LOCUS       NM_010287               3586 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus G protein-coupled receptor 83 (Gpr83), transcript
            variant 1, mRNA.
ACCESSION   NM_010287
VERSION     NM_010287.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3586)
  AUTHORS   Zhang,D., Turecek,J., Choi,S., Delisle,M., Pamplona,C.L.,
            Meltzer,S. and Ginty,D.D.
  TITLE     C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway
  JOURNAL   bioRxiv (2024)
   PUBMED   38915692
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3586)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3586)
  AUTHORS   Zhu,Q., Ge,J., Liu,Y., Xu,J.W., Yan,S. and Zhou,F.
  TITLE     Decoding anterior-posterior axis emergence among mouse, monkey, and
            human embryos
  JOURNAL   Dev Cell 58 (1), 63-79 (2023)
   PUBMED   36626872
REFERENCE   4  (bases 1 to 3586)
  AUTHORS   Kim,Y., Kim,C., Lee,H., Kim,M., Zheng,H., Lim,J.Y., Yun,H.I.,
            Jeon,M., Choi,J. and Hwang,S.W.
  TITLE     Gpr83 Tunes Nociceptor Function, Controlling Pain
  JOURNAL   Neurotherapeutics 20 (1), 325-337 (2023)
   PUBMED   36352334
  REMARK    GeneRIF: Gpr83 Tunes Nociceptor Function, Controlling Pain.
REFERENCE   5  (bases 1 to 3586)
  AUTHORS   Fakira,A.K., Lueptow,L.M., Trimbake,N.A. and Devi,L.A.
  TITLE     PEN Receptor GPR83 in Anxiety-Like Behaviors: Differential
            Regulation in Global vs Amygdalar Knockdown
  JOURNAL   Front Neurosci 15, 675769 (2021)
   PUBMED   34512237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3586)
  AUTHORS   Parker,R., Liu,M., Eyre,H.J., Copeland,N.G., Gilbert,D.J.,
            Crawford,J., Sutherland,G.R., Jenkins,N.A. and Herzog,H.
  TITLE     Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic
            organisation and assignment to human chromosome 11q21.1 and 2p14
            and mouse chromosome 9 and 6
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 369-375 (2000)
   PUBMED   10760605
REFERENCE   7  (bases 1 to 3586)
  AUTHORS   Buaas,F.W., Lee,K., Edelhoff,S., Disteche,C. and Braun,R.E.
  TITLE     Cloning and characterization of the mouse interleukin enhancer
            binding factor 3 (Ilf3) homolog in a screen for RNA binding
            proteins
  JOURNAL   Mamm Genome 10 (5), 451-456 (1999)
   PUBMED   10337617
REFERENCE   8  (bases 1 to 3586)
  AUTHORS   Ashby,B.
  TITLE     Co-expression of prostaglandin receptors with opposite effects: a
            model for homeostatic control of autocrine and paracrine signaling
  JOURNAL   Biochem Pharmacol 55 (3), 239-246 (1998)
   PUBMED   9484788
  REMARK    Review article
REFERENCE   9  (bases 1 to 3586)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 3586)
  AUTHORS   Harrigan,M.T., Campbell,N.F. and Bourgeois,S.
  TITLE     Identification of a gene induced by glucocorticoids in murine
            T-cells: a potential G protein-coupled receptor
  JOURNAL   Mol Endocrinol 5 (9), 1331-1338 (1991)
   PUBMED   1663214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035356.1, AK081276.1, AK041527.1 and AK030359.1.
            
            On Jul 18, 2015 this sequence version replaced NM_010287.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081276.1, AK035356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AK035356.1         2-33
            33-2230             AK081276.1         2-2199
            2231-3107           AK041527.1         2077-2953
            3108-3586           AK030359.1         3780-4258
FEATURES             Location/Qualifiers
     source          1..3586
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 4.4 cM"
     gene            1..3586
                     /gene="Gpr83"
                     /gene_synonym="Gir; Gpr72; RP105; RP39; RP82"
                     /note="G protein-coupled receptor 83"
                     /db_xref="GeneID:14608"
                     /db_xref="MGI:MGI:95712"
     exon            1..711
                     /gene="Gpr83"
                     /gene_synonym="Gir; Gpr72; RP105; RP39; RP82"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1596
                     /gene="Gpr83"
                     /gene_synonym="Gir; Gpr72; RP105; RP39; RP82"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; probable G-protein coupled receptor 83;
                     glucocorticoid-induced receptor"
                     /codon_start=1
                     /product="G-protein coupled receptor 83 isoform 1
                     precursor"
                     /protein_id="NP_034417.1"
                     /db_xref="CCDS:CCDS22829.1"
                     /db_xref="GeneID:14608"
                     /db_xref="MGI:MGI:95712"
                     /translation="MKVPPVLLLFLLSSVRATEQPQVVTEHPSMEAALTGPNASSHFW
                     ANYTFSDWQNFVGRRRYGAESQNPTVKALLIVAYSFTIVFSLFGNVLVCHVIFKNQRM
                     HSATSLFIVNLAVADIMITLLNTPFTLVRFVNSTWVFGKGMCHVSRFAQYCSLHVSAL
                     TLTAIAVDRHQVIMHPLKPRISITKGVIYIAVIWVMATFFSLPHAICQKLFTFKYSED
                     IVRSLCLPDFPEPADLFWKYLDLATFILLYLLPLFIISVAYARVAKKLWLCNTIGDVT
                     TEQYLALRRKKKTTVKMLVLVVVLFALCWFPLNCYVLLLSSKAIHTNNALYFAFHWFA
                     MSSTCYNPFIYCWLNENFRVELKALLSMCQRPPKPQEDRLPSPVPSFRVAWTEKSHGR
                     RAPLPNHHLPSSQIQSGKTDLSSVEPVVAMS"
     exon            712..837
                     /gene="Gpr83"
                     /gene_synonym="Gir; Gpr72; RP105; RP39; RP82"
                     /inference="alignment:Splign:2.1.0"
     exon            838..971
                     /gene="Gpr83"
                     /gene_synonym="Gir; Gpr72; RP105; RP39; RP82"
                     /inference="alignment:Splign:2.1.0"
     exon            972..3586
                     /gene="Gpr83"
                     /gene_synonym="Gir; Gpr72; RP105; RP39; RP82"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3567..3572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr83"
                     /gene_synonym="Gir; Gpr72; RP105; RP39; RP82"
                     /note="hexamer: AATAAA"
     polyA_site      3586
                     /gene="Gpr83"
                     /gene_synonym="Gir; Gpr72; RP105; RP39; RP82"
                     /note="major polyA site"
ORIGIN      
        1 ataaaagtgc tgcgagccgg gcgagcgcca ccgaggaccg aggtgggtgg cagtcggcac
       61 catcaggctc ccttggcgtt tcggagtttt ctctgtggtc ccgactctcc ggaggatctc
      121 ggttgtctcc caagtcggaa cctggcacgg tccaggttca ctcggaggtc cgggcttcct
      181 ctgtgccccg tgcccctcgc tcccaggctc cctctgtggt gtggactcct ctagcccggt
      241 gcgctcagcc cctcgcaccc agcctccagg cacagagccc ggcagggagc tcagcccttg
      301 tgcctagagc tgcagtggct ggacatgaag gttcctcctg tcctgcttct ctttcttctg
      361 tcctcagtgc gagctactga gcaaccgcag gtcgtcactg agcatcccag catggaggca
      421 gccctgaccg ggcccaacgc ctcctcgcac ttctgggcca actacacttt ctctgactgg
      481 cagaacttcg tgggcaggag acgttatggg gccgagtccc agaaccccac ggtgaaagca
      541 ctgctcatcg tggcctactc attcaccatc gtcttctcgc tcttcggtaa tgtcctggtc
      601 tgtcatgtca tcttcaagaa ccagcgcatg cactcggcca ccagcctctt cattgtcaac
      661 ctggcagtgg cggacatcat gatcacattg ctcaacacgc ccttcacttt ggtccgcttt
      721 gtgaacagca catgggtgtt tgggaagggc atgtgtcatg tcagtcgctt tgctcagtac
      781 tgttctctac atgtctcagc actgactctg acagctatcg cagtggaccg ccaccaggtc
      841 atcatgcatc cactgaagcc tcggatctcc atcaccaagg gtgtcatata tattgctgtc
      901 atctgggtca tggctacctt cttctctctg ccacatgcca tctgccagaa actgtttacc
      961 ttcaagtaca gtgaggacat tgtgcgctcc ctctgcctgc cggacttccc ggagccagct
     1021 gacctcttct ggaagtatct ggacctggcc accttcatcc tgctctacct acttccactc
     1081 ttcattatct cagtggccta tgctcgtgtg gccaagaagc tgtggctctg taacaccatt
     1141 ggcgacgtga ccacagagca gtacctcgcc ctgcgacgca agaagaagac caccgtgaag
     1201 atgctggtgc ttgtggtagt cctctttgcc ctctgctggt tccctctcaa ctgctatgtc
     1261 ctcctcttgt ccagcaaggc catccacacc aacaatgccc tctactttgc cttccactgg
     1321 tttgccatga gcagtacttg ttataacccc ttcatctact gctggctcaa tgagaacttt
     1381 agggttgagc ttaaggcatt gctgagcatg tgccaaaggc cacccaagcc gcaggaagac
     1441 aggctaccct ccccagttcc ttccttcagg gtggcatgga cagagaagag ccatggtcgg
     1501 agggctccac tacctaatca ccacttgccc tcttcccaga tccagtctgg gaagacagat
     1561 ctgtcatctg tggaacccgt tgtggccatg agttagggaa agctggaagt tggtggggga
     1621 gggttctttc ctctcacaat tgaccagaca ctaacagagt tggaaagtaa cacagaagca
     1681 gtgagatgct tgggttccta ggaacctgtc cagccccatc tgatttgcaa actttctaga
     1741 agatgccatg aggtggtgtg tgtagatctt tgagcaagag ctctggaaac cacctcagct
     1801 tcaacagagg ctggtccagt caaccacctc caattgtgta gcatctgcca ccttgccctt
     1861 cctactgctg agcaaccaca gggggacttg agccatacta ttggtgggcc tgccccacat
     1921 gctcagaaaa gaacaggcac aaaggctttc tgaagtcatt ggaacaggaa taatcacaca
     1981 gcttcagtga ccttggctct atccatgacc agacaggacc cattttggct tcttaaaaac
     2041 aaagagaaat tagtattgcc actttgaaaa gttcagaaaa gtaaagaaat gagttcagcc
     2101 ctcaatttgt aaaaaaagga aaaaagaaaa aaaaaagaaa aagaaagaaa aaagcctgtt
     2161 aatatgctgt aaatttatct gtagctttgc cttctgtgtg tgtacatttg tacttttaaa
     2221 atcctgaact acacgtgtcc atgtagattg taataattag caagaaactg gaatatatca
     2281 gagtattatt gaattcctcc gtaatgaatg gggcccctca gtaaatgaga atagaaggga
     2341 gaggagagga gagcaaggtg agggtcaact ctgtcttgta actagcgatg ggtggggcct
     2401 agccccaccc taagtggtta ctaccaagat gagcagcaca caggagagct gggtggtagg
     2461 agcccttccc ctgacctcca gaaacaagaa ggggtgaacc actgttcctt tttaatggac
     2521 aatgagagcc ttgctttcca ataagctgga aataattgtg cttagacacc tcatctgccc
     2581 aagctgtcta gacagggcat ttttctgttg tctgaatgat gaaaaaaaat ttttcacacc
     2641 agttcctgag agaagatttc cctgtctaca tcacttgaga aattcatgtg tcattttttc
     2701 aaaacttacc ggcttcttaa agcaacttta ggccttaagg gcccctttgt cagagaaatc
     2761 tcattccagg tagccagcaa tttcatcacc ttccatatgg tattgctgac tcgcagcatc
     2821 acccattgac agatgtgtca ggcagaaccg actctacacc caagcccaga gcggtggctg
     2881 ccattgtact agcttcagat tcccatctcc tcacagagct gtcatggaga caaagcgtct
     2941 ttgtggagct gagagggaaa ctgaggcttg agggaaaaga ggctcatcca agactcattt
     3001 agaactctca gttggtaact gaagcaccaa ttggttaagc ctgatttggt aacaaaccta
     3061 ggggttttct taaactaatc aatccatggg agtgttagaa aatttccaaa attaaaaaaa
     3121 gtcatctaca gaacagcaga tttttaaaga aaaatgtctt ggtgagggta gaaggagatt
     3181 tccaaatata aagtgagttt ttgaggccac agcttctgca actgtcctga tctctgtaat
     3241 gtcagctggt acctgtgagt tgcatctttc ctatggccaa ggagagtcag cctgaggaca
     3301 ggtagctgca gcacacagtg tgtcttcccc agagaactgt ggaaagagct tcagtcacac
     3361 ctccctaagg agagctgaag atagtgccct gtcacagagt aggccctcag ggccgcatct
     3421 cctgttggtc cctgtctgct cccttcccca tattctctgt atgcatctga gcagatgtaa
     3481 ctggtaacag tgactgtggt ctttgtgaag cctgagtttt tccaatatgc tctaaagtgt
     3541 gctttattgt aagtcactgt aagcgcaata aaacctcttc tctgtg
//
