LOCUS       NM_001411426            3498 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus G-protein coupled receptor 88 (Gpr88), transcript
            variant 4, mRNA.
ACCESSION   NM_001411426
VERSION     NM_001411426.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3498)
  AUTHORS   Mansky,R.H., Greguske,E.A., Yu,D., Zarate,N., Intihar,T.A.,
            Tsai,W., Brown,T.G., Thayer,M.N., Kumar,K. and Gomez-Pastor,R.
  TITLE     Tumor suppressor p53 regulates heat shock factor 1 protein
            degradation in Huntington's disease
  JOURNAL   Cell Rep 42 (3), 112198 (2023)
   PUBMED   36867535
REFERENCE   2  (bases 1 to 3498)
  AUTHORS   Schoettner,K., Alonso,M., Button,M., Goldfarb,C., Herrera,J.,
            Quteishat,N., Meyer,C., Bergdahl,A. and Amir,S.
  TITLE     Characterization of Affective Behaviors and Motor Functions in Mice
            With a Striatal-Specific Deletion of Bmal1 and Per2
  JOURNAL   Front Physiol 13, 922080 (2022)
   PUBMED   35755440
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3498)
  AUTHORS   Rebeillard,F., De Gois,S., Pietrancosta,N., Mai,T.H., Lai-Kuen,R.,
            Kieffer,B.L., Giros,B., Massart,R., Darmon,M. and Diaz,J.
  TITLE     The Orphan GPCR Receptor, GPR88, Interacts with Nuclear Protein
            Partners in the Cerebral Cortex
  JOURNAL   Cereb Cortex 32 (3), 479-489 (2022)
   PUBMED   34247243
  REMARK    GeneRIF: The Orphan GPCR Receptor, GPR88, Interacts with Nuclear
            Protein Partners in the Cerebral Cortex.
REFERENCE   4  (bases 1 to 3498)
  AUTHORS   de Zavalia,N., Schoettner,K., Goldsmith,J.A., Solis,P., Ferraro,S.,
            Parent,G. and Amir,S.
  TITLE     Bmal1 in the striatum influences alcohol intake in a sexually
            dimorphic manner
  JOURNAL   Commun Biol 4 (1), 1227 (2021)
   PUBMED   34702951
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3498)
  AUTHORS   Thomson,D.M., Openshaw,R.L., Mitchell,E.J., Kouskou,M.,
            Millan,M.J., Mannoury la Cour,C., Morris,B.J. and Pratt,J.A.
  TITLE     Impaired working memory, cognitive flexibility and reward
            processing in mice genetically lacking Gpr88: Evidence for a key
            role for Gpr88 in multiple cortico-striatal-thalamic circuits
  JOURNAL   Genes Brain Behav 20 (2), e12710 (2021)
   PUBMED   33078498
  REMARK    GeneRIF: Impaired working memory, cognitive flexibility and reward
            processing in mice genetically lacking Gpr88: Evidence for a key
            role for Gpr88 in multiple cortico-striatal-thalamic circuits.
REFERENCE   6  (bases 1 to 3498)
  AUTHORS   Quintana,A., Sanz,E., Wang,W., Storey,G.P., Guler,A.D., Wanat,M.J.,
            Roller,B.A., La Torre,A., Amieux,P.S., McKnight,G.S., Bamford,N.S.
            and Palmiter,R.D.
  TITLE     Lack of GPR88 enhances medium spiny neuron activity and alters
            motor- and cue-dependent behaviors
  JOURNAL   Nat Neurosci 15 (11), 1547-1555 (2012)
   PUBMED   23064379
  REMARK    GeneRIF: This study demonistrated that lack of GPR88 enhances
            medium spiny neuron activity and alters motor- and cue-dependent
            behaviors
REFERENCE   7  (bases 1 to 3498)
  AUTHORS   Parker,J.G., Beutler,L.R. and Palmiter,R.D.
  TITLE     The contribution of NMDA receptor signaling in the corticobasal
            ganglia reward network to appetitive Pavlovian learning
  JOURNAL   J Neurosci 31 (31), 11362-11369 (2011)
   PUBMED   21813695
REFERENCE   8  (bases 1 to 3498)
  AUTHORS   Beutler,L.R., Wanat,M.J., Quintana,A., Sanz,E., Bamford,N.S.,
            Zweifel,L.S. and Palmiter,R.D.
  TITLE     Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and
            D2R-expressing medium spiny neurons is required for amphetamine
            sensitization
  JOURNAL   Proc Natl Acad Sci U S A 108 (10), 4206-4211 (2011)
   PUBMED   21368124
REFERENCE   9  (bases 1 to 3498)
  AUTHORS   Logue,S.F., Grauer,S.M., Paulsen,J., Graf,R., Taylor,N., Sung,M.A.,
            Zhang,L., Hughes,Z., Pulito,V.L., Liu,F., Rosenzweig-Lipson,S.,
            Brandon,N.J., Marquis,K.L., Bates,B. and Pausch,M.
  TITLE     The orphan GPCR, GPR88, modulates function of the striatal dopamine
            system: a possible therapeutic target for psychiatric disorders?
  JOURNAL   Mol Cell Neurosci 42 (4), 438-447 (2009)
   PUBMED   19796684
  REMARK    GeneRIF: The modulatory role of Gpr88 in striatal dopamine function
            suggests it may be a new target for treatments for psychiatric
            disorders.
REFERENCE   10 (bases 1 to 3498)
  AUTHORS   Mizushima,K., Miyamoto,Y., Tsukahara,F., Hirai,M., Sakaki,Y. and
            Ito,T.
  TITLE     A novel G-protein-coupled receptor gene expressed in striatum
  JOURNAL   Genomics 69 (3), 314-321 (2000)
   PUBMED   11056049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122888.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ187044.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-420               AC122888.5         1643-2062
            421-3498            AC122888.5         2385-5462
FEATURES             Location/Qualifiers
     source          1..3498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 50.23 cM"
     gene            1..3498
                     /gene="Gpr88"
                     /gene_synonym="Strg"
                     /note="G-protein coupled receptor 88"
                     /db_xref="GeneID:64378"
                     /db_xref="MGI:MGI:1927653"
     exon            1..420
                     /gene="Gpr88"
                     /gene_synonym="Strg"
                     /inference="alignment:Splign:2.1.0"
     exon            421..3498
                     /gene="Gpr88"
                     /gene_synonym="Strg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3356..3361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr88"
                     /gene_synonym="Strg"
                     /note="hexamer: AATAAA"
     polyA_site      3381
                     /gene="Gpr88"
                     /gene_synonym="Strg"
                     /note="major polyA site"
     regulatory      3478..3483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr88"
                     /gene_synonym="Strg"
                     /note="hexamer: ATTAAA"
     polyA_site      3498
                     /gene="Gpr88"
                     /gene_synonym="Strg"
                     /note="major polyA site"
ORIGIN      
        1 acatcagcca gcgctcttgc ttggagcaca gggtgcgctc ctctccagct cagtttcttc
       61 tgctcttgta gccaggcatc ttcgctgctg ctgcctgcct gcccaccctt ctgggcttgc
      121 agcctaccgc ttgactttct ccaattctac tgccagctga ggagactccc cacagctgtt
      181 ggctcctgcc tgggaccatg tgtggggatg ctgcacggga gaagcaaggc gcttgctcct
      241 ggcacgggtc ccagctcagt ttctcctgtt gacttctgga ccacagatgc tgctgccgag
      301 gaggtatttc ctggcatctc tccctctgct atcaccagct aaggactggc cccaaatcaa
      361 ggtacctcta ctccctctct ttggcgtttt tcccagctag gagatatcta ctttctctcg
      421 caggcaagtg ccaggatggg ccacgctaca cgaagccaac gctagggcgc gaggtgtgaa
      481 gagttggcca gaatgaccaa ctcctcctcc acttcgacct ccaccactac cgggggatcg
      541 ctgctgctgc tctgcgagga agaagaatcg tgggcgggcc ggcggatccc ggtgtctctc
      601 ctgtactcgg gcctggccat cgggggcacg ctggccaacg gtatggtcat ctatctcgtg
      661 tcgtccttcc gaaagctgca gaccaccagc aacgccttca tcgtgaatgg ctgcgccgcg
      721 gatctcagcg tctgcgccct ctggatgcca caggaggcgg tgctggggct cctgccctcg
      781 ggctccgcgg agcccccggg ggactgggac ggtggcggag gcagctaccg cctgctccgg
      841 ggcgggttgt tgggcctcgg gctcactgtg tcccttctgt cccattgcct cgtggcgctg
      901 aaccgctacc tgctcatcac cagggcgcct gccacctacc aggtgctcta ccaacggcgc
      961 cacacggtgg gcatgctggc actgtcctgg gcgctcgcct tgggtctggt gctgctgctc
     1021 ccgccctggg ctcctaagcc cggagccgag ccaccgcaag tccactaccc cgcgctcctg
     1081 gcggcgggag cgctgcttgc gcagacggcg ctgctgttgc actgctacct gggcatcgtg
     1141 cgccgcgtgc gcgtcagcgt caagcgggtc agcgtgctca acttccacct gctgcaccag
     1201 ctacccggct gcgccgccgc cgccgccgcc ttccccgccg ccccgcacgc gccgggtccg
     1261 ggaggcgccg cgcatcccgc gcagcctcaa cccctgccgg ccgctctgca gcctcgccgg
     1321 gcgcagcggc gtctcagcgg cttgtcggtg ctgctgctct gctgcgtctt cctgctggcc
     1381 acgcagccgc tggtgtgggt gagcctggcc agtggcttct ccctcccggt gccctggggc
     1441 gtgcaggcgg ccagctggct cctgtgctgc gccctgtcgg cgctcaaccc gctgctctac
     1501 acgtggagga acgaggagtt ccgcagatcc gtgcgatctg tcctgccggg cgtcggggac
     1561 gcggctgcgg ccgccgcggc cgccaccgcg gtgccagcca tgtcccaggc gcaactgggt
     1621 acccgggcgg ctggccagca ctggtaacac accttgcttg gagaggcttc ctaagccacc
     1681 tgccgcactg cctccttctt ttgtaagcta tccccagccc cagggaagat cccagtggag
     1741 aacattttgc cttcctcccc agtgcaatac cagaaccaag gtcttcccct aaagggagtc
     1801 ccaattgtgt gcggccattg acgtttaccc ttttgtttct gtgttttaaa gacacccgtg
     1861 ggtccatcca gacactcaga ctgcaaggac ttgtaaactg gcatttttag agaaccagtt
     1921 aatttatttc aagtttgctt ttgaaaaaga gctttcatat cataacgtac aacccttcca
     1981 acctccaccg tcttatatac gaagcgcctt gagtgtgtgt gtgcatgagc caaagggaat
     2041 accgttgatg aagagactgt gtgtagatag tatcctaacc acactttctt ctgttagagt
     2101 ttagtctttg tatattgacc tggaagagtg aaaccacagg tgtgtacacc gtcgtgagtt
     2161 gccactgaga cctcaggccc tttattctta aaagggcttt ttttattgag tcatttttga
     2221 aatgagattg actctcagcc agtgaggaaa caaaccaaat ttattatttt actctcctct
     2281 ctatttattt ctaaggtgga aagctaccgt cgagtgttaa agcgaaaaaa tgtcaagttt
     2341 tggattggtc agaaaccaga aatggaattt taaaagcaaa aacaggggga gctatctatt
     2401 ttgggtagca ctttcacata ttctgaagca tgcacacttc ttgctaccca catttgtaac
     2461 tgatttattt gcctctgagt gtgattgcag ctttgaacat tctgtactat aatggttgct
     2521 aaggggaatg actcctgtag tctctttaaa atatctcaat gcacatgaca taattaaaca
     2581 ctaataccat aattgcatag ctaatgttag ctgccattgc atgctcctag atgttagaac
     2641 ttactgggca tgtggtacac aaagcaatac ccattagaca aggacatttt acttcttcca
     2701 gacaccagaa gaaaaggtct tttaatcatc tgaaaagaga tgtagatgaa cccgtggctc
     2761 cctagagttc ttgtcttgac ctggcttatg agaaaactcc catttgggga ctttatctcc
     2821 caaatgaaac caatggtcag ggtgataaaa ttcagattgg ctccatcaag ttacctgtgc
     2881 gttttagggg ttaaacaagc cacacgttag gaagtaacac tgttttatgt tgttcatata
     2941 tattacaaaa acatttatta ttagtatcat gtctgttgaa gatggaatca ggcagacagt
     3001 tatgcagaag gagaatattt cgaatgggac tctgttctcc aatgtatcag ttgaggtttg
     3061 cagtcttcat ctttgatttc ctaaatgtat agatgcattt acaatgtaca aaaaacaaaa
     3121 acaaaaacac tgaaatcgtt ttgtaaaatt aaacagggaa gaaagtaaca ggaggcctag
     3181 accagtctgt tatccacata aaatctgggg ccaaatagcc tcaattaact gtgtaattca
     3241 ggagcaaaga cagcttgctt tgttgcactc ttggaccaag aatggtaaga acatttgtat
     3301 ttttgaaaaa attgggagac acgggaaaca gatattttat agcaaggcaa aataaaataa
     3361 atatgtttgt cactaacaat acgttggcag tcatgtcatt aaccaaactg tgtgcatgtg
     3421 tcatttttct cttacgaaga tttcttctgt ttccagtttc ctggattcag atatttaatt
     3481 aaagtttcca taatgctt
//
