-1037 (2022)
   PUBMED   35045987
REFERENCE   5  (bases 1 to 2072)
  AUTHORS   Guo,W., Li,K., Sun,B., Xu,D., Tong,L., Yin,H., Liao,Y., Song,H.,
            Wang,T., Jing,B., Hu,M., Liu,S., Kuang,Y., Ling,J., Li,Q., Wu,Y.,
            Wang,Q., Yao,F., Zhou,B.P., Lin,S.H. and Deng,J.
  TITLE     Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake
            via Xc- for Glutathione Synthesis in Lung Cancer
  JOURNAL   Cancer Res 81 (3), 552-566 (2021)
   PUBMED   33229341
REFERENCE   6  (bases 1 to 2072)
  AUTHORS   Deng,J., Fujimoto,J., Ye,X.F., Men,T.Y., Van Pelt,C.S., Chen,Y.L.,
            Lin,X.F., Kadara,H., Tao,Q., Lotan,D. and Lotan,R.
  TITLE     Knockout of the tumor suppressor gene Gprc5a in mice leads to
            NF-kappaB activation in airway epithelium and promotes lung
            inflammation and tumorigenesis
  JOURNAL   Cancer Prev Res (Phila) 3 (4), 424-437 (2010)
   PUBMED   20354164
  REMARK    GeneRIF: Gprc5a loss enhances NF-kappaB activation in lung
            epithelial cells
REFERENCE   7  (bases 1 to 2072)
  AUTHORS   Tao,Q., Fujimoto,J., Men,T., Ye,X., Deng,J., Lacroix,L.,
            Clifford,J.L., Mao,L., Van Pelt,C.S., Lee,J.J., Lotan,D. and
            Lotan,R.
  TITLE     Identification of the retinoic acid-inducible Gprc5a as a new lung
            tumor suppressor gene
  JOURNAL   J Natl Cancer Inst 99 (22), 1668-1682 (2007)
   PUBMED   18000218
REFERENCE   8  (bases 1 to 2072)
  AUTHORS   Carter,M., Chen,X., Slowinska,B., Minnerath,S., Glickstein,S.,
            Shi,L., Campagne,F., Weinstein,H. and Ross,M.E.
  TITLE     Crooked tail (Cd) model of human folate-responsive neural tube
            defects is mutated in Wnt coreceptor lipoprotein receptor-related
            protein 6
  JOURNAL   Proc Natl Acad Sci U S A 102 (36), 12843-12848 (2005)
   PUBMED   16126904
REFERENCE   9  (bases 1 to 2072)
  AUTHORS   Xu,J., Tian,J. and Shapiro,S.D.
  TITLE     Normal lung development in RAIG1-deficient mice despite unique lung
            epithelium-specific expression
  JOURNAL   Am J Respir Cell Mol Biol 32 (5), 381-387 (2005)
   PUBMED   15677768
  REMARK    GeneRIF: Data show that targeted inactivation of Raig1 did not
            cause significant developmental defects, and tha epithelial cell
            differentiation was normal and lung structure was intact.
REFERENCE   10 (bases 1 to 2072)
  AUTHORS   Tao,Q., Cheng,Y., Clifford,J. and Lotan,R.
  TITLE     Characterization of the murine orphan G-protein-coupled receptor
            gene Rai3 and its regulation by retinoic acid
  JOURNAL   Genomics 83 (2), 270-280 (2004)
   PUBMED   14706456
  REMARK    GeneRIF: analysis of the Rai3 gene promoter revealed that the
            proximal region harbors most of the elements necessary for its
            regulation, including GC boxes and Sp1-, AP1-, and AP2-binding
            sites, and a retinoic acid response element
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131718.5.
            
            On Mar 21, 2009 this sequence version replaced NM_181444.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039217.1, SRR5189685.198425.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC131718.5         145781-145894       c
            115-1053            AC131718.5         132072-133010       c
            1054-1109           AC131718.5         128058-128113       c
            1110-2072           AC131718.5         126847-127809       c
FEATURES             Location/Qualifiers
     source          1..2072
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 65.83 cM"
     gene            1..2072
                     /gene="Gprc5a"
                     /gene_synonym="Rai3; Raig1"
                     /note="G protein-coupled receptor, family C, group 5,
                     member A"
                     /db_xref="GeneID:232431"
                     /db_xref="MGI:MGI:1891250"
     exon            1..114
                     /gene="Gprc5a"
                     /gene_synonym="Rai3; Raig1"
                     /inference="alignment:Splign:2.1.0"
     exon            115..1053
                     /gene="Gprc5a"
                     /gene_synonym="Rai3; Raig1"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1196
                     /gene="Gprc5a"
                     /gene_synonym="Rai3; Raig1"
                     /note="RAIG-1; retinoic acid-induced gene 1 protein;
                     retinoic acid induced 3"
                     /codon_start=1
                     /product="retinoic acid-induced protein 3"
                     /protein_id="NP_852109.2"
                     /db_xref="CCDS:CCDS20644.1"
                     /db_xref="GeneID:232431"
                     /db_xref="MGI:MGI:1891250"
                     /translation="MTTPRAAPSGCRSDLDSRYHRLCDLAEGWGIALETLAAVGAVAT
                     VACMFALVFLICKVQDSNKRKMLPAQFLFLLGVLGVFGLTFAFIIKLDGATGPTRFFL
                     FGVLFAICFSCLLAHAFNLIKLVRGRKPLSWLVILSLAVGFSLVQDVIAIEYLVLTMN
                     RTNVNVFSELPAPRRNEDFVMLLIYVLVLMVLTFFASFLVFCGSFSGWKRHGFHICFT
                     SFLSIAIWVAWIVLLLIPDIDRKWDDTILSTALVANGWVFLAFYILPEFRQLPRQRSP
                     TDYPVEDAFCKPQLMKQSYGVENRAYSQEEITQGLEMGDTLYAPYSTHFQLQNHQKDF
                     SIPRAQAPASPYNDYEGRKGDS"
     exon            1054..1109
                     /gene="Gprc5a"
                     /gene_synonym="Rai3; Raig1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..2072
                     /gene="Gprc5a"
                     /gene_synonym="Rai3; Raig1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2036..2041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gprc5a"
                     /gene_synonym="Rai3; Raig1"
                     /note="hexamer: AATAAA"
     polyA_site      2072
                     /gene="Gprc5a"
                     /gene_synonym="Rai3; Raig1"
                     /note="major polyA site"
ORIGIN      
        1 ggccaaggcg ggatccttgt cccaggacct gcccagtagc caggggttga gcgctctcgc
       61 ctttcacgcg tgagtcgcaa gttctcgctt caccccgagc gccgcggcgc ccaggaccaa
      121 ccagaatgac tactcctaga gctgccccta gcggttgccg ctcagacctg gattccaggt
      181 accacagact ttgtgacctg gcggaaggct ggggcatcgc gttggaaaca ctggctgccg
      241 tcggggctgt ggctaccgtg gcttgcatgt ttgcactcgt tttcctcatc tgcaaagtgc
      301 aggactccaa caaaagaaag atgctccccg cccagttcct cttcctcctg ggagtgctag
      361 gggtctttgg cctcaccttc gccttcatca tcaagctgga tggggccaca ggacccacgc
      421 gcttcttcct cttcggagtc ctcttcgcca tctgcttctc ttgcctcctg gcccacgctt
      481 tcaacttgat caagctggtc cgagggagga agcccctgtc gtggcttgtg atcctcagcc
      541 tggcggtggg cttcagcctg gtccaggacg tcattgccat tgaatacctg gtcctcacca
      601 tgaacaggac caacgtcaat gtcttttctg agctgcctgc tcctcggcgc aatgaggatt
      661 tcgtcatgct cctcatttac gtgctcgtct tgatggtgct gaccttcttc gcatccttct
      721 tggttttctg tggatccttc tctggctgga agagacacgg gttccacata tgcttcacct
      781 cgttcctctc cattgccatc tgggtggcct ggatcgttct gctcctgatt cccgacattg
      841 accggaaatg ggatgatacc attctcagca cagccttggt ggccaacggc tgggttttcc
      901 tggcgtttta tatcttgccc gagtttcgac agctcccaag gcaacggagc cccactgatt
      961 acccagttga agatgctttt tgtaaacctc agctcatgaa gcagagctat ggtgtggaga
     1021 acagagccta ctcccaagag gaaatcaccc aaggtcttga gatgggggac acactctatg
     1081 caccttattc cacccatttt cagctacaga atcaccaaaa ggatttctct atcccgaggg
     1141 cccaggcccc ggccagtccg tacaatgact acgaagggcg caaaggcgac agctaactgt
     1201 tgggaagagt gggacaacca gaggcaggta gcagcaggtc cagccaggaa tcctgctgat
     1261 gtgaactgaa cccagggcat cccagggaaa cggtacagag aggcttgcaa cctgcccagc
     1321 acaccgccgt cttgcctggg gctgctaagc ctaacaaact gtcttcaaag agctccaggg
     1381 tttcatttgc cccattccta ggacacttct gggaggtggg agtcttggca actccgggtg
     1441 agactcttac ctctcccggg agtatgagca aacctccagt catctgactg ctcactgttt
     1501 ggtcatcctt ggaagccaat tcacctaacc cacggtgggt tctatgagga tttgctccat
     1561 accaagcaga actgaagatt tggataaacc cagaaaggtc tgggtctccg ccttgtccat
     1621 ctcatccaca ctggaagcta atctgatcgc gccctccaag gctttcctgc cgggggagga
     1681 acggctaaag gtcacgtgtc taccctcagt gcactgcccc acagtgacct cttggtgcag
     1741 acactgattt ccaagggcca cattttcatc ccaatcgcct ccaaactcac tgccaacccc
     1801 agacctctgt gtcctttgcc aggagctctt tgggatatta ctggagtaga caaggtctgt
     1861 ttctctctgc caggagaatt tgggttttgt tctcgctata aattcctggc ccttgctctc
     1921 ccccccccca ccccatcctc agtaatacgc tcaccctgac ctcctgacct ccctacgtgt
     1981 ctattcttgg gatgggatgt atttgttatg tggtaagtta ttcacctggg tatgcaataa
     2041 agatgtggtc acaactattt ttaaaatcta aa
//
