LOCUS       NM_001379626            2294 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus G protein-coupled receptor 63 (Gpr63), transcript
            variant 2, mRNA.
ACCESSION   NM_001379626 XM_006538382
VERSION     NM_001379626.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2294)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2294)
  AUTHORS   Snedeker,J., Gibbons,W.J. Jr., Paulding,D.F., Abdelhamed,Z.,
            Prows,D.R. and Stottmann,R.W.
  TITLE     Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants
  JOURNAL   PLoS Genet 15 (11), e1008467 (2019)
   PUBMED   31730647
  REMARK    GeneRIF: This validated Gpr63 as a modifier of multiple Ttc21b
            neural phenotypes and strongly supports Gpr63 as a causal gene
            (i.e., a quantitative trait gene, QTG) within the Moaq1 QTL.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2294)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 2294)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2294)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   6  (bases 1 to 2294)
  AUTHORS   Brunskill,E.W., Aronow,B.J., Georgas,K., Rumballe,B.,
            Valerius,M.T., Aronow,J., Kaimal,V., Jegga,A.G., Yu,J.,
            Grimmond,S., McMahon,A.P., Patterson,L.T., Little,M.H. and
            Potter,S.S.
  TITLE     Atlas of gene expression in the developing kidney at microanatomic
            resolution
  JOURNAL   Dev Cell 15 (5), 781-791 (2008)
   PUBMED   19000842
  REMARK    Erratum:[Dev Cell. 2009 Mar;16(3):482. Yu, Jing [added]]
REFERENCE   7  (bases 1 to 2294)
  AUTHORS   Kawasawa,Y., Kume,K., Nakade,S., Haga,H., Izumi,T. and Shimizu,T.
  TITLE     Brain-specific expression of novel G-protein-coupled receptors,
            with homologies to Xenopus PSP24 and human GPR45
  JOURNAL   Biochem Biophys Res Commun 276 (3), 952-956 (2000)
   PUBMED   11027574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772223.7 and AL772199.11.
            
            On Apr 10, 2020 this sequence version replaced XM_006538382.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927936.1364360.1,
                                           SRR7652917.643079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AL772223.7         187427-187611
            186-2294            AL772199.11        17204-19312
FEATURES             Location/Qualifiers
     source          1..2294
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 10.53 cM"
     gene            1..2294
                     /gene="Gpr63"
                     /gene_synonym="Psp24-2; PSP24beta"
                     /note="G protein-coupled receptor 63"
                     /db_xref="GeneID:81006"
                     /db_xref="MGI:MGI:2135884"
     exon            1..185
                     /gene="Gpr63"
                     /gene_synonym="Psp24-2; PSP24beta"
                     /inference="alignment:Splign:2.1.0"
     exon            186..2294
                     /gene="Gpr63"
                     /gene_synonym="Psp24-2; PSP24beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1611
                     /gene="Gpr63"
                     /gene_synonym="Psp24-2; PSP24beta"
                     /note="G protein-coupled receptor PSP24-2; PSP24-beta"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 63"
                     /protein_id="NP_001366555.1"
                     /db_xref="GeneID:81006"
                     /db_xref="MGI:MGI:2135884"
                     /translation="MVVSGVLTAPAVLTAPHSGTSNTTFVVFENSHVNITAPLPFQHP
                     SAGPLLRYSLETMTSPGFSSLAVNSTAVTPAPAVFKSLNLAVQIILSAIMIFILFVSF
                     LGNLVVCLMVYQKAAMRSAINILLASLAFADMLLAVLNMPFALVTILTTRWIFGKFFC
                     RLSAMFFWLFVIEGVAILLIISIDRFLIIVQRQDKLNPYRAKVLIAVSWATAFSVAFP
                     LAVGNPDLQIPSRAPQCVFGYTTNSGYQAYVILISLISFFIPFLVILYSFMGILNTLR
                     HNALRIHSYPEGICLSQASKLGLMSLQRPFQMSIDMGFKTRAFTTILILFAVFIVCWA
                     PFTTYSLVATFSKHFYYQHNFFEISTWLLWLCYLKSALNPLIYYWRIKKFHDACLDMM
                     PKSFKFLPRLPGHTRRRIRPSAVYVCGEHRTVL"
     regulatory      2257..2262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr63"
                     /gene_synonym="Psp24-2; PSP24beta"
                     /note="hexamer: ATTAAA"
     polyA_site      2294
                     /gene="Gpr63"
                     /gene_synonym="Psp24-2; PSP24beta"
                     /note="major polyA site"
ORIGIN      
        1 gggagccgcc ggcagccggc aaggcggagg cactgccggg cgatgccccg actctccgcc
       61 gccgcctcgg cctcctcctg cgccgggggc tcggagctgt ggagctgcgg tgcgatgtcc
      121 gcaaagttcc gggaggcagc ggtcgcctac tccccgccgt cccgccgcgg cgccttttgt
      181 gcgaggcaaa aggattcttg tggaagatgg agctgtgtcc attttccaga atgtgtatcc
      241 gagcccatca gtggaacctg acctgacagc gctgtatgga aatgcccgaa gaggacccac
      301 ctttctgcct caacctgcca tcctcctaaa aacatggttg tctcaggagt gttgactgct
      361 ccggcagtgt tgactgcgcc ccattctgga acatccaaca cgacgtttgt agtctttgaa
      421 aactcccacg tgaatattac ggctccgcta ccatttcagc atcctagcgc tggtccgctg
      481 cttagataca gccttgaaac catgactagc cctggattta gctccttggc agtgaacagc
      541 acagctgtga ctccagcacc agcagttttt aagagcctaa acttagcggt tcagattatc
      601 ctttcagcca taatgatatt tattctcttt gtgtctttcc ttggaaactt ggttgtttgc
      661 ctcatggtgt accaaaaagc tgccatgcgt tctgcaatta acatcctcct tgccagcctg
      721 gcgtttgcag acatgctgct tgcagtactg aacatgccct ttgctctggt aactattctt
      781 actaccagat ggatatttgg gaaattcttc tgccggttgt cggctatgtt tttctggttg
      841 tttgtgatag agggagtagc catcctgctc attattagta tcgataggtt tctgattata
      901 gttcagaggc aagataagct aaatccctat agggctaagg tcctcattgc agtctcctgg
      961 gcaactgctt tttctgtagc ttttcctttg gccgtgggaa accctgatct gcagatacct
     1021 tccagagccc cacagtgcgt gtttggatac acaaccaatt ctggatacca ggcttatgtg
     1081 attttgattt cactcatttc cttctttata cctttcctgg tcatattata ttcatttatg
     1141 ggcatcctca atacccttcg gcataatgcc ttgaggattc atagctaccc cgaagggata
     1201 tgcctcagcc aggccagcaa actcggtctc atgagtctac agagaccctt ccaaatgagc
     1261 atcgacatgg gctttaaaac acgtgccttt accaccattc tgatcctctt tgccgttttc
     1321 attgtctgct gggccccatt caccacctac agccttgtgg ctaccttcag taagcacttc
     1381 tactatcagc acaacttctt tgagattagc acctggctac tctggctctg ctacctcaag
     1441 tctgcattga acccactgat atactactgg aggattaaga agttccacga tgcctgctta
     1501 gatatgatgc ccaagtcttt caagttcttg ccacggctcc ctggtcacac aaggcgacgg
     1561 attcgcccta gtgccgtcta cgtgtgtggg gaacatcgga cggtgttgtg aatacccgaa
     1621 ctcttgaaac atatcgagcg attatggttt ttgattgact gagttttttt ttttttcata
     1681 tggcttctaa agttttattg gtttttatag tgtgtgtgta cgtgtgtgtg ggggtgggtg
     1741 ggtgtgtaaa aggaatggta aatactttga aaccaaggat atattgtaag aaagtggtca
     1801 catatgttta cctctaggtt aagaaatgtt ttgagtgtgt gtcgggagtg gattttgcta
     1861 gttcagttga ctggttttat ttttgtagca tgaatcggga ttgcgcttca ttgaacctgc
     1921 agctaacttg aattgtaggt ggtttttatg ctgctgagtg aggtaagctt agttgagttg
     1981 atcagttccc ttttcctctc ccacaagcca ctgctgctca ttgctatctt atcagagtca
     2041 aatccctctg cctctcagtt ggtagatgtt aagttttatt taaaaacaaa acccagggag
     2101 gttagtggcg ttgtaatggt tattacagtt tactttggag cactttaaga gacaatgtac
     2161 agattcattc agttgtattt cttagaatcg tttttaatac atgacatgtt gtgtcgtggg
     2221 agatatgcgc tgatgatgtc tagatagacg gcttttatta aaaaatgttt tatctgcatg
     2281 tacaatttca aaaa
//
