LOCUS       NM_026081               5900 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus G protein-coupled receptor associated sorting protein
            1 (Gprasp1), transcript variant 1, mRNA.
ACCESSION   NM_026081
VERSION     NM_026081.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5900)
  AUTHORS   Li,R., Xiao,X., Yan,Y., Yu,L., Lv,C., Zhang,Y., Hong,T., Zhang,H.
            and Wang,Y.
  TITLE     GPRASP1 loss-of-function links to arteriovenous malformations by
            endothelial activating GPR4 signals
  JOURNAL   Brain 147 (4), 1571-1586 (2024)
   PUBMED   37787182
  REMARK    GeneRIF: GPRASP1 loss-of-function links to arteriovenous
            malformations by endothelial activating GPR4 signals.
REFERENCE   2  (bases 1 to 5900)
  AUTHORS   Schamiloglu,S., Lewis,E., Keeshen,C.M., Hergarden,A.C., Bender,K.J.
            and Whistler,J.L.
  TITLE     Arrestin-3 Agonism at Dopamine D3 Receptors Defines a Subclass of
            Second-Generation Antipsychotics That Promotes Drug Tolerance
  JOURNAL   Biol Psychiatry 94 (7), 531-542 (2023)
   PUBMED   36931452
REFERENCE   3  (bases 1 to 5900)
  AUTHORS   Morales-Hernandez,A., Benaksas,C., Chabot,A., Caprio,C.,
            Ferdous,M., Zhao,X., Kang,G. and McKinney-Freeman,S.
  TITLE     GPRASP proteins are critical negative regulators of hematopoietic
            stem cell transplantation
  JOURNAL   Blood 135 (14), 1111-1123 (2020)
   PUBMED   32027737
  REMARK    GeneRIF: GPRASP proteins are critical negative regulators of
            hematopoietic stem cell transplantation.
REFERENCE   4  (bases 1 to 5900)
  AUTHORS   Parente,A., Boukredine,A., Baraige,F., Duprat,N.,
            Gondran-Tellier,V., Magnol,L. and Blanquet,V.
  TITLE     GASP-2 overexpressing mice exhibit a hypermuscular phenotype with
            contrasting molecular effects compared to GASP-1 transgenics
  JOURNAL   FASEB J 34 (3), 4026-4040 (2020)
   PUBMED   31960486
REFERENCE   5  (bases 1 to 5900)
  AUTHORS   Walker,R.G., Angerman,E.B., Kattamuri,C., Lee,Y.S., Lee,S.J. and
            Thompson,T.B.
  TITLE     Alternative binding modes identified for growth and differentiation
            factor-associated serum protein (GASP) family antagonism of
            myostatin
  JOURNAL   J Biol Chem 290 (12), 7506-7516 (2015)
   PUBMED   25657005
  REMARK    GeneRIF: present the First low resolution solution structure of
            myostatin-free and myostatin-bound states of GASP-1 and GASP-2
REFERENCE   6  (bases 1 to 5900)
  AUTHORS   Monestier,O., Brun,C., Heu,K., Passet,B., Malhouroux,M., Magnol,L.,
            Vilotte,J.L. and Blanquet,V.
  TITLE     Ubiquitous Gasp1 overexpression in mice leads mainly to a
            hypermuscular phenotype
  JOURNAL   BMC Genomics 13, 541 (2012)
   PUBMED   23046573
  REMARK    GeneRIF: Overexpression of Gasp1 led to an increase in muscle mass
            observed not before day 15 of postnatal life.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5900)
  AUTHORS   Mathis,C., Bott,J.B., Candusso,M.P., Simonin,F. and Cassel,J.C.
  TITLE     Impaired striatum-dependent behavior in GASP-1-knock-out mice
  JOURNAL   Genes Brain Behav 10 (3), 299-308 (2011)
   PUBMED   21091868
  REMARK    GeneRIF: The pattern of behavioral deficits observed in
            GASP-1-deficient mice is coherent with current knowledge of the
            role of striatal G protein-coupled receptor(GPCR)s in
            acquisition/expression of skilled behavior and motivation.
REFERENCE   8  (bases 1 to 5900)
  AUTHORS   Thompson,D., Martini,L. and Whistler,J.L.
  TITLE     Altered ratio of D1 and D2 dopamine receptors in mouse striatum is
            associated with behavioral sensitization to cocaine
  JOURNAL   PLoS One 5 (6), e11038 (2010)
   PUBMED   20543951
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5900)
  AUTHORS   Boeuf,J., Trigo,J.M., Moreau,P.H., Lecourtier,L., Vogel,E.,
            Cassel,J.C., Mathis,C., Klosen,P., Maldonado,R. and Simonin,F.
  TITLE     Attenuated behavioural responses to acute and chronic cocaine in
            GASP-1-deficient mice
  JOURNAL   Eur J Neurosci 30 (5), 860-868 (2009)
   PUBMED   19712096
REFERENCE   10 (bases 1 to 5900)
  AUTHORS   Simonin,F., Karcher,P., Boeuf,J.J., Matifas,A. and Kieffer,B.L.
  TITLE     Identification of a novel family of G protein-coupled receptor
            associated sorting proteins
  JOURNAL   J Neurochem 89 (3), 766-775 (2004)
   PUBMED   15086532
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB619497.1, BC070413.1 and BC058970.1.
            
            On Oct 1, 2004 this sequence version replaced NM_026081.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created using sequences from
            two different strains, C57BL/6J and C57BL/6, because no single
            transcript from the same strain was available for the full length
            of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070413.1, SRR10223969.20056.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BB619497.1         2-53
            53-5319             BC070413.1         1-5267
            5320-5877           BC058970.1         3988-4545
            5878-5900           BC070413.1         5825-5847
FEATURES             Location/Qualifiers
     source          1..5900
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 57.26 cM"
     gene            1..5900
                     /gene="Gprasp1"
                     /gene_synonym="2210415K24Rik; 3110031O14Rik; GASP; GASP1"
                     /note="G protein-coupled receptor associated sorting
                     protein 1"
                     /db_xref="GeneID:67298"
                     /db_xref="MGI:MGI:1917418"
     exon            1..287
                     /gene="Gprasp1"
                     /gene_synonym="2210415K24Rik; 3110031O14Rik; GASP; GASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..364
                     /gene="Gprasp1"
                     /gene_synonym="2210415K24Rik; 3110031O14Rik; GASP; GASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            365..491
                     /gene="Gprasp1"
                     /gene_synonym="2210415K24Rik; 3110031O14Rik; GASP; GASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..564
                     /gene="Gprasp1"
                     /gene_synonym="2210415K24Rik; 3110031O14Rik; GASP; GASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..759
                     /gene="Gprasp1"
                     /gene_synonym="2210415K24Rik; 3110031O14Rik; GASP; GASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..848
                     /gene="Gprasp1"
                     /gene_synonym="2210415K24Rik; 3110031O14Rik; GASP; GASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..925
                     /gene="Gprasp1"
                     /gene_synonym="2210415K24Rik; 3110031O14Rik; GASP; GASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1002
                     /gene="Gprasp1"
                     /gene_synonym="2210415K24Rik; 3110031O14Rik; GASP; GASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1074
                     /gene="Gprasp1"
                     /gene_synonym="2210415K24Rik; 3110031O14Rik; GASP; GASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1157
                     /gene="Gprasp1"
                     /gene_synonym="2210415K24Rik; 3110031O14Rik; GASP; GASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..5878
                     /gene="Gprasp1"
                     /gene_synonym="2210415K24Rik; 3110031O14Rik; GASP; GASP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5855..5860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gprasp1"
                     /gene_synonym="2210415K24Rik; 3110031O14Rik; GASP; GASP1"
                     /note="hexamer: AATAAA"
     polyA_site      5877
                     /gene="Gprasp1"
                     /gene_synonym="2210415K24Rik; 3110031O14Rik; GASP; GASP1"
                     /note="major polyA site"
ORIGIN      
        1 gtagccgcgc ctagtgcgtc ccggcggatg taggtagcta tgtagtcgct tcgtgaggga
       61 ccggagagag gagtgggtac cgaaaggtga cagtaatttg ctagtcatgg cccttcatct
      121 tgtcctacat cccaagctcc cggcaagccc ctaaattaca gtcgccgcca ttgcctctgc
      181 tccctgcggc ggactgccga cggcgtttgc ctgcctcctt tctgtgtggg aaggcgccgc
      241 cggagagaac gcacctaaga aaactgcctt ggattcaagc agaacaggtt tgccagatct
      301 gctgcagggc ttgtcgccag tggaaacaga gaaaggagga aacaatccct tggcaagagc
      361 gcagatctcc cctagcctag aataccagct gtgagcactt ctctcagtgg agatcttcat
      421 agtgcaatcg gaccaaatcc tctggaaaca ttctgtatct caaatgcccc gtggagtaca
      481 ctcttaccca gaccaacagc aaccaccact gctcttaaga caggtggacc atcctgtggc
      541 tgcattgttc aaccatttga acaggcgagc tggcttgccg cagtctacgc agcccctgcc
      601 tgtttggtgc agaggcgtgg ggacaggaca catctctgcc attccactcg cgcgcaaagc
      661 gttaaagacc agtgagagga tccgccgagg acagagaaca cccaggaata ggagtcggac
      721 gtgggggagc ccagggacct gggccgtgcg cctggccagg tctggcatat tctggcaagc
      781 cacggtgagc atctatagac cagaagcttg agaaaagagg aacaggaaaa tggcgtggat
      841 ttctggagcc ctgctttaag gctggtcagt tcttcaagca agggaagaag gcttcaaggc
      901 gactgtctca aatctctgga gattgccctg ctttaaggct ggtcagttct tcaagcaagg
      961 gaagaaggct tcaaggcgac tgtctcagat ctctggagat tgtcctgctt taaggctggt
     1021 cagttcttca agcaagggaa gaaggcttca aggcgactgt ctcagatctt ggaggactcc
     1081 ctgcagtgag tcagctgttg gtctttaaca ccacttgaac gcagagaaga ggggagacct
     1141 gcaccacatc tgtgaaggtc gcctgccgtg gctgcttggt ggtgctgagg ttgctgctga
     1201 ccagtgcaat catcaggtct gcactcaccc aggacctgtc catcgtcctc cagcttgatt
     1261 tcagctcttc tgcagtgtat ctgtgttatt gactgagact gcttgggtag gagcctcact
     1321 gagtgctgaa ttgtcatttc aggctaattc tttgtaatct cataccctca cttatctaag
     1381 atcgtcgtgc agagctatcc tgtaacagat ctctagtgaa ggctcactgt tgttaagtca
     1441 tatacagtag acttgattga acttgtacta tgactagggc agaggttgag cctggtgccc
     1501 aggcaaaggc tgaaaataag cctggggatg agaatgctaa tgctgctgaa gtagagcctg
     1561 aagccccatt ggtggtcaga cccaaggtta ggacacaaat catgactgga gcaaggccca
     1621 aagtgaagcc taagggtacc cctggagcaa gacctaaagg tgaaaccagt acaccaggtg
     1681 gggcatatgc caaatgtaaa cctaaggcaa tccctattgc tcgatccaag catgatgccc
     1741 aagtgtgggc cccaaataag tttcgtggcg agtccatgtc aaagatggga aagcaatgtc
     1801 agatcagtgc tgcagaccct ccactgctca gtaatgattc tgggatggtt gctcaagcta
     1861 agtgcctgcc tgtagataga gaacttgcta atatggacac tgagagtatt cccaaaaagg
     1921 ctaattctcc agctggattc cagccttcct atggctcaga ggagggaacc aatatggggt
     1981 cctggtaccg tgccaggcct gtccccaaag gagaggccta tgagaattcc gatttcaaat
     2041 gggcagataa accctcagga agtccctcct tttggaatag agatgaagcc agtacaagat
     2101 ttcgtcctag gaaaagcatg aaggccaata acaggttcag gcatatggcc aaacaagagg
     2161 caaataccat gcctaggcac aaaaacaaac aagagttcta taatatttcc agttctgatt
     2221 ctgaggatga gtctggtaaa actccctggt tctggcccaa agacaagacc aaagtctggt
     2281 ctaagcccaa agaagagccc aatagtaggt cctggtttag gtctaagaaa gaagtccgtg
     2341 ttgaatccac ttctgggtct gaatgtgaaa atcctacaaa atctttgttt tggtctggag
     2401 aagaggctaa atctagatcc aaacccagag ccaggaaagg ggtcaatatg agggccaggc
     2461 agcaggccaa gcgagaagct tgcagtgatg ccatgtctgg agctatagat acaaataaga
     2521 aagagtcctg gttcttgcct gaagagaaag ctaatgtttt ttcaaagtct aagacaaaga
     2581 aagagcccag aaccagagca gtgccaaagg aagaagtcaa aactaaggcc agagcaagta
     2641 ccaagcaaga agccaggcca gaggaggaag tcctcgttgg ggcttggttc tgggacaccc
     2701 aggagtccac tatggcagat aggataagca tcaagaccac ttttgtagag gaggagccca
     2761 ttgttggaga ttggttctgg agtgaagaag aagccagtgt ggactctgag acctgtcata
     2821 catccagacc cagggctaag gaggagcaag ttagtagttt ctgtttaggg tctggaaaga
     2881 agagcagtat ggaaagtggg ccaaaggcta cttctaaatc tatgccagta gctaaggagg
     2941 atgaggtcgt tattgggtcc tggttctggg cagatgatga agagatcaac ttacaggctg
     3001 atgacgagtc tatttttgga tcttggttct ggggcactgg tgagaacagc cttagatctg
     3061 ttggagtcaa ttgtgagaag atgccgaagg ctggagaaaa agaagttact gattcctggt
     3121 tctgggctgg agatgtcaat acagaggctg aggttgaaga acaggccagg tcggcatcta
     3181 caaaagcaac aatctttgtg ccttggtttt ggtctgaaaa gcagccgaac atggatttag
     3241 ggtctgaacc ttgctcagat atcatggcag gagctgagga ggagcccata attgggccct
     3301 ggttctgggc taaagtagat aatagtgtgg aggctgaagt taacagtaag tctagccttg
     3361 aggatgagga agaacccatt agatcccctt ggtttggggc cagagaacaa accgatatga
     3421 agtatgcagc tggtatcaga tacaagccta tggcagaagc tgaggatgct aacaaaaagt
     3481 cttgtgtctg ggcaaaagaa ccctgtttgt atcctaccaa tagagaatgc ttgaaatcta
     3541 ctctgggaga aaaagaagac actgttgatc catggctctg gtccaataat tatccaagga
     3601 ccaagaccat cacagggtcc tggctatggg ctgcagaaga gggaaatata gatgatgaga
     3661 ctggagaaaa gattaaacta ccaactttag aggacaatgc attcaattct tggttctgga
     3721 aagaaaatga agaaagcatt gtagaggctc ccaagagaga agaattcagg ccagaagcgg
     3781 aagaggaaga cattattggt tcttggtttt gggctgggga tgaagacagg tttgagccag
     3841 ctgctaagat taatgaagag aacaagatag catctgaaga tgaagataca gttggatcct
     3901 ggttctgggg caatgaagag gccagtctag aggcagtgag aaggggtact tttgagtctg
     3961 ctcctgggat taaggaagag aaagttactg ggtcatggtt ctggactgat aaggccaaag
     4021 taggggctgg gtcccagact gtcgaaactg ggtcagaaac tgaagaggaa gcaatttttg
     4081 agtccttgat ctgggctgca aaaaaggaca gtattcaagc aggagtaaag cgtgtgtcca
     4141 agccaaaaga tgacggtaac atagctgttg ggtcctggct ctggtctagt gacaaggcca
     4201 caaaagaagc taaaactctg attgtcagtg aggccagtcc agaaaatggg aaagagtcag
     4261 ttgttaagtt tgggtcaaga gcaaaagatg aggtgattaa caagactggc agtggtgaca
     4321 attgtaaaca tagtacagaa gctgaaacca tagtgggagc ctggttctgg gaaggagatg
     4381 aagctagctt tgaatcaaat cctgtacctg tatgcaaggc cgtttgtgaa cccgagtctt
     4441 cagctgagca cgaacctgac ccttcccgca ggcctcagag ctgggatgag gtcactgttc
     4501 agtttaaggc tggtccgtgg ggaaaagctg gcttcccacc catgaacccc ttcagattcc
     4561 ccaaagaagc ggcatctctg tttgcagaaa tgtttggggg aaagcctaag cttgtggaag
     4621 ttggtccaga aagggagcct gaaccccagt tcccatttca gtatgatccc tcttaccgct
     4681 cagtccgaga aattcgcgag catcttaagg ccagggaaag tgcacagcca gagaattggt
     4741 cttgcaactg catccagtgt gagcttagaa ttggttctga ggagtttgag gagcttcttt
     4801 tactgatgga cagaaatcgt gatcctttta tccatgagat atctaagatt gcaatgggca
     4861 tgcgaggtgc ttctcagttt acccgggatt tcattcgaaa ctcgggcgtt gtctccctga
     4921 ttgaagcctt acttaactat ccgtcctccc gagtgaggac aaggtttttg gaaaatatgg
     4981 tccgcatggc tcccccttat ccagacctga acatgattga gacatacgtg tgtcagattt
     5041 gcgaggacac ctttgactat gacttggatt cccctgatca gttgtccgga ttgacaatga
     5101 ttacacacct cactgctact tctgactatc acaaggtggt tgtcaattac ttggctgggt
     5161 ttttctactt actgaattca ggcaatacca aaacaaggtt tcatgttctg aaactgctac
     5221 tgaatttgtc tgaaaacctt gtcatgacaa aacgcctact tgttactgat tcggtgtcag
     5281 aatttatgga ccttattaat agggaggagt cagatgaaaa cattcaaatt gttcttgcaa
     5341 tatttgagac tatcagtaaa catattcaaa aagaggcact gttttctgat gatgatgatg
     5401 atgatgaaga agaagatgca gtgaatcttg aaccatttat ttctgcattc cgtgaggctg
     5461 aaaaaattgc caaggaacta aaacgcaaac ctggcaatca aaaagcaccc tgaagcagta
     5521 caacaaaaac aaaaagtaat ttgactaacc ctttgcctcc ggttgtcctt ttgttcctga
     5581 gtcatctgac cctcaaatac tgctttgctt tcccagctgc ttccttgttt cagtgtacct
     5641 ctctaatgct ggtggcaatt ctacccaacc ctgtgtactc tgtattatcg ttctgatgcc
     5701 aaatgaagat acaactgaaa acacatgaca cttgttgatg acgcttgttg tgttgattgt
     5761 gatgttcagt atttgagtgt aaagtgaact gagccgttgt aaataagatg cccttctaaa
     5821 tgttgttctc gtgtatattt gagtcttgtg cttcaataaa ggtctatgtg aaagtgagaa
     5881 aaaaaaaaaa aaaaaaaaaa
//
