LOCUS       NM_001033290            2550 bp    mRNA    linear   ROD 12-SEP-2023
DEFINITION  Mus musculus G protein-coupled receptor 55 (Gpr55), mRNA.
ACCESSION   NM_001033290 XM_136804
VERSION     NM_001033290.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2550)
  AUTHORS   Ono T, Yamashita T, Kano R, Inoue M, Okada S, Kano K, Koizumi S,
            Iwabuchi K, Hirabayashi Y, Matsuo I, Nakashima Y, Kamiguchi H,
            Kohro Y and Tsuda M.
  TITLE     GPR55 contributes to neutrophil recruitment and mechanical pain
            induction after spinal cord compression in mice
  JOURNAL   Brain Behav Immun 110, 276-287 (2023)
   PUBMED   36898418
  REMARK    GeneRIF: GPR55 contributes to neutrophil recruitment and mechanical
            pain induction after spinal cord compression in mice.
REFERENCE   2  (bases 1 to 2550)
  AUTHORS   Rosenberg EC, Chamberland S, Bazelot M, Nebet ER, Wang X, McKenzie
            S, Jain S, Greenhill S, Wilson M, Marley N, Salah A, Bailey S,
            Patra PH, Rose R, Chenouard N, Sun SED, Jones D, Buzsaki G,
            Devinsky O, Woodhall G, Scharfman HE, Whalley BJ and Tsien RW.
  TITLE     Cannabidiol modulates excitatory-inhibitory ratio to counter
            hippocampal hyperactivity
  JOURNAL   Neuron 111 (8), 1282-1300 (2023)
   PUBMED   36787750
REFERENCE   3  (bases 1 to 2550)
  AUTHORS   McCloskey AG, Miskelly MG, Lafferty RA, Flatt PR and McKillop AM.
  TITLE     Antidiabetic actions of GPR55 agonist Abn-CBD and sitagliptin in
            obese-diabetic high fat fed mice
  JOURNAL   Biochem Pharmacol 208, 115398 (2023)
   PUBMED   36581052
  REMARK    GeneRIF: Antidiabetic actions of GPR55 agonist Abn-CBD and
            sitagliptin in obese-diabetic high fat fed mice.
REFERENCE   4  (bases 1 to 2550)
  AUTHORS   Anderson LL, Bahceci DA, Hawkins NA, Everett-Morgan D, Banister SD,
            Kearney JA and Arnold JC.
  TITLE     Heterozygous deletion of Gpr55 does not affect a
            hyperthermia-induced seizure, spontaneous seizures or survival in
            the Scn1a+/- mouse model of Dravet syndrome
  JOURNAL   PLoS One 18 (1), e0280842 (2023)
   PUBMED   36701411
  REMARK    GeneRIF: Heterozygous deletion of Gpr55 does not affect a
            hyperthermia-induced seizure, spontaneous seizures or survival in
            the Scn1a+/- mouse model of Dravet syndrome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2550)
  AUTHORS   Guillamat-Prats R, Hering D, Derle A, Rami M, Hardtner C, Santovito
            D, Rinne P, Bindila L, Hristov M, Pagano S, Vuilleumier N, Schmid
            S, Janjic A, Enard W, Weber C, Maegdefessel L, Faussner A,
            Hilgendorf I and Steffens S.
  TITLE     GPR55 in B cells limits atherosclerosis development and regulates
            plasma cell maturation
  JOURNAL   Nat Cardiovasc Res 1, 1056-1071 (2022)
   PUBMED   36523570
REFERENCE   6  (bases 1 to 2550)
  AUTHORS   Pietr M, Kozela E, Levy R, Rimmerman N, Lin YH, Stella N, Vogel Z
            and Juknat A.
  TITLE     Differential changes in GPR55 during microglial cell activation
  JOURNAL   FEBS Lett 583 (12), 2071-2076 (2009)
   PUBMED   19464294
  REMARK    GeneRIF: GPR55 might be involved in neuroinflammation and its
            expression is controlled by the state of microglial activation.
REFERENCE   7  (bases 1 to 2550)
  AUTHORS   Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva
            B, Hong HK, Chong JL, Buhr ED, Lee C, Takahashi JS, Imai S and Bass
            J.
  TITLE     Circadian clock feedback cycle through NAMPT-mediated NAD+
            biosynthesis
  JOURNAL   Science 324 (5927), 651-654 (2009)
   PUBMED   19299583
REFERENCE   8  (bases 1 to 2550)
  AUTHORS   Staton PC, Hatcher JP, Walker DJ, Morrison AD, Shapland EM, Hughes
            JP, Chong E, Mander PK, Green PJ, Billinton A, Fulleylove M,
            Lancaster HC, Smith JC, Bailey LT, Wise A, Brown AJ, Richardson JC
            and Chessell IP.
  TITLE     The putative cannabinoid receptor GPR55 plays a role in mechanical
            hyperalgesia associated with inflammatory and neuropathic pain
  JOURNAL   Pain 139 (1), 225-236 (2008)
   PUBMED   18502582
  REMARK    GeneRIF: In a model of neuropathic hypersensitivity, there is no
            mechanical hyperalgesia present in male or female GPR55-deficient
            mice at any time point up to 28 days post-ligation.
REFERENCE   9  (bases 1 to 2550)
  AUTHORS   Johns DG, Behm DJ, Walker DJ, Ao Z, Shapland EM, Daniels DA,
            Riddick M, Dowell S, Staton PC, Green P, Shabon U, Bao W, Aiyar N,
            Yue TL, Brown AJ, Morrison AD and Douglas SA.
  TITLE     The novel endocannabinoid receptor GPR55 is activated by atypical
            cannabinoids but does not mediate their vasodilator effects
  JOURNAL   Br J Pharmacol 152 (5), 825-831 (2007)
   PUBMED   17704827
REFERENCE   10 (bases 1 to 2550)
  AUTHORS   Toomey NL, Deyev VV, Wood C, Boise LH, Scott D, Liu LH, Cabral L,
            Podack ER, Barber GN and Harrington WJ Jr.
  TITLE     Induction of a TRAIL-mediated suicide program by interferon alpha
            in primary effusion lymphoma
  JOURNAL   Oncogene 20 (48), 7029-7040 (2001)
   PUBMED   11704827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY089906.1, BC115579.1, AC107707.10 and BY759107.1.
            
            [WARNING] On Jan 24, 2024 this sequence was replaced by
            NM_001033290.3.
            
            On Aug 5, 2006 this sequence version replaced NM_001033290.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146484.1, BC115578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               BY089906.1         1-282
            283-1213            BC115579.1         123-1053
            1214-1928           AC107707.10        1384-2098
            1929-2550           BY759107.1         84-705
FEATURES             Location/Qualifiers
     source          1..2550
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.94 cM"
     gene            1..2550
                     /gene="Gpr55"
                     /gene_synonym="CTFL; Gm218; Lpir1"
                     /note="G protein-coupled receptor 55"
                     /db_xref="GeneID:227326"
                     /db_xref="MGI:MGI:2685064"
     exon            1..221
                     /gene="Gpr55"
                     /gene_synonym="CTFL; Gm218; Lpir1"
                     /inference="alignment:Splign:2.1.0"
     exon            222..2550
                     /gene="Gpr55"
                     /gene_synonym="CTFL; Gm218; Lpir1"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1213
                     /gene="Gpr55"
                     /gene_synonym="CTFL; Gm218; Lpir1"
                     /codon_start=1
                     /product="G-protein coupled receptor 55"
                     /protein_id="NP_001028462.2"
                     /db_xref="CCDS:CCDS15115.1"
                     /db_xref="GeneID:227326"
                     /db_xref="MGI:MGI:2685064"
                     /translation="MSQPERDNCSFDSVDKLTRTLQLAVHIPTFLLGLVLNLLAIRGF
                     SAFLKKRKLDYIATSIYMINLAVFDLLLVLSLPFKMVLPQVESPLPSFCTLVECLYFI
                     SMYGSVFTICFISLDRFLAIQYPILASHLRSPRKTFGICCIIWMLVWIGSIPIYTFHR
                     EVERYKCFHNMSDVTWSASVFFPLEIFGFLLPMGIMGFCSYRSIHILLRRPDSTEDWV
                     QQRDTKGWVQKRACIWTIATNLVIFVVSFLPVHLGFFLQYLVRNRFILDCRMKQGISL
                     FLQLSLCFSNINCCLDVFCYYFVIKEFRMRIKAHRPSTIKLVNQDTMVSRG"
ORIGIN      
        1 tttgctctct gtaagccgct catgtgactg ctctcaaggt ggccaggcat cttcagtctc
       61 cgttggtgga gaatgtggtc cacctagagg gcaggaaagg ggacttctct tggagacttc
      121 aaggctggga ctcattggta ctcctaagct gtctgaccac tcatgggaac catctgggct
      181 tggggacaga agtgtgacca aatctgggat ttggagcaga ggcacgaaca tgagccagcc
      241 agagcgtgac aactgctcat tcgattccgt ggataagctt accagaacct tgcagctggc
      301 agtccatatc cccaccttcc tccttggcct ggttctcaac ctactggcca tccgaggctt
      361 cagtgccttc ctaaagaaga ggaagctgga ctatatcgcc acttctatct acatgatcaa
      421 cttggctgtt ttcgatttac tgctggtgct ctccctccca ttcaagatgg tcctgccaca
      481 agtggagtcc cccttgccgt ccttctgcac tctggtggag tgcctctact tcatcagcat
      541 gtatgggagt gtcttcacca tctgcttcat cagcctggac aggttcctgg ccatccagta
      601 cccgatcctg gctagccatc tccggtcgcc caggaagacc tttgggatct gctgcatcat
      661 ctggatgctg gtctggatcg gaagcatccc catctacacc ttccacaggg aagtggagag
      721 atacaagtgc tttcacaaca tgtcggatgt cacctggagt gccagtgtct tcttccccct
      781 ggagatcttt ggcttcctcc ttcccatggg catcatgggc ttctgttcct ataggagtat
      841 tcacatcctg ctgcgccgtc cagacagcac tgaggactgg gtccaacaga gagacactaa
      901 gggctgggta caaaagagag cctgcatctg gaccattgct accaatcttg tcatctttgt
      961 ggtctccttt ctcccagtgc acttgggctt cttcctgcag tatctggtga ggaaccgctt
     1021 tatcttggac tgcagaatga agcagggcat cagcttgttc ctgcagttgt ctctgtgttt
     1081 ctccaacatc aactgctgcc ttgatgtttt ttgctactac tttgtcatca aagaatttcg
     1141 catgcgcatc aaggcccacc ggccctccac aatcaagctg gtcaaccagg ataccatggt
     1201 ctccaggggc taagagaagg tacctctctc aagggaagga aaacacagtc ctaaattctc
     1261 ataaagaccc tcctgggctt ggcttggctt ttgacactcg ctgagtacca tctctgttct
     1321 ttatactcct acaacctttt cacatcacct ggatgggtga cagatgtcac acttgttttg
     1381 agtttggtaa agaaccaggt gaattcttca tttctaagtc taaaatgtat gaagcagaag
     1441 aaccaaaaac aaacaaacaa acaaacaaaa cccaaaacgt agcttgaaaa gtctgtatct
     1501 cagctttccc atctttccat tctgttggag agtctagaaa ggaagcgaaa gggcagggaa
     1561 tttagagtgg ttttgtggtg attcagggct agggaagaaa tatgtcttca agatggagca
     1621 agcttgtact atttttccag tctcttctga agctctcttg gcgattacct cacagaaatg
     1681 aggacaaaga gggcttttta agggctgaga aggattaggt ggagggaggg gggctgtgtg
     1741 aagcaggttg tgtggaaaca ggagacatga cagagccaat ggggacacag tggaaagggg
     1801 cagagtagca agggagtaaa gtataccccg ggaaggaaag agacatgcta gagttggaac
     1861 tggtgccccc tctcctattg ccatctggta gcgatgctgt cccaggacta agcaagattt
     1921 agcctaaaaa gagagctctt ttgaaggtgg ccagccttct gacttggaca gcctaggaag
     1981 gagtgcatta caccagtatg aaggggatga ggaagagctg gtcttcactt ggttcagctc
     2041 aacggtaaca gaatgaagtt gtccttattg tgcctggttg ggtgactcta tctaagaagc
     2101 tggccaggga ttgggggctg ggaaaggcta tcttcaccaa gcagcacaaa ggtctgcatt
     2161 tgaggaaggt ggtagggcct caccagttcc tggagggaaa tggcagacag ctgaaccagc
     2221 gtgggaacct tcatcggctc ctctggctca ggagaaggag ctcccagcga cagctgaaag
     2281 cctcactctc catggctcag ccgtaggaga gagtaaaata attagaagga taaattgtgg
     2341 ggtgtttttg caagacggaa ggagtgggac aggaagaatc ccaggagact tcgtgtgctt
     2401 taggaagaaa agctaactag gtagaatatc cagggtcaga ggccaggggt gggatgagca
     2461 catggggagg ggcaggggaa gatggaactg tagctagaat ctgggagctg tccacagagc
     2521 agaagatgga ggtgtggcaa gatgtagggg
//
