LOCUS       NM_030720               1519 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus G protein-coupled receptor 84 (Gpr84), transcript
            variant 1, mRNA.
ACCESSION   NM_030720
VERSION     NM_030720.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1519)
  AUTHORS   Mitchell,J.S., Spanier,J.A., Dwyer,A.J., Knutson,T.P.,
            Alkhatib,M.H., Qian,G., Weno,M.E., Chen,Y., Shaheen,Z.R.,
            Tucker,C.G., Kangas,T.O., Morales,M.S., Silva,N., Kaisho,T.,
            Farrar,M.A. and Fife,B.T.
  TITLE     CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin
            A adopt a distinct effector fate and are pathogenic in autoimmune
            diabetes
  JOURNAL   Immunity 57 (10), 2399-2415 (2024)
   PUBMED   39214091
REFERENCE   2  (bases 1 to 1519)
  AUTHORS   Kanemoto,S.
  TITLE     G protein-coupled receptor 84 gene expression is regulated by the
            ER stress response in the liver
  JOURNAL   J Biochem 176 (1), 55-68 (2024)
   PUBMED   38471516
  REMARK    GeneRIF: G protein-coupled receptor 84 gene expression is regulated
            by the ER stress response in the liver.
REFERENCE   3  (bases 1 to 1519)
  AUTHORS   Cooper,P.O., Kleb,S.S., Noonepalle,S.K., Amuso,V.M., Varshney,R.,
            Rudolph,M.C., Dhaliwal,T.K., Nguyen,D.V., Mazumder,M.F.,
            Babirye,N.S., Gupta,R., Nguyen,B.N. and Shook,B.A.
  TITLE     G-protein-coupled receptor 84 regulates acute inflammation in
            normal and diabetic skin wounds
  JOURNAL   Cell Rep 43 (6), 114288 (2024)
   PUBMED   38814782
  REMARK    GeneRIF: G-protein-coupled receptor 84 regulates acute inflammation
            in normal and diabetic skin wounds.
REFERENCE   4  (bases 1 to 1519)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1519)
  AUTHORS   Li,J., Ma,A., Zhang,R., Chen,Y., Bolyard,C., Zhao,B., Wang,C.,
            Pich,T., Li,W., Sun,N., Ma,Q., Wen,H., Clinton,S.K., Carson,W.E.
            3rd, Li,Z. and Xin,G.
  TITLE     Targeting metabolic sensing switch GPR84 on macrophages for cancer
            immunotherapy
  JOURNAL   Cancer Immunol Immunother 73 (3), 52 (2024)
   PUBMED   38349405
  REMARK    GeneRIF: Targeting metabolic sensing switch GPR84 on macrophages
            for cancer immunotherapy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1519)
  AUTHORS   Bouchard,C., Page,J., Bedard,A., Tremblay,P. and Vallieres,L.
  TITLE     G protein-coupled receptor 84, a microglia-associated protein
            expressed in neuroinflammatory conditions
  JOURNAL   Glia 55 (8), 790-800 (2007)
   PUBMED   17390309
  REMARK    GeneRIF: in mice suffering from endotoxemia, microglia express
            GPR84 in a strong and sustained manner
REFERENCE   7  (bases 1 to 1519)
  AUTHORS   Wang,J., Wu,X., Simonavicius,N., Tian,H. and Ling,L.
  TITLE     Medium-chain fatty acids as ligands for orphan G protein-coupled
            receptor GPR84
  JOURNAL   J Biol Chem 281 (45), 34457-34464 (2006)
   PUBMED   16966319
REFERENCE   8  (bases 1 to 1519)
  AUTHORS   Venkataraman,C. and Kuo,F.
  TITLE     The G-protein coupled receptor, GPR84 regulates IL-4 production by
            T lymphocytes in response to CD3 crosslinking
  JOURNAL   Immunol Lett 101 (2), 144-153 (2005)
   PUBMED   15993493
  REMARK    GeneRIF: primary stimulation of T cells with anti-CD3 resulted in
            increased interleukin-4 but not interleukin-2 or interferon -gamma
            production in GPR84(-/-) mice compared to wild-type mice
REFERENCE   9  (bases 1 to 1519)
  AUTHORS   Yousefi,S., Cooper,P.R., Potter,S.L., Mueck,B. and Jarai,G.
  TITLE     Cloning and expression analysis of a novel G-protein-coupled
            receptor selectively expressed on granulocytes
  JOURNAL   J Leukoc Biol 69 (6), 1045-1052 (2001)
   PUBMED   11404393
REFERENCE   10 (bases 1 to 1519)
  AUTHORS   Wittenberger,T., Schaller,H.C. and Hellebrand,S.
  TITLE     An expressed sequence tag (EST) data mining strategy succeeding in
            the discovery of new G-protein coupled receptors
  JOURNAL   J Mol Biol 307 (3), 799-813 (2001)
   PUBMED   11273702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164069.9.
            
            On Sep 13, 2022 this sequence version replaced NM_030720.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF272948.1, BC023249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415128 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC164069.9         33092-33188
            98-1519             AC164069.9         33842-35263
FEATURES             Location/Qualifiers
     source          1..1519
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.88 cM"
     gene            1..1519
                     /gene="Gpr84"
                     /gene_synonym="EX33"
                     /note="G protein-coupled receptor 84"
                     /db_xref="GeneID:80910"
                     /db_xref="MGI:MGI:1934129"
     exon            1..97
                     /gene="Gpr84"
                     /gene_synonym="EX33"
                     /inference="alignment:Splign:2.1.0"
     exon            98..1519
                     /gene="Gpr84"
                     /gene_synonym="EX33"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1296
                     /gene="Gpr84"
                     /gene_synonym="EX33"
                     /note="orphan G protein-coupled receptor 84"
                     /codon_start=1
                     /product="G-protein coupled receptor 84"
                     /protein_id="NP_109645.1"
                     /db_xref="CCDS:CCDS27902.1"
                     /db_xref="GeneID:80910"
                     /db_xref="MGI:MGI:1934129"
                     /translation="MWNSSDANFSCYHESVLGYRYFAIIWGVAVAVTGTVGNVLTLLA
                     LAIRPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGAVFCRIFGLLLFT
                     SNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVGSWVVGVTSFAPLWNVFV
                     LVPVVCTCSFDRMRGRPYTTILMGIYFVLGLSSVGVFYCLIHRQVKRAARALDQYGLH
                     QASIRSHQVAGTQEAMPGHFQELDSGVASRGPSEGISSEPVSAATTQTLEGDSSEAGG
                     QGIRKAAQQIAERSLPEVHRKPRETAGARRATDAPSEFGKVTRMCFAVFLCFALSYIP
                     FLLLNILDARGRAPRVVHMVAANLTWLNSCINPVLYAAMNRQFRHAYGSILKRGPQSF
                     RRFH"
     regulatory      1494..1499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr84"
                     /gene_synonym="EX33"
                     /note="hexamer: AATAAA"
     polyA_site      1519
                     /gene="Gpr84"
                     /gene_synonym="EX33"
                     /note="major polyA site"
ORIGIN      
        1 agaaaagctg gaagcctgac tgcccctcaa aagacctgct ctttaggtga gctagatatt
       61 gtttactgaa gacaagtgtg aaaactggga acctcagtct ccatcatgtg gaacagctca
      121 gatgccaact tctcctgcta ccatgagtct gtgttgggct atcgatactt tgcaattatc
      181 tggggcgtgg cagtggctgt gacaggcacg gtgggcaatg tgctcactct gctggccttg
      241 gccattcgtc ccaagctccg aacccgcttc aacctgctca ttgccaacct caccctggct
      301 gatctactct actgcacgct cctgcagcct ttctccgtgg acacatacct ccacctccat
      361 tggcgtaccg gcgcggtctt ctgtagaata tttggactcc tcctctttac ttccaattct
      421 gtctccatcc tcaccctctg tctcattgct ctaggacgct acctcctcat tgcccaccct
      481 aagctctttc cccaggtttt cagtgccaag gggatcgtgc tggcactggt gggcagctgg
      541 gttgtggggg tgaccagctt tgcccccctc tggaatgttt ttgtcttggt gccagttgtc
      601 tgcacctgca gctttgaccg catgcgaggc cggccttaca ccaccatcct catgggcatc
      661 tactttgtgc ttgggctcag cagcgtgggc gtcttctact gcctcatcca ccggcaagtg
      721 aagcgtgcgg ctcgagcact ggaccaatac gggctgcatc aggccagcat ccgctctcat
      781 caggtggctg ggacacaaga agccatgcct ggccacttcc aggagctaga cagcggggtt
      841 gcctcaagag ggcccagcga ggggatttca tctgagccag tcagtgctgc gaccacgcag
      901 accctggaag gtgattcgtc agaagctggg ggccagggca ttagaaaggc agctcaacag
      961 atcgcagaga gaagccttcc agaagtgcat cgcaagcccc gggaaactgc aggagctcgc
     1021 agagccacag atgccccatc agagttcggg aaggtgaccc gtatgtgctt cgcagtgttc
     1081 ctctgcttcg ccctcagcta catccccttc ctgttgctca acattctgga cgccaggggc
     1141 cgtgctccac gagtagtgca catggtggct gccaacctca cctggctcaa cagctgcatc
     1201 aaccctgtgc tctatgcagc catgaaccgc cagtttcgcc acgcgtatgg ctccatcctg
     1261 aaacgcgggc cacagagttt ccgccggttc cattaaagct atttaaagct agtagtccat
     1321 tcaccaggac aggccaaaca tccggaacca gagtggcctg cagaggacag gacaggagcc
     1381 cttcagtcct tgggtatttc acagacaacc tcagtggtat agaggtacac cactttccca
     1441 ttcaggaatc agtgtgtcaa ccctgtgtga cccaaggagt gtggttaatt attaataaag
     1501 acattgcatc cccccctca
//
