LOCUS       NM_001177674            2958 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus G protein-coupled receptor 68 (Gpr68), transcript
            variant 3, mRNA.
ACCESSION   NM_001177674
VERSION     NM_001177674.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2958)
  AUTHORS   Williams,M.D., Morgan,J.S., Bullock,M.T., Poovey,C.E.,
            Wisniewski,M.E., Francisco,J.T., Barajas-Nunez,J.A., Hijazi,A.M.,
            Theobald,D., Sriramula,S., Mansfield,K.D., Holland,N.A. and
            Tulis,D.A.
  TITLE     pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation
            through Rap1A
  JOURNAL   Am J Physiol Heart Circ Physiol 327 (5), H1210-H1229 (2024)
   PUBMED   39269448
  REMARK    GeneRIF: pH-sensing GPR68 inhibits vascular smooth muscle cell
            proliferation through Rap1A.
REFERENCE   2  (bases 1 to 2958)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2958)
  AUTHORS   Shore,D., Griggs,N., Graffeo,V., Amin,A.R.M.R., Zha,X.M., Xu,Y. and
            McAleer,J.P.
  TITLE     GPR68 limits the severity of chemical-induced oral epithelial
            dysplasia
  JOURNAL   Sci Rep 13 (1), 353 (2023)
   PUBMED   36611126
  REMARK    GeneRIF: GPR68 limits the severity of chemical-induced oral
            epithelial dysplasia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2958)
  AUTHORS   Nogueira,P.A.S., Moura-Assis,A., Razolli,D.S., Bombassaro,B.,
            Zanesco,A.M., Gaspar,J.M., Donato Junior,J. and Velloso,L.A.
  TITLE     The orphan receptor GPR68 is expressed in the hypothalamus and is
            involved in the regulation of feeding
  JOURNAL   Neurosci Lett 781, 136660 (2022)
   PUBMED   35489647
  REMARK    GeneRIF: The orphan receptor GPR68 is expressed in the hypothalamus
            and is involved in the regulation of feeding.
REFERENCE   5  (bases 1 to 2958)
  AUTHORS   Nayak,A.P., Deshpande,D.A., Shah,S.D., Villalba,D.R., Yi,R.,
            Wang,N. and Penn,R.B.
  TITLE     OGR1-dependent regulation of the allergen-induced asthma phenotype
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 321 (6), L1044-L1054 (2021)
   PUBMED   34668419
  REMARK    GeneRIF: OGR1-dependent regulation of the allergen-induced asthma
            phenotype.
REFERENCE   6  (bases 1 to 2958)
  AUTHORS   Mogi,C., Tobo,M., Tomura,H., Murata,N., He,X.D., Sato,K.,
            Kimura,T., Ishizuka,T., Sasaki,T., Sato,T., Kihara,Y., Ishii,S.,
            Harada,A. and Okajima,F.
  TITLE     Involvement of proton-sensing TDAG8 in extracellular
            acidification-induced inhibition of proinflammatory cytokine
            production in peritoneal macrophages
  JOURNAL   J Immunol 182 (5), 3243-3251 (2009)
   PUBMED   19234222
REFERENCE   7  (bases 1 to 2958)
  AUTHORS   Frick,K.K., Krieger,N.S., Nehrke,K. and Bushinsky,D.A.
  TITLE     Metabolic acidosis increases intracellular calcium in bone cells
            through activation of the proton receptor OGR1
  JOURNAL   J Bone Miner Res 24 (2), 305-313 (2009)
   PUBMED   18847331
  REMARK    GeneRIF: OGR1 induces an increase in Ca(i) in response to acidic
            medium and is a prime candidate for an osteoblast proton sensor.
REFERENCE   8  (bases 1 to 2958)
  AUTHORS   Iwai,K., Koike,M., Ohshima,S., Miyatake,K., Uchiyama,Y., Saeki,Y.
            and Ishii,M.
  TITLE     RGS18 acts as a negative regulator of osteoclastogenesis by
            modulating the acid-sensing OGR1/NFAT signaling pathway
  JOURNAL   J Bone Miner Res 22 (10), 1612-1620 (2007)
   PUBMED   17576169
  REMARK    GeneRIF: regulator of G-protein signaling 18 acts as a negative
            regulator of the acidosis-induced osteoclastogenic OGR1/NFAT
            signaling pathway
REFERENCE   9  (bases 1 to 2958)
  AUTHORS   Ikeno,Y., Konno,N., Cheon,S.H., Bolchi,A., Ottonello,S.,
            Kitamoto,K. and Arioka,M.
  TITLE     Secretory phospholipases A2 induce neurite outgrowth in PC12 cells
            through lysophosphatidylcholine generation and activation of G2A
            receptor
  JOURNAL   J Biol Chem 280 (30), 28044-28052 (2005)
   PUBMED   15927955
REFERENCE   10 (bases 1 to 2958)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126262.4.
            
            On Mar 24, 2020 this sequence version replaced NM_001177674.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.15740.1,
                                           SRR7345562.880975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream ORF predicted to
                                                inhibit translation from
                                                upstream AUG
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC126262.4         105167-105304
            139-227             AC126262.4         116475-116563
            228-2958            AC126262.4         125135-127865
FEATURES             Location/Qualifiers
     source          1..2958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 51.1 cM"
     gene            1..2958
                     /gene="Gpr68"
                     /gene_synonym="Ogr1"
                     /note="G protein-coupled receptor 68"
                     /db_xref="GeneID:238377"
                     /db_xref="MGI:MGI:2441763"
     exon            1..138
                     /gene="Gpr68"
                     /gene_synonym="Ogr1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..227
                     /gene="Gpr68"
                     /gene_synonym="Ogr1"
                     /inference="alignment:Splign:2.1.0"
     exon            228..2958
                     /gene="Gpr68"
                     /gene_synonym="Ogr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..1454
                     /gene="Gpr68"
                     /gene_synonym="Ogr1"
                     /note="sphingosylphosphorylcholine receptor"
                     /codon_start=1
                     /product="ovarian cancer G-protein coupled receptor 1"
                     /protein_id="NP_001171145.1"
                     /db_xref="CCDS:CCDS26109.1"
                     /db_xref="GeneID:238377"
                     /db_xref="MGI:MGI:2441763"
                     /translation="MGNITTENSSLSCPIDHTIHQTLAPVVYVTVLVVGFPANCLSLY
                     FGYLQIKARNELGVYLCNLTIADLFYICSLPFWLQYVLQHDDWSHGDLSCQVCGILLY
                     ENIYISVGFLCCISIDRYLAVAHPFRFHQFRTLKAAVGVSVLIWAKELLTSIYFLNHK
                     EVIEDEDQHRVCFEHYPIQAWQRSINYYRFLVGFLFPICLLLASYQGILRAVRRSHGT
                     QKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSLWERNCEFAKSIFNVYHFSLLLTS
                     FNCVADPVLYCFVSETTHRDLARLRGACLAVLTCSRTSRAREAYPLGAPEASGKSGAQ
                     GEEPELLTKLHSAFQTPSSLGVGGPSTVGLA"
     regulatory      2935..2940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr68"
                     /gene_synonym="Ogr1"
                     /note="hexamer: AATAAA"
     polyA_site      2958
                     /gene="Gpr68"
                     /gene_synonym="Ogr1"
                     /note="major polyA site"
ORIGIN      
        1 aggaatctcg cacaacgtgg cccagagtgg ctaggagaaa gggacctgcg tgccttgcag
       61 gagtccccag cctttccagg aggcgcacgc actgcaccag aggacatcag gcccgcgtcc
      121 cagactgtcg ctgcacagga ttgagagagg gagagctcgt ccgcgtgcag cgttgtccag
      181 acactgccaa gttgagctgt aggagtacag ctggcggagg actgaggggg gtccgcctac
      241 caccagtgat gcctagatcc tgatacattt gcatcacctt ctataaacaa gatggcaaga
      301 gagggattgg ctccatctcc aagcccatga ggaataaggc tccttctggc ccaaagatgg
      361 ggaacatcac tacagaaaac tcctcactat cttgccccat cgaccacacc atccaccaga
      421 cactagcccc agtggtctat gtgaccgtgc tggtggtggg cttcccagcc aactgcctgt
      481 ccctctactt cgggtacttg cagatcaagg cccggaatga gctgggagtg tacctgtgta
      541 acctgaccat tgcagacctg ttctatatct gttcacttcc cttctggctg cagtacgtgc
      601 ttcagcacga cgactggtcc catggtgacc tatcctgcca ggtgtgtggc atcctcctct
      661 atgagaacat ttacatcagc gtgggcttcc tctgctgcat ctccatcgac cgctacctgg
      721 ctgtggccca ccccttccgc ttccaccagt tccgcaccct gaaggcagcc gtgggtgtca
      781 gtgtgctcat ctgggccaag gagctgctga ccagcatcta cttcctcaat cacaaggagg
      841 tcattgagga cgaggaccag caccgagtct gctttgagca ttaccctatc caggcctggc
      901 agcgtagcat caactactac cgcttcctgg tgggctttct cttccccatc tgcctgctgc
      961 tggcctccta ccagggcatc ctgcgggctg tgcgccgcag ccacggcaca cagaagagcc
     1021 gcaaggacca gattcagcgg ctggtgctca gcaccgtggt catcttcctg gcttgctttc
     1081 taccctacca cgtgctgctg ctggtacgca gcctctggga gagaaactgt gagtttgcca
     1141 agagcatctt caacgtctat cacttctccc tcctcctcac cagcttcaac tgtgtagctg
     1201 acccggtgct gtactgcttt gtcagtgaga ccactcacag ggacctagcc cgcctccgag
     1261 gagcctgcct agctgtcctt acctgctcta ggacaagcag ggccagggag gcctaccctc
     1321 tgggtgcccc tgaggcctct gggaaaagtg gggcccaggg cgaggaacct gaattgttaa
     1381 ccaagctcca ctcagccttc cagaccccta gctcactggg agtgggaggg ccctccacag
     1441 tggggttggc ctagcttgag tcacgtgtat gaggctaagt taggccctga gctttcacca
     1501 acaggccttg tggtcgggag cttgcatggt ggctgtctcc cactttacca tgtacgggtg
     1561 cctctctcct caggaaggaa ccatggtttg ggccacagcc aggtccctct ggcccctgga
     1621 aacctgctcc gtgtcctgag cctgggcact gctgactgtg tgaatgagcc ctgtctcctc
     1681 ccatgttctt ggtggccgcc tgggctgcag atgggaggga gtcggcatcg tcacttccag
     1741 gagatttgca aagagcagca ggcctggggt gcggagagga gggtaggacc ctgcgtggtc
     1801 acctgccaag ccttccagtg cccctgttgt cacagacgat accagcccaa gtgtgctatg
     1861 gtcttgtgtg acacaggaag ctatatagcc accatcagta tttgagcttg cctctaaact
     1921 agtctaggcc agaggactgg ttaaggtgaa gaacaggggc ggggttggtg gctagggata
     1981 acagcagaga ggcagtcagg gaagaaaccc cagcatcagg cacgtctcac tttacagaac
     2041 ttatggaaca gggccccacc cccaagggct gatggcaaag aaaccccagg gatgccggag
     2101 agatgtcagg ggccctcaaa acatcgtact aaagcttaat aagaagactt aggcctaaaa
     2161 ctgcgtcctt agccaagttc ctggcacaca gggtttctct gtgtagccct ggctgtcttg
     2221 gaactcactc tgtagaccag gctggcttcg aactcagaaa tccgcctgcc tctgcctccc
     2281 aagtgttagg attaaaggcg tgcgccacca ctgcccagcc ctaattagct ttttgtgtcc
     2341 gtctagtcta agtgtcagac ctgagagcct aagggagaag aaagagggag aatataaaaa
     2401 aaatggcagg gtgtccatgg caactgtatg ccaagacatt gatactaact aggatcatgt
     2461 atctgttgtc agtaattcct acccttctcc ccatgcacca tagagcatcc agcagctttt
     2521 gagaggagtg tgacagtgac agtttcccag agttcctaag tgcaatgaac taaccacaca
     2581 cacacacaca cacacacaca cacacaatca tgtctcgtga ccacaggttt ggcttaagct
     2641 gcattttggt ataggagagt tggcagagat ggctgcatgc cagaaagacc tacaccttcc
     2701 ccagcctcgg tccttacagg ccaatggtga tagctaagtg ttctgtgcct cctcatccca
     2761 cagtatttcc cctgtttgac ctgaaattct ggattctcac tggcttggac tggagcaagc
     2821 taagcccagc tccccttact aaggagtgct gtatttttgt attgttttct ctcttatgcc
     2881 aagtatccct gtgttggact gtgaggtggg tttatgtagt gacttcagtc agcaaataaa
     2941 acaaagtagc caatcata
//
