LOCUS       NM_175490               2938 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus G protein-coupled receptor 75 (Gpr75), mRNA.
ACCESSION   NM_175490
VERSION     NM_175490.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2938)
  AUTHORS   Jiang,Y., Xun,Y. and Zhang,Z.
  TITLE     Central regulation of feeding and body weight by ciliary GPR75
  JOURNAL   J Clin Invest 134 (19), e182121 (2024)
   PUBMED   39137039
  REMARK    GeneRIF: GPR75 is a ciliary protein expressed in the brain and
            plays an important role in regulating food intake.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2938)
  AUTHORS   Leeson-Payne,A., Iyinikkel,J., Malcolm,C., Lam,B.Y.H., Sommer,N.,
            Dowsett,G.K.C., Martinez de Morentin,P.B., Thompson,D.,
            Mackenzie,A., Chianese,R., Kentistou,K., Gardner,E.J.,
            Perry,J.R.B., Grassmann,F., Speakman,J.R., Rochford,J.J.,
            Yeo,G.S.H., Murray,F. and Heisler,L.K.
  TITLE     Loss of GPR75 protects against non-alcoholic fatty liver disease
            and body fat accumulation
  JOURNAL   Cell Metab 36 (5), 1076-1087 (2024)
   PUBMED   38653246
  REMARK    GeneRIF: Loss of GPR75 protects against non-alcoholic fatty liver
            disease and body fat accumulation.
REFERENCE   3  (bases 1 to 2938)
  AUTHORS   D'Addario,C.A., Matsumura,S., Kitagawa,A., Lainer,G.M., Zhang,F.,
            D'silva,M., Khan,M.Y., Froogh,G., Gruzdev,A., Zeldin,D.C.,
            Schwartzman,M.L. and Gupte,S.A.
  TITLE     Global and endothelial G-protein coupled receptor 75 (GPR75)
            knockout relaxes pulmonary artery and mitigates hypoxia-induced
            pulmonary hypertension
  JOURNAL   Vascul Pharmacol 153, 107235 (2023)
   PUBMED   37742819
REFERENCE   4  (bases 1 to 2938)
  AUTHORS   Vasudevan,S., Samuels,I.S. and Park,P.S.
  TITLE     Gpr75 knockout mice display age-dependent cone photoreceptor cell
            loss
  JOURNAL   J Neurochem 167 (4), 538-555 (2023)
   PUBMED   37840219
  REMARK    GeneRIF: Gpr75 knockout mice display age-dependent cone
            photoreceptor cell loss.
REFERENCE   5  (bases 1 to 2938)
  AUTHORS   Speidell,A., Walton,S., Campbell,L.A., Tomassoni-Ardori,F.,
            Tessarollo,L., Corbo,C., Taraballi,F. and Mocchetti,I.
  TITLE     Mice deficient for G-protein-coupled receptor 75 display altered
            presynaptic structural protein expression and disrupted fear
            conditioning recall
  JOURNAL   J Neurochem 165 (6), 827-841 (2023)
   PUBMED   36978267
  REMARK    GeneRIF: Mice deficient for G-protein-coupled receptor 75 display
            altered presynaptic structural protein expression and disrupted
            fear conditioning recall.
REFERENCE   6  (bases 1 to 2938)
  AUTHORS   Hossain,S., Gilani,A., Pascale,J., Villegas,E., Diegisser,D.,
            Agostinucci,K., Kulaprathazhe,M.M., Dirice,E., Garcia,V. and
            Schwartzman,M.L.
  TITLE     Gpr75-deficient mice are protected from high-fat diet-induced
            obesity
  JOURNAL   Obesity (Silver Spring) 31 (4), 1024-1037 (2023)
   PUBMED   36854900
  REMARK    GeneRIF: Gpr75-deficient mice are protected from high-fat
            diet-induced obesity.
REFERENCE   7  (bases 1 to 2938)
  AUTHORS   Akbari,P., Gilani,A., Sosina,O., Kosmicki,J.A., Khrimian,L.,
            Fang,Y.Y., Persaud,T., Garcia,V., Sun,D., Li,A., Mbatchou,J.,
            Locke,A.E., Benner,C., Verweij,N., Lin,N., Hossain,S.,
            Agostinucci,K., Pascale,J.V., Dirice,E., Dunn,M., Kraus,W.E.,
            Shah,S.H., Chen,Y.I., Rotter,J.I., Rader,D.J., Melander,O.,
            Still,C.D., Mirshahi,T., Carey,D.J., Berumen-Campos,J.,
            Kuri-Morales,P., Alegre-Diaz,J., Torres,J.M., Emberson,J.R.,
            Collins,R., Balasubramanian,S., Hawes,A., Jones,M., Zambrowicz,B.,
            Murphy,A.J., Paulding,C., Coppola,G., Overton,J.D., Reid,J.G.,
            Shuldiner,A.R., Cantor,M., Kang,H.M., Abecasis,G.R., Karalis,K.,
            Economides,A.N., Marchini,J., Yancopoulos,G.D., Sleeman,M.W.,
            Altarejos,J., Della Gatta,G., Tapia-Conyer,R., Schwartzman,M.L.,
            Baras,A., Ferreira,M.A.R. and Lotta,L.A.
  CONSRTM   Regeneron Genetics Center; DiscovEHR Collaboration
  TITLE     Sequencing of 640,000 exomes identifies GPR75 variants associated
            with protection from obesity
  JOURNAL   Science 373 (6550) (2021)
   PUBMED   34210852
REFERENCE   8  (bases 1 to 2938)
  AUTHORS   Liu,B., Hassan,Z., Amisten,S., King,A.J., Bowe,J.E., Huang,G.C.,
            Jones,P.M. and Persaud,S.J.
  TITLE     The novel chemokine receptor, G-protein-coupled receptor 75, is
            expressed by islets and is coupled to stimulation of insulin
            secretion and improved glucose homeostasis
  JOURNAL   Diabetologia 56 (11), 2467-2476 (2013)
   PUBMED   23979485
  REMARK    GeneRIF: Although CCL5 is implicated in the pathogenesis of
            diabetes through activation of CCRs, it has beneficial effects on
            beta cells through GPR75 activation.
REFERENCE   9  (bases 1 to 2938)
  AUTHORS   Ignatov,A., Robert,J., Gregory-Evans,C. and Schaller,H.C.
  TITLE     RANTES stimulates Ca2+ mobilization and inositol trisphosphate
            (IP3) formation in cells transfected with G protein-coupled
            receptor 75
  JOURNAL   Br J Pharmacol 149 (5), 490-497 (2006)
   PUBMED   17001303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141614.1 and BQ175263.1.
            
            On Mar 19, 2011 this sequence version replaced NM_175490.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141614.1, SRR1660819.141259.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2881              AK141614.1         2-2882
            2882-2938           BQ175263.1         1-57                c
FEATURES             Location/Qualifiers
     source          1..2938
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 18.16 cM"
     gene            1..2938
                     /gene="Gpr75"
                     /note="G protein-coupled receptor 75"
                     /db_xref="GeneID:237716"
                     /db_xref="MGI:MGI:2441843"
     exon            1..185
                     /gene="Gpr75"
                     /inference="alignment:Splign:2.1.0"
     exon            186..2926
                     /gene="Gpr75"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1916
                     /gene="Gpr75"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 75"
                     /protein_id="NP_780699.2"
                     /db_xref="CCDS:CCDS24508.1"
                     /db_xref="GeneID:237716"
                     /db_xref="MGI:MGI:2441843"
                     /translation="MNTSAPLQNVPNATLLNMPPLHGGNSTSLQEGLRDFIHTATLVT
                     CTFLLAIIFCLGSYGNFIVFLSFFDPSFRKFRTNFDFMILNLSFCDLFICGVTAPMFT
                     FVLFFSSASSIPDSFCFTFHLTSSGFVIMSLKMVAVIALHRLRMVMGKQPNCTASFSC
                     ILLLTLLLWATSFTLATLATLRTNKSHLCLPMSSLMDGEGKAILSLYVVDFTFCVAVV
                     SVSYIMIAQTLRKNAQVKKCPPVITVDASRPQPFMGASVKGNGDPIQCTMPALYRNQN
                     YNKLQHSQTHGYTKNINQMPIPSASRLQLVSAINFSTAKDSKAVVTCVVIVLSVLVCC
                     LPLGISLVQMVLSDNGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLRRKVLWCLR
                     YTGLGFLCCKQKTRLRAMGKGNLEINRNKSSHHETNSAYMLSPKPQRKFVDQACGPSH
                     SKESAASPKVSAGHQPCGQSSSTPINTRIEPYYSIYNSSPSQQESGPANLPPVNSFGF
                     ASSYIAMHYYTTNDLMQEYDSTSAKQIPIPSV"
     regulatory      2898..2903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr75"
                     /note="hexamer: AATAAA"
     polyA_site      2926
                     /gene="Gpr75"
                     /note="major polyA site"
ORIGIN      
        1 agagggaggg gccgcgcccc gggttcggtg actgcgccgc gcgcccggct cgcctaggct
       61 cccgggatgc gcggaggcgg cagcgatggc gatgatgact ctagcccggc agcttccagg
      121 ccaccgggca cagatagggt cactactgcg acacggagga ggaagggcgg cgctgaggcc
      181 agctggctta tcttctttgg cacatgctcg tcgtctgtga gctgagatcc tgactctttt
      241 cctgctgaat ttattttttt gagaacacaa gaaagagaca cctctctctg aagatgaaca
      301 caagtgcccc gcttcagaat gtccccaatg ccaccttgct aaacatgcct cccctgcacg
      361 ggggaaatag cacttctctc caggaaggtc ttcgagattt tatccacaca gccaccttgg
      421 tgacctgcac ttttctgctt gccatcatct tctgtctagg ctcttatgga aattttattg
      481 tcttcttgtc tttctttgac ccatccttca ggaagttcag aaccaacttt gatttcatga
      541 tcttgaacct gtctttctgt gatctgttca tctgtggggt cacagccccc atgttcacct
      601 tcgtgctgtt cttcagctca gccagtagca tcccagatag cttctgcttc accttccacc
      661 ttaccagctc aggcttcgtc atcatgtccc tcaagatggt ggctgtgatt gctctgcacc
      721 ggctccggat ggtgatgggg aagcagccta attgtacagc ctccttttcc tgcatcttgc
      781 tccttaccct tcttctctgg gcgaccagct ttacacttgc caccttggct acactgagaa
      841 ccaataagtc ccacctgtgt ctccccatgt ccagtcttat ggatggggaa gggaaagcca
      901 ttctgtctct gtatgttgtt gactttacct tctgtgttgc tgtggtgtct gtctcttata
      961 ttatgattgc tcaaaccctt cggaaaaatg ctcaagtaaa aaagtgcccc ccggtgatca
     1021 cagttgatgc ttccagacca cagccattca tgggggcctc tgtgaaggga aatggagatc
     1081 ccatccagtg caccatgcca gctctgtata ggaaccagaa ttataacaaa ctgcagcaca
     1141 gtcaaactca tggatacact aagaatatca accagatgcc aatcccctca gccagtcgac
     1201 tccagctggt atcagccatc aacttctcta ctgccaagga ttccaaagcc gtggtcacct
     1261 gtgtggtcat cgtgttgtca gtcctggtgt gctgtcttcc tcttgggatt tccctggtgc
     1321 aaatggttct gtctgacaat ggcagtttta tcctttacca gtttgaactg tttggattta
     1381 ctctgatatt tttcaagtca ggattaaatc cttttatata ttctcggaac agtgctgggc
     1441 tgagaaggaa agtactctgg tgcctgagat acactggcct gggctttctc tgctgcaaac
     1501 agaaaactcg acttcgggcc atgggaaaag ggaaccttga aatcaataga aacaaatctt
     1561 ctcatcatga gacaaactct gcctacatgc tgtctccaaa accacagaga aaatttgtgg
     1621 accaggcttg tggcccaagt cactcaaagg aaagtgcagc gagtcccaaa gtttctgctg
     1681 gacatcaacc ctgtggtcaa agcagttcca cacccatcaa cactaggatt gaaccttact
     1741 atagcatcta taacagcagc ccttcccagc aggagagcgg tccggcaaac ttgcctccag
     1801 tgaactcttt tgggtttgcc agttcctaca tcgccatgca ctattacacc accaatgatt
     1861 tgatgcagga atatgacagc acgtcagcaa aacaaattcc tatcccctct gtttaacatg
     1921 gccagcgagt ctggagggaa tggttttcta ttctaactaa gcaagccttt aaaagagttt
     1981 gcaaagcaaa acctggactc aactgaacac ttgacaattt gattttcttt tgtttataat
     2041 attagtatct gggttggctt catggtttct tgacatttta agatttgatg taaaagttta
     2101 tttcaacttc tactctaatc tatgtcccaa tactttatat taaactgcta agaagatgct
     2161 aggatctatc ctactgatga ccttttaagt cagtattatg ggactttaga tatgtattgg
     2221 ctacattttc tttctttcca tttatttatt tactcacttt atatcctgat tgaagcccca
     2281 cctctcctcc cagtacccgc tcacatggcc cttctcccaa ttcctactac cctttatttc
     2341 tgaaaagggg gaggttcctc ctgggtaacc aacccaccct ggcacctcaa gtcactgcag
     2401 gactaggtat atcctctgcc actaaggcca gacatggcag cccaattacg ggagcaggat
     2461 tcacagacag gaaatagagt cagggacaac cactgctcta tttgttggga gacccacatg
     2521 aagaccaagc tgttacaaat gtgctggtga gcctaggtcc agctcatatg tgctctttag
     2581 ttggtggttc agtctctggg agccttcaag ggtcaggtta gttgcctctg ttggtattct
     2641 gaaggggtac ctattccctc caggttcctc aatccttccc ccaactcatt cacaagactt
     2701 cccaggctca gtctaatgtt tcgctgtggt actctgcatc tgtttctgtc aactgctata
     2761 atttggctac attttttaaa atgtgtttga aaaaaaaatg atctttctga agtgttattt
     2821 ttataaaaat atggaatttg tgtttttgaa gtactgaaac agcaaacagt gtactttttt
     2881 tggtggcaag tgatttaaat aaaaaactta ctattaaagc aaaaaaaaaa aaaaaaaa
//
