LOCUS       NP_001317596             370 aa            linear   ROD 01-JUN-2024
DEFINITION  probable G-protein coupled receptor 85 [Mus musculus].
ACCESSION   NP_001317596 XP_011239379
VERSION     NP_001317596.1
DBSOURCE    REFSEQ: accession NM_001330667.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 370)
  AUTHORS   Sakai,A., Yasui,T., Watanave,M., Tatsumi,R., Yamamoto,Y.,
            Takano,W., Tani,Y., Okamura,I., Hirai,H. and Takeda,S.
  TITLE     Development of novel potent ligands for GPR85, an orphan G
            protein-coupled receptor expressed in the brain
  JOURNAL   Genes Cells 27 (5), 345-355 (2022)
   PUBMED   35194900
  REMARK    GeneRIF: Development of novel potent ligands for GPR85, an orphan G
            protein-coupled receptor expressed in the brain.
REFERENCE   2  (residues 1 to 370)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 370)
  AUTHORS   Chen,Q., Kogan,J.H., Gross,A.K., Zhou,Y., Walton,N.M., Shin,R.,
            Heusner,C.L., Miyake,S., Tajinda,K., Tamura,K. and Matsumoto,M.
  TITLE     SREB2/GPR85, a schizophrenia risk factor, negatively regulates
            hippocampal adult neurogenesis and neurogenesis-dependent learning
            and memory
  JOURNAL   Eur J Neurosci 36 (5), 2597-2608 (2012)
   PUBMED   22697179
  REMARK    GeneRIF: The results indicate that SREB2 is a negative regulator of
            adult neurogenesis and consequential cognitive functions.
REFERENCE   4  (residues 1 to 370)
  AUTHORS   Ito,J., Ito,M., Nambu,H., Fujikawa,T., Tanaka,K., Iwaasa,H. and
            Tokita,S.
  TITLE     Anatomical and histological profiling of orphan G-protein-coupled
            receptor expression in gastrointestinal tract of C57BL/6J mice
  JOURNAL   Cell Tissue Res 338 (2), 257-269 (2009)
   PUBMED   19763624
REFERENCE   5  (residues 1 to 370)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   6  (residues 1 to 370)
  AUTHORS   Lattin,J.E., Schroder,K., Su,A.I., Walker,J.R., Zhang,J.,
            Wiltshire,T., Saijo,K., Glass,C.K., Hume,D.A., Kellie,S. and
            Sweet,M.J.
  TITLE     Expression analysis of G Protein-Coupled Receptors in mouse
            macrophages
  JOURNAL   Immunome Res 4, 5 (2008)
   PUBMED   18442421
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 370)
  AUTHORS   Matsumoto,M., Straub,R.E., Marenco,S., Nicodemus,K.K.,
            Matsumoto,S., Fujikawa,A., Miyoshi,S., Shobo,M., Takahashi,S.,
            Yarimizu,J., Yuri,M., Hiramoto,M., Morita,S., Yokota,H.,
            Sasayama,T., Terai,K., Yoshino,M., Miyake,A., Callicott,J.H.,
            Egan,M.F., Meyer-Lindenberg,A., Kempf,L., Honea,R.,
            Vakkalanka,R.K., Takasaki,J., Kamohara,M., Soga,T., Hiyama,H.,
            Ishii,H., Matsuo,A., Nishimura,S., Matsuoka,N., Kobori,M.,
            Matsushime,H., Katoh,M., Furuichi,K. and Weinberger,D.R.
  TITLE     The evolutionarily conserved G protein-coupled receptor SREB2/GPR85
            influences brain size, behavior, and vulnerability to schizophrenia
  JOURNAL   Proc Natl Acad Sci U S A 105 (16), 6133-6138 (2008)
   PUBMED   18413613
  REMARK    GeneRIF: Theses data implicate SREB2 as a potential risk factor for
            psychiatric disorders.
REFERENCE   8  (residues 1 to 370)
  AUTHORS   Hellebrand,S., Wittenberger,T., Schaller,H.C. and
            Hermans-Borgmeyer,I.
  TITLE     Gpr85, a novel member of the G-protein coupled receptor family,
            prominently expressed in the developing mouse cerebral cortex
  JOURNAL   Brain Res Gene Expr Patterns 1 (1), 13-16 (2001)
   PUBMED   15018813
REFERENCE   9  (residues 1 to 370)
  AUTHORS   Hellebrand,S., Schaller,H.C. and Wittenberger,T.
  TITLE     The brain-specific G-protein coupled receptor GPR85 with identical
            protein sequence in man and mouse maps to human chromosome 7q31
  JOURNAL   Biochim Biophys Acta 1493 (1-2), 269-272 (2000)
   PUBMED   10978537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY125022.1, AC113309.7, BC065154.1 and CF738797.1.
            
            On Sep 1, 2016 this sequence version replaced XP_011239379.1.
            
            Transcript Variant: This variant (3) lacks an alternate exon in the
            5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.237990.1,
                                           SRR7974084.28152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..370
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 5.76 cM"
     Protein         1..370
                     /product="probable G-protein coupled receptor 85"
                     /note="super conserved receptor expressed in brain 2"
                     /calculated_mol_wt=41864
     Site            3
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P60894.1)"
     Region          21..350
                     /region_name="7tmA_SREB2_GPR85"
                     /note="super conserved receptor expressed in brain 2 (or
                     GPR85), member of the class A family of
                     seven-transmembrane G protein-coupled receptors; cd15218"
                     /db_xref="CDD:320346"
     Region          22..48
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320346"
     Site            26..46
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60894.1)"
     Region          55..80
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320346"
     Site            58..78
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60894.1)"
     Site            order(77,80..81,94..99,101..102,105,150,152..156,179,
                     182..184,186..188,190..191,298,301..302,304..305,308,
                     317..318,320..322,325,328..329)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320346"
     Site            83
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P60894.1)"
     Region          94..124
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320346"
     Site            97..117
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60894.1)"
     Region          136..158
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320346"
     Site            138..158
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60894.1)"
     Region          179..208
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320346"
     Site            182
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P60894.1)"
     Site            189..209
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60894.1)"
     Region          278..308
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320346"
     Site            287..307
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60894.1)"
     Site            314..334
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60894.1)"
     Region          318..343
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320346"
     CDS             1..370
                     /gene="Gpr85"
                     /gene_synonym="2900026B03Rik"
                     /coded_by="NM_001330667.1:1092..2204"
                     /db_xref="CCDS:CCDS19916.1"
                     /db_xref="GeneID:64450"
                     /db_xref="MGI:MGI:1927851"
ORIGIN      
        1 manyshaadn ilqnlsplta flkltslgfi igvsvvgnll isillvkdkt lhrapyyfll
       61 dlccsdilrs aicfpfvfns vkngstwtyg tltckviafl gvlscfhtaf mlfcisvtry
      121 laiahhrfyt krltfwtcla vicmvwtlsv amafppvldv gtysfireed qctfqhrsfr
      181 andslgfmll lalillatql vylkliffvh drrkmkpvqf vaavsqnwtf hgpgasgqaa
      241 anwlagfgrg ptpptllgir qnanttgrrr llvldefkme krisrmfyim tflfltlwgp
      301 ylvacywrvf argpvvpggf ltaavwmsfa qaginpfvci fsnrelrrcf sttllycrks
      361 rlprepycvi
//
