LOCUS       NM_026229               1752 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus G protein-coupled receptor 89 (Gpr89), transcript
            variant 1, mRNA.
ACCESSION   NM_026229
VERSION     NM_026229.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1752)
  AUTHORS   Zhong,X., Su,L., Yang,Y., Nair-Gill,E., Tang,M., Anderton,P.,
            Li,X., Wang,J., Zhan,X., Tomchick,D.R., Brautigam,C.A.,
            Moresco,E.M.Y., Choi,J.H. and Beutler,B.
  TITLE     Genetic and structural studies of RABL3 reveal an essential role in
            lymphoid development and function
  JOURNAL   Proc Natl Acad Sci U S A 117 (15), 8563-8572 (2020)
   PUBMED   32220963
REFERENCE   2  (bases 1 to 1752)
  AUTHORS   Sou,Y.S., Kakuta,S., Kamikubo,Y., Niisato,K., Sakurai,T.,
            Parajuli,L.K., Tanida,I., Saito,H., Suzuki,N., Sakimura,K.,
            Maeda,Y., Kinoshita,T., Uchiyama,Y. and Koike,M.
  TITLE     Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in
            Golgi pH Regulator-Deficient Mice
  JOURNAL   eNeuro 6 (3) (2019)
   PUBMED   31118204
  REMARK    GeneRIF: These results indicate that GPHR-dependent Golgi luminal
            acidification plays an essential role in the structural and
            functional maintenance of purkinje cells and basket cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1752)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   4  (bases 1 to 1752)
  AUTHORS   Tarutani,M., Nakajima,K., Uchida,Y., Takaishi,M., Goto-Inoue,N.,
            Ikawa,M., Setou,M., Kinoshita,T., Elias,P.M., Sano,S. and Maeda,Y.
  TITLE     GPHR-dependent functions of the Golgi apparatus are essential for
            the formation of lamellar granules and the skin barrier
  JOURNAL   J Invest Dermatol 132 (8), 2019-2025 (2012)
   PUBMED   22572823
REFERENCE   5  (bases 1 to 1752)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 1752)
  AUTHORS   Johannesson,M., Olsson,L.M., Lindqvist,A.K., Moller,S., Koczan,D.,
            Wester-Rosenlof,L., Thiesen,H.J., Ibrahim,S. and Holmdahl,R.
  TITLE     Gene expression profiling of arthritis using a QTL chip reveals a
            complex gene regulation of the Cia5 region in mice
  JOURNAL   Genes Immun 6 (7), 575-583 (2005)
   PUBMED   16015370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127297.4.
            
            On Mar 21, 2023 this sequence version replaced NM_026229.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010729.1, AK016787.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC127297.4         45768-45898
            132-191             AC127297.4         52529-52588
            192-295             AC127297.4         53644-53747
            296-402             AC127297.4         57476-57582
            403-504             AC127297.4         58113-58214
            505-625             AC127297.4         60157-60277
            626-706             AC127297.4         61091-61171
            707-816             AC127297.4         68452-68561
            817-905             AC127297.4         70371-70459
            906-998             AC127297.4         70914-71006
            999-1094            AC127297.4         75357-75452
            1095-1184           AC127297.4         77531-77620
            1185-1250           AC127297.4         78538-78603
            1251-1752           AC127297.4         79486-79987
FEATURES             Location/Qualifiers
     source          1..1752
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.01 cM"
     gene            1..1752
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /note="G protein-coupled receptor 89"
                     /db_xref="GeneID:67549"
                     /db_xref="MGI:MGI:1914799"
     exon            1..131
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1457
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein GPR89; Golgi pH regulator"
                     /codon_start=1
                     /product="Golgi pH regulator isoform 1"
                     /protein_id="NP_080505.1"
                     /db_xref="CCDS:CCDS17650.1"
                     /db_xref="GeneID:67549"
                     /db_xref="MGI:MGI:1914799"
                     /translation="MSFLIDSSIMITSQILFFGFGWLFFMRQLFKDYEVRQYVVQVIF
                     SVTFAFSCTMFELIIFEILGVLNSSSRYFHWKLNLCVILLILVFMVPFYIGYFIVSNI
                     QLLHKQRLLFSCLLWLTFMYFFWKLGDPFPILSPKHGILSIEQLISRVGVIGVTLMAL
                     LSGFGAVNCPYTYMSYFLRNVTDTDILALERRLLQTMDMIISKKKRMAVARRTMFQRG
                     DVQNKPSGLWGMLKSVTASAPGSENLTLIQQEVDALEELSRQLFLETADLYATKERIE
                     YSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVLDRVGKTDPVTRGIEITVNYLGIQF
                     DVKFWSQHISFILVGIIIVTSIRGLLITLTKFFYAISSSKSSNVIVLLLAQIMGMYFV
                     SSVLLIRMSMPPEYRTIITEVLGELQFNFYHRWFDVIFLVSALSSILFLYLAHKQAPE
                     KHMAP"
     exon            132..191
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /inference="alignment:Splign:2.1.0"
     exon            192..295
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /inference="alignment:Splign:2.1.0"
     exon            296..402
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /inference="alignment:Splign:2.1.0"
     exon            403..504
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /inference="alignment:Splign:2.1.0"
     exon            505..625
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /inference="alignment:Splign:2.1.0"
     exon            626..706
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /inference="alignment:Splign:2.1.0"
     exon            707..816
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /inference="alignment:Splign:2.1.0"
     exon            817..905
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /inference="alignment:Splign:2.1.0"
     exon            906..998
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1094
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1184
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1250
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1752
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1733..1738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /note="hexamer: AGTAAA"
     polyA_site      1752
                     /gene="Gpr89"
                     /gene_synonym="4933412D19Rik; Gpr89a; SH120"
                     /note="major polyA site"
ORIGIN      
        1 aggccgccta ccacagcagg tggacaggtc ttaagccgcg gcttctctga ggggtagaca
       61 gctgggcatg ggcctcccga ggcttcgcca tgagcttcct gatcgactcc agcatcatga
      121 tcacctccca gatactgttt tttggattcg gatggctttt cttcatgcgc cagttgttta
      181 aggactatga ggtgcgtcag tatgtggtgc aggtgatctt ctccgtgacc tttgcatttt
      241 catgcaccat gtttgagctt atcatctttg agatcttggg agttctgaac agcagctccc
      301 gttacttcca ttggaaactg aacctgtgtg tgattctgct catcctggtt ttcatggtgc
      361 ccttctacat tggttacttt atcgtgagta acatccagct gttgcacaaa cagcgcctgc
      421 tcttttcctg tctcttatgg ctgaccttta tgtacttctt ctggaagctg ggagacccat
      481 tccccatact cagcccaaag cacgggatct tgtccataga gcagctcatc agccgggtag
      541 gcgtaatcgg ggtgacgctc atggctctgc tttccggatt tggtgctgtc aactgtccgt
      601 acacatacat gtcctacttc ctcaggaacg tgactgacac agatattctt gccctggaac
      661 ggcgactgct gcagaccatg gacatgatca taagcaaaaa gaaaagaatg gccgtggcac
      721 ggagaaccat gttccagaga ggggatgtgc agaacaagcc gtcgggactc tggggcatgc
      781 tgaagagcgt tactgcctca gccccgggaa gtgaaaatct gactcttatc caacaggaag
      841 tggatgcttt ggaagaactg agcaggcagc tttttctgga aacagctgat ctgtatgcta
      901 caaaggaaag aattgaatac tcgaaaacat tcaagggaaa gtattttaat ttcctgggtt
      961 attttttctc tatttactgt gtctggaaaa tttttatggc taccatcaat attgttcttg
     1021 atcgagttgg gaaaactgac cctgtcacca gaggcatcga gatcactgtg aattatctgg
     1081 gaatccagtt tgacgtgaag ttctggtctc agcacatctc cttcattctg gttggaataa
     1141 tcattgtcac atccatcaga ggactgctga tcacactcac caagttcttt tatgccatct
     1201 ccagcagcaa gtcctccaac gtcatcgtcc tgctgttagc gcagataatg ggtatgtact
     1261 tcgtgtcctc tgtactgctg atccgaatga gcatgccccc ggagtaccgc accataatca
     1321 cagaggtcct cggggagctt cagttcaact tctatcaccg ttggtttgat gtcatcttcc
     1381 tggtcagtgc cctctccagc atattgttcc tctatctggc tcacaaacag gcaccagaga
     1441 agcatatggc cccctgaact cagactccct gccaacttca ggaaaggaga cacagtgggg
     1501 agaccagagc ctacagctct ttacacaggc agagctgcga gttctgttct gcctcaggca
     1561 cacgcctact tcctcctgag atactggagt cacttcgact gaggcacaag aagaaaaccc
     1621 gcagcattca gcagggagcc gcatggatct gaggctgtgc agtgaggagg agagggccag
     1681 agcatgagga taccccggaa atcctgacta cacggcttcc ctcgaaaatg ctagtaaagt
     1741 cagtttgtaa ca
//
