LOCUS       NM_001163015            3784 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus G protein-coupled receptor associated sorting protein
            2 (Gprasp2), transcript variant 1, mRNA.
ACCESSION   NM_001163015 XM_001474790 XM_001474818 XM_001481276 XM_142154
VERSION     NM_001163015.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3784)
  AUTHORS   Pereira,M.I., Laranjo,M., Gomes,M., Edfawy,M. and Peca,J.
  TITLE     Maternal behaviours disrupted by Gprasp2 deletion modulate
            neurodevelopmental trajectory in progeny
  JOURNAL   Sci Rep 14 (1), 12484 (2024)
   PUBMED   38816497
  REMARK    GeneRIF: Maternal behaviours disrupted by Gprasp2 deletion modulate
            neurodevelopmental trajectory in progeny.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3784)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3784)
  AUTHORS   Lu,Y., Zhang,M., Wei,Q., Chen,Z., Xing,G., Yao,J. and Cao,X.
  TITLE     Disruption of Gprasp2 down-regulates Hedgehog signaling and leads
            to apoptosis in auditory cells
  JOURNAL   Biochem Biophys Res Commun 574, 1-7 (2021)
   PUBMED   34418635
  REMARK    GeneRIF: Disruption of Gprasp2 down-regulates Hedgehog signaling
            and leads to apoptosis in auditory cells.
REFERENCE   4  (bases 1 to 3784)
  AUTHORS   Morales-Hernandez,A., Benaksas,C., Chabot,A., Caprio,C.,
            Ferdous,M., Zhao,X., Kang,G. and McKinney-Freeman,S.
  TITLE     GPRASP proteins are critical negative regulators of hematopoietic
            stem cell transplantation
  JOURNAL   Blood 135 (14), 1111-1123 (2020)
   PUBMED   32027737
  REMARK    GeneRIF: GPRASP proteins are critical negative regulators of
            hematopoietic stem cell transplantation.
REFERENCE   5  (bases 1 to 3784)
  AUTHORS   Edfawy,M., Guedes,J.R., Pereira,M.I., Laranjo,M., Carvalho,M.J.,
            Gao,X., Ferreira,P.A., Caldeira,G., Franco,L.O., Wang,D.,
            Cardoso,A.L., Feng,G., Carvalho,A.L. and Peca,J.
  TITLE     Abnormal mGluR-mediated synaptic plasticity and autism-like
            behaviours in Gprasp2 mutant mice
  JOURNAL   Nat Commun 10 (1), 1431 (2019)
   PUBMED   30926797
  REMARK    GeneRIF: Manipulating the levels of Gprasp2 bidirectionally
            modulates the surface availability of mGluR5 and produces
            alterations in dendritic complexity, spine density and synaptic
            maturation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3784)
  AUTHORS   Walker,R.G., Angerman,E.B., Kattamuri,C., Lee,Y.S., Lee,S.J. and
            Thompson,T.B.
  TITLE     Alternative binding modes identified for growth and differentiation
            factor-associated serum protein (GASP) family antagonism of
            myostatin
  JOURNAL   J Biol Chem 290 (12), 7506-7516 (2015)
   PUBMED   25657005
  REMARK    GeneRIF: present the First low resolution solution structure of
            myostatin-free and myostatin-bound states of GASP-1 and GASP-2
REFERENCE   7  (bases 1 to 3784)
  AUTHORS   Zhou,J., Goldberg,E.M., Leu,N.A., Zhou,L., Coulter,D.A. and
            Wang,P.J.
  TITLE     Respiratory failure, cleft palate and epilepsy in the mouse model
            of human Xq22.1 deletion syndrome
  JOURNAL   Hum Mol Genet 23 (14), 3823-3829 (2014)
   PUBMED   24569167
REFERENCE   8  (bases 1 to 3784)
  AUTHORS   Zhou,J., McCarrey,J.R. and Wang,P.J.
  TITLE     A 1.1-Mb segmental deletion on the X chromosome causes meiotic
            failure in male mice
  JOURNAL   Biol Reprod 88 (6), 159 (2013)
   PUBMED   23677977
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3784)
  AUTHORS   Lloyd,S.E., Onwuazor,O.N., Beck,J.A., Mallinson,G., Farrall,M.,
            Targonski,P., Collinge,J. and Fisher,E.M.
  TITLE     Identification of multiple quantitative trait loci linked to prion
            disease incubation period in mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (11), 6279-6283 (2001)
   PUBMED   11353827
REFERENCE   10 (bases 1 to 3784)
  AUTHORS   Yehiely,F., Bamborough,P., Da Costa,M., Perry,B.J., Thinakaran,G.,
            Cohen,F.E., Carlson,G.A. and Prusiner,S.B.
  TITLE     Identification of candidate proteins binding to prion protein
  JOURNAL   Neurobiol Dis 3 (4), 339-355 (1997)
   PUBMED   9173930
  REMARK    Erratum:[Neurobiol Dis 2002 Jun;10(1):67-8]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL683822.8.
            
            On Feb 3, 2022 this sequence version replaced NM_001163015.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC117923.2, SRR1660815.43246.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               AL683822.8         95206-95403
            199-326             AL683822.8         95886-96013
            327-403             AL683822.8         96534-96610
            404-475             AL683822.8         96760-96831
            476-547             AL683822.8         96994-97065
            548-630             AL683822.8         97362-97444
            631-3784            AL683822.8         97719-100872
FEATURES             Location/Qualifiers
     source          1..3784
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 57.3 cM"
     gene            1..3784
                     /gene="Gprasp2"
                     /gene_synonym="5330440H13Rik; GASP-2; GASP2; Prpl5"
                     /note="G protein-coupled receptor associated sorting
                     protein 2"
                     /db_xref="GeneID:245607"
                     /db_xref="MGI:MGI:2442071"
     exon            1..198
                     /gene="Gprasp2"
                     /gene_synonym="5330440H13Rik; GASP-2; GASP2; Prpl5"
                     /inference="alignment:Splign:2.1.0"
     exon            199..326
                     /gene="Gprasp2"
                     /gene_synonym="5330440H13Rik; GASP-2; GASP2; Prpl5"
                     /inference="alignment:Splign:2.1.0"
     exon            327..403
                     /gene="Gprasp2"
                     /gene_synonym="5330440H13Rik; GASP-2; GASP2; Prpl5"
                     /inference="alignment:Splign:2.1.0"
     exon            404..475
                     /gene="Gprasp2"
                     /gene_synonym="5330440H13Rik; GASP-2; GASP2; Prpl5"
                     /inference="alignment:Splign:2.1.0"
     exon            476..547
                     /gene="Gprasp2"
                     /gene_synonym="5330440H13Rik; GASP-2; GASP2; Prpl5"
                     /inference="alignment:Splign:2.1.0"
     exon            548..630
                     /gene="Gprasp2"
                     /gene_synonym="5330440H13Rik; GASP-2; GASP2; Prpl5"
                     /inference="alignment:Splign:2.1.0"
     exon            631..3784
                     /gene="Gprasp2"
                     /gene_synonym="5330440H13Rik; GASP-2; GASP2; Prpl5"
                     /inference="alignment:Splign:2.1.0"
     CDS             947..3427
                     /gene="Gprasp2"
                     /gene_synonym="5330440H13Rik; GASP-2; GASP2; Prpl5"
                     /note="prion protein ligand 5"
                     /codon_start=1
                     /product="G-protein coupled receptor-associated sorting
                     protein 2"
                     /protein_id="NP_001156487.1"
                     /db_xref="CCDS:CCDS53191.1"
                     /db_xref="GeneID:245607"
                     /db_xref="MGI:MGI:2442071"
                     /translation="MTGAEVETGSQAKPDKKPQEEVAGGAERESEAPLVVRPKVRPQA
                     PATSGARPKTETKSSSRARPKTETQSVSGTRHRMSGARPRSEAQLMSGARPKTDARAV
                     GGARPKTEAKPIPGARPKGDAQAWAHSEFGAEAMPRAERAHLSNSVTWPPVNVGSATV
                     TKSKSLSMNTELASMGSEIFSGTQGQPGIEPWFGPREEANMGSWCYPRPRAREETSNE
                     SADENSTMSSFWTREETSIRSWPREEVNTRSRHRAKHQTNARSKPRSKQDPYIDSLSG
                     SEDEASNPFCFWAGENTNDMFRARGRDEANARPKIRTKREDYFEDEDEIYKESWLLPG
                     EEGNRFRRRDKEEPNKTLKNENEKDVKNDETVEQESRLEEEVIIGSWFWAEQETNVEA
                     GASAICDAEPGAEEGAIGGSLFWTEEKPSLGAVARDEVRPESEEEALFGSWFWDRDEA
                     CFDPNPTPVYTAKSRYRDPEEDLNLASRPKTWDEVTIEFKPPCHGLGFPSPRPFIIPE
                     GASGNSEEKAKNAELGAEGEEQDSVAQRDLPEPEFPFQYDPSYRSVQEIREHLKARES
                     AQPENWSCTCIQCELRISSAEFEELLLLMDRIRDPFIHEIAKIAMGMRTASQFTRDFI
                     RDSGVVSLIEALMNYPSSRVRTNFLENMVHMAPPYPNLNMIETFICQVCEETLSHSVN
                     SPEQLTGMRMLRHLTITTDYHVLIANYVSGFLALLTTGDARTKFHVLKMLLNLSDNPM
                     VAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIVKSGAMSLLDDDFSLEPL
                     VSAFHEFEELAKQLQIQIDNQNDPEEGQ"
     regulatory      3755..3760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gprasp2"
                     /gene_synonym="5330440H13Rik; GASP-2; GASP2; Prpl5"
                     /note="hexamer: AATAAA"
     polyA_site      3784
                     /gene="Gprasp2"
                     /gene_synonym="5330440H13Rik; GASP-2; GASP2; Prpl5"
                     /note="major polyA site"
ORIGIN      
        1 gaggagagct ggcttgtcgc atcctgcgca gcccctgcct gtttggtgca gaggcgtggg
       61 gacaggacac atctctgcca ttccactcgc gcgcaaagcg ttaaaggcca gtgagaggat
      121 ctgcagagga cagagaacac ccaggaatag gagtcggacg tgggggagcc cagggacctg
      181 ggccgtgcgc ctggccaggc ttctgattga tggaaagtga cctgtctgca tggtaggtct
      241 ggcatattct gacaggccac ggtgagcatc tatagaccag aagcttgaga aaagaagaag
      301 agaaaaaaca gcgcggattt ctggagccct gctttaaggc tggtcagttc ttcaagcaag
      361 ggaagaaggc ttcaaggcga ctgtctcaaa tctctggaga ttgccctgct ttaaggctgg
      421 tcagttcttc aagcaaggga agaaggcttc aaggcgactg tctcagatct tggagccctg
      481 ctttaaggct agccagttct tcaagcaagg gaagaaggct tcaaggcgac tgtctcagat
      541 cttggaggac tccctgcagt gagtcagctg ttggtcttta acaccacttg aacgcagaga
      601 agaggggaga cctgcaccac atctgtgaag gtcgcctgcc gtggctgctt ggtggtgctg
      661 aggttgctgc tgaccagtgc aatcatcagg tctgcactca cccaggacct gtccatcgtc
      721 ctccagcttg atttcagctc ttctgcagtg tatctgtgtt attgactgag actgcttggg
      781 taggagtctc attggtactg gattagttgg tcatttacac cttgttcctc actatatatc
      841 ttgagtactc aaaggtcaga gtgggaaggt acaatactgt gacagacctg tcattgagac
      901 tgaggctttg gtaggcattc ttaaattgag ccttctaact tgtaccatga ctggggcaga
      961 agttgagacc ggttctcagg ccaagcctga taagaagcct caggaagagg tcgcaggtgg
     1021 ggctgagaga gaaagtgaag cccctctggt ggtcagaccc aaagtcaggc ctcaggctcc
     1081 agcaacaagt ggtgctaggc ccaaaactga aactaaatct tcctctcggg caaggcctaa
     1141 aactgaaacc cagtcagtgt ctggaacaag acaccgaatg agtggagcaa ggccgagatc
     1201 tgaggctcaa ttaatgtctg gggccaggcc taaaaccgat gccagggcag taggtggtgc
     1261 tcgccctaag actgaggcca agccaatccc aggagcaagg cctaagggtg atgcccaggc
     1321 ttgggcccac agtgagtttg gagccgaggc aatgccacgt gctgagagag cacacttatc
     1381 taattctgtc acatggccac cagtcaatgt tgggtctgca actgttacta aatctaagag
     1441 tctgtctatg aatacagaac tggccagtat gggtagtgaa atcttttctg gcacccaggg
     1501 tcagcctgga atcgagccct ggtttggacc gagagaagag gctaatatgg gttcttggtg
     1561 ctatcccagg cccagagcca gagaggagac ctctaatgag tctgcagatg aaaactctac
     1621 aatgtcttct ttctggacta gagaggagac tagtatcaga tcatggccca gggaagaggt
     1681 gaacactagg tccaggcaca gggctaaaca tcagactaat gccaggtcga agcccagatc
     1741 caaacaagat ccctatattg attctttgtc tgggtccgag gatgaggcca gtaacccatt
     1801 ctgcttttgg gctggagaaa atactaatga catgtttagg gccagaggca gggatgaggc
     1861 gaatgccaga cccaagatca ggacaaagag agaggactat tttgaagatg aagatgagat
     1921 ctataaagag tcctggcttt tgcctgggga agagggtaat agatttaggc gccgagacaa
     1981 ggaagagcct aataagacct tgaaaaatga gaacgaaaaa gatgttaaaa atgatgaaac
     2041 agtcgaacaa gagtccaggc ttgaggagga agtcattatt gggtcctggt tctgggcaga
     2101 acaggagact aatgtggagg ctggagcttc agcaatctgt gacgctgaac caggggctga
     2161 agagggggcc attggtggat ccctgttctg gaccgaagaa aagcctagtt tgggggctgt
     2221 ggccagagat gaggtcaggc ctgagtctga agaagaggca ctatttgggt cctggttttg
     2281 ggatagggat gaggcctgct ttgacccaaa tcctactcct gtgtacacag ctaagagcag
     2341 gtacagagat ccagaagagg atcttaattt agcatccagg cccaaaacct gggacgaggt
     2401 taccatcgaa ttcaaacctc cttgccatgg gcttgggttc ccttccccaa gaccctttat
     2461 cattcctgaa ggggcttctg gaaatagtga ggaaaaagcc aagaatgcag agcttggcgc
     2521 agagggggaa gagcaggact ctgtggctca gcgtgatctt cctgaacccg agtttccatt
     2581 tcagtatgat ccctcttacc gctcagtcca ggaaattcgc gagcatctta aggccaggga
     2641 aagtgcacag ccagagaatt ggtcttgcac ctgcatccag tgtgagctta gaattagttc
     2701 tgcagaattt gaggagcttc ttttactgat ggacaggatt cgtgatcctt ttatccatga
     2761 gatagctaag attgcaatgg gcatgagaac tgcttctcag tttacccggg atttcattcg
     2821 cgattcgggt gttgtctcac tgattgaagc cttgatgaat tatccttcct cccgagtgag
     2881 gactaatttt ttggaaaaca tggttcacat ggctccccct tatccaaatc taaacatgat
     2941 tgagacattt atttgtcaag tgtgtgagga gacactttca catagcgtga attcccctga
     3001 acagctaact ggaatgagga tgcttagaca tctcactata actactgact atcacgtact
     3061 gattgccaat tacgtgtctg ggtttctcgc cttattaacc acaggcgatg caagaaccaa
     3121 gtttcatgtt ctgaaaatgc tgttgaactt gtctgacaat ccgatggtgg caaaaaaact
     3181 attcagtgcc aaagctctat caatatttgt gggtctcttt aacatagagg agactaatga
     3241 taacattcag attgttatta aaatgtttca gaacatcagt aatattgtaa aaagtggagc
     3301 gatgtcttta cttgatgatg atttcagtct tgagccgctt gtttctgcat ttcatgaatt
     3361 tgaagagcta gctaaacagc tgcagatcca aatagacaat caaaatgatc ccgaggaggg
     3421 acagtaaagt tagtgtgatt taaccacctg ccactcatca gccttatgtt cccaaagagt
     3481 cccaaatagt gctttggtgt tcacagtctg tttctgtgtc gtaacttata tttttaatgc
     3541 taatgttaac ttgtcaatct cttgttgtga gctggatcgt ttgtggatgc caaaaatgaa
     3601 tatcagaact gaaaacacac ttgttgctat ttgtcttacc gtccagattg tgatattttt
     3661 tagtgttgag ctcccagtga agcaagtcat atgtgtaagc tatcctgcta tttgtcattt
     3721 aaacatgtgg ttctctgctt gagtctgggt tttcaataaa gttcgatgtt aaagttgcca
     3781 taaa
//
