LOCUS       NM_001330667            3543 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus G protein-coupled receptor 85 (Gpr85), transcript
            variant 3, mRNA.
ACCESSION   NM_001330667 XM_011241077
VERSION     NM_001330667.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3543)
  AUTHORS   Sakai,A., Yasui,T., Watanave,M., Tatsumi,R., Yamamoto,Y.,
            Takano,W., Tani,Y., Okamura,I., Hirai,H. and Takeda,S.
  TITLE     Development of novel potent ligands for GPR85, an orphan G
            protein-coupled receptor expressed in the brain
  JOURNAL   Genes Cells 27 (5), 345-355 (2022)
   PUBMED   35194900
  REMARK    GeneRIF: Development of novel potent ligands for GPR85, an orphan G
            protein-coupled receptor expressed in the brain.
REFERENCE   2  (bases 1 to 3543)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3543)
  AUTHORS   Chen,Q., Kogan,J.H., Gross,A.K., Zhou,Y., Walton,N.M., Shin,R.,
            Heusner,C.L., Miyake,S., Tajinda,K., Tamura,K. and Matsumoto,M.
  TITLE     SREB2/GPR85, a schizophrenia risk factor, negatively regulates
            hippocampal adult neurogenesis and neurogenesis-dependent learning
            and memory
  JOURNAL   Eur J Neurosci 36 (5), 2597-2608 (2012)
   PUBMED   22697179
  REMARK    GeneRIF: The results indicate that SREB2 is a negative regulator of
            adult neurogenesis and consequential cognitive functions.
REFERENCE   4  (bases 1 to 3543)
  AUTHORS   Ito,J., Ito,M., Nambu,H., Fujikawa,T., Tanaka,K., Iwaasa,H. and
            Tokita,S.
  TITLE     Anatomical and histological profiling of orphan G-protein-coupled
            receptor expression in gastrointestinal tract of C57BL/6J mice
  JOURNAL   Cell Tissue Res 338 (2), 257-269 (2009)
   PUBMED   19763624
REFERENCE   5  (bases 1 to 3543)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   6  (bases 1 to 3543)
  AUTHORS   Lattin,J.E., Schroder,K., Su,A.I., Walker,J.R., Zhang,J.,
            Wiltshire,T., Saijo,K., Glass,C.K., Hume,D.A., Kellie,S. and
            Sweet,M.J.
  TITLE     Expression analysis of G Protein-Coupled Receptors in mouse
            macrophages
  JOURNAL   Immunome Res 4, 5 (2008)
   PUBMED   18442421
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3543)
  AUTHORS   Matsumoto,M., Straub,R.E., Marenco,S., Nicodemus,K.K.,
            Matsumoto,S., Fujikawa,A., Miyoshi,S., Shobo,M., Takahashi,S.,
            Yarimizu,J., Yuri,M., Hiramoto,M., Morita,S., Yokota,H.,
            Sasayama,T., Terai,K., Yoshino,M., Miyake,A., Callicott,J.H.,
            Egan,M.F., Meyer-Lindenberg,A., Kempf,L., Honea,R.,
            Vakkalanka,R.K., Takasaki,J., Kamohara,M., Soga,T., Hiyama,H.,
            Ishii,H., Matsuo,A., Nishimura,S., Matsuoka,N., Kobori,M.,
            Matsushime,H., Katoh,M., Furuichi,K. and Weinberger,D.R.
  TITLE     The evolutionarily conserved G protein-coupled receptor SREB2/GPR85
            influences brain size, behavior, and vulnerability to schizophrenia
  JOURNAL   Proc Natl Acad Sci U S A 105 (16), 6133-6138 (2008)
   PUBMED   18413613
  REMARK    GeneRIF: Theses data implicate SREB2 as a potential risk factor for
            psychiatric disorders.
REFERENCE   8  (bases 1 to 3543)
  AUTHORS   Hellebrand,S., Wittenberger,T., Schaller,H.C. and
            Hermans-Borgmeyer,I.
  TITLE     Gpr85, a novel member of the G-protein coupled receptor family,
            prominently expressed in the developing mouse cerebral cortex
  JOURNAL   Brain Res Gene Expr Patterns 1 (1), 13-16 (2001)
   PUBMED   15018813
REFERENCE   9  (bases 1 to 3543)
  AUTHORS   Hellebrand,S., Schaller,H.C. and Wittenberger,T.
  TITLE     The brain-specific G-protein coupled receptor GPR85 with identical
            protein sequence in man and mouse maps to human chromosome 7q31
  JOURNAL   Biochim Biophys Acta 1493 (1-2), 269-272 (2000)
   PUBMED   10978537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY125022.1, AC113309.7, BC065154.1 and CF738797.1.
            
            On Sep 1, 2016 this sequence version replaced XM_011241077.1.
            
            Transcript Variant: This variant (3) lacks an alternate exon in the
            5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.237990.1,
                                           SRR7974084.28152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                BY125022.1         2-80
            80-80               AC113309.7         89059-89059         c
            81-94               BY125022.1         82-95
            95-350              BC065154.1         1-256
            351-935             CF738797.1         1-585
            936-2924            BC065154.1         966-2954
            2925-3543           AC113309.7         83648-84266         c
FEATURES             Location/Qualifiers
     source          1..3543
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 5.76 cM"
     gene            1..3543
                     /gene="Gpr85"
                     /gene_synonym="2900026B03Rik"
                     /note="G protein-coupled receptor 85"
                     /db_xref="GeneID:64450"
                     /db_xref="MGI:MGI:1927851"
     exon            1..301
                     /gene="Gpr85"
                     /gene_synonym="2900026B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            302..921
                     /gene="Gpr85"
                     /gene_synonym="2900026B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            922..3543
                     /gene="Gpr85"
                     /gene_synonym="2900026B03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             1092..2204
                     /gene="Gpr85"
                     /gene_synonym="2900026B03Rik"
                     /note="super conserved receptor expressed in brain 2"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 85"
                     /protein_id="NP_001317596.1"
                     /db_xref="CCDS:CCDS19916.1"
                     /db_xref="GeneID:64450"
                     /db_xref="MGI:MGI:1927851"
                     /translation="MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISIL
                     LVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGV
                     LSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDV
                     GTYSFIREEDQCTFQHRSFRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPV
                     QFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDE
                     FKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGI
                     NPFVCIFSNRELRRCFSTTLLYCRKSRLPREPYCVI"
     regulatory      2901..2906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr85"
                     /gene_synonym="2900026B03Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2924
                     /gene="Gpr85"
                     /gene_synonym="2900026B03Rik"
                     /note="major polyA site"
     regulatory      3516..3521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr85"
                     /gene_synonym="2900026B03Rik"
                     /note="hexamer: TATAAA"
     polyA_site      3537
                     /gene="Gpr85"
                     /gene_synonym="2900026B03Rik"
                     /note="major polyA site"
ORIGIN      
        1 agcgatgagg tattttactg ctgtctcgag atcgaattat tactgtagag agatattttt
       61 ttctatttca ttaacagatt attataaagc aataagcttg caggaagaca agcagacgtt
      121 tcaccttggg aattaatgaa agcgtgcctg ctagctttta aggggtgaag agtgggtagt
      181 tgtttaaaat cttaccccac cctcgcaaaa actctttgga aatgggagaa tcgagacgtg
      241 gatgattctt ggggcgttcc taatcaccag gtgtcagact atgtggtgtt tgtggactgg
      301 tctagcgtgc caaatcaaag atcagcaggg ggaaaaatca tttgagaaga attctacaag
      361 gcgcatccaa tgcttagcag gaccaccctg acagagaaag gaagacgatg tttggggaag
      421 gcgagggttc ggggcagctg gggcggaggc ggccgtccgc ggcacggtgg cttcgtgcgc
      481 tgccctaggg gaagaggatg ggcctgaggt ccgggaagag ccttcccgag ccccccactg
      541 ccaatgcatg cggggaggga aaagttccga agctgcctcg agggaacaaa agcctgattt
      601 ggggccggct gaactggaca ggactttgaa gcaaagccag cctgctccgg agacaggcag
      661 gggttcctgc tggctcggcg gaggccggag caagcctcgc cgccgccctc gccaccgcgc
      721 cgccgccgcc gcggcccctg cgttactggg ggagacggtg ccgctgcgac aggggaggac
      781 gcggctggag ctgaaggagg ctccaacgcg caggcgccgc cgagccctgc ctggatgctc
      841 agtcaaggca ctcaggaaaa aaaaatcagc aatttataga aagaagaagc tatagtctgt
      901 cgggatatcc aacaccaaca gatgttctga tggcaaatca aacggaaggc aagaggaagc
      961 atggccacag atcggatctg atctctttgt ggattacatt ttcagtaaaa tgtatggatc
     1021 tatcttttcc ttgttcttat atctagatca tgagacttga ctgaggctgt ttccttatcc
     1081 tccatccatc tatggcgaac tatagccatg cagccgacaa cattttgcaa aatctctcgc
     1141 ctctaacagc ctttctgaaa ctgacttccc tgggtttcat aataggagtc agcgttgtgg
     1201 gcaaccttct gatctccatt ttgctagtga aagataagac cttgcataga gctccttact
     1261 acttcctgct ggatctgtgc tgctcagaca tcctcagatc tgcaatttgt tttccatttg
     1321 tattcaactc tgtcaaaaat ggctccacct ggacttacgg gactctgact tgcaaagtga
     1381 ttgccttcct gggggttttg tcctgtttcc acactgcctt catgctcttc tgcatcagcg
     1441 tcaccagata cttagccatc gcccatcacc gcttctatac aaagaggctg accttttgga
     1501 cgtgtttggc tgtgatctgc atggtgtgga ctctgtccgt ggccatggca ttccccccag
     1561 ttttagatgt aggcacctac tccttcatta gggaggagga tcaatgcacc ttccaacacc
     1621 gctccttcag ggctaacgat tccctaggat ttatgctgct ccttgctctc atcctcctag
     1681 ccacacagct tgtctacctc aagctgatat tttttgtcca cgatcgaagg aaaatgaagc
     1741 cagtccagtt tgtagcagca gtgagtcaga actggacctt tcatggccct ggagctagcg
     1801 gccaggcagc tgccaattgg ctagcaggat ttggaagggg tcccacacca cccaccttgc
     1861 tgggcatcag gcaaaatgcg aataccacag gcagaaggcg gctattggtc ttggatgagt
     1921 tcaaaatgga gaaaagaatc agcagaatgt tttatataat gactttcctc ttcctaacct
     1981 tgtggggtcc ctacctggtg gcctgctatt ggagagtttt tgcacgaggg cctgtagtac
     2041 cagggggatt tctaacagcc gctgtctgga tgagtttcgc ccaagcagga atcaatccct
     2101 ttgtctgcat tttctccaac agggagctga ggcgctgttt cagcacaacc cttctttact
     2161 gcagaaaatc caggttacca agggaacctt actgtgttat atgagggagc atctgtaaat
     2221 ctttagcctt gtgaaacact aaccctctct gctaagcaat tgtggcctgt agccatgtct
     2281 ggagaagaaa accaaggatg ggaatcagca gtgacaagga tttgggcaac attctgcagt
     2341 ctttgcaata gttcacctat aatcctattt taaatctcgg agtgatcctg ctgactgctg
     2401 gcgaaggttt gtaattaaga aaggacagaa ccactgccct aagtttcttt ctgtgggtga
     2461 acactagata acgaaagtag caggtgctaa gtatcagtgc taaatgctgt gtatatcatt
     2521 acatatgaaa aaaaacttca aaaaacaatt agcattggac attttaataa attaagttga
     2581 catgaggtaa atgtgttgat aaaagctaat tttagaagtt tgaagacttt aaaacatttc
     2641 atactatttt tgttttgcaa agactacact actgggggac ttaacagtac tgtaattctt
     2701 aaaagatgtg ccatgaatta ttggggtaca ccactttaaa cacgccttgt aagtttgggg
     2761 gagcattcca aagcagtata ttggttccaa ttagagttta ccttttttgt attaatatat
     2821 tgctatttct aaataccact ttccttccct accagtgaaa ttgctagcat tgaactgtat
     2881 tatgtgtttt ttgttgattc agtaaaaaaa aagaaaaaga aaaagtttcc agtttgtttc
     2941 tattttacaa atgctagata tctctctggg aggcaacatg aatggaatca actgaccaga
     3001 gatgagcagt tcgaaaaatg cagaataaac acgtgttgcc ttaaagggtt atctagtatc
     3061 cttcatcttc tttagcagtg gagcagtagt caagaggcaa tgaatcagta actggtcctg
     3121 gctgctcatc gggaagtgca tggaagagca ttgaatactt gtctaatggt ttggtttgga
     3181 aattaaggtg cacaccatta gtataatgag attttcttct gaggtgtgct gcccattcta
     3241 gtggggtcta agaagcagac agttgatatg tgtttatact gtatgtcagc tgtcaggggc
     3301 gcccacagcc ttcgtatgac atctggcata acttgtgaag catttattgt atggaaggca
     3361 cagtcttctt tatactttct gcacattcag tgtattggtc ctttaaatta tttcagtttt
     3421 aacttgtgaa agcttataat atgatttctg gtattttaga aatacattag attctgtgag
     3481 tctcattctt taagatacag atgtgtgaac ttcaatataa agttgcattt gccaaaattt
     3541 atc
//
