LOCUS       NM_199058               1804 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus G protein-coupled receptor 6 (Gpr6), mRNA.
ACCESSION   NM_199058 XM_006512533
VERSION     NM_199058.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1804)
  AUTHORS   Soleilhavoup,C., Travaglio,M., Patrick,K., Garcao,P., Boobalan,E.,
            Adolfs,Y., Spriggs,R.V., Moles-Garcia,E., Dhiraj,D., Oosterveen,T.,
            Ferri,S.L., Abel,T., Brodkin,E.S., Pasterkamp,R.J., Brooks,B.P. and
            Panman,L.
  TITLE     Nolz1 expression is required in dopaminergic axon guidance and
            striatal innervation
  JOURNAL   Nat Commun 11 (1), 3111 (2020)
   PUBMED   32561725
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1804)
  AUTHORS   Xu,Z., Liang,Q., Song,X., Zhang,Z., Lindtner,S., Li,Z., Wen,Y.,
            Liu,G., Guo,T., Qi,D., Wang,M., Wang,C., Li,H., You,Y., Wang,X.,
            Chen,B., Feng,H., Rubenstein,J.L. and Yang,Z.
  TITLE     SP8 and SP9 coordinately promote D2-type medium spiny neuron
            production by activating Six3 expression
  JOURNAL   Development 145 (14) (2018)
   PUBMED   29967281
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1804)
  AUTHORS   Tischfield,D.J., Saraswat,D.K., Furash,A., Fowler,S.C.,
            Fuccillo,M.V. and Anderson,S.A.
  TITLE     Loss of the neurodevelopmental gene Zswim6 alters striatal
            morphology and motor regulation
  JOURNAL   Neurobiol Dis 103, 174-183 (2017)
   PUBMED   28433741
REFERENCE   4  (bases 1 to 1804)
  AUTHORS   Oeckl,P. and Ferger,B.
  TITLE     Increased susceptibility of G-protein coupled receptor 6 deficient
            mice to MPTP neurotoxicity
  JOURNAL   Neuroscience 337, 218-223 (2016)
   PUBMED   27651149
REFERENCE   5  (bases 1 to 1804)
  AUTHORS   Zhang,Q., Zhang,Y., Wang,C., Xu,Z., Liang,Q., An,L., Li,J., Liu,Z.,
            You,Y., He,M., Mao,Y., Chen,B., Xiong,Z.Q., Rubenstein,J.L. and
            Yang,Z.
  TITLE     The Zinc Finger Transcription Factor Sp9 Is Required for the
            Development of Striatopallidal Projection Neurons
  JOURNAL   Cell Rep 16 (5), 1431-1444 (2016)
   PUBMED   27452460
REFERENCE   6  (bases 1 to 1804)
  AUTHORS   Budry,L., Balsalobre,A., Gauthier,Y., Khetchoumian,K., L'honore,A.,
            Vallette,S., Brue,T., Figarella-Branger,D., Meij,B. and Drouin,J.
  TITLE     The selector gene Pax7 dictates alternate pituitary cell fates
            through its pioneer action on chromatin remodeling
  JOURNAL   Genes Dev 26 (20), 2299-2310 (2012)
   PUBMED   23070814
REFERENCE   7  (bases 1 to 1804)
  AUTHORS   Lobo,M.K., Cui,Y., Ostlund,S.B., Balleine,B.W. and Yang,X.W.
  TITLE     Genetic control of instrumental conditioning by striatopallidal
            neuron-specific S1P receptor Gpr6
  JOURNAL   Nat Neurosci 10 (11), 1395-1397 (2007)
   PUBMED   17934457
  REMARK    GeneRIF: Gpr6 is the first striatopallidal neuron-specific genetic
            regulator of instrumental conditioning in a mammal.
REFERENCE   8  (bases 1 to 1804)
  AUTHORS   Tanaka,S., Ishii,K., Kasai,K., Yoon,S.O. and Saeki,Y.
  TITLE     Neural expression of G protein-coupled receptors GPR3, GPR6, and
            GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth
  JOURNAL   J Biol Chem 282 (14), 10506-10515 (2007)
   PUBMED   17284443
REFERENCE   9  (bases 1 to 1804)
  AUTHORS   Ignatov,A., Lintzel,J., Kreienkamp,H.J. and Schaller,H.C.
  TITLE     Sphingosine-1-phosphate is a high-affinity ligand for the G
            protein-coupled receptor GPR6 from mouse and induces intracellular
            Ca2+ release by activating the sphingosine-kinase pathway
  JOURNAL   Biochem Biophys Res Commun 311 (2), 329-336 (2003)
   PUBMED   14592418
  REMARK    GeneRIF: identification, characterization and cloning; identified
            sphingosine-1-phosphate as a high-affinity ligand
REFERENCE   10 (bases 1 to 1804)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX236691.1, AK139367.1 and AW046789.1.
            
            On or before Dec 30, 2017 this sequence version replaced
            XM_006512533.2, NM_199058.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX236691.1, AK139367.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CX236691.1         1-5
            6-1787              AK139367.1         2-1783
            1788-1804           AW046789.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.08 cM"
     gene            1..1804
                     /gene="Gpr6"
                     /gene_synonym="Gm233"
                     /note="G protein-coupled receptor 6"
                     /db_xref="GeneID:140741"
                     /db_xref="MGI:MGI:2155249"
     exon            1..164
                     /gene="Gpr6"
                     /gene_synonym="Gm233"
                     /inference="alignment:Splign:2.1.0"
     exon            165..1791
                     /gene="Gpr6"
                     /gene_synonym="Gm233"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1275
                     /gene="Gpr6"
                     /gene_synonym="Gm233"
                     /note="sphingosine 1-phosphate receptor GPR6"
                     /codon_start=1
                     /product="G-protein coupled receptor 6"
                     /protein_id="NP_951013.1"
                     /db_xref="CCDS:CCDS23802.1"
                     /db_xref="GeneID:140741"
                     /db_xref="MGI:MGI:2155249"
                     /translation="MNASAAALNESQVVAVAAEGAAAAATAAGAPDTGEWGPPAASAA
                     LGGGGGPNGSLELSSQLPAGPSGLLLSAVNPWDVLLCVSGTVIAGENALVVALIASTP
                     ALRTPMFVLVGSLATADLLAGCGLILHFVFQYVVPSETVSLLMVGFLVASFAASVSSL
                     LAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLADRTSCS
                     VVRPLTRSHVALLSTSFFVVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATR
                     KGVGTLAVVLGTFGASWLPFAIYCVVGSQEDPAIYTYATLLPATYNSMINPIIYAFRN
                     QEIQRALWLLFCGCFQSKVPFRSRSPSEV"
     regulatory      1768..1773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpr6"
                     /gene_synonym="Gm233"
                     /note="hexamer: AATAAA"
     polyA_site      1791
                     /gene="Gpr6"
                     /gene_synonym="Gm233"
                     /note="major polyA site"
ORIGIN      
        1 ctctcactcg cagcgaaggt ggctcagcga caggcgacca gtactttcct ctttgacgcg
       61 gggcagcctt ctgcaggcag ctgctcggac cgcgcaggga ggatagccag gcacacagcc
      121 gcggagcgca tgaccagaga ctcccgggat ccctgactcc ccagggagca acatctagcg
      181 gcgatgaacg ctagcgccgc cgcgctcaac gagtcccaag tggtggcagt agcggccgag
      241 ggagcggcag ctgcggctac agcagcaggg gcaccggaca ccggcgaatg gggaccccca
      301 gcagcatccg cagcgctggg aggcggcggc ggacctaacg ggtcactgga gctgtcttct
      361 cagctgccag cagggccctc gggactactg ctttcggcag tgaatccctg ggatgtgctg
      421 ctgtgcgtgt cgggaactgt gatcgcaggc gaaaatgcgc tggtggtggc gctcatcgcg
      481 tccactcccg cgctgcgcac gcccatgttt gtgctcgtgg gtagtctggc cactgctgac
      541 ctgttggcgg gctgtggcct catcttacac ttcgtgttcc agtacgtggt gccctcggag
      601 actgtgagcc tgctcatggt gggcttcctg gtggcgtcct ttgccgcctc agtcagcagc
      661 ctgcttgcta tcacagttga ccgttacctg tctttgtaca acgcgctcac ctactactcg
      721 cgccggaccc tgttgggcgt gcacctcttg ctagcagcca cctggacagt gtccctcggg
      781 ttggggttgc tgcctgttct aggctggaac tgcttggccg accgcacgtc ctgcagcgtg
      841 gtgcgccccc tgacacgcag ccatgtggcg ttgctctcta cttccttctt cgtggtcttt
      901 ggcatcatgc tgcacttgta cgtgcgcatc tgccaggtgg tctggcgcca cgcccaccag
      961 atcgctttgc aacagcattg cctagcaccg ccccacttag cagccaccag aaagggagtg
     1021 ggaactttgg ccgtggtgct aggcactttt ggggccagct ggctgccctt cgccatctat
     1081 tgtgtggtgg gtagccaaga ggacccggcc atctacactt atgccaccct gttgcctgcc
     1141 acctataact ccatgatcaa tcccatcatc tatgccttcc gcaaccagga gatccagcgt
     1201 gccttgtggc tcctgttctg tggctgtttc caatccaaag tgcccttccg ctccaggtcc
     1261 cccagtgagg tctgaagggc tcctcgtgtt ccctcacaaa caccacaaac ccaacatgcc
     1321 agcctttggt gagcgtcaag gtgcctgctg atgaactctt gaggtgtcag tggtgcaaat
     1381 ctgactctgc tggagcaaag ggactgaacg tgaacgcaac gaactgactc agacaaagag
     1441 gcttgttggc attttacata tacagtgtat acatgtgtac atatatatac aaatctttgt
     1501 atcttctgag gtgttcagga cctggagctt cctgttctgt gaaaaccaaa caaaatgtgg
     1561 ttgtatactc aatcgtacat cacatttgtc aagtgaagac attccaatac tgcttaataa
     1621 tagcacttta tttttagctg ctgaaatgcc aagacagtgt tgccatcccc aagagcagga
     1681 gaaagggagt ctaagatgta tttttgttgt atgtgataga gtattttgct gcacatgcat
     1741 cgtaaactac aacatatttt gtacacaaat aaacacatta taaaaatata aaaaaaaaaa
     1801 aaaa
//
