LOCUS       NP_034417                423 aa            linear   ROD 28-AUG-2024
DEFINITION  G-protein coupled receptor 83 isoform 1 precursor [Mus musculus].
ACCESSION   NP_034417
VERSION     NP_034417.1
DBSOURCE    REFSEQ: accession NM_010287.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 423)
  AUTHORS   Zhang,D., Turecek,J., Choi,S., Delisle,M., Pamplona,C.L.,
            Meltzer,S. and Ginty,D.D.
  TITLE     C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway
  JOURNAL   bioRxiv (2024)
   PUBMED   38915692
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 423)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 423)
  AUTHORS   Zhu,Q., Ge,J., Liu,Y., Xu,J.W., Yan,S. and Zhou,F.
  TITLE     Decoding anterior-posterior axis emergence among mouse, monkey, and
            human embryos
  JOURNAL   Dev Cell 58 (1), 63-79 (2023)
   PUBMED   36626872
REFERENCE   4  (residues 1 to 423)
  AUTHORS   Kim,Y., Kim,C., Lee,H., Kim,M., Zheng,H., Lim,J.Y., Yun,H.I.,
            Jeon,M., Choi,J. and Hwang,S.W.
  TITLE     Gpr83 Tunes Nociceptor Function, Controlling Pain
  JOURNAL   Neurotherapeutics 20 (1), 325-337 (2023)
   PUBMED   36352334
  REMARK    GeneRIF: Gpr83 Tunes Nociceptor Function, Controlling Pain.
REFERENCE   5  (residues 1 to 423)
  AUTHORS   Fakira,A.K., Lueptow,L.M., Trimbake,N.A. and Devi,L.A.
  TITLE     PEN Receptor GPR83 in Anxiety-Like Behaviors: Differential
            Regulation in Global vs Amygdalar Knockdown
  JOURNAL   Front Neurosci 15, 675769 (2021)
   PUBMED   34512237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 423)
  AUTHORS   Parker,R., Liu,M., Eyre,H.J., Copeland,N.G., Gilbert,D.J.,
            Crawford,J., Sutherland,G.R., Jenkins,N.A. and Herzog,H.
  TITLE     Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic
            organisation and assignment to human chromosome 11q21.1 and 2p14
            and mouse chromosome 9 and 6
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 369-375 (2000)
   PUBMED   10760605
REFERENCE   7  (residues 1 to 423)
  AUTHORS   Buaas,F.W., Lee,K., Edelhoff,S., Disteche,C. and Braun,R.E.
  TITLE     Cloning and characterization of the mouse interleukin enhancer
            binding factor 3 (Ilf3) homolog in a screen for RNA binding
            proteins
  JOURNAL   Mamm Genome 10 (5), 451-456 (1999)
   PUBMED   10337617
REFERENCE   8  (residues 1 to 423)
  AUTHORS   Ashby,B.
  TITLE     Co-expression of prostaglandin receptors with opposite effects: a
            model for homeostatic control of autocrine and paracrine signaling
  JOURNAL   Biochem Pharmacol 55 (3), 239-246 (1998)
   PUBMED   9484788
  REMARK    Review article
REFERENCE   9  (residues 1 to 423)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (residues 1 to 423)
  AUTHORS   Harrigan,M.T., Campbell,N.F. and Bourgeois,S.
  TITLE     Identification of a gene induced by glucocorticoids in murine
            T-cells: a potential G protein-coupled receptor
  JOURNAL   Mol Endocrinol 5 (9), 1331-1338 (1991)
   PUBMED   1663214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035356.1, AK081276.1, AK041527.1 and AK030359.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081276.1, AK035356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 4.4 cM"
     Protein         1..423
                     /product="G-protein coupled receptor 83 isoform 1
                     precursor"
                     /note="probable G-protein coupled receptor 83;
                     glucocorticoid-induced receptor"
                     /calculated_mol_wt=46272
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1883
     mat_peptide     18..423
                     /product="G-protein coupled receptor 83.
                     /id=PRO_0000012804"
                     /note="propagated from UniProtKB/Swiss-Prot (P30731.2)"
                     /calculated_mol_wt=46272
     Site            38
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P30731.2)"
     Site            46
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P30731.2)"
     Region          72..356
                     /region_name="7tmA_GPR83"
                     /note="G protein-coupled receptor 83, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; cd15389"
                     /db_xref="CDD:320511"
     Site            72..92
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30731.2)"
     Region          73..99
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320511"
     Region          106..131
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320511"
     Site            108..129
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30731.2)"
     Site            order(128,131..132,144..149,151..152,155,198,200..204,236,
                     239..241,243..245,247..248,305,308..309,311..312,315,
                     323..324,326..328,331,334..335)
                     /site_type="other"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:320511"
     Site            134
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P30731.2)"
     Region          144..174
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320511"
     Site            146..167
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30731.2)"
     Region          185..206
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320511"
     Site            187..208
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30731.2)"
     Region          236..265
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320511"
     Site            239..260
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30731.2)"
     Region          285..315
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320511"
     Site            294..315
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30731.2)"
     Region          324..349
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320511"
     Site            328..348
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30731.2)"
     Region          389..423
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P30731.2)"
     CDS             1..423
                     /gene="Gpr83"
                     /gene_synonym="Gir; Gpr72; RP105; RP39; RP82"
                     /coded_by="NM_010287.3:325..1596"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS22829.1"
                     /db_xref="GeneID:14608"
                     /db_xref="MGI:MGI:95712"
ORIGIN      
        1 mkvppvlllf llssvrateq pqvvtehpsm eaaltgpnas shfwanytfs dwqnfvgrrr
       61 ygaesqnptv kallivaysf tivfslfgnv lvchvifknq rmhsatslfi vnlavadimi
      121 tllntpftlv rfvnstwvfg kgmchvsrfa qycslhvsal tltaiavdrh qvimhplkpr
      181 isitkgviyi aviwvmatff slphaicqkl ftfkysediv rslclpdfpe padlfwkyld
      241 latfillyll plfiisvaya rvakklwlcn tigdvtteqy lalrrkkktt vkmlvlvvvl
      301 falcwfplnc yvlllsskai htnnalyfaf hwfamsstcy npfiycwlne nfrvelkall
      361 smcqrppkpq edrlpspvps frvawteksh grraplpnhh lpssqiqsgk tdlssvepvv
      421 ams
//
